stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Abortion, Spontaneous D000022 12 associated lipids
Acne Vulgaris D000152 35 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amnesia D000647 12 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Olfaction Disorders D000857 17 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Bacterial Infections D001424 21 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Brain Edema D001929 20 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchitis D001991 6 associated lipids
Burns D002056 34 associated lipids
Calculi D002137 3 associated lipids
Cattle Diseases D002418 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Chancroid D002602 4 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Decalcification, Pathologic D003649 1 associated lipids
Dermatitis D003872 30 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Edema D004487 152 associated lipids
Fatty Liver D005234 48 associated lipids
Foreign Bodies D005547 5 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Gonorrhea D006069 7 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypopituitarism D007018 7 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Hypothyroidism D007037 32 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Infertility D007246 3 associated lipids
Insulin Resistance D007333 99 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with stearic acid

Download all related citations
Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Christensen E et al. Beta-oxidation of medium chain (C8-C14) fatty acids studied in isolated liver cells. 1989 Biochim. Biophys. Acta pmid:2752017
Collins JM and Grogan WM Comparison between flow cytometry and fluorometry for the kinetic measurement of membrane fluidity parameters. 1989 Cytometry pmid:2917474
Garcia Zevallos M and Farkas T Manipulation of plasma membrane physical state affects desaturase activity in rat lymphocytes. 1989 Arch. Biochem. Biophys. pmid:2786374
Singh H et al. Mitochondrial and peroxisomal beta-oxidation of stearic and lignoceric acids by rat brain. 1989 J. Neurochem. pmid:2809586
Burrows GE et al. A comparison of the various routes of administration of erythromycin in cattle. 1989 J. Vet. Pharmacol. Ther. pmid:2810478
Wada M et al. Mechanism of biosynthesis of unsaturated fatty acids in Pseudomonas sp. strain E-3, a psychrotrophic bacterium. 1989 J. Bacteriol. pmid:2753856
Friedman E et al. Fecal diglycerides as selective endogenous mitogens for premalignant and malignant human colonic epithelial cells. 1989 Cancer Res. pmid:2910475
Demediuk P et al. Changes in free fatty acids, phospholipids, and cholesterol following impact injury to the rat spinal cord. 1989 J. Neurosci. Res. pmid:2520534
Yoshida S et al. Effect of phospholipase A2 and free fatty acids on lipid-protein interactions in long- and very-long-chain fatty acyl-CoA elongation enzyme systems of brain microsomes. 1989 Biochim. Biophys. Acta pmid:2502180
Wolf BA et al. Secretagogue-induced diacylglycerol accumulation in isolated pancreatic islets. Mass spectrometric characterization of the fatty acyl content indicates multiple mechanisms of generation. 1989 Biochemistry pmid:2504278
Furr HC et al. The effect of dietary fatty acid composition on liver retinyl ester (vitamin A ester) composition in the rat. 1989 J. Nutr. pmid:2703916
Thiel C and Kadenbach B Influence of non-esterified fatty acids on respiratory control of reconstituted cytochrome-c oxidase. 1989 FEBS Lett. pmid:2546826
Yodono H et al. [A case of hepatocellular carcinoma effectively treated by intraarterial infusion of CDDP and other agents]. 1989 Gan To Kagaku Ryoho pmid:2551253
Buttke TM et al. Absence of unsaturated fatty acid synthesis in murine T lymphocytes. 1989 Proc. Natl. Acad. Sci. U.S.A. pmid:2569740
Beardshall K et al. Saturation of fat and cholecystokinin release: implications for pancreatic carcinogenesis. 1989 Lancet pmid:2572741
Hillered L and Chan PH Brain mitochondrial swelling induced by arachidonic acid and other long chain free fatty acids. 1989 J. Neurosci. Res. pmid:2531232
Leak RE and Woodford JD Pharmaceutical development of ondansetron tablets. 1989 Eur J Cancer Clin Oncol pmid:2533901
Rendu F et al. Ajoene, the antiplatelet compound derived from garlic, specifically inhibits platelet release reaction by affecting the plasma membrane internal microviscosity. 1989 Biochem. Pharmacol. pmid:2539823
Fenner GP and Parks LW Gas chromatographic analysis of intact steryl esters in wild type Saccharomyces cerevisiae and in an ester accumulating mutant. 1989 Lipids pmid:2674578
Hamedani P et al. Acute and chronic Legionnaires' disease and co-existent tuberculosis: a trial of erythromycin. 1989 Curr Med Res Opin pmid:2680287
Arslanagić N et al. Eradication of endemic syphilis in Bosnia. 1989 Genitourin Med pmid:2646207
Periti P et al. Clinical pharmacokinetic properties of the macrolide antibiotics. Effects of age and various pathophysiological states (Part I). 1989 Clin Pharmacokinet pmid:2656049
Judd JT et al. Relationship of dietary fat to plasma fatty acids, blood pressure, and urinary eicosanoids in adult men. 1989 J Am Coll Nutr pmid:2607069
Williams RO and McGinity JW Compaction properties of microcrystalline cellulose and sodium sulfathiazole in combination with talc or magnesium stearate. 1989 J Pharm Sci pmid:2614693
Kaukoranta-Tolvanen SS et al. Effect of erythromycin acistrate and erythromycin stearate on human colonic microflora. 1989 Scand. J. Infect. Dis. pmid:2617212
Luhrs CA and Slomiany BL A human membrane-associated folate binding protein is anchored by a glycosyl-phosphatidylinositol tail. 1989 J. Biol. Chem. pmid:2557328
Linden DJ and Routtenberg A cis-Fatty acids, which activate protein kinase C, attenuate Na+ and Ca2+ currents in mouse neuroblastoma cells. 1989 J. Physiol. (Lond.) pmid:2559978
Bora PS et al. Purification to homogeneity and characterization of major fatty acid ethyl ester synthase from human myocardium. 1989 FEBS Lett. pmid:2599089
Sharma BK and Erdman RA In vitro degradation of choline from selected feedstuffs and choline supplements. 1989 J. Dairy Sci. pmid:2600236
Punnonen K and Jansén CT UVB irradiation and distribution of arachidonic acid (20:4) and stearic acid (18:0) in human keratinocytes. 1989 Photodermatol pmid:2473452
Pahuja SL and Hochberg RB A comparison of the fatty acid esters of estradiol and corticosterone synthesized by tissues of the rat. 1989 J. Biol. Chem. pmid:2492532
Shires SE et al. Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. 1989 Biochim. Biophys. Acta pmid:2493807
Severin SE et al. Synapsin I from human brain. Phosphorylation by Ca2+, phospholipid-dependent protein kinase. 1989 FEBS Lett. pmid:2513229
Adeyeye A et al. Studies on the antigenic S-type lipopolysaccharides of Brucella abortus strains 7 and Mustapha. 1989 Int. J. Biol. Macromol. pmid:2518732
Haeffner EW and Friedel R Induction of an endothermic transition in the Arrhenius plot of fatty acid uptake by lipid-depleted ascites tumor cells. 1989 Biochim. Biophys. Acta pmid:2775760
Broderick PA Characterizing stearate probes in vitro for the electrochemical detection of dopamine and serotonin. 1989 Brain Res. pmid:2776030
Burke JP and Fenton MR Plasma and cellular zinc levels and membrane lipid composition in streptozotocin diabetic rats. 1989 Comp. Biochem. Physiol., B pmid:2776432
Männistö PT et al. Efficacy of erythromycin acistrate (2'-acetyl erythromycin stearate) and erythromycin stearate in experimental infections in mice. 1989 J. Pharmacol. Exp. Ther. pmid:2778707
Paris A and Rao D Biosynthesis of estradiol-17 beta fatty acyl esters by microsomes derived from bovine liver and adrenals. 1989 J. Steroid Biochem. pmid:2779237
Deasy PB and O'Neill CT Bioadhesive dosage form for peroral administration of timolol base. 1989 Pharm Acta Helv pmid:2780757
Mohsenin V and Gee JL Oxidation of alpha 1-protease inhibitor: role of lipid peroxidation products. 1989 J. Appl. Physiol. pmid:2787317
Bentejac M et al. Utilization of high-density lipoprotein sphingomyelin by the developing and mature brain in the rat. 1989 J. Neurochem. pmid:2709013
Mortimer BC et al. The effect of added monoacylglycerols on the removal from plasma of chylomicron-like emulsions injected intravenously in rats. 1989 Biochim. Biophys. Acta pmid:2713386
Mitropoulos KA et al. The activation of the contact phase of coagulation by physiologic surfaces in plasma: the effect of large negatively charged liposomal vesicles. 1989 Blood pmid:2713491
Biesalski HK and Weiser H Sensitive analysis of retinyl esters by isocratic adsorption chromatography. 1989 J. Clin. Chem. Clin. Biochem. pmid:2746165
Kitajima J et al. [Studies on the constituents of trichosanthes root. III. Constituents of roots of Trichosanthes bracteata Voigt]. 1989 Yakugaku Zasshi pmid:2760813
Brodersen R et al. Serum albumin binding of palmitate and stearate. Multiple binding theory for insoluble ligands. 1989 Eur. J. Biochem. pmid:2731550
Beck JC et al. Growth of epithelium from a preneoplastic mammary outgrowth in response to mammary adipose tissue. 1989 In Vitro Cell. Dev. Biol. pmid:2732196
Yamreudeewong W et al. Effect of antacid coadministration on the bioavailability of erythromycin stearate. 1989 Clin Pharm pmid:2743731
Skrede S et al. The effects of alkylthioacetic acids (3-thia fatty acids) on fatty acid metabolism in isolated hepatocytes. 1989 Biochim. Biophys. Acta pmid:2804058
Bulut-Oner F et al. Sustained release isoniazid tablets. I--Formulation and in vitro evaluation. 1989 Jul-Aug Farmaco pmid:2590371
Kosukhin AB et al. [The mechanism of formation of spectrum of nonesterified fatty acids in biological fluids of rabbits with alimentary hypercholesterolemia]. 1989 Mar-Apr Vopr. Med. Khim. pmid:2741412
Bly JE et al. Differential effects of temperature and exogenous fatty acids on mitogen-induced proliferation in channel catfish T and B lymphocytes. 1990 Comp Biochem Physiol A Comp Physiol pmid:1970529
Svedberg J et al. Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes. 1990 Diabetes pmid:2185108
Imamura K et al. Colony-stimulating factor 1 activates protein kinase C in human monocytes. 1990 EMBO J. pmid:2196173
Wei S et al. [Chemical constituents in the stem of Premna crassa Hand. -Mazz]. 1990 Zhongguo Zhong Yao Za Zhi pmid:2093323
Pourbohloul SC and Buttke TM Identification of T-helper cells as the target of stearic acid-inhibition in primary antibody responses in vitro. 1990 Int. J. Immunopharmacol. pmid:2149847
Schlame M et al. Relationship between lipid saturation and lipid-protein interaction in liver mitochondria modified by catalytic hydrogenation with reference to cardiolipin molecular species. 1990 Biochem. J. pmid:2154183
Guzmán A and García R Effects of fatty ethers and stearic acid on the gastrointestinal absorption of insulin. 1990 P R Health Sci J pmid:2077554
Alegría AE et al. Semiquinones derived from anthraquinone-containing antitumor drugs can partition into phosphatidylcholine bilayers. 1990 Biochim. Biophys. Acta pmid:2166575
Kitagawa S et al. Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. 1990 Biochim. Biophys. Acta pmid:2166588
Fujii H and Kakinuma K Studies on the superoxide releasing site in plasma membranes of neutrophils with ESR spin-labels. 1990 J. Biochem. pmid:2172228
Hsiao WL et al. Effects of specific fatty acids on cell transformation induced by an activated c-H-ras oncogene. 1990 Oncogene pmid:2107493
Anel A et al. Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. 1990 Biochim. Biophys. Acta pmid:2114179
Nicholson ML et al. Inhibition of experimental colorectal carcinogenesis by dietary N-6 polyunsaturated fats. 1990 Carcinogenesis pmid:2124952
Fletcher JE et al. Fatty acids modulate calcium-induced calcium release from skeletal muscle heavy sarcoplasmic reticulum fractions: implications for malignant hyperthermia. 1990 Biochem. Cell Biol. pmid:2125224
Zaridze DG et al. [Fatty acid composition of phospholipids of erythrocyte membranes and risk of breast cancer]. 1990 Vopr Onkol pmid:2126901
Singh H et al. Metabolism of branched chain fatty acids in peroxisomal disorders. 1990 J. Inherit. Metab. Dis. pmid:1700192
Mensink RP and Katan MB Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects. 1990 N. Engl. J. Med. pmid:2374566
Newman MJ Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2371287
Kedryna T et al. Pyruvate kinase from cytosolic fractions of the Ehrlich ascites tumour, normal mouse liver and skeletal muscle. 1990 Biochim. Biophys. Acta pmid:2354196
Ong CN et al. Biological monitoring of workers exposed to lead stearate. 1990 J Appl Toxicol pmid:2335713
Persad RA et al. Erythrocyte stearic to oleic acid ratio in prostatic carcinoma. 1990 Br J Urol pmid:2337746
Neoptolemos JP and Thomas BS Erythrocyte membrane stearic acid: oleic acid ratios in colorectal cancer using tube capillary column gas liquid chromatography. 1990 Ann. Clin. Biochem. pmid:2310156
Alakhov VYu AV et al. Increasing cytostatic effects of ricin A chain and Staphylococcus aureus enterotoxin A through in vitro hydrophobization with fatty acid residues. 1990 Biotechnol. Appl. Biochem. pmid:2310510
Ahmad SN et al. Fatty acid incorporation into membranes of dispersed rat submandibular salivary gland cells and their effect on adenylate cyclase activity. 1990 Arch. Oral Biol. pmid:2281999
Bentejac M et al. Metabolic fate of sphingomyelin of high-density lipoprotein in rat plasma. 1990 Lipids pmid:2079870
Metz SA and Dunlop M Production of phosphatidylethanol by phospholipase D phosphatidyl transferase in intact or dispersed pancreatic islets: evidence for the in situ metabolism of phosphatidylethanol. 1990 Arch. Biochem. Biophys. pmid:2125821
Trinchera M et al. Recycling of glucosylceramide and sphingosine for the biosynthesis of gangliosides and sphingomyelin in rat liver. 1990 Biochem. J. pmid:2241913
Kelly SB et al. Erythrocyte stearic acid desaturation in patients with colorectal carcinoma. 1990 Dis. Colon Rectum pmid:2242696
Bogdarin IuA and Goncharov NP [Effects of ovariectomy on the composition of fatty acids of phospholipids in Java macaques with cholestasis]. 1990 Biull Eksp Biol Med pmid:2118815
Privat JP et al. Incorporation of spin-labeled fatty acids into bovine brain clathrin coated vesicles. 1990 Biochim. Biophys. Acta pmid:2158352
Yoshizawa H and Koishi M The coating and the encapsulation of an interactive powder mixture and its application to sustained release preparations. 1990 J. Pharm. Pharmacol. pmid:1982136
McIlhinney RA and McGlone K Evidence for a non-myristoylated pool of the 80 kDa protein kinase C substrate of rat brain. 1990 Biochem. J. pmid:2244873
Chaudry A et al. Essential fatty acid distribution in the plasma and tissue phospholipids of patients with benign and malignant prostatic disease. 1991 Br. J. Cancer pmid:1764380
Takahashi R et al. Fatty acid composition of serum phospholipids in an elderly institutionalized Japanese population. 1991 J. Nutr. Sci. Vitaminol. pmid:1765844
DeÄ­neka SE et al. [Experimental data on the effects of lead, barium, silver, zinc and calcium stearates on the cardiovascular system]. 1991 Gig Tr Prof Zabol pmid:1794723
Applegate KR and Glomset JA Effect of acyl chain unsaturation on the conformation of model diacylglycerols: a computer modeling study. 1991 J. Lipid Res. pmid:1797944
Buttke TM et al. Correlation between low-temperature immunosuppression and the absence of unsaturated fatty acid synthesis in murine T cells. 1991 Comp. Biochem. Physiol., B pmid:1799970
Denke MA and Grundy SM Effects of fats high in stearic acid on lipid and lipoprotein concentrations in men. 1991 Am. J. Clin. Nutr. pmid:1845606
Morgan H et al. Proton transport at the monolayer-water interface. 1991 Biochim. Biophys. Acta pmid:1848448
YashRoy RC Protein heat denaturation and study of membrane lipid-protein interactions by spin label ESR. 1991 J. Biochem. Biophys. Methods pmid:1848569
Qian MW and Eaton JW Iron translocation by free fatty acids. 1991 Am. J. Pathol. pmid:1750512
Koike R et al. Physiological significance of fatty acid elongation system in adrenoleukodystrophy. 1991 J. Neurol. Sci. pmid:1880537
Mehta JR et al. Lipid fluidity and composition of the erythrocyte membrane from healthy dogs and Labrador retrievers with hereditary muscular dystrophy. 1991 Neurochem. Res. pmid:1908955
Nelson JM et al. Cadmium ion-induced alterations of phospholipid metabolism in endothelial cells. 1991 Am. J. Respir. Cell Mol. Biol. pmid:1910817
Nagao M et al. Arachidonic acid metabolism in articular chondrocytes. 1991 Clin. Orthop. Relat. Res. pmid:1914309
Ulmann L et al. Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. 1991 Biochim. Biophys. Acta pmid:1657182
Duane PG et al. Relationship of oxidant-mediated cytotoxicity to phospholipid metabolism in endothelial cells. 1991 Am. J. Respir. Cell Mol. Biol. pmid:2021479
Nowak G and Kaletha K Molecular forms of human kidney AMP-deaminase. 1991 Adv. Exp. Med. Biol. pmid:1781367