stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fodorová M et al. | Structural features of lipid A of Rickettsia typhi. | 2011 | Acta Virol. | pmid:21434703 |
Ropero J et al. | Near-infrared chemical imaging slope as a new method to study tablet compaction and tablet relaxation. | 2011 | Appl Spectrosc | pmid:21396195 |
Junk MJ et al. | DEER in biological multispin-systems: a case study on the fatty acid binding to human serum albumin. | 2011 | J. Magn. Reson. | pmid:21450500 |
Franch-Lage F et al. | Fast assessment of the surface distribution of API and excipients in tablets using NIR-hyperspectral imaging. | 2011 | Int J Pharm | pmid:21419207 |
Xu QC et al. | Enhanced photocatalytic activity of C-N-codoped TiO2 films prepared via an organic-free approach. | 2011 | J. Hazard. Mater. | pmid:21316842 |
Zhou QT et al. | Characterization of the surface properties of a model pharmaceutical fine powder modified with a pharmaceutical lubricant to improve flow via a mechanical dry coating approach. | 2011 | J Pharm Sci | pmid:21455980 |
Sheikh KA et al. | Influence of hydration state and homologue composition of magnesium stearate on the physical chemical properties of liquid paraffin lipogels. | 2011 | Int J Pharm | pmid:21457766 |
Severino P et al. | Polymorphism, crystallinity and hydrophilic-lipophilic balance of stearic acid and stearic acid-capric/caprylic triglyceride matrices for production of stable nanoparticles. | 2011 | Colloids Surf B Biointerfaces | pmid:21543196 |
Zhou QT et al. | Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties. | 2011 | Int J Pharm | pmid:21527321 |
Wang S et al. | Insertion of an esterase gene into a specific locust pathogen (Metarhizium acridum) enables it to infect caterpillars. | 2011 | PLoS Pathog. | pmid:21731492 |
Manzano E et al. | Study of the GC-MS determination of the palmitic-stearic acid ratio for the characterisation of drying oil in painting: La Encarnación by Alonso Cano as a case study. | 2011 | Talanta | pmid:21530791 |
Paczkowski S and Schütz S | Post-mortem volatiles of vertebrate tissue. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21720824 |
Prabhakar N et al. | Polyaniline Langmuir-Blodgett film based aptasensor for ochratoxin A detection. | 2011 | Biosens Bioelectron | pmid:21514815 |
Fini A et al. | Diclofenac salts, part 6: release from lipid microspheres. | 2011 | J Pharm Sci | pmid:21523784 |
Wahjudi PN et al. | Turnover of nonessential fatty acids in cardiolipin from the rat heart. | 2011 | J. Lipid Res. | pmid:21957203 |
Haghjou N et al. | Sustained release intraocular drug delivery devices for treatment of uveitis. | 2011 | J Ophthalmic Vis Res | pmid:22454753 |
Paul D et al. | Proteome and membrane fatty acid analyses on Oligotropha carboxidovorans OM5 grown under chemolithoautotrophic and heterotrophic conditions. | 2011 | PLoS ONE | pmid:21386900 |
Ash MM et al. | Phytosterol stearate esters elicit similar responses on plasma lipids and cholesterol absorption but different responses on fecal neutral sterol excretion and hepatic free cholesterol in male Syrian hamsters. | 2011 | Nutr Res | pmid:21840470 |
Broderick PA and Kolodny EH | Biosensors for brain trauma and dual laser doppler flowmetry: enoxaparin simultaneously reduces stroke-induced dopamine and blood flow while enhancing serotonin and blood flow in motor neurons of brain, in vivo. | 2011 | Sensors (Basel) | pmid:22346571 |
Rojas J and Kumar V | Comparative evaluation of silicified microcrystalline cellulose II as a direct compression vehicle. | 2011 | Int J Pharm | pmid:21708237 |
Ely DR and Carvajal MT | Determination of the scale of segregation of low dose tablets using hyperspectral imaging. | 2011 | Int J Pharm | pmid:21601625 |
Neji SB et al. | Esterification of fatty acid over Tunisian acid activated clay: kinetic study. | 2011 | J Oleo Sci | pmid:21606617 |
Whitney TR et al. | Redberry juniper as a roughage source in lamb feedlot rations: wool and carcass characteristics, meat fatty acid profiles, and sensory panel traits. | 2011 | Meat Sci. | pmid:21570776 |
Yalcin H et al. | Effect of gamma-irradiation on some chemical characteristics and volatile content of linseed. | 2011 | J Med Food | pmid:21548804 |
Dong Z et al. | Preparation and in vitro, in vivo evaluations of norfloxacin-loaded solid lipid nanopartices for oral delivery. | 2011 | Drug Deliv | pmid:21554156 |
Oosterveer MH et al. | Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function. | 2011 | Nutr Metab (Lond) | pmid:22201701 |
Zhang Y et al. | α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes. | 2011 | Lipids Health Dis | pmid:21592363 |
Ting TC et al. | Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells. | 2011 | J. Biol. Chem. | pmid:21596756 |
Man TY et al. | Dietary manipulation reveals an unexpected inverse relationship between fat mass and adipose 11β-hydroxysteroid dehydrogenase type 1. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21406612 |
Pingali K et al. | Evaluation of strain-induced hydrophobicity of pharmaceutical blends and its effect on drug release rate under multiple compression conditions. | 2011 | Drug Dev Ind Pharm | pmid:20942612 |
Arora G et al. | Formulation and evaluation of controlled release matrix mucoadhesive tablets of domperidone using Salvia plebeian gum. | 2011 | J Adv Pharm Technol Res | pmid:22171313 |
Sathiyaraj S et al. | Lornoxicam gastro retentive floating matrix tablets: Design and in vitro evaluation. | 2011 | J Adv Pharm Technol Res | pmid:22171312 |
Solanki SS and Dahima R | Formulation and evaluation of aceclofenac mouth-dissolving tablet. | 2011 | J Adv Pharm Technol Res | pmid:22171305 |
Negi JS et al. | Effect of bioadhesion on initial in vitro buoyancy of effervescent floating matrix tablets of ciprofloxacin HCL. | 2011 | J Adv Pharm Technol Res | pmid:22171304 |
Stahl J et al. | The effect of formulation vehicles on the in vitro percutaneous permeation of ibuprofen. | 2011 | BMC Pharmacol. | pmid:22168832 |
Raynes Greenow CH et al. | Antibiotics for ureaplasma in the vagina in pregnancy. | 2011 | Cochrane Database Syst Rev | pmid:21901685 |
Walash MI et al. | Development and validation of stability indicating method for determination of sertraline following ICH guidlines and its determination in pharmaceuticals and biological fluids. | 2011 | Chem Cent J | pmid:21996025 |
El-Enany NM et al. | Spectrofluorimetric determination of sertraline in dosage forms and human plasma through derivatization with 9-fluorenylmethyl chloroformate. | 2011 | Chem Cent J | pmid:21978386 |
D'Ambrosio DN et al. | Distinct populations of hepatic stellate cells in the mouse liver have different capacities for retinoid and lipid storage. | 2011 | PLoS ONE | pmid:21949825 |
Yin AW and Huang SJ | [Research on chemical constituents of xuefu zhuyu decoction]. | 2011 | Zhong Yao Cai | pmid:22372145 |
Nurul Syazana MS et al. | Antiproliferative effect of methanolic extraction of tualang honey on human keloid fibroblasts. | 2011 | BMC Complement Altern Med | pmid:21943200 |
Rajpurohit H et al. | Hordeum vulgare hull in the design of fast disintegrating tablets. | 2011 | J Young Pharm | pmid:21897660 |
Patel D et al. | Design of Controlled Release Non-erodible Polymeric Matrix Tablet Using Microwave Oven-assisted Sintering Technique. | 2011 | J Young Pharm | pmid:21897655 |
Tachibana H | Green tea polyphenol sensing. | 2011 | Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. | pmid:21422740 |
Huntemann M et al. | Complete genome sequence of the thermophilic sulfur-reducer Hippea maritima type strain (MH(2)). | 2011 | Stand Genomic Sci | pmid:21886857 |
Véret J et al. | Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells. | 2011 | Biochem. J. | pmid:21592087 |
Fernandez C et al. | Altered desaturation and elongation of fatty acids in hormone-sensitive lipase null mice. | 2011 | PLoS ONE | pmid:21738729 |
Singhal A et al. | Colon-targeted quercetin delivery using natural polymer to enhance its bioavailability. | 2011 | Pharmacognosy Res | pmid:21731393 |
Li FQ et al. | A novel spray-dried nanoparticles-in-microparticles system for formulating scopolamine hydrobromide into orally disintegrating tablets. | 2011 | Int J Nanomedicine | pmid:21720502 |
Eggerath J et al. | EDX-Element Analysis of the In Vitro Effect of Fluoride Oral Hygiene Tablets on Artificial Caries Lesion Formation and Remineralization in Human Enamel. | 2011 | Open Dent J | pmid:21687564 |
Jeon I et al. | Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tablets. | 2011 | J Pharm Bioallied Sci | pmid:21687348 |
Tong M et al. | The effect of Zn-Al-hydrotalcites composited with calcium stearate and β-diketone on the thermal stability of PVC. | 2011 | Int J Mol Sci | pmid:21673921 |
Duangjit S et al. | Characterization and In Vitro Skin Permeation of Meloxicam-Loaded Liposomes versus Transfersomes. | 2011 | J Drug Deliv | pmid:21490750 |
Lim J et al. | Solution structures of the acyl carrier protein domain from the highly reducing type I iterative polyketide synthase CalE8. | 2011 | PLoS ONE | pmid:21674045 |
Kumaravelrajan R et al. | Development and evaluation of controlled porosity osmotic pump for nifedipine and metoprolol combination. | 2011 | Lipids Health Dis | pmid:21477386 |
Kordyukova LV et al. | Linker and/or transmembrane regions of influenza A/Group-1, A/Group-2, and type B virus hemagglutinins are packed differently within trimers. | 2011 | Biochim. Biophys. Acta | pmid:21420932 |
Wang L et al. | Rectal microbicides: clinically relevant approach to the design of rectal specific placebo formulations. | 2011 | AIDS Res Ther | pmid:21385339 |
Sahu SK et al. | Hydrophobically modified carboxymethyl chitosan nanoparticles targeted delivery of paclitaxel. | 2011 | J Drug Target | pmid:20367067 |
Salem H et al. | Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler. | 2011 | Int J Nanomedicine | pmid:21383856 |
Nicholls HT et al. | Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. | 2011 | Diabetes | pmid:21378177 |
Meng Y et al. | Two-step synthesis of fatty acid ethyl ester from soybean oil catalyzed by Yarrowia lipolytica lipase. | 2011 | Biotechnol Biofuels | pmid:21366905 |
Intorre F et al. | Differential effect of cheese fatty acid composition on blood lipid profile and redox status in normolipidemic volunteers: a pilot study. | 2011 | Int J Food Sci Nutr | pmid:21591986 |
Idris AM | Screening of conditions controlling spectrophotometric sequential injection analysis. | 2011 | Chem Cent J | pmid:21333024 |
Ordelheide AM et al. | The myocyte expression of adiponectin receptors and PPARδ is highly coordinated and reflects lipid metabolism of the human donors. | 2011 | Exp Diabetes Res | pmid:21331343 |
Gresback R et al. | Combined plasma gas-phase synthesis and colloidal processing of InP/ZnS core/shell nanocrystals. | 2011 | Nanoscale Res Lett | pmid:21711589 |
Desai D et al. | Fatty acid and water-soluble polymer-based controlled release drug delivery system. | 2011 | J Pharm Sci | pmid:21374622 |
Prajapati ST et al. | Formulation and evaluation of controlled-release tablet of zolpidem tartrate by melt granulation technique. | 2011 | ISRN Pharm | pmid:22389845 |
Kulinowski P et al. | Magnetic resonance imaging and image analysis for assessment of HPMC matrix tablets structural evolution in USP Apparatus 4. | 2011 | Pharm. Res. | pmid:21181545 |
Christian F et al. | Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. | 2011 | J. Biol. Chem. | pmid:21177871 |
Gallardo LA et al. | Europium stearate additives delay oxidation of UHMWPE for orthopaedic applications: a pilot study. | 2011 | Clin. Orthop. Relat. Res. | pmid:21153455 |
Mantzaris MD et al. | Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells. | 2011 | FEBS J. | pmid:21182590 |
Wang GG et al. | Self-assembled biomimetic superhydrophobic CaCO3 coating inspired from fouling mineralization in geothermal water. | 2011 | Langmuir | pmid:21919516 |
Basu BJ and Manasa J | Effect of deposition parameters on the wettability and microstructure of superhydrophobic films with hierarchical micro-nano structures. | 2011 | J Colloid Interface Sci | pmid:21864844 |
Su Z et al. | Effect of octreotide-polyethylene glycol(100) monostearate modification on the pharmacokinetics and cellular uptake of nanostructured lipid carrier loaded with hydroxycamptothecine. | 2011 | Mol. Pharm. | pmid:21770405 |
Hayashi Y et al. | Modeling of latent structure of indomethacin solid dispersion tablet using Bayesian networks. | 2011 | Drug Dev Ind Pharm | pmid:21702729 |
Naumowicz M et al. | Impedance analysis of complex formation equilibria in phosphatidylcholine bilayers containing decanoic acid or decylamine. | 2011 | Cell Biochem. Biophys. | pmid:21340532 |
Hsouna AB et al. | Chemical composition, cytotoxicity effect and antimicrobial activity of Ceratonia siliqua essential oil with preservative effects against Listeria inoculated in minced beef meat. | 2011 | Int. J. Food Microbiol. | pmid:21601302 |
Petelska AD and Figaszewski ZA | The equilibria of phosphatidylcholine-fatty acid and phosphatidylcholine-amine in monolayers at the air/water interface. | 2011 | Colloids Surf B Biointerfaces | pmid:20888195 |
Laus MN et al. | Activation of the plant mitochondrial potassium channel by free fatty acids and acyl-CoA esters: a possible defence mechanism in the response to hyperosmotic stress. | 2011 | J. Exp. Bot. | pmid:20801915 |
Fameau AL et al. | Smart foams: switching reversibly between ultrastable and unstable foams. | 2011 | Angew. Chem. Int. Ed. Engl. | pmid:21780260 |
Gremos S et al. | Direct enzymatic acylation of cellulose pretreated in BMIMCl ionic liquid. | 2011 | Bioresour. Technol. | pmid:20888759 |
Li S et al. | Preparation, characterization, pharmacokinetics and tissue distribution of solid lipid nanoparticles loaded with tetrandrine. | 2011 | AAPS PharmSciTech | pmid:21811889 |
Klein CM and Jenkins TC | Docosahexaenoic acid elevates trans-18:1 isomers but is not directly converted into trans-18:1 isomers in ruminal batch cultures. | 2011 | J. Dairy Sci. | pmid:21854940 |
Waters LJ et al. | Controlled microwave processing applied to the pharmaceutical formulation of ibuprofen. | 2011 | AAPS PharmSciTech | pmid:21842309 |
Corvis Y et al. | Physicochemical stability of solid dispersions of enantiomeric or racemic ibuprofen in stearic acid. | 2011 | J Pharm Sci | pmid:21905027 |
Gao Q et al. | Synthesis and characterization of novel amphiphilic copolymer stearic acid-coupled F127 nanoparticles for nano-technology based drug delivery system. | 2011 | Colloids Surf B Biointerfaces | pmid:21906917 |
Khan FN and Dehghan MH | Enhanced bioavailability of atorvastatin calcium from stabilized gastric resident formulation. | 2011 | AAPS PharmSciTech | pmid:21879394 |
Tsai MJ et al. | Oral apomorphine delivery from solid lipid nanoparticles with different monostearate emulsifiers: pharmacokinetic and behavioral evaluations. | 2011 | J Pharm Sci | pmid:20740670 |
Varshosaz J et al. | Lipid nanocapsule-based gels for enhancement of transdermal delivery of ketorolac tromethamine. | 2011 | J Drug Deliv | pmid:22175029 |
Taylor M and Elhissi AM | Predicting the physical properties of tablets from ATR-FTIR spectra using partial least squares regression. | 2011 | Pharm Dev Technol | pmid:20100067 |
Du YZ et al. | Quaternary complexes composed of plasmid DNA/protamine/fish sperm DNA/stearic acid grafted chitosan oligosaccharide micelles for gene delivery. | 2011 | Int. J. Biol. Macromol. | pmid:21035503 |
Bhattacharjee A et al. | Deposition of stearate-oleate rich seed fat in Mangifera indica is mediated by a FatA type acyl-ACP thioesterase. | 2011 | Phytochemistry | pmid:21130480 |
Yuan H et al. | Stearic acid-g-chitosan polymeric micelle for oral drug delivery: in vitro transport and in vivo absorption. | 2011 | Mol. Pharm. | pmid:21138243 |
Krogmann A et al. | Inflammatory response of human coronary artery endothelial cells to saturated long-chain fatty acids. | 2011 | Microvasc. Res. | pmid:21112343 |
Sekharan TR et al. | Formulation and Evaluation of Hydroxypropyl Methylcellulose-based Controlled Release Matrix Tablets for Theophylline. | 2011 | Indian J Pharm Sci | pmid:22707833 |
Nagarsekar KS et al. | Antioxidant and antilipid peroxidation potential of supercritical fluid extract and ethanol extract of leaves of vitex negundo linn. | 2011 | Indian J Pharm Sci | pmid:22707827 |
Bazzini AA et al. | Metabolic and miRNA profiling of TMV infected plants reveals biphasic temporal changes. | 2011 | PLoS ONE | pmid:22174812 |
Masareddy R et al. | Development of Orodispersible Tizanidine HCl Tablets Using Spray Dried Coprocessed Exipient Bases. | 2011 | Indian J Pharm Sci | pmid:22707822 |
Göker M et al. | Complete genome sequence of the thermophilic sulfur-reducer Desulfurobacterium thermolithotrophum type strain (BSA(T)) from a deep-sea hydrothermal vent. | 2011 | Stand Genomic Sci | pmid:22675590 |
Lan DM et al. | A novel cold-active lipase from Candida albicans: cloning, expression and characterization of the recombinant enzyme. | 2011 | Int J Mol Sci | pmid:21747717 |