stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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Pacini L et al. | Arachidonic acid modulates [14C]stearic acid incorporation into phosphatidylinositol, in human neuroblastoma cells. | 1997 | J. Neurooncol. | pmid:9049841 |
Murthy KS and Samyn JC | Effect of shear mixing on in vitro drug release of capsule formulations containing lubricants. | 1977 | J Pharm Sci | pmid:903855 |
Brun T et al. | Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1. | 1997 | Diabetes | pmid:9032094 |
Mutanen M and Aro A | Coagulation and fibrinolysis factors in healthy subjects consuming high stearic or trans fatty acid diets. | 1997 | Thromb. Haemost. | pmid:9031457 |
Staprans I et al. | Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats. | 1996 | J. Lipid Res. | pmid:9026539 |
Mizushima H et al. | Phase behavior of artificial stratum corneum lipids containing a synthetic pseudo-ceramide: a study of the function of cholesterol. | 1996 | J. Lipid Res. | pmid:9026533 |
Rhee SK et al. | Desaturation and interconversion of dietary stearic and palmitic acids in human plasma and lipoproteins. | 1997 | Am. J. Clin. Nutr. | pmid:9022530 |
Kleinschmidt JH et al. | Interaction of bee venom melittin with zwitterionic and negatively charged phospholipid bilayers: a spin-label electron spin resonance study. | 1997 | Biophys. J. | pmid:9017202 |
Paumen MB et al. | Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. | 1997 | J. Biol. Chem. | pmid:9013572 |
Santos MJ et al. | Influence of dietary fish on fatty acid composition of the erythrocyte membrane in coronary heart disease patients. | 1996 | Int J Vitam Nutr Res | pmid:8979167 |