stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Staiger H et al. | Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro. | 2005 | Diabetologia | pmid:16132959 |
Parra-Barraza H et al. | Chitosan-cholesterol and chitosan-stearic acid interactions at the air-water interface. | 2005 Sep-Oct | Biomacromolecules | pmid:16153076 |
Gelders GG et al. | Potato phosphorylase catalyzed synthesis of amylose-lipid complexes. | 2005 Sep-Oct | Biomacromolecules | pmid:16153100 |
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Thijssen MA and Mensink RP | Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. | 2005 | Am. J. Clin. Nutr. | pmid:16155261 |
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Kiuru PS and Wähälä K | Microwave-assisted synthesis of deuterium labeled estrogen fatty acid esters. | 2006 | Steroids | pmid:16198386 |
Vueba ML et al. | Role of cellulose ether polymers on ibuprofen release from matrix tablets. | 2005 | Drug Dev Ind Pharm | pmid:16207613 |
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Zeman M et al. | N-3 fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination. | 2006 | J. Nutr. Biochem. | pmid:16214329 |
Terán M et al. | Hydrophilic and lipophilic radiopharmaceuticals as tracers in pharmaceutical development: in vitro--in vivo studies. | 2005 | BMC Nucl Med | pmid:16232323 |
Nohynek GJ et al. | Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing age. | 2006 | Toxicol. Lett. | pmid:16243460 |
Lee J | Intrinsic adhesion properties of poly(vinyl pyrrolidone) to pharmaceutical materials: humidity effect. | 2005 | Macromol Biosci | pmid:16245267 |
Bajaj M et al. | Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients. | 2005 | Diabetes | pmid:16249438 |
Choi HJ et al. | Structure and thermal behavior of a layered silver hydroxyalkanecarboxylate. | 2003 | J Colloid Interface Sci | pmid:16256665 |
Lad MD et al. | Protein-lipid interactions at the air/water interface. | 2005 | Phys Chem Chem Phys | pmid:16273149 |
Chiang EP et al. | Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. | 2005 | Arthritis Res. Ther. | pmid:16277693 |
Segre N et al. | Surface characterization of recycled tire rubber to be used in cement paste matrix. | 2002 | J Colloid Interface Sci | pmid:16290558 |
Garcia Marquez MA et al. | [The effect of two lubricants (magnesium stearate and pruv) in the formation of tablets of four anti-ulcer agents/ by means of direct compression]. | 1992 | Pharm Acta Helv | pmid:1631172 |
Jahn T and Steffens KJ | Press chamber coating as external lubrication for high speed rotary presses: lubricant spray rate optimization. | 2005 | Drug Dev Ind Pharm | pmid:16316850 |
Thijssen MA et al. | Stearic, oleic, and linoleic acids have comparable effects on markers of thrombotic tendency in healthy human subjects. | 2005 | J. Nutr. | pmid:16317124 |
Mayer KM et al. | Linking enzyme sequence to function using Conserved Property Difference Locator to identify and annotate positions likely to control specific functionality. | 2005 | BMC Bioinformatics | pmid:16318626 |
Garton NJ and Sutcliffe IC | Identification of a lipoarabinomannan-like lipoglycan in the actinomycete Gordonia bronchialis. | 2006 | Arch. Microbiol. | pmid:16320036 |
Fukami J et al. | Development of fast disintegrating compressed tablets using amino acid as disintegration accelerator: evaluation of wetting and disintegration of tablet on the basis of surface free energy. | 2005 | Chem. Pharm. Bull. | pmid:16327184 |
Bonanome A et al. | Metabolic effects of dietary stearic acid in mice: changes in the fatty acid composition of triglycerides and phospholipids in various tissues. | 1992 | Atherosclerosis | pmid:1632865 |
Wang L et al. | [Synthesis, characterization and evaluation of octadecyl ester-bonded monolithic column]. | 2005 | Se Pu | pmid:16350795 |
Tatavarti AS et al. | Assessment of NIR spectroscopy for nondestructive analysis of physical and chemical attributes of sulfamethazine bolus dosage forms. | 2005 | AAPS PharmSciTech | pmid:16353969 |
Soares LA et al. | Dry granulation and compression of spray-dried plant extracts. | 2005 | AAPS PharmSciTech | pmid:16353993 |
Navaneethan CV et al. | Application of powder rheometer to determine powder flow properties and lubrication efficiency of pharmaceutical particulate systems. | 2005 | AAPS PharmSciTech | pmid:16353997 |
Pérez-Vich B et al. | Molecular analysis of the high stearic acid content in sunflower mutant CAS-14. | 2006 | Theor. Appl. Genet. | pmid:16362273 |
Wurster DE et al. | The influence of magnesium stearate on the Hiestand Tableting Indices and other related mechanical properties of maltodextrins. | 2005 | Pharm Dev Technol | pmid:16370175 |
Wyttenbach N et al. | Drug-excipient compatibility testing using a high-throughput approach and statistical design. | 2005 | Pharm Dev Technol | pmid:16370179 |
Pirozhkov SV et al. | Effect of chronic consumption of ethanol and vitamin E on fatty acid composition and lipid peroxidation in rat heart tissue. | 1992 Jul-Aug | Alcohol | pmid:1637499 |
Demirbas A et al. | Adsorption thermodynamics of stearic acid onto bentonite. | 2006 | J. Hazard. Mater. | pmid:16386845 |
Ding EL et al. | Chocolate and prevention of cardiovascular disease: a systematic review. | 2006 | Nutr Metab (Lond) | pmid:16390538 |
Douliez JP et al. | Self-assembly of fatty acid-alkylboladiamine salts. | 2006 | Langmuir | pmid:16401110 |