stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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Summers LK et al. | Use of structured triacylglycerols containing predominantly stearic and oleic acids to probe early events in metabolic processing of dietary fat. | 1999 | J. Lipid Res. | pmid:10508209 |
Vargas CI and Ghaly ES | Kinetic release of theophylline from hydrophilic swellable matrices. | 1999 | Drug Dev Ind Pharm | pmid:10518245 |
Chajès V et al. | Fatty-acid composition in serum phospholipids and risk of breast cancer: an incident case-control study in Sweden. | 1999 | Int. J. Cancer | pmid:10521790 |
Xiao Y and Li X | Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation. | 1999 | Brain Res. | pmid:10536218 |
Mano T et al. | Proton MR spectroscopy of Sjögren-Larsson's syndrome. | 1999 | AJNR Am J Neuroradiol | pmid:10543638 |
Kumar VB et al. | Changes in membrane fatty acids and delta-9 desaturase in senescence accelerated (SAMP8) mouse hippocampus with aging. | 1999 | Life Sci. | pmid:10573183 |
Bretillon L et al. | Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro. | 1999 | Lipids | pmid:10574661 |
Dürig T et al. | An investigation into the erosion behaviour of a high drug-load (85%) particulate system designed for an extended-release matrix tablet. Analysis of erosion kinetics in conjunction with variations in lubrication, porosity and compaction rate. | 1999 | J. Pharm. Pharmacol. | pmid:10579678 |
Kikuchi K et al. | Fatty acid composition of choline and ethanolamine glycerophospholipid subclasses in heart tissue of mammals and migratory and demersal fish. | 1999 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:10582315 |
Connor WE | Harbingers of coronary heart disease: dietary saturated fatty acids and cholesterol. Is chocolate benign because of its stearic acid content? | 1999 | Am. J. Clin. Nutr. | pmid:10584037 |