stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Whitby CP et al. | Effect of oil soluble surfactant in emulsions stabilised by clay particles. | 2008 | J Colloid Interface Sci | pmid:18452938 |
He X et al. | Formulation development and process scale up of a high shear wet granulation formulation containing a poorly wettable drug. | 2008 | J Pharm Sci | pmid:18449937 |
John Wallace R | Gut microbiology - broad genetic diversity, yet specific metabolic niches. | 2008 | Animal | pmid:22443591 |
Chen Y et al. | Isolation of 5-hydroxypyrrolidin-2-one and other constituents from the young fronds of Pteridium aquilinum. | 2008 | J Nat Med | pmid:18437503 |
Riegler J et al. | Blue shift of CdSe/ZnS nanocrystal-labels upon DNA-hybridization. | 2008 | J Nanobiotechnology | pmid:18489732 |
Simon MN et al. | Persistent activation of Akt or ERK prevents the toxicity induced by saturated and polyunsaturated fatty acids in RINm5F β-cells. | 2008 | Toxicol In Vitro | pmid:18395405 |
Arida AI and Al-Tabakha MM | Cellactose a co-processed excipient: a comparison study. | 2008 | Pharm Dev Technol | pmid:18379907 |
Ranji A et al. | Determination of calcium stearate in polyolefin samples by gas chromatographic technique after performing dispersive liquid-liquid microextraction. | 2008 | Anal Sci | pmid:18469468 |
McHedlov-Petrossyan NO et al. | Fluorescent dye N,N'-dioctadecylrhodamine as a new interfacial acid-base indicator. | 2008 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:17681854 |
Jones PJ | Dietary agents that target gastrointestinal and hepatic handling of bile acids and cholesterol. | 2008 | J Clin Lipidol | pmid:21291720 |
Shah RB et al. | Comparative evaluation of flow for pharmaceutical powders and granules. | 2008 | AAPS PharmSciTech | pmid:18446489 |
Lee YH et al. | Separation and determination of polyethylene glycol fatty acid esters in cosmetics by a reversed-phase HPLC/ELSD. | 2008 | Talanta | pmid:18371826 |
Darole PS et al. | Formulation and evaluation of microemulsion based delivery system for amphotericin B. | 2008 | AAPS PharmSciTech | pmid:18446472 |
Flasiński M et al. | Per-6-O-(tert-butyldimethylsilyl)cyclodextrins (TBDMS-CDs) in Langmuir monolayers: the importance of a spreading solvent in the preparation of LB layers suitable for sensor application. | 2008 | J Phys Chem B | pmid:18358030 |
Liao KS et al. | Superhydrophobic surfaces formed using layer-by-layer self-assembly with aminated multiwall carbon nanotubes. | 2008 | Langmuir | pmid:18324860 |
Fujimoto Y et al. | Stearic acid potently modulates the activity of cyclooxygenase-1, but not cyclooxygenase-2, in the form of its CoA ester. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18083017 |
Hentschel A et al. | Beta-carotene-loaded nanostructured lipid carriers. | 2008 | J. Food Sci. | pmid:18298743 |
Salas JJ et al. | The biochemical characterization of a high-stearic acid sunflower mutant reveals the coordinated regulation of stearoyl-acyl carrier protein desaturases. | 2008 | Plant Physiol. Biochem. | pmid:18023195 |
Georget DM et al. | A study on maize proteins as a potential new tablet excipient. | 2008 | Eur J Pharm Biopharm | pmid:18294824 |
Lee DY and Fiehn O | High quality metabolomic data for Chlamydomonas reinhardtii. | 2008 | Plant Methods | pmid:18442406 |
Sun CC | On the mechanism of reduced tabletability of granules prepared by roller compaction. | 2008 | Int J Pharm | pmid:18024020 |
Xie L et al. | Quality-by-design (QbD): effects of testing parameters and formulation variables on the segregation tendency of pharmaceutical powder measured by the ASTM D 6940-04 segregation tester. | 2008 | J Pharm Sci | pmid:18271036 |
Gouda AA and Hassan WS | Spectrophotometric determination of etodolac in pure form and pharmaceutical formulations. | 2008 | Chem Cent J | pmid:18410679 |
Lee WJ and Chen YC | Novolak PF resins prepared from phenol liquefied Cryptomeria japonica and used in manufacturing moldings. | 2008 | Bioresour. Technol. | pmid:18243689 |
Kim CH et al. | Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. | 2008 | Anaerobe | pmid:17996466 |
Zaccone A et al. | Correlation between colloidal stability and surfactant adsorption/association phenomena studied by light scattering. | 2008 | J Phys Chem B | pmid:18229917 |
Hu FQ et al. | Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin. | 2008 | Eur J Pharm Biopharm | pmid:17997293 |
Wakasawa T et al. | Solid-state compatibility studies using a high-throughput and automated forced degradation system. | 2008 | Int J Pharm | pmid:18215480 |
Vögler O et al. | Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats. | 2008 | Int J Obes (Lond) | pmid:18059405 |
Tanka-Salamon A et al. | Suppressed catalytic efficiency of plasmin in the presence of long-chain fatty acids. Identification of kinetic parameters from continuous enzymatic assay with Monte Carlo simulation. | 2008 | FEBS J. | pmid:18279394 |
Jose R et al. | Dependence of luminescence efficiency of cdse quantum dots on chemical environments. | 2008 | J Nanosci Nanotechnol | pmid:19198279 |
Ruths M et al. | Friction of fatty acids in nanometer-sized contacts of different adhesive strength. | 2008 | Langmuir | pmid:18085802 |
Piao ZZ et al. | Colonic release and reduced intestinal tissue damage of coated tablets containing naproxen inclusion complex. | 2008 | Int J Pharm | pmid:17928177 |
Jones OA et al. | A metabolomics based approach to assessing the toxicity of the polyaromatic hydrocarbon pyrene to the earthworm Lumbricus rubellus. | 2008 | Chemosphere | pmid:17928029 |
Rhee YS et al. | Application of instrumental evaluation of color for the pre-formulation and formulation of rabeprazole. | 2008 | Int J Pharm | pmid:17919858 |
Vehring R | Pharmaceutical particle engineering via spray drying. | 2008 | Pharm. Res. | pmid:18040761 |
Wu H et al. | Process analytical technology (PAT): quantification approaches in terahertz spectroscopy for pharmaceutical application. | 2008 | J Pharm Sci | pmid:17722101 |
Guo J et al. | Phenolic molding compound filled with nonmetals of waste PCBs. | 2008 | Environ. Sci. Technol. | pmid:18284173 |
Nyblom HK et al. | Glucose-induced de novo synthesis of fatty acyls causes proportional increases in INS-1E cellular lipids. | 2008 | NMR Biomed | pmid:17691080 |
Werle M | Natural and synthetic polymers as inhibitors of drug efflux pumps. | 2008 | Pharm. Res. | pmid:17896100 |
Moate PJ et al. | Milk fatty acids II: prediction of the production of individual fatty acids in bovine milk. | 2008 | J. Dairy Sci. | pmid:18292274 |
Almaya A and Aburub A | Effect of particle size on compaction of materials with different deformation mechanisms with and without lubricants. | 2008 | AAPS PharmSciTech | pmid:18431664 |
Bushra R et al. | Formulation development and optimization of Ibuprofen tablets by direct compression method. | 2008 | Pak J Pharm Sci | pmid:18390440 |
Kuno Y et al. | Effect of the type of lubricant on the characteristics of orally disintegrating tablets manufactured using the phase transition of sugar alcohol. | 2008 | Eur J Pharm Biopharm | pmid:18396020 |
Kauffman JF et al. | Near infrared spectroscopy of magnesium stearate hydrates and multivariate calibration of pseudopolymorph composition. | 2008 | J Pharm Sci | pmid:17546666 |
Moore IM et al. | Methotrexate-induced alterations in beta-oxidation correlate with cognitive abilities in children with acute lymphoblastic leukemia. | 2008 | Biol Res Nurs | pmid:18398226 |
Bacher C et al. | Compressibility and compactibility of granules produced by wet and dry granulation. | 2008 | Int J Pharm | pmid:18407441 |
Teixeira AC et al. | Phase behaviour of binary mixtures involving tristearin, stearyl stearate and stearic acid: thermodynamic study and BAM observation at the air-water interface and AFM analysis of LB films. | 2008 | Chem. Phys. Lipids | pmid:18407835 |
Gmucová K et al. | Orientation ordering of nanoparticle Ag/Co cores controlled by electric and magnetic fields. | 2008 | Chemphyschem | pmid:18386264 |
Navarro-Tarazaga ML et al. | Fatty acid effect on hydroxypropyl methylcellulose-beeswax edible film properties and postharvest quality of coated 'Ortanique' mandarins. | 2008 | J. Agric. Food Chem. | pmid:18950188 |
Dillon R et al. | Development of a novel LC/MS method to quantitate cellular stearoyl-CoA desaturase activity. | 2008 | Anal. Chim. Acta | pmid:18790132 |
Pi K et al. | [Study on liposoluble constituents of Teucrium labiosum]. | 2008 | Zhong Yao Cai | pmid:18973016 |
Hernández ML et al. | The utilization and desaturation of oleate and linoleate during glycerolipid biosynthesis in olive (Olea europaea L.) callus cultures. | 2008 | J. Exp. Bot. | pmid:18515829 |
Fang YP et al. | Physicochemical and safety evaluation of 5-aminolevulinic acid in novel liposomes as carrier for skin delivery. | 2008 | J Liposome Res | pmid:18348070 |
Dou M et al. | [Orthogonal experiments for optimizing the formulation and preparation conditions of temozolomide solid lipid nanoparticles]. | 2008 | Sheng Wu Yi Xue Gong Cheng Xue Za Zhi | pmid:19024463 |
Vartorelli MR et al. | Spin-labeled stearic acid behavior and perturbations on the structure of a gel-phase-lipid bilayer in water: 5-, 12- and 16-SASL. | 2008 | J Phys Chem B | pmid:19055388 |
Liu Q et al. | Cobalt nanowires prepared by heterogeneous nucleation in propanediol and their catalytic properties. | 2008 | Nanotechnology | pmid:21828879 |
Zhang JX et al. | Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat. | 2008 | Chem. Senses | pmid:18515819 |
Ishima Y et al. | S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding. | 2008 | J. Biol. Chem. | pmid:18940810 |
Lockridge JB et al. | Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acids. | 2008 | J. Lipid Res. | pmid:18387886 |
Xue R et al. | A serum metabolomic investigation on hepatocellular carcinoma patients by chemical derivatization followed by gas chromatography/mass spectrometry. | 2008 | Rapid Commun. Mass Spectrom. | pmid:18767022 |
Sadhu HG et al. | Poisoning of workers working in small lead-based units. | 2008 | Indian J Occup Environ Med | pmid:20040974 |
Kirtsreesakul V et al. | Microbiology and antimicrobial susceptibility patterns of commensal flora in the middle nasal meatus. | 2008 | Ann. Otol. Rhinol. Laryngol. | pmid:19140538 |
McNamara RK et al. | Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. | 2008 | Psychiatry Res | pmid:18715653 |
Ellison CD et al. | Measuring the distribution of density and tabletting force in pharmaceutical tablets by chemical imaging. | 2008 | J Pharm Biomed Anal | pmid:18539424 |
Fernández EG et al. | Rapid development and optimization of tablet manufacturing using statistical tools. | 2008 | AAPS PharmSciTech | pmid:18459048 |
Xu G and Fang Y | Studies of surface-enhanced Raman scattering of C60 Langmuir-Blodgett film on a new substrate. | 2008 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:17889595 |
Chang CK et al. | Roller compaction, granulation and capsule product dissolution of drug formulations containing a lactose or mannitol filler, starch, and talc. | 2008 | AAPS PharmSciTech | pmid:18459052 |
Zeng Q et al. | Highly luminescent CdSe/ZnSe core-shell quantum dots of one-pot preparation in octadecene. | 2008 | J Nanosci Nanotechnol | pmid:18468151 |
Kordyukova LV et al. | S acylation of the hemagglutinin of influenza viruses: mass spectrometry reveals site-specific attachment of stearic acid to a transmembrane cysteine. | 2008 | J. Virol. | pmid:18596092 |
Asadi A et al. | Interaction of bovine serum albumin with some novel PEG-containing diblock copolymers. | 2008 | Int. J. Biol. Macromol. | pmid:18602419 |
Miguélez-Morán AM et al. | The effect of lubrication on density distributions of roller compacted ribbons. | 2008 | Int J Pharm | pmid:18602976 |
Wan F et al. | Studies on PEG-modified SLNs loading vinorelbine bitartrate (I): preparation and evaluation in vitro. | 2008 | Int J Pharm | pmid:18450394 |
Richardson AD et al. | Central carbon metabolism in the progression of mammary carcinoma. | 2008 | Breast Cancer Res. Treat. | pmid:17879159 |
Kumon M et al. | Application and mechanism of inhalation profile improvement of DPI formulations by mechanofusion with magnesium stearate. | 2008 | Chem. Pharm. Bull. | pmid:18451547 |
Zhang XG et al. | Reversal activity of nanostructured lipid carriers loading cytotoxic drug in multi-drug resistant cancer cells. | 2008 | Int J Pharm | pmid:18586075 |
Simonsick WJ and Petkovska VI | Detailed structural elucidation of polyesters and acrylates using Fourier transform mass spectrometry. | 2008 | Anal Bioanal Chem | pmid:18719895 |
Almeida IF et al. | Moisturizing effect of oleogel/hydrogel mixtures. | 2008 | Pharm Dev Technol | pmid:18720247 |
Badillo N and Ghaly ES | In vitro evaluation of theophylline matrices using xyloglucan. | 2008 | Pharm Dev Technol | pmid:18720251 |
Ling XY et al. | Supramolecular layer-by-layer assembly of 3D multicomponent nanostructures via multivalent molecular recognition. | 2008 | Int J Mol Sci | pmid:19325764 |
Tolson J et al. | A green humidifier chamber. | 2008 | Eur. Respir. J. | pmid:18669801 |
Bigucci F et al. | Chitosan salts coated with stearic acid as colon-specific delivery systems for vancomycin. | 2008 | Drug Deliv | pmid:18763159 |
Ye YQ et al. | Core-modified chitosan-based polymeric micelles for controlled release of doxorubicin. | 2008 | Int J Pharm | pmid:18096336 |
Aleong JM et al. | Ice recrystallization inhibition in ice cream by propylene glycol monostearate. | 2008 | J. Food Sci. | pmid:19021802 |
Li Y and Weng W | Surface modification of hydroxyapatite by stearic acid: characterization and in vitro behaviors. | 2008 | J Mater Sci Mater Med | pmid:17569011 |
Johansson TP and Leach GW | A low temperature phase transition in Langmuir-Blodgett films. | 2008 | J Phys Chem B | pmid:18855435 |
Mazumder B et al. | Flow of Formulation Granules through a Conical Hopper. | 2008 | Indian J Pharm Sci | pmid:21369452 |
Shah DA et al. | Stability Indicating RP-HPLC Estimation of Atorvastatin Calcium and Amlodipine Besylate in Pharmaceutical Formulations. | 2008 | Indian J Pharm Sci | pmid:21369436 |
Yonezawa T et al. | Regulation of hormone-sensitive lipase expression by saturated fatty acids and hormones in bovine mammary epithelial cells. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18755148 |
Zhang XX et al. | Effects of breast cancer resistance protein inhibitors and pharmaceutical excipients on decreasing gastrointestinal toxicity of camptothecin analogs. | 2008 | Acta Pharmacol. Sin. | pmid:18954535 |
Panda DS et al. | Evaluation of Gum of Moringa oleifera as a Binder and Release Retardant in Tablet Formulation. | 2008 | Indian J Pharm Sci | pmid:21394258 |
Teixeira AC et al. | Microdomains in mixed monolayers of oleanolic and stearic acids: thermodynamic study and BAM observation at the air-water interface and AFM and FTIR analysis of LB monolayers. | 2007 Sep-Oct | Chem. Phys. Lipids | pmid:17583687 |
Naidu KA et al. | P53 enhances ascorbyl stearate-induced G2/M arrest of human ovarian cancer cells. | 2007 Nov-Dec | Anticancer Res. | pmid:18225552 |
Ishak RA et al. | Preparation, in vitro and in vivo evaluation of stomach-specific metronidazole-loaded alginate beads as local anti-Helicobacter pylori therapy. | 2007 | J Control Release | pmid:17412443 |
Rosenberger TA et al. | Bovine brain diacylglycerol lipase: substrate specificity and activation by cyclic AMP-dependent protein kinase. | 2007 | Lipids | pmid:17393225 |
Celleno L et al. | A Dietary supplement containing standardized Phaseolus vulgaris extract influences body composition of overweight men and women. | 2007 | Int J Med Sci | pmid:17299581 |
Stimson L et al. | Stearic acid spin labels in lipid bilayers: insight through atomistic simulations. | 2007 | J Phys Chem B | pmid:17929861 |
Wu SD et al. | The role and mechanism of fatty acids in gallstones. | 2007 | HBPD INT | pmid:17690037 |
Wu H et al. | Process analytical technology (PAT): effects of instrumental and compositional variables on terahertz spectral data quality to characterize pharmaceutical materials and tablets. | 2007 | Int J Pharm | pmid:17590292 |
Jaimini M et al. | Formulation and evaluation of famotidine floating tablets. | 2007 | Curr Drug Deliv | pmid:17269917 |