stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Matsuura T et al. | Effect of Alcohols on the Phase Behavior and Emulsification of a Sucrose Fatty Acid Ester/Water/Edible Oil System. | 2018 | J Oleo Sci | pmid:29367483 |
Beg S et al. | QbD-driven development and evaluation of nanostructured lipid carriers (NLCs) of Olmesartan medoxomil employing multivariate statistical techniques. | 2018 | Drug Dev Ind Pharm | pmid:29048242 |
Hara A et al. | Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs. | 2017 | Biochem. Pharmacol. | pmid:28450226 |
Kondo H et al. | Effect of the External Lubrication Method for a Rotary Tablet Press on the Adhesion of the Film Coating Layer. | 2017 | Chem. Pharm. Bull. | pmid:28867712 |
Shiino K et al. | Melt Adsorption as a Manufacturing Method for Fine Particles of Wax Matrices without Any Agglomerates. | 2017 | Chem. Pharm. Bull. | pmid:28768926 |
Guan Q et al. | In vitro and in vivo evaluation of docetaxel-loaded stearic acid-modified Bletilla striata polysaccharide copolymer micelles. | 2017 | PLoS ONE | pmid:28334044 |
Shazly GA | Ciprofloxacin Controlled-Solid Lipid Nanoparticles: Characterization, In Vitro Release, and Antibacterial Activity Assessment. | 2017 | Biomed Res Int | pmid:28194408 |
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Houghton SC et al. | Intake of dietary fat and fat subtypes and risk of premenstrual syndrome in the Nurses' Health Study II. | 2017 | Br. J. Nutr. | pmid:29189192 |
Yamamoto K et al. | Effect of Magnesium Stearate Mono- and Dihydrate Dispersibilities on Physical Properties of Tablets. | 2017 | Chem. Pharm. Bull. | pmid:29093289 |
Soliman HM et al. | Synthesis and Application of a New Amphiphilic Antioxidant. | 2017 | J Oleo Sci | pmid:29021490 |
Meng Y et al. | Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28712865 |
Prasinou P et al. | Fatty acid-based lipidomics and membrane remodeling induced by apoE3 and apoE4 in human neuroblastoma cells. | 2017 | Biochim Biophys Acta Biomembr | pmid:28688796 |
Oki E et al. | Polymorphisms of the TNF-α gene interact with plasma fatty acids on inflammatory biomarker profile: a population-based, cross-sectional study in São Paulo, Brazil. | 2017 | Br. J. Nutr. | pmid:28633686 |
Naing C and Whittaker MA | Anabolic steroids for treating pressure ulcers. | 2017 | Cochrane Database Syst Rev | pmid:28631809 |
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Cosenza G et al. | A novel polymorphism in the oxytocin receptor encoding gene (OXTR) affects milk fatty acid composition in Italian Mediterranean river buffalo. | 2017 | J. Dairy Res. | pmid:28524009 |
Chitprasert P and Ngamekaue N | Stability Enhancement of Ocimum Sanctum Linn. Essential Oils Using Stearic Acid in Aluminum Carboxymethyl Cellulose Film-Coated Gelatin Microcapsules. | 2017 | J. Food Sci. | pmid:28494101 |
Mirabi P et al. | Does different BMI influence oocyte and embryo quality by inducing fatty acid in follicular fluid? | 2017 | Taiwan J Obstet Gynecol | pmid:28420500 |
Yang D et al. | Liposomes Incorporating Transferrin and Stearic Acid-modified Octa-arginine for siRNA Delivery. | 2017 | Anticancer Res. | pmid:28373438 |
Yang TS et al. | Functionalities of chitosan conjugated with stearic acid and gallic acid and application of the modified chitosan in stabilizing labile aroma compounds in an oil-in-water emulsion. | 2017 | Food Chem | pmid:28317761 |
Trementozzi AN et al. | Engineered particles demonstrate improved flow properties at elevated drug loadings for direct compression manufacturing. | 2017 | Int J Pharm | pmid:28284921 |
Sguizzato M et al. | Solid lipid nanoparticles for the delivery of 1,3,5-triaza-7-phosphaadamantane (PTA) platinum (II) carboxylates. | 2017 | Mater Sci Eng C Mater Biol Appl | pmid:28254304 |
Koranne S et al. | Investigation of Spatial Heterogeneity of Salt Disproportionation in Tablets by Synchrotron X-ray Diffractometry. | 2017 | Mol. Pharm. | pmid:28195490 |
Lau M et al. | Co-milled API-lactose systems for inhalation therapy: impact of magnesium stearate on physico-chemical stability and aerosolization performance. | 2017 | Drug Dev Ind Pharm | pmid:28122460 |
Wan Y et al. | Design and evaluation of a stearylated multicomponent peptide-siRNA nanocomplex for efficient cellular siRNA delivery. | 2017 | Nanomedicine (Lond) | pmid:28093948 |
Cella C et al. | Calcium Stearate as an Effective Alternative to Poly(vinyl alcohol) in Poly-Lactic-co-Glycolic Acid Nanoparticles Synthesis. | 2017 | Biomacromolecules | pmid:28030952 |
Zhao L et al. | Serum stearic acid/palmitic acid ratio as a potential predictor of diabetes remission after Roux-en-Y gastric bypass in obesity. | 2017 | FASEB J. | pmid:28007782 |
Hsein H et al. | Denatured Whey Protein Powder as a New Matrix Excipient: Design and Evaluation of Mucoadhesive Tablets for Sustained Drug Release Applications. | 2017 | Pharm. Res. | pmid:28004316 |
Bayard M et al. | Free fatty acids and their esters modulate isothermal crystallization of anhydrous milk fat. | 2017 | Food Chem | pmid:27719901 |
Thirupathi G et al. | Role of Isradipine Loaded Solid Lipid Nanoparticles on the Pharmacodynamic Effect in Rats. | 2017 | Drug Res (Stuttg) | pmid:27992936 |
Wahl PR et al. | Continuous monitoring of API content, API distribution and crushing strength after tableting via near-infrared chemical imaging. | 2017 | Int J Pharm | pmid:27923700 |
Oyeyinka SA et al. | Physicochemical and Mechanical Properties of Bambara Groundnut Starch Films Modified with Stearic Acid. | 2017 | J. Food Sci. | pmid:27886659 |
De Weirdt R et al. | Mucosa-associated biohydrogenating microbes protect the simulated colon microbiome from stress associated with high concentrations of poly-unsaturated fat. | 2017 | Environ. Microbiol. | pmid:27883264 |
Heim CB and Gillman JD | Genotyping-by-Sequencing-Based Investigation of the Genetic Architecture Responsible for a ∼Sevenfold Increase in Soybean Seed Stearic Acid. | 2017 | G3 (Bethesda) | pmid:27866151 |
Anbalagan P et al. | Influence of the Punch Head Design on the Physical Quality of Tablets Produced in a Rotary Press. | 2017 | J Pharm Sci | pmid:27842972 |
Delaney SP et al. | Characterization of Synthesized and Commercial Forms of Magnesium Stearate Using Differential Scanning Calorimetry, Thermogravimetric Analysis, Powder X-Ray Diffraction, and Solid-State NMR Spectroscopy. | 2017 | J Pharm Sci | pmid:27836109 |
Dudhipala N and Veerabrahma K | Improved anti-hyperlipidemic activity of Rosuvastatin Calcium via lipid nanoparticles: Pharmacokinetic and pharmacodynamic evaluation. | 2017 | Eur J Pharm Biopharm | pmid:27810472 |
Wang XH et al. | High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2. | 2017 | Front Pharmacol | pmid:28555106 |
Song S et al. | Identification of pork flavour precursors from enzyme-treated lard using Maillard model system assessed by GC-MS and partial least squares regression. | 2017 | Meat Sci. | pmid:27792915 |
Han Y et al. | Natural variations in stearoyl-acp desaturase genes affect the conversion of stearic to oleic acid in maize kernel. | 2017 | Theor. Appl. Genet. | pmid:27717956 |
Hosaka S and Tokunaga Y | Differences in Powder Properties of Two 1,4-Dihydropyridine-Type Compounds Evaluated through Thermal Analysis. | 2017 | Chem. Pharm. Bull. | pmid:29199222 |
Narang AS et al. | Assessment of Tablet Surface Hardness by Laser Ablation and Its Correlation With the Erosion Tendency of Core Tablets. | 2017 | J Pharm Sci | pmid:27686683 |
Pantub K et al. | Preparation of Salicylic Acid Loaded Nanostructured Lipid Carriers Using Box-Behnken Design: Optimization, Characterization and Physicochemical Stability. | 2017 | J Oleo Sci | pmid:29199206 |
Qu L et al. | Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression. | 2017 | J Pharm Sci | pmid:27665128 |
Yuan M et al. | Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain. | 2017 | Int J Nanomedicine | pmid:29184406 |
Liu W and Lu G | Partial Hydrogenation of Sunflower Oil-derived FAMEs Catalyzed by the Efficient and Recyclable Palladium Nanoparticles in Polyethylene Glycol. | 2017 | J Oleo Sci | pmid:28924078 |
Ivanova EP et al. | Bactericidal activity of self-assembled palmitic and stearic fatty acid crystals on highly ordered pyrolytic graphite. | 2017 | Acta Biomater | pmid:28688988 |
Spigoni V et al. | Stearic acid at physiologic concentrations induces in vitro lipotoxicity in circulating angiogenic cells. | 2017 | Atherosclerosis | pmid:28892713 |
Xue J et al. | A novel and organic solvent-free preparation of solid lipid nanoparticles using natural biopolymers as emulsifier and stabilizer. | 2017 | Int J Pharm | pmid:28802794 |
Lapham DP and Lapham JL | Gas adsorption on commercial magnesium stearate: Effects of degassing conditions on nitrogen BET surface area and isotherm characteristics. | 2017 | Int J Pharm | pmid:28779986 |
Nagy B et al. | In-line Raman spectroscopic monitoring and feedback control of a continuous twin-screw pharmaceutical powder blending and tableting process. | 2017 | Int J Pharm | pmid:28723408 |
Soni K et al. | Lipid drug conjugate nanoparticle as a potential nanocarrier for the oral delivery of pemetrexed diacid: Formulation design, characterization, ex vivo, and in vivo assessment. | 2017 | Int. J. Biol. Macromol. | pmid:28499946 |
Chang C et al. | pH-responsive nanoparticle assembly from peptide amphiphiles for tumor targeting drug delivery. | 2017 | J Biomater Sci Polym Ed | pmid:28467173 |
Shilpi D et al. | Improved Stability and Enhanced Oral Bioavailability of Atorvastatin Loaded Stearic Acid Modified Gelatin Nanoparticles. | 2017 | Pharm. Res. | pmid:28466393 |
Kumar R and Sinha VR | Lipid Nanocarrier: an Efficient Approach Towards Ocular Delivery of Hydrophilic Drug (Valacyclovir). | 2017 | AAPS PharmSciTech | pmid:27368921 |
Lakhssassi N et al. | Stearoyl-Acyl Carrier Protein Desaturase Mutations Uncover an Impact of Stearic Acid in Leaf and Nodule Structure. | 2017 | Plant Physiol. | pmid:28461402 |
Noor NM et al. | Preparation and characterization of dutasteride-loaded nanostructured lipid carriers coated with stearic acid-chitosan oligomer for topical delivery. | 2017 | Eur J Pharm Biopharm | pmid:28412472 |
Sapra M et al. | Engineering of layered, lipid-encapsulated drug nanoparticles through spray-drying. | 2017 | Colloids Surf B Biointerfaces | pmid:28340484 |
Lee W et al. | Novel protein acetyltransferase, Rv2170, modulates carbon and energy metabolism in Mycobacterium tuberculosis. | 2017 | Sci Rep | pmid:28250431 |
Crowley ME et al. | Near-infrared monitoring of roller compacted ribbon density: Investigating sources of variation contributing to noisy spectral data. | 2017 | Eur J Pharm Sci | pmid:28216342 |
Lau M et al. | Investigation into the Manufacture and Properties of Inhalable High-Dose Dry Powders Produced by Comilling API and Lactose with Magnesium Stearate. | 2017 | AAPS PharmSciTech | pmid:28070849 |
Thotakura N et al. | Chitosan-Stearic Acid Based Polymeric Micelles for the Effective Delivery of Tamoxifen: Cytotoxic and Pharmacokinetic Evaluation. | 2017 | AAPS PharmSciTech | pmid:27287243 |
Zhou Y et al. | An oxygen slow-releasing material and its application in water remediation as oxygen supplier. | 2017 | Environ Technol | pmid:28041538 |
Kelidari HR et al. | Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability. | 2017 | AAPS PharmSciTech | pmid:27834054 |
Wang W et al. | Synthesis, self-assembly, and in vitro toxicity of fatty acids-modified Bletilla striata polysaccharide. | 2017 | Artif Cells Nanomed Biotechnol | pmid:26754958 |
Maphalla TG and Emmambux MN | Functionality of maize, wheat, teff and cassava starches with stearic acid and xanthan gum. | 2016 | Carbohydr Polym | pmid:26572436 |
Du J and Li L | Which one performs better for targeted lung cancer combination therapy: pre- or post-bombesin-decorated nanostructured lipid carriers? | 2016 | Drug Deliv | pmid:26455787 |
Kumar Gaur P et al. | Nanovesicles of nitrendipine with lipid complex for transdermal delivery: pharmacokinetic and pharmacodynamic studies. | 2016 | Artif Cells Nanomed Biotechnol | pmid:26375758 |
Li X et al. | Preparation of co-spray dried cushioning agent containing stearic acid for protecting pellet coatings when compressed. | 2016 | Drug Dev Ind Pharm | pmid:26289006 |
Uğurlu T and Halaçoğlu MD | Effects of hexagonal boron nitride on dry compression mixture of Avicel DG and Starch 1500. | 2016 | Pharm Dev Technol | pmid:25716058 |
Jójárt I et al. | Study of the compressibility of chewing gum and its applicability as an oral drug delivery system. | 2016 | Pharm Dev Technol | pmid:25673279 |
Yan G et al. | Preparation and evaluation of liver-targeting micelles loaded with oxaliplatin. | 2016 | Artif Cells Nanomed Biotechnol | pmid:25287740 |
Pradhan M et al. | Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders. | 2016 | Artif Cells Nanomed Biotechnol | pmid:25229831 |
Martins AB and Santana RM | Effect of carboxylic acids as compatibilizer agent on mechanical properties of thermoplastic starch and polypropylene blends. | 2016 | Carbohydr Polym | pmid:26453854 |
Yin L et al. | Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis. | 2016 | Toxicol In Vitro | pmid:26820058 |
Guan Q et al. | Docetaxel-Loaded Self-Assembly Stearic Acid-Modified Bletilla striata Polysaccharide Micelles and Their Anticancer Effect: Preparation, Characterization, Cellular Uptake and In Vitro Evaluation. | 2016 | Molecules | pmid:27918445 |
Shur J et al. | From single excipients to dual excipient platforms in dry powder inhaler products. | 2016 | Int J Pharm | pmid:27262269 |
Li T et al. | Defense priming by non-jasmonate producing fatty acids in maize (Zea mays). | 2016 | Plant Signal Behav | pmid:27763804 |
Kanasaki Y et al. | Application of Quartz Crystal Microbalance as a Tool for Detergency Evaluation of Fatty Acid Contamination in Aqueous Systems. | 2016 | J Oleo Sci | pmid:27725481 |
Simon C et al. | Screening of endocrine activity of compounds migrating from plastic baby bottles using a multi-receptor panel of in vitro bioassays. | 2016 | Toxicol In Vitro | pmid:27633901 |
Shah RM et al. | Microwave-assisted formulation of solid lipid nanoparticles loaded with non-steroidal anti-inflammatory drugs. | 2016 | Int J Pharm | pmid:27789371 |
Abreu P et al. | Contractile function recovery in severely injured gastrocnemius muscle of rats treated with either oleic or linoleic acid. | 2016 | Exp. Physiol. | pmid:27579497 |
Garba L et al. | Heterologous Expression of PA8FAD9 and Functional Characterization of a Δ9-Fatty Acid Desaturase from a Cold-Tolerant Pseudomonas sp. A8. | 2016 | Mol. Biotechnol. | pmid:27629791 |
Démuth B et al. | Lubricant-Induced Crystallization of Itraconazole From Tablets Made of Electrospun Amorphous Solid Dispersion. | 2016 | J Pharm Sci | pmid:27290626 |
Meng T et al. | A spermine conjugated stearic acid-g-chitosan oligosaccharide polymer with different types of amino groups for efficient p53 gene therapy. | 2016 | Colloids Surf B Biointerfaces | pmid:27289311 |
Schrank S et al. | Pore blocking: An innovative formulation strategy for the design of alcohol resistant multi-particulate dosage forms. | 2016 | Int J Pharm | pmid:27282540 |
Eltayeb M et al. | Electrosprayed nanoparticle delivery system for controlled release. | 2016 | Mater Sci Eng C Mater Biol Appl | pmid:27207047 |
Zhao H et al. | Self-assembly of hydrogen-bonded supramolecular complexes of nucleic-acid-base and fatty-acid at the liquid-solid interface. | 2016 | Phys Chem Chem Phys | pmid:27170421 |
Afonso MS et al. | Dietary interesterified fat enriched with palmitic acid induces atherosclerosis by impairing macrophage cholesterol efflux and eliciting inflammation. | 2016 | J. Nutr. Biochem. | pmid:27142741 |
Haware RV et al. | Vegetable-derived magnesium stearate functionality evaluation by DM(3) approach. | 2016 | Eur J Pharm Sci | pmid:27108117 |
Wang HJ et al. | Prolongation of the degradation period and improvement of the angiogenesis of zein porous scaffolds in vivo. | 2016 | J Mater Sci Mater Med | pmid:26979976 |
Cheng CL et al. | Spectral and morphological classification of different chronic and acute Taiwanese gallstones via FTIR, SEM and ESEM-EDX microanalyses. | 2016 | Dig Liver Dis | pmid:26976784 |
Moazeni M et al. | Time to overcome fluconazole resistant Candida isolates: Solid lipid nanoparticles as a novel antifungal drug delivery system. | 2016 | Colloids Surf B Biointerfaces | pmid:26974361 |
Lu H et al. | Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway. | 2016 | Diabetologia | pmid:26969487 |
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Michaut A et al. | A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. | 2016 | Toxicol. Appl. Pharmacol. | pmid:26739624 |
Ma F et al. | Improvement of β-TCP/PLLA biodegradable material by surface modification with stearic acid. | 2016 | Mater Sci Eng C Mater Biol Appl | pmid:26952440 |