stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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Christensen E et al. | Beta-oxidation of medium chain (C8-C14) fatty acids studied in isolated liver cells. | 1989 | Biochim. Biophys. Acta | pmid:2752017 |
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Punnonen K and Jansén CT | UVB irradiation and distribution of arachidonic acid (20:4) and stearic acid (18:0) in human keratinocytes. | 1989 | Photodermatol | pmid:2473452 |
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Brodersen R et al. | Serum albumin binding of palmitate and stearate. Multiple binding theory for insoluble ligands. | 1989 | Eur. J. Biochem. | pmid:2731550 |
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Yamreudeewong W et al. | Effect of antacid coadministration on the bioavailability of erythromycin stearate. | 1989 | Clin Pharm | pmid:2743731 |
Skrede S et al. | The effects of alkylthioacetic acids (3-thia fatty acids) on fatty acid metabolism in isolated hepatocytes. | 1989 | Biochim. Biophys. Acta | pmid:2804058 |
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Svedberg J et al. | Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes. | 1990 | Diabetes | pmid:2185108 |
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Fujii H and Kakinuma K | Studies on the superoxide releasing site in plasma membranes of neutrophils with ESR spin-labels. | 1990 | J. Biochem. | pmid:2172228 |
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Persad RA et al. | Erythrocyte stearic to oleic acid ratio in prostatic carcinoma. | 1990 | Br J Urol | pmid:2337746 |
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