stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Beeharry N et al. | Fatty acid protection from palmitic acid-induced apoptosis is lost following PI3-kinase inhibition. | 2004 | Apoptosis | pmid:15314288 |
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Wilson CD and Roscoe SG | Electrochemical quartz crystal nanobalance study of the adsorption/displacement phenomena of proteins and lipids on Pt. | 2004 | Langmuir | pmid:15323501 |
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WAYNE EJ et al. | The use of procaine penicillin with aluminium monostearate in adults. | 1949 | Br Med J | pmid:15407914 |
SPINK JA | Structure of stearic acid films on copper. | 1950 | Nature | pmid:15416726 |
KAGAN BM et al. | Studies of penicillin in pediatrics; III. Procaine penicillin G in sesame oil, in peanut oil with 2% aluminum monostearate and in water with sodium carboxymethylcellulose. | 1950 | Pediatrics | pmid:15417267 |
Lagrost L | Differential effects of cis and trans fatty acid isomers, oleic and elaidic acids, on the cholesteryl ester transfer protein activity. | 1992 | Biochim. Biophys. Acta | pmid:1543738 |
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Ye YQ et al. | [Preparation and characterization of stearic acid-grafted chitosan oligosaccharide polymeric micelles]. | 2004 | Yao Xue Xue Bao | pmid:15491108 |
Geng J et al. | Direct conversion of iron stearate into magnetic Fe and Fe3C nanocrystals encapsulated in polyhedral graphite cages. | 2004 | Chem. Commun. (Camb.) | pmid:15514806 |
Kondo S et al. | Mechanochemical solid-state polymerization (XI): effect of water-insoluble pharmaceutical aids on drug release from mechanically synthesized polymeric prodrugs. | 2004 | Chem. Pharm. Bull. | pmid:15516750 |
von Orelli J and Leuenberger H | Search for technological reasons to develop a capsule or a tablet formulation with respect to wettability and dissolution. | 2004 | Int J Pharm | pmid:15541920 |
Budai M et al. | Effect of UVA radiation on membrane fluidity and radical decay in human fibroblasts as detected by spin labeled stearic acids. | 2004 | J. Photochem. Photobiol. B, Biol. | pmid:15542359 |
Riché EL et al. | Novel long-circulating liposomes containing peptide library-lipid conjugates: synthesis and in vivo behavior. | 2004 | J Drug Target | pmid:15545085 |
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Cury-Boaventura MF and Curi R | Regulation of reactive oxygen species (ROS) production by C18 fatty acids in Jurkat and Raji cells. | 2005 | Clin. Sci. | pmid:15563273 |
van Veen B et al. | Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) microcrystalline cellulose. | 2005 | Eur J Pharm Biopharm | pmid:15567310 |
Lee WN et al. | Metabolic sensitivity of pancreatic tumour cell apoptosis to glycogen phosphorylase inhibitor treatment. | 2004 | Br. J. Cancer | pmid:15599384 |
Strzalka J et al. | Resonant x-ray reflectivity from a bromine-labeled fatty acid Langmuir monolayer. | 2004 | Phys Rev E Stat Nonlin Soft Matter Phys | pmid:15600624 |
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Hirasawa A et al. | Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. | 2005 | Nat. Med. | pmid:15619630 |
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Nkondjock A et al. | Specific fatty acid intake and the risk of pancreatic cancer in Canada. | 2005 | Br. J. Cancer | pmid:15685231 |
Zock PL and Katan MB | Hydrogenation alternatives: effects of trans fatty acids and stearic acid versus linoleic acid on serum lipids and lipoproteins in humans. | 1992 | J. Lipid Res. | pmid:1569387 |
Matsui T et al. | Effect of fatty oil dispersion on oil-containing wastewater treatment. | 2005 | J. Hazard. Mater. | pmid:15721552 |
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Fichtner F et al. | Particle size distribution and evolution in tablet structure during and after compaction. | 2005 | Int J Pharm | pmid:15725568 |
Arai T and Hosoi Y | [Determination of magnesium stearate in pharmaceutical preparations using derivatization with 2-nitrophenylhydrazine and HPLC]. | 2005 | Yakugaku Zasshi | pmid:15738629 |
Petrescu AD et al. | Role of regulatory F-domain in hepatocyte nuclear factor-4alpha ligand specificity. | 2005 | J. Biol. Chem. | pmid:15741159 |
Desbrosses GG et al. | Lotus japonicus metabolic profiling. Development of gas chromatography-mass spectrometry resources for the study of plant-microbe interactions. | 2005 | Plant Physiol. | pmid:15749991 |