stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Halliwell KJ et al. | Release of individual fatty acids from human adipose tissue in vivo after an overnight fast. | 1996 | J. Lipid Res. | pmid:8895050 |
Peck MD et al. | Association of murine splenocyte CD3 complex to the cytoskeleton: absence of modulation by exogenous fatty acids. | 1996 | Cell Biol. Int. | pmid:8938986 |
Kole HK et al. | A synthetic peptide derived from a COOH-terminal domain of the insulin receptor specifically enhances insulin receptor signaling. | 1996 | J. Biol. Chem. | pmid:8940181 |
Kankofer M et al. | The analysis of fatty acid content and phospholipase A2 activity in placenta of cows with and without retained fetal membranes. | 1996 | Zentralbl Veterinarmed A | pmid:8940891 |
Awad AB et al. | The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. | 1996 | Cancer Lett. | pmid:8950205 |
Sun GY | Metabolism of arachidonate and stearate injected simultaneously into the mouse brain. | 1977 | Lipids | pmid:895416 |
Santos MJ et al. | Influence of dietary fish on fatty acid composition of the erythrocyte membrane in coronary heart disease patients. | 1996 | Int J Vitam Nutr Res | pmid:8979167 |
Paumen MB et al. | Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. | 1997 | J. Biol. Chem. | pmid:9013572 |
Kleinschmidt JH et al. | Interaction of bee venom melittin with zwitterionic and negatively charged phospholipid bilayers: a spin-label electron spin resonance study. | 1997 | Biophys. J. | pmid:9017202 |
Rhee SK et al. | Desaturation and interconversion of dietary stearic and palmitic acids in human plasma and lipoproteins. | 1997 | Am. J. Clin. Nutr. | pmid:9022530 |
Mizushima H et al. | Phase behavior of artificial stratum corneum lipids containing a synthetic pseudo-ceramide: a study of the function of cholesterol. | 1996 | J. Lipid Res. | pmid:9026533 |
Staprans I et al. | Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats. | 1996 | J. Lipid Res. | pmid:9026539 |
Mutanen M and Aro A | Coagulation and fibrinolysis factors in healthy subjects consuming high stearic or trans fatty acid diets. | 1997 | Thromb. Haemost. | pmid:9031457 |
Brun T et al. | Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1. | 1997 | Diabetes | pmid:9032094 |
Murthy KS and Samyn JC | Effect of shear mixing on in vitro drug release of capsule formulations containing lubricants. | 1977 | J Pharm Sci | pmid:903855 |
Pacini L et al. | Arachidonic acid modulates [14C]stearic acid incorporation into phosphatidylinositol, in human neuroblastoma cells. | 1997 | J. Neurooncol. | pmid:9049841 |
Hussey HJ and Tisdale MJ | Mechanism of the anti-tumour effect of 2,3,5-trimethyl-6-(3-pyridylmethyl) 1,4-benzoquinone (CV-6504). | 1997 | Br. J. Cancer | pmid:9062405 |
Pai T and Yeh YY | Stearic acid modifies very low density lipoprotein lipid composition and particle size differently from shorter-chain saturated fatty acids in cultured rat hepatocytes. | 1997 | Lipids | pmid:9075203 |
Tanaka H et al. | In situ observation of bovine serum albumin-adsorbed stearic acid monolayer by Brewster angle microscopy. | 1997 | J. Biochem. | pmid:9089391 |
Yamashita T and Tsubura E | [Influence of meal on the plasma concentration of patients received repeated administration of OE-7, erythromycin stearate capsules (author's transl)]. | 1977 | Jpn J Antibiot | pmid:909141 |
Gonzalez-Castro MY et al. | Effects of blanching, freezing and freeze-drying on the fatty acid contents of green beans. | 1996 | Z Lebensm Unters Forsch | pmid:9123974 |
Aro A et al. | Stearic acid, trans fatty acids, and dairy fat: effects on serum and lipoprotein lipids, apolipoproteins, lipoprotein(a), and lipid transfer proteins in healthy subjects. | 1997 | Am. J. Clin. Nutr. | pmid:9129471 |
Frohlich BT et al. | Formation and cell-medium partitioning of autoinhibitory free fatty acids and cyclodextrin's effect in the cultivation of Bordetella pertussis. | 1996 | J. Biotechnol. | pmid:9147447 |
Di Pierro D et al. | Separation of representative lipid compounds of biological membranes and lipid derivatives from peroxidized polyunsaturated fatty acids by reversed phase high-performance liquid chromatography. | 1997 | Free Radic. Res. | pmid:9167935 |
Wang H et al. | Apolipoprotein secretion and lipid synthesis: regulation by fatty acids in newborn swine intestinal epithelial cells. | 1997 | Am. J. Physiol. | pmid:9176199 |
Vorum H et al. | Palmitate and stearate binding to human serum albumin. Determination of relative binding constants. | 1997 | J. Pept. Res. | pmid:9176819 |
Fellner V et al. | Effect of nigericin, monensin, and tetronasin on biohydrogenation in continuous flow-through ruminal fermenters. | 1997 | J. Dairy Sci. | pmid:9178132 |
Hassel CA et al. | Dietary stearic acid reduces plasma and hepatic cholesterol concentrations without increasing bile acid excretion in cholesterol-fed hamsters. | 1997 | J. Nutr. | pmid:9187629 |
Williams JP et al. | Regulation of osteoclastic bone resorption by glucose. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9207213 |
Clandinin MT et al. | Omega-3 fatty acid intake results in a relationship between the fatty acid composition of LDL cholesterol ester and LDL cholesterol content in humans. | 1997 | Biochim. Biophys. Acta | pmid:9219909 |
Noker PE et al. | Metabolism of 14C-labelled sucrose esters of stearic acid in rats. | 1997 | Food Chem. Toxicol. | pmid:9225017 |
Dhillon HS et al. | Time course of changes in lactate and free fatty acids after experimental brain injury and relationship to morphologic damage. | 1997 | Exp. Neurol. | pmid:9225757 |
Yamamoto A and Kawashima Y | Perfluorodecanoic acid enhances the formation of oleic acid in rat liver. | 1997 | Biochem. J. | pmid:9230124 |
Khomutov GB et al. | Interaction of copper ions with stearic acid Langmuir monolayers and formation of cluster structures in monolayers and Langmuir-Blodgett films. | 1997 | Membr Cell Biol | pmid:9231365 |
Sparks JD et al. | Effects of fatty acids on apolipoprotein B secretion by McArdle RH-7777 rat hepatoma cells. | 1997 | Biochim. Biophys. Acta | pmid:9233686 |
Alvarez-Ortega R et al. | Characterization of polar and nonpolar seed lipid classes from highly saturated fatty acid sunflower mutants. | 1997 | Lipids | pmid:9270974 |
Wagner K et al. | Influence of duodenal infusion of nicotinic acid on the milk fat composition of dairy cows. | 1997 | Arch Tierernahr | pmid:9272222 |
Moers A and Schrezenmeir J | Palmitic acid but not stearic acid inhibits NO-production in endothelial cells. | 1997 | Exp. Clin. Endocrinol. Diabetes | pmid:9288552 |
West RR and Stafford DA | Occupational exposures and haematological abnormalities among ordnance factory workers: a case control study. | 1997 | Leuk. Res. | pmid:9301689 |
Bondarenko LB et al. | Fatty acids hydroxamic derivatives as inhibitors of 5-lipoxygenase. | 1997 | Adv. Exp. Med. Biol. | pmid:9321992 |
Yamashita T et al. | [Studies on erythromycin stearate capsules (OE-7) (author's transl)]. | 1976 | Jpn J Antibiot | pmid:933342 |
Dürig T and Fassihi R | Mechanistic evaluation of binary effects of magnesium stearate and talc as dissolution retardants at 85% drug loading in an experimental extended-release formulation. | 1997 | J Pharm Sci | pmid:9344163 |
Neubert R et al. | Structure of stratum corneum lipids characterized by FT-Raman spectroscopy and DSC. II. Mixtures of ceramides and saturated fatty acids. | 1997 | Chem. Phys. Lipids | pmid:9353900 |
Ali I and Steele JE | Fatty acids stimulate trehalose synthesis in trophocytes of the cockroach (Periplaneta americana) fat body. | 1997 | Gen. Comp. Endocrinol. | pmid:9356224 |
Piel J et al. | Cellulysin from the plant parasitic fungus Trichoderma viride elicits volatile biosynthesis in higher plants via the octadecanoid signalling cascade. | 1997 | FEBS Lett. | pmid:9369200 |
Kogure K et al. | Effect of dicetylphosphate or stearic acid on spontaneous transfer of protein from influenza virus-infected cells to dimyristoylphosphatidylcholine liposomes. | 1997 | Biochim. Biophys. Acta | pmid:9370255 |
Pérez FR et al. | cis-FFA do not alter membrane depolarization but block Ca2+ influx and GH secretion in KCl-stimulated somatotroph cells. Suggestion for a direct cis-FFA perturbation of the Ca2+ channel opening. | 1997 | Biochim. Biophys. Acta | pmid:9371418 |
Ali I and Steele JE | Evidence that free fatty acids in trophocytes of Periplaneta americana fat body may be regulated by the activity of phospholipase A2 and cyclooxygenase. | 1997 | Insect Biochem. Mol. Biol. | pmid:9404012 |
Storm H et al. | Comparison of a carbohydrate-rich diet and diets rich in stearic or palmitic acid in NIDDM patients. Effects on lipids, glycemic control, and diurnal blood pressure. | 1997 | Diabetes Care | pmid:9405898 |
Miyamoto M et al. | Design and preparation of gadolinium-reservoir microcapsules for neutron-capture therapy by means of the Wurster process. | 1997 | Chem. Pharm. Bull. | pmid:9433776 |