stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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KladnÃcková I et al. | Release of albumin from oligoester plastic matrices: effect of magnesium oxide and bivalent stearates. | 2006 Jan-Feb | Drug Deliv | pmid:16401590 |
Suresh Y and Das UN | Differential effect of saturated, monounsaturated, and polyunsaturated fatty acids on alloxan-induced diabetes mellitus. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16412622 |
Hackl H et al. | Molecular processes during fat cell development revealed by gene expression profiling and functional annotation. | 2005 | Genome Biol. | pmid:16420668 |
Ehling S et al. | Formation of acrylamide from lipids. | 2005 | Adv. Exp. Med. Biol. | pmid:16438301 |
Polat M | Kinetic estimation of the adsorbate distribution on the surface from adsorbed amounts. | 2006 | J Colloid Interface Sci | pmid:16445933 |
Wang ZJ et al. | Neuroprotective effect of the stearic acid against oxidative stress via phosphatidylinositol 3-kinase pathway. | 2006 | Chem. Biol. Interact. | pmid:16448636 |
Templer J et al. | Influence of C18 long chain fatty acids on hydrogen metabolism. | 2006 Jan-Feb | Biotechnol. Prog. | pmid:16454511 |
Squier TC et al. | Resolution of phospholipid conformational heterogeneity in model membranes by spin-label EPR and frequency-domain fluorescence spectroscopy. | 1991 | Biophys. J. | pmid:1646658 |
Swaminathan V et al. | Measurement of the surface energy of lubricated pharmaceutical powders by inverse gas chromatography. | 2006 | Int J Pharm | pmid:16469458 |
Barman S and Vasudevan S | Contrasting melting behavior of zinc stearate and zinc oleate. | 2006 | J Phys Chem B | pmid:16471580 |
Fang Q et al. | Ascorbyl stearate inhibits cell proliferation and tumor growth in human ovarian carcinoma cells by targeting the PI3K/AKT pathway. | 2006 Jan-Feb | Anticancer Res. | pmid:16475700 |
Sampath H and Ntambi JM | The fate and intermediary metabolism of stearic acid. | 2005 | Lipids | pmid:16477801 |
Kris-Etherton PM et al. | Dietary stearic acid and risk of cardiovascular disease: intake, sources, digestion, and absorption. | 2005 | Lipids | pmid:16477802 |
Mensink RP | Effects of stearic acid on plasma lipid and lipoproteins in humans. | 2005 | Lipids | pmid:16477803 |
Sanders TA and Berry SE | Influence of stearic acid on postprandial lipemia and hemostatic function. | 2005 | Lipids | pmid:16477806 |
Tholstrup T | Influence of stearic acid on hemostatic risk factors in humans. | 2005 | Lipids | pmid:16477807 |
Streichman S et al. | EPR study of the hydrophobic interaction of spectrin with fatty acids. | 1991 | Biochim. Biophys. Acta | pmid:1648396 |
Wei Y et al. | Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16492686 |
Mirmehrabi M et al. | Thermodynamic modeling of activity coefficient and prediction of solubility: Part 2. Semipredictive or semiempirical models. | 2006 | J Pharm Sci | pmid:16493593 |
Mirmehrabi M et al. | Thermodynamic modeling of activity coefficient and prediction of solubility: Part 1. Predictive models. | 2006 | J Pharm Sci | pmid:16493594 |
Mahomed K et al. | Erythrocyte omega-3, omega-6 and trans fatty acids in relation to risk of preeclampsia among women delivering at Harare Maternity Hospital, Zimbabwe. | 2007 | Physiol Res | pmid:16497090 |
Shen Q et al. | Modulation of intestinal P-glycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies. | 2006 | Int J Pharm | pmid:16500056 |
Irita K et al. | Substitution by fatty acids for phosphatidylserine in a reconstitution of phorbol ester binding to protein kinase C. | 1991 | Int. J. Biochem. | pmid:1650723 |
Fukuda S et al. | Augmentation of vaccenate production and suppression of vaccenate biohydrogenation in cultures of mixed ruminal microbes. | 2006 | J. Dairy Sci. | pmid:16507700 |
Alves M and Peric M | An EPR study of the interfacial properties of phosphatidylcholine vesicles with different lipid chain lengths. | 2006 | Biophys. Chem. | pmid:16517048 |
Matsumoto K et al. | Electron paramagnetic resonance decay constant and oxidative stresses in liver microsomes of the selenium-deficient rat. | 2006 | J. Nutr. Biochem. | pmid:16517143 |
Brouwer DH et al. | Size selective dustiness and exposure; simulated workplace comparisons. | 2006 | Ann Occup Hyg | pmid:16524926 |
Serebryakova MV et al. | Mass spectrometric sequencing and acylation character analysis of C-terminal anchoring segment from Influenza A hemagglutinin. | 2006 | Eur J Mass Spectrom (Chichester) | pmid:16531651 |
Townsend WE et al. | Effect of level of endophyte infection, nitrogen fertilization rate, grazing period, and paddock exchange on some chemical properties of four bovine tissues. | 1991 | J. Anim. Sci. | pmid:1653201 |
Hasegawa T et al. | Molecular orientation analysis of a single-monolayer Langmuir-Blodgett film on a thin glass plate by infrared multiple-angle incidence resolution spectrometry. | 2006 | Anal. Chem. | pmid:16536405 |
Biswas S et al. | Formation of complex films with water-soluble CTAB molecules. | 2006 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:16549387 |
Qi S et al. | An investigation into the interaction between taste masking fatty acid microspheres and alkaline buffer using thermal and spectroscopic analysis. | 2006 | J Pharm Sci | pmid:16552746 |
Best CA et al. | Method to assess fatty acid ethyl ester binding to albumin. | Alcohol Alcohol. | pmid:16554377 | |
Wang Y and Wu W | In situ evading of phagocytic uptake of stealth solid lipid nanoparticles by mouse peritoneal macrophages. | 2006 May-Jun | Drug Deliv | pmid:16556570 |
Nazzal S and Khan MA | Controlled release of a self-emulsifying formulation from a tablet dosage form: stability assessment and optimization of some processing parameters. | 2006 | Int J Pharm | pmid:16563673 |
Renaville B et al. | Eicosapentaenoic acid and 3,10 dithia stearic acid inhibit the desaturation of trans-vaccenic acid into cis-9, trans-11-conjugated linoleic acid through different pathways in Caco-2 and T84 cells. | 2006 | Br. J. Nutr. | pmid:16571147 |
Ulmann L et al. | Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. | 1991 | Biochim. Biophys. Acta | pmid:1657182 |
Zhu K et al. | Two aerobic pathways for the formation of unsaturated fatty acids in Pseudomonas aeruginosa. | 2006 | Mol. Microbiol. | pmid:16573679 |
Mora PC et al. | Differential scanning calorimetry as a screening technique in compatibility studies of DHEA extended release formulations. | 2006 | J Pharm Biomed Anal | pmid:16574368 |
iHoroz BB et al. | Influence of aluminum tristearate and sucrose stearate as the dispersing agents on physical properties and release characteristics of eudragit RS microspheres. | 2006 | AAPS PharmSciTech | pmid:16584146 |
Xu L et al. | A new triterpene and dibenzocyclooctadiene lignans from Schisandra propinqua (WALL.) BAILL. | 2006 | Chem. Pharm. Bull. | pmid:16595961 |
Hu FQ et al. | Novel self-aggregates of chitosan oligosaccharide grafted stearic acid: preparation, characterization and protein association. | 2006 | Pharmazie | pmid:16599258 |
Killen BU and Corrigan OI | Effect of soluble filler on drug release from stearic acid based compacts. | 2006 | Int J Pharm | pmid:16600537 |
Okazaki K et al. | The significance of C16 fatty acids in the sn-2 positions of glycerolipids in the photosynthetic growth of Synechocystis sp. PCC6803. | 2006 | Plant Physiol. | pmid:16603667 |
Wang Y et al. | Chain orientation and headgroup structure in Langmuir monolayers of stearic acid and metal stearate (Ag, Co, Zn, and Pb) studied by infrared reflection-absorption spectroscopy. | 2006 | J Chem Phys | pmid:16613467 |
Schmidt WF et al. | Stearic acid solubility and cubic phase volume. | 2006 | Chem. Phys. Lipids | pmid:16616908 |
Zornetzer GA et al. | Solution structures of spinach acyl carrier protein with decanoate and stearate. | 2006 | Biochemistry | pmid:16618110 |
Khairuzzaman A et al. | Zero-order release of aspirin, theophylline and atenolol in water from novel methylcellulose glutarate matrix tablets. | 2006 | Int J Pharm | pmid:16621361 |
Wang Y et al. | Chronic effects of different non-esterified fatty acids on pancreatic islets of rats. | 2006 | Endocrine | pmid:16622307 |
Isaac G et al. | Sulfatide with short fatty acid dominates in astrocytes and neurons. | 2006 | FEBS J. | pmid:16623713 |