stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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SOLOFF LA and WIEDEMAN MP | BIOMICROSCOPIC OBSERVATIONS ON VASOCONSTRICTIVE AND THROMBOGENIC EFFECTS PRODUCED BY LONG-CHAIN SATURATED FATTY ACIDS WITHIN THE VASCULATURE OF THE WING OF AN UNANAESTHETIZED BAT. | 1963 | Nature | pmid:14058613 |
GREGORY JN and SPINK JA | Lubricating properties of molecular layers of stearic acid and calcium stearate on metal surfaces. | 1947 | Nature | pmid:20291788 |
Senyilmaz D et al. | Regulation of mitochondrial morphology and function by stearoylation of TFR1. | 2015 | Nature | pmid:26214738 |
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SPINK JA | Structure of stearic acid films on copper. | 1950 | Nature | pmid:15416726 |
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Teyssier G et al. | [Adult-type respiratory distress syndrome in children. Course of the palmitic acid/stearic acid ratio in tracheal aspirations]. | 1981 | Nouv Presse Med | pmid:7290945 |
Sabbah A | [Letter: Immunodepressive action of erythromycin ethyl-succinate and erythromycin stearate. Study by the lymphoblastic transformation test and natural and rheumatoid rosette test]. | 1976 | Nouv Presse Med | pmid:1264643 |
Beckurts TE et al. | Kinetics of different 123I- and 14C-labelled fatty acids in normal and diabetic rat myocardium in vivo. | 1985 | Nucl Med Commun | pmid:4047532 |
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van den Berg SA et al. | High levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity. | 2010 | Nutr Metab (Lond) | pmid:20346174 |
Wang L et al. | Plasma fatty acid composition and incidence of coronary heart disease in middle aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. | 2003 | Nutr Metab Cardiovasc Dis | pmid:14717057 |
Ash MM et al. | Phytosterol stearate esters elicit similar responses on plasma lipids and cholesterol absorption but different responses on fecal neutral sterol excretion and hepatic free cholesterol in male Syrian hamsters. | 2011 | Nutr Res | pmid:21840470 |
Castellanos-Tapia L et al. | Apolipoprotein E isoforms 3/3 and 3/4 differentially interact with circulating stearic, palmitic, and oleic fatty acids and lipid levels in Alaskan Natives. | 2015 | Nutr Res | pmid:25727313 |
Kurotani K et al. | High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance. | 2012 | Nutr Res | pmid:23084639 |
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Park MY et al. | Hog millet (Panicum miliaceum L.)-supplemented diet ameliorates hyperlipidemia and hepatic lipid accumulation in C57BL/6J-ob/ob mice. | 2011 | Nutr Res Pract | pmid:22259675 |
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POLYOXYETHYLENE stearates in food. | 1955 | Nutr. Rev. | pmid:14394517 | |
Cerf ME and Herrera E | High Fat Diet Administration during Specific Periods of Pregnancy Alters Maternal Fatty Acid Profiles in the Near-Term Rat. | 2016 | Nutrients | pmid:26742067 |
Wong RH et al. | Chronic effects of a wild green oat extract supplementation on cognitive performance in older adults: a randomised, double-blind, placebo-controlled, crossover trial. | 2012 | Nutrients | pmid:22690320 |
Mu L et al. | Erythrocyte saturated fatty acids and systemic inflammation in adults. | 2014 Nov-Dec | Nutrition | pmid:25280420 |