stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Watanabe R et al. | Molecular cloning of a cDNA encoding a novel fatty acid-binding protein from rat skin. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8166694 |
Lee WN et al. | Measurement of fractional lipid synthesis using deuterated water (2H2O) and mass isotopomer analysis. | 1994 | Am. J. Physiol. | pmid:8166257 |
Darmani H et al. | Effect of interferon-gamma on membrane conformation in the macrophage-like cell line P388D. | 1993 | J. Interferon Res. | pmid:8151138 |
Wonsil BJ et al. | Dietary and ruminally derived trans-18:1 fatty acids alter bovine milk lipids. | 1994 | J. Nutr. | pmid:8145078 |
Golovina EA and Tikhonov AN | The structural differences between the embryos of viable and nonviable wheat seeds as studied with the EPR spectroscopy of lipid-soluble spin labels. | 1994 | Biochim. Biophys. Acta | pmid:8142440 |
Ghaly ES et al. | Controlled release of theophylline from inert matrices: effect of channeling material on release rate. | 1993 | P R Health Sci J | pmid:8140202 |
Rule DC | Effects of dietary fatty acid composition on glycerophosphate acyltransferase activity in rat adipose tissue and liver. | 1994 | Int. J. Biochem. | pmid:8138047 |
Burdick S et al. | Different mechanisms of uptake of stearic acid and cholesterol into rabbit jejunal brush border membrane vesicles. | 1993 | Lipids | pmid:8121247 |
Redgrave TG et al. | The condensing effects of egg lecithin and cholesterol on triolein monolayers are inhibited by substitution of one saturated acyl chain in the triacylglycerol. | 1994 | Biochim. Biophys. Acta | pmid:8117751 |
Melander A | Influence of food on the bioavailability of drugs. | 1978 Sep-Oct | Clin Pharmacokinet | pmid:81118 |
Rabinowitz JL and Myerson RM | Changes in the lipid content of rat lymph after the ingestion of [14C] long-chain fatty acids. | 1994 | Life Sci. | pmid:8107533 |
Arnould T et al. | Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1. | 1993 | Am. J. Physiol. | pmid:8098907 |
Sylvester PW et al. | Fatty acid modulation of epidermal growth factor-induced mouse mammary epithelial cell proliferation in vitro. | 1994 | Exp. Cell Res. | pmid:8082717 |
Sargent JR et al. | Nervonic acid and demyelinating disease. | 1994 | Med. Hypotheses | pmid:8072429 |
Vestemar V et al. | Binding of (+)- and (-)-isomers and racemate of etomoxir to human serum albumin and effect of stearic acid and stanozolol. | 1994 | J Pharm Sci | pmid:8046600 |
Hoebeke M et al. | Quenching of merocyanine 540 triplet state by nitroxyl radicals in liposomal systems: a laser flash photolysis study. | 1994 | J. Photochem. Photobiol. B, Biol. | pmid:8014755 |
Ellingson JS and Seenaiah B | The selective use of stearoyl-polyunsaturated molecular species of phosphatidylcholine and phosphatidylethanolamine for the synthesis of phosphatidylserine. | 1994 | Biochim. Biophys. Acta | pmid:8011673 |
Taylor AJ | Erythrocyte membrane fatty acid composition in hypercholesterolaemia. | 1994 | Ann. Clin. Biochem. | pmid:7979101 |
Kritchevsky D | Stearic acid metabolism and atherogenesis: history. | 1994 | Am. J. Clin. Nutr. | pmid:7977159 |
Grundy SM | Influence of stearic acid on cholesterol metabolism relative to other long-chain fatty acids. | 1994 | Am. J. Clin. Nutr. | pmid:7977157 |
Vanderveen JE | Regulatory history for stearic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7977156 |
Metabolic Consequences of Stearic Acid Relative to Other Long-Chain Fatty Acids, Atlanta, Georgia, November 5-6, 1993 and Chocolate in Perspective: Cocoa Butter, a Unique Saturated Fat, Dallas, Texas, February 9, 1994. Symposium proceedings. | 1994 | Am. J. Clin. Nutr. | pmid:7977155 | |
Schoene NW et al. | Dissimilar responses of platelets to dietary stearic and palmitic acids. | 1994 | Am. J. Clin. Nutr. | pmid:7977151 |
Blair IA et al. | Dietary stearic acid and thromboxane-prostacyclin biosynthesis in normal human subjects. | 1994 | Am. J. Clin. Nutr. | pmid:7977150 |
Hoak JC | Stearic acid, clotting, and thrombosis. | 1994 | Am. J. Clin. Nutr. | pmid:7977149 |
Denke MA | Role of beef and beef tallow, an enriched source of stearic acid, in a cholesterol-lowering diet. | 1994 | Am. J. Clin. Nutr. | pmid:7977148 |
Dougherty RM et al. | Total and low-density-lipoprotein cholesterol lipoprotein fractions and fecal fatty acid excretion of men consuming diets containing high concentrations of stearic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7977147 |
Kris-Etherton PM and Mustad VA | Chocolate feeding studies: a novel approach for evaluating the plasma lipid effects of stearic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7977145 |
Emken EA | Metabolism of dietary stearic acid relative to other fatty acids in human subjects. | 1994 | Am. J. Clin. Nutr. | pmid:7977144 |
Denke MA | Effects of cocoa butter on serum lipids in humans: historical highlights. | 1994 | Am. J. Clin. Nutr. | pmid:7977142 |
Fuller CJ and Jialal I | Effects of antioxidants and fatty acids on low-density-lipoprotein oxidation. | 1994 | Am. J. Clin. Nutr. | pmid:7977141 |
Adewusi SR and Ilori MO | Nutritional evaluation of spent grains from sorghum malts and maize grit. | 1994 | Plant Foods Hum Nutr | pmid:7971786 |
Ikeda I et al. | Lymphatic transport of stearic acid and its effect on cholesterol transport in rats. | 1994 | J. Nutr. Sci. Vitaminol. | pmid:7965216 |
Shenai JP and Chytil F | Effect of maternal dexamethasone treatment on fetal lung vitamin A stores in the perinatal rat. | 1994 | Int J Vitam Nutr Res | pmid:7960497 |
Awad AB et al. | In vitro activation and inhibition of rat colonic phospholipase D by fatty acids. | 1994 | Cancer Lett. | pmid:7954345 |
Oe H et al. | Calcium overload and cardiac myocyte cell damage induced by arachidonate lipoxygenation. | 1994 | Am. J. Physiol. | pmid:7943384 |
Richieri GV et al. | Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. | 1994 | J. Biol. Chem. | pmid:7929039 |
Young AC et al. | Structural studies on human muscle fatty acid binding protein at 1.4 A resolution: binding interactions with three C18 fatty acids. | 1994 | Structure | pmid:7922029 |
Scholz WK | An ibotenate-selective metabotropic glutamate receptor mediates protein phosphorylation in cultured hippocampal pyramidal neurons. | 1994 | J. Neurochem. | pmid:7908944 |
Zoukhri D and Dartt DA | Cholinergic activation of phospholipase D in lacrimal gland acini is independent of protein kinase C and calcium. | 1995 | Am. J. Physiol. | pmid:7900776 |
Warhurst DC et al. | The chemotherapy of rodent malaria, XXIV. The blood schizontocidal action of erythromycin upon Plasmodium berghei. | 1976 | Ann Trop Med Parasitol | pmid:788656 |
Percival L et al. | A case study of dermatitis based on a collaborative approach between occupational physicians and industrial hygienists. | 1995 | Am Ind Hyg Assoc J | pmid:7856518 |
Catalá A et al. | Interaction of rat liver microsomes containing saturated or unsaturated fatty acids with fatty acid binding protein: peroxidation effect. | 1994 | Mol. Cell. Biochem. | pmid:7845387 |
de Alaniz MJ and Marra CA | Role of delta 9 desaturase activity in the maintenance of high levels of monoenoic fatty acids in hepatoma cultured cells. | 1994 | Mol. Cell. Biochem. | pmid:7845382 |
Kaewvichit S and Tucker IG | The release of macromolecules from fatty acid matrices: complete factorial study of factors affecting release. | 1994 | J. Pharm. Pharmacol. | pmid:7837038 |
Shoji Y et al. | Effect of topical preparation of mycophenolic acid on experimental allergic contact dermatitis of guinea-pigs induced by dinitrofluorobenzene. | 1994 | J. Pharm. Pharmacol. | pmid:7815276 |
Aggarwal M et al. | The effect of Cd2+ on lipid components of sunflower (Helianthus annuus L.) seeds. | 1995 | Plant Foods Hum Nutr | pmid:7792263 |
Lai HC et al. | Alteration of plasma lipids in the rat by fractionation of modified milk fat (butterfat). | 1995 | J. Dairy Sci. | pmid:7790571 |
Fujimoto Y et al. | Effects of fatty acyl coenzyme A esters on lipoxygenase and cyclooxygenase metabolism of arachidonic acid in rabbit platelets. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7784474 |
Lai HC and Ney DM | Corn oil, palm oil and butterfat fractions affect postprandial lipemia and lipoprotein lipase in meal-fed rats. | 1995 | J. Nutr. | pmid:7782908 |