stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Mottram AR et al. | Fatty acids antagonize bupivacaine-induced I(Na) blockade. | 2011 | Clin Toxicol (Phila) | pmid:21970771 |
Balducci AG et al. | Layered lipid microcapsules for mesalazine delayed-release in children. | 2011 | Int J Pharm | pmid:22001795 |
Kumar RV and Sinha VR | Tailoring of drug delivery of 5-fluorouracil to the colon via a mixed film coated unit system. | 2011 | Acta Pharm | pmid:21945913 |
Jeon JH et al. | Novel lipolytic enzymes identified from metagenomic library of deep-sea sediment. | 2011 | Evid Based Complement Alternat Med | pmid:21845199 |
Jing F et al. | Phylogenetic and experimental characterization of an acyl-ACP thioesterase family reveals significant diversity in enzymatic specificity and activity. | 2011 | BMC Biochem. | pmid:21831316 |
Dani KG et al. | Structural and functional analyses of a saturated acyl ACP thioesterase, type B from immature seed tissue of Jatropha curcas. | 2011 | Plant Biol (Stuttg) | pmid:21489096 |
Huang HY et al. | Co-delivery of anti-vascular endothelial growth factor siRNA and doxorubicin by multifunctional polymeric micelle for tumor growth suppression. | 2011 | J Biomed Mater Res A | pmid:21465641 |
Hisazumi J et al. | Quantification of pharmaceutical polymorphs and prediction of dissolution rate using theophylline tablet by terahertz spectroscopy. | 2011 | Chem. Pharm. Bull. | pmid:21467671 |
Guntupalli R et al. | Phage Langmuir monolayers and Langmuir-Blodgett films. | 2011 | Colloids Surf B Biointerfaces | pmid:20843668 |
Saeed M et al. | Assessment of diffuse transmission and reflection modes in near-infrared quantification, part 2: DIFFuse reflection information depth. | 2011 | J Pharm Sci | pmid:20862671 |
Wadher KJ et al. | Formulation and evaluation of a sustained-release tablets of metformin hydrochloride using hydrophilic synthetic and hydrophobic natural polymers. | 2011 | Indian J Pharm Sci | pmid:22303065 |
Wang K et al. | Oxaliplatin-incorporated micelles eliminate both cancer stem-like and bulk cell populations in colorectal cancer. | 2011 | Int J Nanomedicine | pmid:22238509 |
Du YZ et al. | Receptor-mediated gene delivery by folic acid-modified stearic acid-grafted chitosan micelles. | 2011 | Int J Nanomedicine | pmid:21845046 |
Sharma S et al. | RP-HPLC Method for Simultaneous Estimation of Nitazoxanide and Ofloxacin in Tablets. | 2011 | Indian J Pharm Sci | pmid:22131628 |
Lavigne JP et al. | Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infections. | 2011 | BMC Res Notes | pmid:22126300 |
Bailey JA et al. | Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. | 2011 | PLoS ONE | pmid:21799757 |
Elokely KM et al. | Fluorescence Spectrometric Determination of Drugs Containing α-Methylene Sulfone/Sulfonamide Functional Groups Using N-Methylnicotinamide Chloride as a Fluorogenic Agent. | 2011 | Int J Anal Chem | pmid:21647288 |
Ip K et al. | Analysis of complex metabolic behavior through pathway decomposition. | 2011 | BMC Syst Biol | pmid:21639889 |
Ion G et al. | Effects of canola and corn oil mimetic on Jurkat cells. | 2011 | Lipids Health Dis | pmid:21631947 |
Yang J et al. | Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes. | 2011 | BMC Genomics | pmid:21631939 |
Roberts LD et al. | The contrasting roles of PPARδ and PPARγ in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue. | 2011 | Genome Biol. | pmid:21843327 |
Chabukswar A et al. | Six sigma: process of understanding the control and capability of ranitidine hydrochloride tablet. | 2011 | J Young Pharm | pmid:21607050 |
Lacaze C et al. | The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership. | 2011 | Malar. J. | pmid:21605361 |
Liu Y et al. | Graphene and graphene oxide: two ideal choices for the enrichment and ionization of long-chain fatty acids free from matrix-assisted laser desorption/ionization matrix interference. | 2011 | Rapid Commun. Mass Spectrom. | pmid:22006384 |
Fabiano A et al. | Metabolomic analysis of bronchoalveolar lavage fluid in preterm infants complicated by respiratory distress syndrome: preliminary results. | 2011 | J. Matern. Fetal. Neonatal. Med. | pmid:21781003 |
Wang Y et al. | [Analysis of plasma metabonomics of mini-swines with qi deficiency and blood stasis syndrome due to chronic myocardial ischemia]. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:21288451 |
Islam A and Ehsan A | Comparison of suture material and technique of closure of subcutaneous fat and skin in caesarean section. | 2011 | N Am J Med Sci | pmid:22540072 |
Green CD and Olson LK | Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21266672 |
Pniewski T et al. | Low-dose oral immunization with lyophilized tissue of herbicide-resistant lettuce expressing hepatitis B surface antigen for prototype plant-derived vaccine tablet formulation. | 2011 | J. Appl. Genet. | pmid:21107787 |
González-Mira E et al. | Potential use of nanostructured lipid carriers for topical delivery of flurbiprofen. | 2011 | J Pharm Sci | pmid:20575052 |
Peter A et al. | Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21045174 |
Kasliwal N et al. | Formulation, development, and performance evaluation of metoclopramide HCl oro-dispersible sustained release tablet. | 2011 | Arch. Pharm. Res. | pmid:22076769 |
Asahi H et al. | Plasmodium falciparum: differing effects of non-esterified fatty acids and phospholipids on intraerythrocytic growth in serum-free medium. | 2011 | Exp. Parasitol. | pmid:21095186 |
Seow LJ et al. | Anti-angiogenic activity of Gynura segetum leaf extracts and its fractions. | 2011 | J Ethnopharmacol | pmid:21167271 |
Price ER et al. | Carnitine palmitoyl transferase activity and whole muscle oxidation rates vary with fatty acid substrate in avian flight muscles. | 2011 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:21153644 |
Lin Y et al. | Nucleating effect of calcium stearate coated CaCO(3) nanoparticles on polypropylene. | 2011 | J Colloid Interface Sci | pmid:21122873 |
MacDonald AM et al. | A modified supported bilayer/diblock polymer--working towards a tunable coating for capillary electrophoresis. | 2011 | J Chromatogr A | pmid:21122870 |
Liu X et al. | Synthesis of high quality and stability CdS quantum dots with overlapped nucleation-growth process in large scale. | 2011 | J Colloid Interface Sci | pmid:21040929 |
Aardema H et al. | Oleic acid prevents detrimental effects of saturated fatty acids on bovine oocyte developmental competence. | 2011 | Biol. Reprod. | pmid:21311036 |
Pingali K et al. | Mixing order of glidant and lubricant--influence on powder and tablet properties. | 2011 | Int J Pharm | pmid:21356286 |
Morinaga N et al. | Synthesis of fatty acid sterol esters using cholesterol esterase from Trichoderma sp. AS59. | 2011 | Enzyme Microb. Technol. | pmid:22113022 |
Lee DM et al. | Oxidative stress and inflammation in renal patients and healthy subjects. | 2011 | PLoS ONE | pmid:21829457 |
Lipasek RA et al. | Effects of anticaking agents and relative humidity on the physical and chemical stability of powdered vitamin C. | 2011 | J. Food Sci. | pmid:22417544 |
Stingl JC et al. | Protocol for minimizing the risk of metachronous adenomas of the colorectum with green tea extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population. | 2011 | BMC Cancer | pmid:21851602 |
Andaloussi SE et al. | Application of PepFect peptides for the delivery of splice-correcting oligonucleotides. | 2011 | Methods Mol. Biol. | pmid:21053143 |
Yu DG et al. | Coaxial electrospinning with organic solvent for controlling the size of self-assembled nanoparticles. | 2011 | Chem. Commun. (Camb.) | pmid:21107459 |
Das SC et al. | Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate. | 2011 | Eur J Pharm Sci | pmid:21621612 |
Laverroux S et al. | Isomerization of vaccenic acid to cis and trans C18:1 isomers during biohydrogenation by rumen microbes. | 2011 | Lipids | pmid:21706384 |
Someshwar K et al. | Formulation and evaluation of effervescent floating tablets of tizanidine hydrochloride. | 2011 | Acta Pharm | pmid:21684848 |
Pereira MG et al. | Trypanosoma cruzi epimastigotes are able to store and mobilize high amounts of cholesterol in reservosome lipid inclusions. | 2011 | PLoS ONE | pmid:21818313 |