stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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PILZ W and HOERLEIN H | [INVESTIGATIONS CONCERNING ENZYMES OF HUMAN BLOOD, VIII. THE POSSIBLE ROLE OF ARYLESTERASE I IN HUMAN FAT METABOLISM]. | 1964 | Hoppe-Seyler's Z. Physiol. Chem. | pmid:14124985 |
WAIBEL PE and MRAZ FR | CALCIUM, STRONTIUM AND PHOSPHORUS UTILIZATION BY CHICKS AS INFLUENCED BY NUTRITIONAL AND ENDOCRINE VARIATIONS. | 1964 | J. Nutr. | pmid:14210023 |
VAHOUNY GV et al. | MICELLAR-SOLUBILIZED SUBSTRATES AND CHOLESTEROL ESTERASE ACTIVITY IN VITRO. | 1964 | Arch. Biochem. Biophys. | pmid:14211570 |
SHELTON DC et al. | THE UPTAKE AND DISTRIBUTION OF STEARIC ACID BY SUBCELLULAR COMPONENTS OF INTESTINAL MUCOSA. | 1964 | Am. J. Clin. Nutr. | pmid:14240483 |
JACKSON HD et al. | FORMATION OF KETONE BODIES FROM LONG-CHAIN FATTY ACIDS IN RUMEN EPITHELIUM AND LIVER FROM KETOTIC SHEEP. | 1964 | Arch. Biochem. Biophys. | pmid:14240563 |
GOTO Y et al. | EXPERIMENTAL STUDY ON THE LIPID METABOLISM IN THE HEART MUSCLE. | 1964 | Jpn. Circ. J. | pmid:14167720 |
KRITCHEVSKY D | EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS FED CHOLESTEROL-FREE DIETS. | 1964 Jan-Feb | J Atheroscler Res | pmid:14112225 |
MAKLEIT JK et al. | THIN LAYER AND GAS CHROMATOGRAPHIC ANALYSIS OF SYPHILIS ANTIGENS. | 1964-1965 | Acta Microbiol Acad Sci Hung | pmid:14314670 |
KANFER J | OBSERVATIONS ON CEREBROSIDE METABOLISM IN VIVO. | 1965 | J. Biol. Chem. | pmid:14275111 |
Keys A et al. | Serum cholesterol response to changes in the diet: IV. Particular saturated fatty acids in the diet. | 1965 | Metab. Clin. Exp. | pmid:25286466 |