stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with stearic acid?
Related references are published most in these journals:
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What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vilim A et al. | A simple thin-layer chromatographic identification procedure for erythromycin base, stearate, estolate and ethylsuccinate. | 1977 | J. Chromatogr. | pmid:838805 |
| Burns CP et al. | Fatty acid utilization by L1210 murine leukemia cells. | 1977 | Cancer Res. | pmid:558821 |
| Roguinsky M and Serieys F | [Treatment of mastitis in dry cows: treatment of all cows vs treatment of infected cows only (author's transl)]. | 1977 | Ann. Rech. Vet. | pmid:606146 |
| Sun GY | Metabolism of arachidonate and stearate injected simultaneously into the mouse brain. | 1977 | Lipids | pmid:895416 |
| Murthy KS and Samyn JC | Effect of shear mixing on in vitro drug release of capsule formulations containing lubricants. | 1977 | J Pharm Sci | pmid:903855 |
| Yamashita T and Tsubura E | [Influence of meal on the plasma concentration of patients received repeated administration of OE-7, erythromycin stearate capsules (author's transl)]. | 1977 | Jpn J Antibiot | pmid:909141 |
| Galpin JR and Allen JC | The influence of micelle formation on lipoxygenase kinetics. | 1977 | Biochim. Biophys. Acta | pmid:409436 |
| Bolton P and Harwood JL | Some characteristics of soluble fatty acid synthesis in germinating pea seeds. | 1977 | Biochim. Biophys. Acta | pmid:20971 |
| Rowe RC | The adhesion of film coatings to tablet surfaces--the effect of some direct compression excipients and lubricants. | 1977 | J. Pharm. Pharmacol. | pmid:22617 |
| Sixsmith D | The properties of tablets containing microcrystalline cellulose. | 1977 | J. Pharm. Pharmacol. | pmid:15069 |
| Newton JM and Razzo FN | The in vitro bioavailability of various drugs formulated as hard gelatin capsules. | 1977 | J. Pharm. Pharmacol. | pmid:17668 |
| Newton JM and Razzo FN | The influence of additives on the presentation of a drug in hard gelatin capsules. | 1977 | J. Pharm. Pharmacol. | pmid:17694 |
| Donaldson RP and Beevers H | Lipid composition of organelles from germinating castor bean endosperm. | 1977 | Plant Physiol. | pmid:16659829 |
| Uyesaka N | Lanthanum and some other cation-induced changes in fluidity of synaptosomal membrane studied with nitroxide stearate spin labels. J. Membrane Biol. 27:283. | 1977 | J. Membr. Biol. | pmid:190405 |
| Paavolainen M et al. | Penetration of erythromycin stearate into maxillary sinus mucosa and secretion in chronic maxillary sinusitis. | 1977 Sep-Oct | Acta Otolaryngol. | pmid:199040 |
| Shepherd J et al. | Effects of dietary polyunsaturated and saturated fat on the properties of high density lipoproteins and the metabolism of apolipoprotein A-I. | 1978 | J. Clin. Invest. | pmid:207739 |
| Hellgren L and Vincent J | Erythromycin stearate in acne vulgaris: its effect on the skin surface lipids and on the activity of purified pancreatic lipase. | 1978 | Dermatologica | pmid:145975 |
| Mäntylä R et al. | Bioavailability and effect of food on the gastrointestinal absorption of two erythromycin derivatives. | 1978 | Ann. Clin. Res. | pmid:367255 |
| Yang YT et al. | Dietary lipid metabolism in lactating dairy cows. | 1978 | J. Dairy Sci. | pmid:568635 |
| Iranloye TA and Parrott EL | Effects of compression force, particle size, and lubricants on dissolution rate. | 1978 | J Pharm Sci | pmid:641763 |
| Gray AP and Yamauchi TN | Steroid antifertility agents. Ionic complexes of basic derivatives for prolonged action. | 1978 | J. Med. Chem. | pmid:671469 |
| Welling PG et al. | Bioavailability of erythromycin stearate: influence of food and fluid volume. | 1978 | J Pharm Sci | pmid:660450 |
| Abramov LA et al. | Acute respiratory distress caused by erythromycin hypersensitivity. | 1978 | Arch. Intern. Med. | pmid:666483 |
| Stein Y et al. | Intralysosomal hydrolysis of cholesterol esters of varying fatty acid composition in cultured human skin fibroblasts. | 1978 | Biochim. Biophys. Acta | pmid:698242 |
| Schuler LA et al. | Effect of luteinizing hormone of the lipid composition of rat ovaries. | 1978 | J. Endocrinol. | pmid:702016 |
| Triggs EJ and Ashley JJ | Oral administration of erythromycin stearate: effect of dosage form on plasma levels. | 1978 | Med. J. Aust. | pmid:713930 |
| Springolo V | [Bioavailability of formulations containing erythromycin base or stearate in soft enteric gelatin capsules]. | 1978 | Boll Chim Farm | pmid:743360 |
| Ahmed M and Enever RP | The influence of magnesium stearate on physical properties and biological availability of sulphadiazine tablet formulations. | 1978 | Pharm Acta Helv | pmid:746045 |
| Patelski J et al. | Effect of substrate composition and concentration on aortic cholesterol ester hydrolase activity. | 1978 | Enzyme | pmid:25174 |
| Meakin BJ et al. | The implication of stearate mould release agents in the loss of benzalkonium chloride from ophthalmic solutions in polyethylene bottles [proceedings]. | 1978 | J. Pharm. Pharmacol. | pmid:32268 |
| Melander A | Influence of food on the bioavailability of drugs. | 1978 Sep-Oct | Clin Pharmacokinet | pmid:81118 |
| Irvine RF et al. | The calcium-dependent phosphatidylinositol-phosphodiesterase of rat brain. Mechanisms of suppression and stimulation. | 1979 | Eur. J. Biochem. | pmid:227685 |
| Butzler JP et al. | Clinical and pharmacological evaluation of different preparations of oral erythromycin. | 1979 | Chemotherapy | pmid:316377 |
| Colmano G et al. | Activated silver coatings for surgical implants. | 1979 | Va Med | pmid:316624 |
| Welling PG et al. | Plasma levels following single and repeated doses of erythromycin estolate and erythromycin stearate. | 1979 | J Pharm Sci | pmid:423080 |
| Lerk CF et al. | Effect of microcrystalline cellulose on liquid penetration in and disintegration of directly compressed tablets. | 1979 | J Pharm Sci | pmid:423092 |
| Saarni H et al. | Erythromycin levels in serum during treatment with erythromycin stearate and base. | 1979 | Ann. Clin. Res. | pmid:397800 |
| Tierno MA and Brenner RR | [Biochemistry of the developmental cycle of Triatoma infestans (Vinchuca). 2. Biosynthesis of fatty acids]. | 1979 | Acta Physiol Lat Am | pmid:400672 |
| Riordan JR et al. | Plasma membrane lipids of human diploid fibroblasts from normal individuals and patients with cystic fibrosis. | 1979 | Biochim. Biophys. Acta | pmid:476136 |
| Bhatia RP and Lordi NG | Conductivity and hardness changes in aged compacts. | 1979 | J Pharm Sci | pmid:458612 |
| Holub BJ and Piekarski J | The formation of phosphatidylinositol by acylation of 2-acyl-sn-glycero-3-phosphorylinositol in rat liver microsomes. | 1979 | Lipids | pmid:459717 |
| Berend N et al. | Plasma and saliva concentrations for a new formulation of erythromycin stearate. | 1979 | Curr Med Res Opin | pmid:467089 |
| Doran TA et al. | Amniotic fluid lecithin/sphingomyelin ratio, palmitic acid, palmitic acid/stearic acid ratio, total cortisol, creatinine, and percentage of lipid-positive cells in assessment of fetal maturity and fetal pulmonary maturity: a comparison. | 1979 | Am. J. Obstet. Gynecol. | pmid:433991 |
| Nielsen GD et al. | [Aspiration of talcum or powder containing zinc stearate by children]. | 1979 | Ugeskr. Laeg. | pmid:442270 |
| Dunlop EM et al. | Penicillin levels in blood and CSF achieved by treatment of syphilis. | 1979 | JAMA | pmid:374763 |
| Malmborg AS | Effect of food on absorption of erythromycin. A study of two derivatives, the stearate and the base. | 1979 | J. Antimicrob. Chemother. | pmid:500517 |
| Wosilait WD and Ryan MP | The effects of oleic acid, tolbutamide, and oxyphenbutazone on the binding of warfarin by human serum albumin. | 1979 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:504792 |
| Rutland J et al. | The influence of food on the bioavailability of new formulations of erythromycin stearate and base. | 1979 | Br J Clin Pharmacol | pmid:508509 |
| Yakatan GJ et al. | Single-dose fasting bioequivalence assessment of erythromycin stearate tablets in man. | 1979 | J Pharmacokinet Biopharm | pmid:512842 |
| Molloy PL and Eisenstadt JM | Erythromycin resistance in mouse L cells. | 1979 | Somatic Cell Genet. | pmid:531731 |
| Stewart AG et al. | The release of a model low-dose drug (riboflavine) from hard gelatin capsule formulations. | 1979 | J. Pharm. Pharmacol. | pmid:32357 |
| Fraschini F et al. | Bactericidal action of an average dose of erythromycin in the bronchi. | 1979 | Curr Med Res Opin | pmid:38063 |
| Russell NJ and Harwood JL | Changes in the acyl lipid composition of photosynthetic bacteria grown under photosynthetic and non-photosynthetic conditions. | 1979 | Biochem. J. | pmid:115463 |
| Lassus A et al. | Erythromycin and lymecycline treatment in chlamydia-positive and Chlamydia-negative non-gonococcal urethritis--a partner-controlled study. | 1979 | Acta Derm. Venereol. | pmid:87096 |
| Kaur R and Grant DJ | Solid dispersions of drugs in polyoxyethylene 40 stearate: dissolution rates and physico-chemical interactions [proceedings]. | 1979 | J. Pharm. Pharmacol. | pmid:42723 |
| Eccleston GM | The structure and stability of O/W emulsions stabilised by polyethylene glycol 1000 monostearate/fatty alcohols [proceedings]. | 1979 | J. Pharm. Pharmacol. | pmid:42725 |
| Moody G et al. | Lubricity measurements of magnesium stearate [proceedings]. | 1979 | J. Pharm. Pharmacol. | pmid:42749 |
| Rambaut PC and Johnston RS | Prolonged weightlessness and calcium loss in man. | 1979 | Acta Astronaut | pmid:11883480 |
| Nicoletti R et al. | [Palmitic acid-stearic acid ratio with reference to the fatty tissue properties in the human species]. | 1979 May-Jun | Arch Kriminol | pmid:573992 |
| Pinzauti S and La Porta E | Assay of a cetylpyridinium-dequalinium chlorides combination in compressed lozenges: uptake of quaternary ammonium salts by magnesium stearate. | 1979 Sep-Oct | J Pharm Belg | pmid:512830 |
| Sanders KL et al. | Relapse of Legionnaires' disease in a renal transplant recipient. | 1980 | Arch. Intern. Med. | pmid:6992727 |
| Fraser DG | Selection of an oral erythromycin product. | 1980 | Am J Hosp Pharm | pmid:6998290 |
| Selenke WM et al. | Nonantibiotic effects of macrolide antibiotics of the oleandomycin-erythromycin group with special reference to their "steroid-sparing" effects. | 1980 | J. Allergy Clin. Immunol. | pmid:6966289 |
| Hambleton PL et al. | Dietary fat and exercise conditioning effect on metabolic parameters in the horse. | 1980 | J. Anim. Sci. | pmid:7204274 |
| Nakagawa H et al. | [Effects of particle size of rifampicin and addition of magnesium stearate on release of rifampicin from hard gelatin capsules (author's transl)]. | 1980 | Yakugaku Zasshi | pmid:7205556 |
| Wenzel DG and Kleoppel JW | Incorporation of saturated and cis- and trans-unsaturated long chain fatty acids in rat myocytes and increased susceptibility to arrhythmias. | 1980 | Toxicology | pmid:7210021 |
| Oriel JD and Ridgway GL | Comparison of erythromycin and oxytetracycline in the treatment of cervical infection by Chlamydia trachomatis. | 1980 | J. Infect. | pmid:7185927 |
| Chien JL and Hogan EL | Characterization of two gangliosides of the paragloboside series from chicken skeletal muscle. | 1980 | Biochim. Biophys. Acta | pmid:7236652 |
| Jordan BR and Harwood JL | Fatty acid elongation by a particulate fraction from germinating pea. | 1980 | Biochem. J. | pmid:7283974 |
| Thompson SE et al. | Gonococcal tenosynovitis-dermatitis and septic arthritis. Intravenous penicillin vs oral erythromycin. | 1980 | JAMA | pmid:7411761 |
| Baker RR and Chang H | The fatty acid composition of lipids of neuronal and glial nuclear fractions isolated from 15-day-old rabbit cerebral cortex. | 1980 | Can. J. Biochem. | pmid:6161681 |
| Hyono A et al. | ESR studies on the membrane properties of a moderately halophilic bacterium. I. Physical properties of lipid bilayers in whole cells. | 1980 | J. Biochem. | pmid:6257661 |
| Pollard MR and Stumpf PK | Biosynthesis of C(20) and C(22) Fatty Acids by Developing Seeds of Limnanthes alba: CHAIN ELONGATION AND Delta5 DESATURATION. | 1980 | Plant Physiol. | pmid:16661496 |
| Udeala OK et al. | Preliminary evaluation of dika fat, a new tablet lubricant. | 1980 | J. Pharm. Pharmacol. | pmid:6102130 |
| Clarke CW et al. | A new formulation of erythromycin stearate: blood and sputum levels in patients with chronic lower respiratory tract infection. | 1980 | J. Antimicrob. Chemother. | pmid:7400071 |
| Matocha M and Wood R | Changes in host animal plasma lipids during hepatoma growth. | 1980 | Lipids | pmid:7401940 |
| Holub BJ et al. | Relative suitability of 1-palmitoyl and 1-stearoyl homologues of 1-acyl-sn-glycerylphosphorylcholine and different acyl donors for phosphatidylcholine synthesis via acyl-CoA:1-acyl-sn-glycero-3-phosphorylcholine acyltransferase in rat lung microsomes. | 1980 | Can. J. Biochem. | pmid:7407680 |
| Morimoto K and Kanoh H | The role of the de novo synthetic pathway in forming molecular species of phospholipids in resting lymphocytes from human tonsils. | 1980 | Biochim. Biophys. Acta | pmid:7353023 |
| Shepherd J et al. | Effects of saturated and polyunsaturated fat diets on the chemical composition and metabolism of low density lipoproteins in man. | 1980 | J. Lipid Res. | pmid:7354257 |
| Wood R et al. | Effect of methyl 2-hexadecynoate on hepatic fatty acid metabolism. | 1980 | Lipids | pmid:7374364 |
| Herrmann H and Gercken G | Incorporation of [1-14C]octadecanol into the lipids of Leishmania donovani. | 1980 | Lipids | pmid:7374369 |
| Craven PA et al. | Calcium-dependent action of osmolality on adenosine 3',5'-monophosphate accumulation in rat renal inner medulla: evidence for a relationship to calcium-responsive arachidonate release and prostaglandin synthesis. | 1980 | J. Clin. Invest. | pmid:6243313 |
| Marlin GE et al. | Plasma and sputum erythromycin concentrations in chronic bronchitis. | 1980 | Thorax | pmid:7434299 |
| Søndergaard D et al. | Magnesium stearate given perorally to rats. A short term study. | 1980 | Toxicology | pmid:7434368 |
| Colmano G et al. | Activation of antibacterial silver coatings on surgical implants by direct current: preliminary studies in rabbits. | 1980 | Am. J. Vet. Res. | pmid:7436092 |
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| Polnikorn N et al. | Penicillin concentrations in cerebrospinal fluid after different treatment regimens for syphilis. | 1980 | Br J Vener Dis | pmid:7448578 |
| Stavchansky S et al. | Correlation of in vivo bioavailability of erythromycin stearate tablets with in vitro tests. | 1980 | J Pharm Sci | pmid:7452460 |
| Kaur R et al. | Comparison of polyethylene glycol and polyoxyethylene stearate as excipients for solid dispersion systems of griseofulvin and tolbutamide I: phase equilibria. | 1980 | J Pharm Sci | pmid:7452463 |
| Kaur R et al. | Comparison of polyethylene glycol and polyoxyethylene stearate as excipients for solid dispersion systems of griseofulvin and tolbutamide II: dissolution and solubility studies. | 1980 | J Pharm Sci | pmid:7452464 |
| Light ND and Bailey AJ | Polymeric C-terminal cross-linked material from type-I collagen. A modified method for purification, anomalous behaviour on gel filtration, molecular weight estimation, carbohydrate content and lipid content. | 1980 | Biochem. J. | pmid:7458897 |
| Nagai J et al. | Increased proportion of medium chain fatty acids in nystatin-resistant yeast mutants. | 1981 | Lipids | pmid:7022083 |
| Bolhuis GK et al. | Interaction of tablet disintegrants and magnesium stearate during mixing I: Effect on tablet disintegration. | 1981 | J Pharm Sci | pmid:7320846 |
| Hsia JC and Kwan NH | Human serum albumin: binding specificity and allosteric effect of parinarate and stearate. A dianionic spin label study. | 1981 | J. Biol. Chem. | pmid:6257712 |
| Cook HW | The influence of trans-acids on desaturation and elongation of fatty acids in developing brain. | 1981 | Lipids | pmid:7329212 |
| Hug G et al. | Reye's syndrome simulacra in liver of mice after treatment with chemical agents and encephalomyocarditis virus. | 1981 | Lab. Invest. | pmid:6265702 |
| d'Avila Nunes M | A spin label study of erythrocyte membranes during simulation of freezing. | 1981 | J. Membr. Biol. | pmid:7253007 |
| Zentner GM et al. | Free fatty acid-induced platelet aggregation: studies with solubilized and nonsolubilized fatty acids. | 1981 | J Pharm Sci | pmid:6101166 |
| Davis PJ et al. | Gel to liquid-crystalline transition temperatures of water dispersions of two pairs of positional isomers of unsaturated mixed-acid phosphatidylcholines. | 1981 | Biochemistry | pmid:7260060 |
| Bertram J and Erwin JA | Isolation of a stearoyl CoA Desaturase form Tetrahymena thermophila. | 1981 | J. Protozool. | pmid:6114174 |