stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Sorek N et al. | An S-acylation switch of conserved G domain cysteines is required for polarity signaling by ROP GTPases. | 2010 | Curr. Biol. | pmid:20451389 |
Reddy TS et al. | Fatty acid composition and arachidonic acid metabolism in vitreous lipids from canine and human eyes. | 1986 | Curr. Eye Res. | pmid:3089690 |
Ubels JL et al. | Vitamin A is stored as fatty acyl esters of retinol in the lacrimal gland. | 1988 | Curr. Eye Res. | pmid:3229120 |
Papanikolaou S et al. | Accumulation of a cocoa-butter-like lipid by Yarrowia lipolytica cultivated on agro-industrial residues. | 2003 | Curr. Microbiol. | pmid:12520368 |
Furusawa H and Koyama N | Effect of fatty acids on the membrane potential of an alkaliphilic bacillus. | 2004 | Curr. Microbiol. | pmid:15057464 |
Poisson JP | Lipid metabolism. | 1995 | Curr. Opin. Lipidol. | pmid:7670747 |
Edwards EK and Edwards EK | Allergic reaction to triethanolamine stearate in a sunscreen. | 1983 | Cutis | pmid:6831931 |
Collins JM and Grogan WM | Comparison between flow cytometry and fluorometry for the kinetic measurement of membrane fluidity parameters. | 1989 | Cytometry | pmid:2917474 |
Shivanand K et al. | In vivo bioavailability studies of sumatriptan succinate buccal tablets. | 2011 | Daru | pmid:22615661 |
Gande S and Rao Y | Sustained-release effervescent floating matrix tablets of baclofen: development, optimization and in vitro-in vivo evaluation in healthy human volunteers. | 2011 | Daru | pmid:22615658 |
Varshosaz J et al. | Development of novel budesonide pellets based on CODES(TM) technology: In vitro/in vivo evaluation in induced colitis in rats. | 2011 | Daru | pmid:22615647 |
Nokhodchi A et al. | Physico-mechanical and dissolution behaviours of ibuprofen crystals crystallized in the presence of various additives. | 2010 | Daru | pmid:22615598 |
Hellgren L and Vincent J | Erythromycin stearate in acne vulgaris: its effect on the skin surface lipids and on the activity of purified pancreatic lipase. | 1978 | Dermatologica | pmid:145975 |
Bleeker J et al. | Effect of systemic erythromycin stearate on the inflammatory lesions and skin surface fatty acids in acne vulgaris. | 1981 | Dermatologica | pmid:6454598 |
Carter-Dawson L et al. | Rhodopsin, 11-cis vitamin A, and interstitial retinol-binding protein (IRBP) during retinal development in normal and rd mutant mice. | 1986 | Dev. Biol. | pmid:3732615 |
Xie FM et al. | [Preparation of stearic acid solid lipid nanoparticles containing podophyllotoxin]. | 2005 | Di Yi Jun Yi Da Xue Xue Bao | pmid:15684011 |
Reyna SM et al. | Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. | 2008 | Diabetes | pmid:18633101 |
Staiger K et al. | Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation. | 2006 | Diabetes | pmid:17065351 |
Chu X et al. | Sterol regulatory element-binding protein-1c mediates increase of postprandial stearic acid, a potential target for improving insulin resistance, in hyperlipidemia. | 2013 | Diabetes | pmid:22966071 |
Mittendorfer B et al. | What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean? | 2003 | Diabetes | pmid:12829627 |
Watanabe Y et al. | The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation. | 2012 | Diabetes | pmid:22396206 |
Eitel K et al. | Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. | 2003 | Diabetes | pmid:12663471 |
Weigert C et al. | Palmitate-induced activation of the hexosamine pathway in human myotubes: increased expression of glutamine:fructose-6-phosphate aminotransferase. | 2003 | Diabetes | pmid:12606504 |
Nicholls HT et al. | Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. | 2011 | Diabetes | pmid:21378177 |
Bajaj M et al. | Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients. | 2005 | Diabetes | pmid:16249438 |
Svedberg J et al. | Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes. | 1990 | Diabetes | pmid:2185108 |
Staiger H et al. | Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans. | 2009 | Diabetes | pmid:19074989 |
Brun T et al. | Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1. | 1997 | Diabetes | pmid:9032094 |
Dobbins RL et al. | The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats. | 2002 | Diabetes | pmid:12031970 |
Mas S et al. | Local non-esterified fatty acids correlate with inflammation in atheroma plaques of patients with type 2 diabetes. | 2010 | Diabetes | pmid:20200316 |
Houmard JA et al. | Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects. | 2002 | Diabetes | pmid:12351433 |
Yeop Han C et al. | Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation. | 2010 | Diabetes | pmid:19934003 |
Kantartzis K et al. | Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. | 2009 | Diabetes | pmid:19651814 |
Bergman BC et al. | Intramuscular lipid metabolism in the insulin resistance of smoking. | 2009 | Diabetes | pmid:19581421 |
Peter A et al. | Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. | 2009 | Diabetes | pmid:19478146 |
Ussher JR et al. | Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase. | 2009 | Diabetes | pmid:19478144 |
Kotronen A et al. | Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver. | 2009 | Diabetes | pmid:18952834 |
Storm H et al. | Comparison of a carbohydrate-rich diet and diets rich in stearic or palmitic acid in NIDDM patients. Effects on lipids, glycemic control, and diurnal blood pressure. | 1997 | Diabetes Care | pmid:9405898 |
Ayvaz G et al. | Acute and chronic effects of different concentrations of free fatty acids on the insulin secreting function of islets. | 2002 | Diabetes Metab. | pmid:12688627 |
Fujio J et al. | Regulation of gut-derived resistin-like molecule beta expression by nutrients. | 2008 | Diabetes Res. Clin. Pract. | pmid:17936398 |
Staiger H et al. | Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro. | 2005 | Diabetologia | pmid:16132959 |
Yu HY et al. | Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells. | 2001 | Diabetologia | pmid:11380080 |
Roberts R et al. | Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans. | 2009 | Diabetologia | pmid:19252892 |
Staiger K et al. | Insulin and its analogue glargine do not affect viability and proliferation of human coronary artery endothelial and smooth muscle cells. | 2005 | Diabetologia | pmid:16078017 |
Lu H et al. | Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway. | 2016 | Diabetologia | pmid:26969487 |
Cheng CL et al. | Spectral and morphological classification of different chronic and acute Taiwanese gallstones via FTIR, SEM and ESEM-EDX microanalyses. | 2016 | Dig Liver Dis | pmid:26976784 |
Hattori Y et al. | Role of phospholipase A2 in cholesterol gallstone formation is associated with biliary phospholipid species selection at the site of hepatic excretion: indirect evidence. | 2000 | Dig. Dis. Sci. | pmid:10961723 |
Kelly SB et al. | Erythrocyte stearic acid desaturation in patients with colorectal carcinoma. | 1990 | Dis. Colon Rectum | pmid:2242696 |
Boshtam M et al. | Serum paraoxonase 1 activity is associated with fatty acid composition of high density lipoprotein. | 2013 | Dis. Markers | pmid:24167374 |
Du J and Li L | Which one performs better for targeted lung cancer combination therapy: pre- or post-bombesin-decorated nanostructured lipid carriers? | 2016 | Drug Deliv | pmid:26455787 |
Desai D et al. | Evaluation of selected micronized poloxamers as tablet lubricants. | 2007 | Drug Deliv | pmid:17994358 |
Zhang JQ et al. | Preparation and characterization of solid lipid nanoparticles containing silibinin. | 2007 | Drug Deliv | pmid:17701527 |
Dong Z et al. | Preparation and in vitro, in vivo evaluations of norfloxacin-loaded solid lipid nanopartices for oral delivery. | 2011 | Drug Deliv | pmid:21554156 |
KladnÃcková I et al. | Release of albumin from oligoester plastic matrices: effect of magnesium oxide and bivalent stearates. | 2006 Jan-Feb | Drug Deliv | pmid:16401590 |
Momoh MA et al. | Influence of magnesium stearate on the physicochemical and pharmacodynamic characteristics of insulin-loaded Eudragit entrapped mucoadhesive microspheres. | 2015 | Drug Deliv | pmid:24670092 |
Nandini PT et al. | Formulation and evaluation of gemcitabine-loaded solid lipid nanoparticles. | 2015 | Drug Deliv | pmid:24283392 |
Luppi B et al. | Gastroresistant microcapsules: new approaches for site-specific delivery of ketoprofen. | 2009 | Drug Deliv | pmid:19555305 |
Wang Y and Wu W | In situ evading of phagocytic uptake of stealth solid lipid nanoparticles by mouse peritoneal macrophages. | 2006 May-Jun | Drug Deliv | pmid:16556570 |
Taneri F et al. | In vitro and in vivo evaluation of oral tablet formulations prepared with ketoconazole and hydroxypropyl-beta-cyclodextrin. | 2010 | Drug Deliv | pmid:20148713 |
Bigucci F et al. | Chitosan salts coated with stearic acid as colon-specific delivery systems for vancomycin. | 2008 | Drug Deliv | pmid:18763159 |
Barakat NS et al. | Controlled-release carbamazepine matrix granules and tablets comprising lipophilic and hydrophilic components. | 2009 | Drug Deliv | pmid:19555310 |
Mahdi ES et al. | Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters. | 2011 | Drug Des Devel Ther | pmid:21792294 |
Abe H and Otsuka M | Effects of lubricant-mixing time on prolongation of dissolution time and its prediction by measuring near infrared spectra from tablets. | 2012 | Drug Dev Ind Pharm | pmid:21954869 |
MuzÃková J and Nováková P | A study of the properties of compacts from silicified microcrystalline celluloses. | 2007 | Drug Dev Ind Pharm | pmid:17654026 |
Maghsoodi M et al. | Improved compaction and packing properties of naproxen agglomerated crystals obtained by spherical crystallization technique. | 2007 | Drug Dev Ind Pharm | pmid:18058318 |
Martino PD et al. | The role of several l-HPCs in preventing tablet capping during direct compression of metronidazole. | 2007 | Drug Dev Ind Pharm | pmid:18097804 |
Aziz HA et al. | Solubility of core materials in aqueous polymeric solution effect on microencapsulation of curcumin. | 2007 | Drug Dev Ind Pharm | pmid:18058323 |
Wei CC and Ge ZQ | Influence of electrolyte and poloxamer 188 on the aggregation kinetics of solid lipid nanoparticles (SLNs). | 2012 | Drug Dev Ind Pharm | pmid:22181005 |
Nande VS et al. | Sustained release microspheres of diclofenac sodium using PEGylated rosin derivatives. | 2007 | Drug Dev Ind Pharm | pmid:17891576 |
Pingali K et al. | Evaluation of strain-induced hydrophobicity of pharmaceutical blends and its effect on drug release rate under multiple compression conditions. | 2011 | Drug Dev Ind Pharm | pmid:20942612 |
Horio T et al. | Measurement of flowability of lubricated powders by the vibrating tube method. | 2013 | Drug Dev Ind Pharm | pmid:22781029 |
Walden M et al. | The effect of ethanol on the release of opioids from oral prolonged-release preparations. | 2007 | Drug Dev Ind Pharm | pmid:17882730 |
Shiromani PK and Clair J | Statistical comparison of high-shear versus low-shear granulation using a common formulation. | 2000 | Drug Dev Ind Pharm | pmid:10738654 |
Rodriguez L et al. | Hot air coating technique as a novel method to produce microparticles. | 2004 | Drug Dev Ind Pharm | pmid:15554215 |
Palmieri GF et al. | Evaluation of the mixing effectiveness of a new powder mixer. | 1998 | Drug Dev Ind Pharm | pmid:15605601 |
Swaminathan V and Kildsig DO | The effect of particle morphology on the physical stability of pharmaceutical powder mixtures: the effect of surface roughness of the carrier on the stability of ordered mixtures. | 2000 | Drug Dev Ind Pharm | pmid:10769777 |
Choi du H et al. | A new experimental design method to optimize formulations focusing on a lubricant for hydrophilic matrix tablets. | 2012 | Drug Dev Ind Pharm | pmid:22348254 |
Stanisz B et al. | Effect of pharmaceutical excipients on the stability of angiotensin-converting enzyme inhibitors in their solid dosage formulations. | 2013 | Drug Dev Ind Pharm | pmid:22348774 |
Cantor SL et al. | Development and optimization of taste-masked orally disintegrating tablets (ODTs) of clindamycin hydrochloride. | 2015 | Drug Dev Ind Pharm | pmid:25000481 |
Vueba ML et al. | Role of cellulose ether polymers on ibuprofen release from matrix tablets. | 2005 | Drug Dev Ind Pharm | pmid:16207613 |
Qu L et al. | Investigation of the potential for direct compaction of a fine ibuprofen powder dry-coated with magnesium stearate. | 2015 | Drug Dev Ind Pharm | pmid:24738790 |
Sudah OS et al. | Mixing of cohesive pharmaceutical formulations in tote (bin) blenders. | 2002 | Drug Dev Ind Pharm | pmid:12378960 |
Siaan M et al. | Influence of Avicel PH-301 on the compressibility of alpha-methyldopa and phenobarbitone in direct compression. | 2000 | Drug Dev Ind Pharm | pmid:10914328 |
Chang RK and Hussain MA | Consolidation behavior of an experimental, cross-linked polyalkyl ammonium polymer. | 2000 | Drug Dev Ind Pharm | pmid:10697761 |
Mani N et al. | Microencapsulation of a hydrophilic drug into a hydrophobic matrix using a salting-out procedure. II. Effects of adsorbents on microsphere properties. | 2004 | Drug Dev Ind Pharm | pmid:15000433 |
Okoye P et al. | To evaluate the effect of various magnesium stearate polymorphs using powder rheology and thermal analysis. | 2012 | Drug Dev Ind Pharm | pmid:22304483 |
Li S et al. | Effect of formulation variables on the floating properties of gastric floating drug delivery system. | 2002 | Drug Dev Ind Pharm | pmid:12236064 |
Simmons DM and Gierer DS | A material sparing test to predict punch sticking during formulation development. | 2012 | Drug Dev Ind Pharm | pmid:22181042 |
Järvinen MA et al. | Continuous direct tablet compression: effects of impeller rotation rate, total feed rate and drug content on the tablet properties and drug release. | 2013 | Drug Dev Ind Pharm | pmid:23163644 |
Alhamami OM | The effects of some physico-chemical factors and pharmaceutical excipients on the bioavailability of nitrofurantoin oily and aqueous suspensions in rats. | 2002 | Drug Dev Ind Pharm | pmid:12026223 |
Kidokoro M et al. | Application of fluidized hot-melt granulation (FHMG) for the preparation of granules for tableting; properties of granules and tablets prepared by FHMG. | 2002 | Drug Dev Ind Pharm | pmid:11858526 |
Hayashi Y et al. | Modeling of latent structure of indomethacin solid dispersion tablet using Bayesian networks. | 2011 | Drug Dev Ind Pharm | pmid:21702729 |
MužÃková J and Eimerová I | A study of the compaction process and the properties of tablets made of a new co-processed starch excipient. | 2011 | Drug Dev Ind Pharm | pmid:21469946 |
Yoshida MI et al. | Thermal behavior study and decomposition kinetics of amiodarone hydrochloride under isothermal conditions. | 2011 | Drug Dev Ind Pharm | pmid:21449701 |
Vargas CI and Ghaly ES | Kinetic release of theophylline from hydrophilic swellable matrices. | 1999 | Drug Dev Ind Pharm | pmid:10518245 |
Osorio JG and Muzzio FJ | Effects of powder flow properties on capsule filling weight uniformity. | 2013 | Drug Dev Ind Pharm | pmid:23902366 |
Lau M et al. | Co-milled API-lactose systems for inhalation therapy: impact of magnesium stearate on physico-chemical stability and aerosolization performance. | 2017 | Drug Dev Ind Pharm | pmid:28122460 |
Jonat S et al. | Influence of compacted hydrophobic and hydrophilic colloidal silicon dioxide on tableting properties of pharmaceutical excipients. | 2005 | Drug Dev Ind Pharm | pmid:16207616 |
Beg S et al. | QbD-driven development and evaluation of nanostructured lipid carriers (NLCs) of Olmesartan medoxomil employing multivariate statistical techniques. | 2018 | Drug Dev Ind Pharm | pmid:29048242 |
Liu C et al. | In situ intestinal absorption of cyclosporine A solid dispersion in rats. | 2008 | Drug Dev Ind Pharm | pmid:18568913 |