stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yamamoto K et al. | Effect of Magnesium Stearate Mono- and Dihydrate Dispersibilities on Physical Properties of Tablets. | 2017 | Chem. Pharm. Bull. | pmid:29093289 |
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Van Rafelghem MJ and Andersen ME | The effects of perfluorodecanoic acid on hepatic stearoyl-coenzyme A desaturase and mixed function oxidase activities in rats. | 1988 | Fundam Appl Toxicol | pmid:2906022 |
Jones RE and Plymate SR | Evidence for the regulation of fatty acid utilization in human sperm by docosahexaenoic acid. | 1988 | Biol. Reprod. | pmid:2905175 |
Beg S et al. | QbD-driven development and evaluation of nanostructured lipid carriers (NLCs) of Olmesartan medoxomil employing multivariate statistical techniques. | 2018 | Drug Dev Ind Pharm | pmid:29048242 |
Soliman HM et al. | Synthesis and Application of a New Amphiphilic Antioxidant. | 2017 | J Oleo Sci | pmid:29021490 |
Avila P et al. | Which salt of erythromycin is most hepatotoxic? | 1988 | Lancet | pmid:2896928 |
Liu W and Lu G | Partial Hydrogenation of Sunflower Oil-derived FAMEs Catalyzed by the Efficient and Recyclable Palladium Nanoparticles in Polyethylene Glycol. | 2017 | J Oleo Sci | pmid:28924078 |
Zara GP et al. | Erythromycin and gastrointestinal motility. | 1987 | Lancet | pmid:2889954 |
Spigoni V et al. | Stearic acid at physiologic concentrations induces in vitro lipotoxicity in circulating angiogenic cells. | 2017 | Atherosclerosis | pmid:28892713 |
Kondo H et al. | Effect of the External Lubrication Method for a Rotary Tablet Press on the Adhesion of the Film Coating Layer. | 2017 | Chem. Pharm. Bull. | pmid:28867712 |
Bergquist SO et al. | Erythromycin in the treatment of pertussis: a study of bacteriologic and clinical effects. | 1987 | Pediatr. Infect. Dis. J. | pmid:2885802 |
Hattori T et al. | Membrane phospholipid composition and membrane fluidity of human brain tumour: a spin label study. | 1987 | Neurol. Res. | pmid:2883605 |
Nakanishi H et al. | Comparative studies on additive effects of sodium dodecylbenzensulfonate and sodium stearate on uptake of chemicals by willow shiner (Gnathopogon caerulescens). | 1987 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:2882933 |
Fatemi SH et al. | The glycophospholipid anchor of Thy-1. Biosynthetic labeling experiments with wild-type and class E Thy-1 negative lymphomas. | 1987 | J. Biol. Chem. | pmid:2881925 |
Gotoh K et al. | Effects of unsaturated fatty acids on the peroxisomal enzyme activities of Tetrahymena pyriformis. | 1986 | J. Biochem. | pmid:2880840 |
Xue J et al. | A novel and organic solvent-free preparation of solid lipid nanoparticles using natural biopolymers as emulsifier and stabilizer. | 2017 | Int J Pharm | pmid:28802794 |
Lapham DP and Lapham JL | Gas adsorption on commercial magnesium stearate: Effects of degassing conditions on nitrogen BET surface area and isotherm characteristics. | 2017 | Int J Pharm | pmid:28779986 |
Shiino K et al. | Melt Adsorption as a Manufacturing Method for Fine Particles of Wax Matrices without Any Agglomerates. | 2017 | Chem. Pharm. Bull. | pmid:28768926 |
Catalá A | Stearic acid desaturation in rat liver microsomes: stimulation by fatty acid binding protein. | 1986 | Acta Physiol Pharmacol Latinoam | pmid:2876583 |
Giudici TA et al. | Methylmalonic and propionic acidemias: lipid profiles of normal and affected human skin fibroblasts incubated with [1-14C]propionate. | 1986 | Biochem. Med. Metab. Biol. | pmid:2872907 |
Nagy B et al. | In-line Raman spectroscopic monitoring and feedback control of a continuous twin-screw pharmaceutical powder blending and tableting process. | 2017 | Int J Pharm | pmid:28723408 |
Hattori T et al. | Attenuation by pentobarbital of free fatty acid and diacylglycerol liberation during global ischaemia in rat brain. | 1986 | Neurol. Res. | pmid:2871507 |
Meng Y et al. | Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28712865 |
Thiel WJ and Sberna FJ | Fluidized bed film coating of an interactive powder mixture to produce microencapsulated 2-5 microns particles. | 1986 | J. Pharm. Pharmacol. | pmid:2871149 |
Tabachnick M and Korcek L | Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. | 1986 | Biochim. Biophys. Acta | pmid:2869786 |
Johansson ME and Nicklasson M | Investigation of the film formation of magnesium stearate by applying a flow-through dissolution technique. | 1986 | J. Pharm. Pharmacol. | pmid:2869127 |
Siegel I et al. | Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. | 1986 | Fertil. Steril. | pmid:2868925 |
Ivanova EP et al. | Bactericidal activity of self-assembled palmitic and stearic fatty acid crystals on highly ordered pyrolytic graphite. | 2017 | Acta Biomater | pmid:28688988 |
Prasinou P et al. | Fatty acid-based lipidomics and membrane remodeling induced by apoE3 and apoE4 in human neuroblastoma cells. | 2017 | Biochim Biophys Acta Biomembr | pmid:28688796 |
Staniforth JN | Relationship between particle packing and the physical stability of powder mixes. | 1985 | J. Pharm. Pharmacol. | pmid:2867136 |
Johansson ME | Influence of the granulation technique and starting material properties on the lubricating effect of granular magnesium stearate. | 1985 | J. Pharm. Pharmacol. | pmid:2867134 |
Crutchley DJ | Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2865954 |
Tse AG et al. | A glycophospholipid tail at the carboxyl terminus of the Thy-1 glycoprotein of neurons and thymocytes. | 1985 | Science | pmid:2865810 |
Oki E et al. | Polymorphisms of the TNF-α gene interact with plasma fatty acids on inflammatory biomarker profile: a population-based, cross-sectional study in São Paulo, Brazil. | 2017 | Br. J. Nutr. | pmid:28633686 |
Naing C and Whittaker MA | Anabolic steroids for treating pressure ulcers. | 2017 | Cochrane Database Syst Rev | pmid:28631809 |
Bangudu AB and Pilpel N | Effects of composition, moisture and stearic acid on the plasto-elasticity and tableting of paracetamol-microcrystalline cellulose mixtures. | 1985 | J. Pharm. Pharmacol. | pmid:2862234 |
Zoeller RA and Wood R | The importance of the stearoyl-CoA desaturase system in octadecenoate metabolism in the Morris hepatoma 7288C. | 1985 | Biochim. Biophys. Acta | pmid:2860925 |
Esezobo S | The effect of some excipients on the physical properties of a paracetamol tablet formulation. | 1985 | J. Pharm. Pharmacol. | pmid:2858567 |
Ragnarsson G and Sjögren J | Force-displacement measurements in tableting. | 1985 | J. Pharm. Pharmacol. | pmid:2858558 |
Wang XH et al. | High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2. | 2017 | Front Pharmacol | pmid:28555106 |
Wang Y et al. | Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue. | 2017 | Biochim. Biophys. Acta | pmid:28526351 |
Cosenza G et al. | A novel polymorphism in the oxytocin receptor encoding gene (OXTR) affects milk fatty acid composition in Italian Mediterranean river buffalo. | 2017 | J. Dairy Res. | pmid:28524009 |
Soni K et al. | Lipid drug conjugate nanoparticle as a potential nanocarrier for the oral delivery of pemetrexed diacid: Formulation design, characterization, ex vivo, and in vivo assessment. | 2017 | Int. J. Biol. Macromol. | pmid:28499946 |
Chitprasert P and Ngamekaue N | Stability Enhancement of Ocimum Sanctum Linn. Essential Oils Using Stearic Acid in Aluminum Carboxymethyl Cellulose Film-Coated Gelatin Microcapsules. | 2017 | J. Food Sci. | pmid:28494101 |
Hoeg JM et al. | Apolipoprotein B synthesized by Hep G2 cells undergoes fatty acid acylation. | 1988 | J. Lipid Res. | pmid:2846736 |
Chang C et al. | pH-responsive nanoparticle assembly from peptide amphiphiles for tumor targeting drug delivery. | 2017 | J Biomater Sci Polym Ed | pmid:28467173 |
Shilpi D et al. | Improved Stability and Enhanced Oral Bioavailability of Atorvastatin Loaded Stearic Acid Modified Gelatin Nanoparticles. | 2017 | Pharm. Res. | pmid:28466393 |
Lakhssassi N et al. | Stearoyl-Acyl Carrier Protein Desaturase Mutations Uncover an Impact of Stearic Acid in Leaf and Nodule Structure. | 2017 | Plant Physiol. | pmid:28461402 |
Hara A et al. | Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs. | 2017 | Biochem. Pharmacol. | pmid:28450226 |