stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Abortion, Spontaneous D000022 12 associated lipids
Acne Vulgaris D000152 35 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amnesia D000647 12 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Olfaction Disorders D000857 17 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Bacterial Infections D001424 21 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Brain Edema D001929 20 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchitis D001991 6 associated lipids
Burns D002056 34 associated lipids
Calculi D002137 3 associated lipids
Cattle Diseases D002418 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Chancroid D002602 4 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Decalcification, Pathologic D003649 1 associated lipids
Dermatitis D003872 30 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Edema D004487 152 associated lipids
Fatty Liver D005234 48 associated lipids
Foreign Bodies D005547 5 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Gonorrhea D006069 7 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypopituitarism D007018 7 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Hypothyroidism D007037 32 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Infertility D007246 3 associated lipids
Insulin Resistance D007333 99 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with stearic acid

Download all related citations
Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Haware RV et al. Vegetable-derived magnesium stearate functionality evaluation by DM(3) approach. 2016 Eur J Pharm Sci pmid:27108117
Hashemi Goradel N et al. Improvement of Liver Cell Therapy in Rats by Dietary Stearic Acid. 2016 Iran. Biomed. J. pmid:27090202
Bentejac M et al. Utilization of high-density lipoprotein sphingomyelin by the developing and mature brain in the rat. 1989 J. Neurochem. pmid:2709013
Furr HC et al. The effect of dietary fatty acid composition on liver retinyl ester (vitamin A ester) composition in the rat. 1989 J. Nutr. pmid:2703916
Wang HJ et al. Prolongation of the degradation period and improvement of the angiogenesis of zein porous scaffolds in vivo. 2016 J Mater Sci Mater Med pmid:26979976
Cheng CL et al. Spectral and morphological classification of different chronic and acute Taiwanese gallstones via FTIR, SEM and ESEM-EDX microanalyses. 2016 Dig Liver Dis pmid:26976784
Moazeni M et al. Time to overcome fluconazole resistant Candida isolates: Solid lipid nanoparticles as a novel antifungal drug delivery system. 2016 Colloids Surf B Biointerfaces pmid:26974361
Lu H et al. Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway. 2016 Diabetologia pmid:26969487
Cooksley WG and Powell LW Erythromycin jaundice: diagnosis by an in vitro challenge test. 1977 Aust N Z J Med pmid:269690
Thilakarathna SH et al. Investigations of in vitro bioaccessibility from interesterified stearic and oleic acid-rich blends. 2016 Food Funct pmid:26961726
Ma F et al. Improvement of β-TCP/PLLA biodegradable material by surface modification with stearic acid. 2016 Mater Sci Eng C Mater Biol Appl pmid:26952440
Zhang C et al. Design and evaluation of an innovative floating and bioadhesive multiparticulate drug delivery system based on hollow structure. 2016 Int J Pharm pmid:26943975
Ma Y et al. Silymarin-Loaded Nanoparticles Based on Stearic Acid-Modified Bletilla striata Polysaccharide for Hepatic Targeting. 2016 Molecules pmid:26938513
Zhang Y et al. CO2/pH-Controllable Viscoelastic Nanostructured Fluid Based on Stearic Acid Soap and Bola-Type Quaternary Ammonium Salt. 2016 Langmuir pmid:26907546
Wang S et al. Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells. 2016 Biochem. Biophys. Res. Commun. pmid:26879142
Šrámek J et al. p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells. 2016 Int J Mol Sci pmid:26861294
Lohan SB et al. Investigation of cutaneous penetration properties of stearic acid loaded to dendritic core-multi-shell (CMS) nanocarriers. 2016 Int J Pharm pmid:26853315
Stahlberg S et al. Probing the Role of Ceramide Headgroup Polarity in Short-Chain Model Skin Barrier Lipid Mixtures by ²H Solid-State NMR Spectroscopy. 2016 Langmuir pmid:26828109
Yin L et al. Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis. 2016 Toxicol In Vitro pmid:26820058
Hamedani P et al. Acute and chronic Legionnaires' disease and co-existent tuberculosis: a trial of erythromycin. 1989 Curr Med Res Opin pmid:2680287
Riobueno CJ Studies on the topical action of 10-undecen-1-il thiopseudourea iodide (AHR-1911) in acute and chronic dermatitis. 1977 J Med pmid:267713
Wang W et al. Synthesis, self-assembly, and in vitro toxicity of fatty acids-modified Bletilla striata polysaccharide. 2017 Artif Cells Nanomed Biotechnol pmid:26754958
Lavergne SN et al. Potential cutaneous hypersensitivity reaction to an inactive ingredient of thyroid hormone supplements in a dog. 2016 Vet. Dermatol. pmid:26748887
Fenner GP and Parks LW Gas chromatographic analysis of intact steryl esters in wild type Saccharomyces cerevisiae and in an ester accumulating mutant. 1989 Lipids pmid:2674578
Cerf ME and Herrera E High Fat Diet Administration during Specific Periods of Pregnancy Alters Maternal Fatty Acid Profiles in the Near-Term Rat. 2016 Nutrients pmid:26742067
Baig MS et al. Application of Box-Behnken design for preparation of levofloxacin-loaded stearic acid solid lipid nanoparticles for ocular delivery: Optimization, in vitro release, ocular tolerance, and antibacterial activity. 2016 Int. J. Biol. Macromol. pmid:26740466
Michaut A et al. A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. 2016 Toxicol. Appl. Pharmacol. pmid:26739624
Liu L et al. Decreasing high postprandial stearic acid in impaired fasting glucose by dietary regulation. 2016 Eur J Clin Nutr pmid:26733041
Adler C et al. Molecularly designed lipid microdomains for solid dispersions using a polymer/inorganic carrier matrix produced by hot-melt extrusion. 2016 Int J Pharm pmid:26721729
Veselỳ M et al. Photocatalytic and Antimicrobial Activity of Printed Hybrid Titania/Silica Layers. 2015 J Nanosci Nanotechnol pmid:26716211
Doignon F et al. Requirement of Phosphoinositides Containing Stearic Acid To Control Cell Polarity. 2015 Mol. Cell. Biol. pmid:26711260
Wood MH et al. Comparative Adsorption of Saturated and Unsaturated Fatty Acids at the Iron Oxide/Oil Interface. 2016 Langmuir pmid:26707597
Fretts AM et al. Associations of Plasma Phospholipid SFAs with Total and Cause-Specific Mortality in Older Adults Differ According to SFA Chain Length. 2016 J. Nutr. pmid:26701797
Bothun GD et al. Cooperative effects of fatty acids and n-butanol on lipid membrane phase behavior. 2016 Colloids Surf B Biointerfaces pmid:26700234
Dong X et al. [Analysis of meibum by gas chromatography-mass spectrometry]. 2015 Zhonghua Yan Ke Za Zhi pmid:26693651
Uvanesh K et al. Effect of Span 60 on the Microstructure, Crystallization Kinetics, and Mechanical Properties of Stearic Acid Oleogels: An In-Depth Analysis. 2016 J. Food Sci. pmid:26677007
Toral PG et al. Does supplemental 18:0 alleviate fish oil-induced milk fat depression in dairy ewes? 2016 J. Dairy Sci. pmid:26627853
Sergeant S et al. Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans. 2016 Br. J. Nutr. pmid:26615716
Sasakura D et al. Application of the quantitative detection of a change in concentration of magnesium stearate in a feeder tube of tableting manufacture by real-time near-infrared spectroscopy. 2015 Pharmazie pmid:26601418
Maphalla TG and Emmambux MN Functionality of maize, wheat, teff and cassava starches with stearic acid and xanthan gum. 2016 Carbohydr Polym pmid:26572436
Periti P et al. Clinical pharmacokinetic properties of the macrolide antibiotics. Effects of age and various pathophysiological states (Part I). 1989 Clin Pharmacokinet pmid:2656049
Miyazaki Y et al. Dry Powder Coating using Planetary Centrifugal Mixer. 2015 J Pharm Pharm Sci pmid:26517137
Imran M and Nadeem M Triacylglycerol composition, physico-chemical characteristics and oxidative stability of interesterified canola oil and fully hydrogenated cottonseed oil blends. 2015 Lipids Health Dis pmid:26510410
Conde-Sieira M et al. Hypothalamic fatty acid sensing in Senegalese sole (Solea senegalensis): response to long-chain saturated, monounsaturated, and polyunsaturated (n-3) fatty acids. 2015 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:26468264
Arslanagić N et al. Eradication of endemic syphilis in Bosnia. 1989 Genitourin Med pmid:2646207
Du J and Li L Which one performs better for targeted lung cancer combination therapy: pre- or post-bombesin-decorated nanostructured lipid carriers? 2016 Drug Deliv pmid:26455787
Martins AB and Santana RM Effect of carboxylic acids as compatibilizer agent on mechanical properties of thermoplastic starch and polypropylene blends. 2016 Carbohydr Polym pmid:26453854
Serra Bonvehi J and Orantes Bermejo FJ Detection of adulterated commercial Spanish beeswax. 2012 Food Chem pmid:26434344
Vervaeck A et al. Fatty acids for controlled release applications: A comparison between prilling and solid lipid extrusion as manufacturing techniques. 2015 Eur J Pharm Biopharm pmid:26428938
Iwao Y [Efficient Pharmaceutical Formulation Designs and Their Development Using Mathematical and Statistical Analysis]. 2015 Yakugaku Zasshi pmid:26423868
Liu Z et al. A novel stearic acid-modified hirudin peptidomimetic with improved pharmacokinetic properties and anticoagulant activity. 2015 Sci Rep pmid:26400022
Boiret M et al. Setting local rank constraints by orthogonal projections for image resolution analysis: application to the determination of a low dose pharmaceutical compound. 2015 Anal. Chim. Acta pmid:26388474
Veit M and Siche S S-acylation of influenza virus proteins: Are enzymes for fatty acid attachment promising drug targets? 2015 Vaccine pmid:26387429
Kumar Gaur P et al. Nanovesicles of nitrendipine with lipid complex for transdermal delivery: pharmacokinetic and pharmacodynamic studies. 2016 Artif Cells Nanomed Biotechnol pmid:26375758
Wang D et al. One-pot synthesized hierarchical zeolite supported metal nanoparticles for highly efficient biomass conversion. 2015 Chem. Commun. (Camb.) pmid:26361087
Xu L et al. The Surface Modification and Antimicrobial Activity of Basic Magnesium Hypochlorite Nanoparticles. 2015 J Nanosci Nanotechnol pmid:26353638
Zhang X et al. Effect of Chemicals on Morphology and Luminescence of CdSe Quantum Dots. 2015 J Nanosci Nanotechnol pmid:26353513
Bhattacharya S et al. Increasing the stearate content in seed oil of Brassica juncea by heterologous expression of MlFatB affects lipid content and germination frequency of transgenic seeds. 2015 Plant Physiol. Biochem. pmid:26351151
Li X et al. Preparation of co-spray dried cushioning agent containing stearic acid for protecting pellet coatings when compressed. 2016 Drug Dev Ind Pharm pmid:26289006
Seethamraju S et al. Reactive interlayer based ultra-low moisture permeable membranes for organic photovoltaic encapsulation. 2015 Phys Chem Chem Phys pmid:26278515
Miao H et al. Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes. 2015 Sci Rep pmid:26271607
Yang W et al. Facile Synthesis of Gd-Cu-In-S/ZnS Bimodal Quantum Dots with Optimized Properties for Tumor Targeted Fluorescence/MR In Vivo Imaging. 2015 ACS Appl Mater Interfaces pmid:26257133
Zhong T et al. Effects of ultrasound treatment on lipid self-association and properties of methylcellulose/stearic acid blending films. 2015 Carbohydr Polym pmid:26256202
He H et al. VB12-coated Gel-Core-SLN containing insulin: Another way to improve oral absorption. 2015 Int J Pharm pmid:26253378
Soliman HM et al. Utilization of Stearic acid Extracted from Olive Pomace for Production of Triazoles, Thiadiazoles and Thiadiazines Derivatives of Potential Biological Activities. 2015 J Oleo Sci pmid:26250422
Fala AM et al. Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α. 2015 Sci Rep pmid:26237540
Xu W et al. Bilayers at High pH in the Fatty Acid Soap Systems and the Applications for the Formation of Foams and Emulsions. 2015 J Phys Chem B pmid:26237503
Hoffmann M et al. Investigation into process-induced de-aggregation of cohesive micronised API particles. 2015 Int J Pharm pmid:26235919
Gong X et al. Dependence of tablet brittleness on tensile strength and porosity. 2015 Int J Pharm pmid:26226338
Liu G et al. Cell membrane-inspired polymeric micelles as carriers for drug delivery. 2015 Biomater Sci pmid:26222292
Qu L et al. Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders. 2015 Eur J Pharm Sci pmid:26215464
Senyilmaz D et al. Regulation of mitochondrial morphology and function by stearoylation of TFR1. 2015 Nature pmid:26214738
Ocloo FCK et al. Effects of stearic acid and gamma irradiation, alone and in combination, on pasting properties of high amylose maize starch. 2016 Food Chem pmid:26212935
Gotoh K et al. Introduction of Atmospheric Pressure Plasma to Aqueous Detergent Processes. 2015 J Oleo Sci pmid:26179001
Hong J et al. Effects of genetic variants for the swine FABP3, HMGA1, MC4R, IGF2, and FABP4 genes on fatty acid composition. 2015 Meat Sci. pmid:26172243
Kaukoranta-Tolvanen SS et al. Effect of erythromycin acistrate and erythromycin stearate on human colonic microflora. 1989 Scand. J. Infect. Dis. pmid:2617212
Park JH et al. Development of DH-I-180-3 loaded lipid nanoparticle for photodynamic therapy. 2015 Int J Pharm pmid:26149935
Williams RO and McGinity JW Compaction properties of microcrystalline cellulose and sodium sulfathiazole in combination with talc or magnesium stearate. 1989 J Pharm Sci pmid:2614693
de Paiva EJ et al. Influence of two different alcohols in the esterification of fatty acids over layered zinc stearate/palmitate. 2015 Bioresour. Technol. pmid:26143001
Astanina K et al. Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells. 2015 Sci Rep pmid:26095213
Ricci M et al. Growth and Dissolution of Calcite in the Presence of Adsorbed Stearic Acid. 2015 Langmuir pmid:26087312
Santos IC et al. Paired-ion electrospray ionization--triple quadrupole tandem mass spectrometry for quantification of anionic surfactants in waters. 2015 Talanta pmid:26078166
Vraníková B et al. Modern evaluation of liquisolid systems with varying amounts of liquid phase prepared using two different methods. 2015 Biomed Res Int pmid:26075249
Judd JT et al. Relationship of dietary fat to plasma fatty acids, blood pressure, and urinary eicosanoids in adult men. 1989 J Am Coll Nutr pmid:2607069
Rizzuti B et al. Fatty acid binding into the highest affinity site of human serum albumin observed in molecular dynamics simulation. 2015 Arch. Biochem. Biophys. pmid:26048999
Patil PS et al. Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity. 2015 Nat Commun pmid:26037164
Onishi H et al. In vitro and in vivo evaluations of buccal tablet formulations of ritodrine hydrochloride. 2015 Biol. Pharm. Bull. pmid:26027834
Muglia C et al. Anaphylaxis to medications containing meat byproducts in an alpha-gal sensitized individual. J Allergy Clin Immunol Pract pmid:26003233
Sharma BK and Erdman RA In vitro degradation of choline from selected feedstuffs and choline supplements. 1989 J. Dairy Sci. pmid:2600236
Cárdenas V et al. Strategy for design NIR calibration sets based on process spectrum and model space: An innovative approach for process analytical technology. 2015 J Pharm Biomed Anal pmid:26001330
Bora PS et al. Purification to homogeneity and characterization of major fatty acid ethyl ester synthase from human myocardium. 1989 FEBS Lett. pmid:2599089
de Sousa FF et al. Low-temperature phase transformation studies in the stearic acid: C form. 2015 Spectrochim Acta A Mol Biomol Spectrosc pmid:25909902
Bulut-Oner F et al. Sustained release isoniazid tablets. I--Formulation and in vitro evaluation. 1989 Jul-Aug Farmaco pmid:2590371
Rehman M et al. Solid and liquid lipid-based binary solid lipid nanoparticles of diacerein: in vitro evaluation of sustained release, simultaneous loading of gold nanoparticles, and potential thermoresponsive behavior. 2015 Int J Nanomedicine pmid:25897224
Harding SV et al. Desaturation index versus isotopically measured de novo lipogenesis as an indicator of acute systemic lipogenesis. 2015 BMC Res Notes pmid:25879456
Silva-Neta IC et al. Expression of genes related to tolerance to low temperature for maize seed germination. 2015 Genet. Mol. Res. pmid:25867416
Patil H et al. Formulation and development of pH-independent/dependent sustained release matrix tablets of ondansetron HCl by a continuous twin-screw melt granulation process. 2015 Int J Pharm pmid:25863118
Bera H et al. Alginate gel-coated oil-entrapped alginate-tamarind gum-magnesium stearate buoyant beads of risperidone. 2015 Int. J. Biol. Macromol. pmid:25861741
Badal Tejedor M et al. Tablet mechanics depend on nano and micro scale adhesion, lubrication and structure. 2015 Int J Pharm pmid:25841569
Rozman Peterka T et al. Solid state compatibility study and characterization of a novel degradation product of tacrolimus in formulation. 2015 J Pharm Biomed Anal pmid:25804434