stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Baichwal AR and Augsburger LL | Variations in the friction coefficients of tablet lubricants and relationship to their physicochemical properties. | 1988 | J. Pharm. Pharmacol. | pmid:2907013 |
Abbott AA et al. | A prospective randomized trial on efficacy of antibiotic prophylaxis in asymptomatic teeth with pulpal necrosis and associated periapical pathosis. | 1988 | Oral Surg. Oral Med. Oral Pathol. | pmid:3144686 |
Takenaka T et al. | Effects of arachidonic acid and the other long-chain fatty acids on the membrane currents in the squid giant axon. | 1988 | J. Membr. Biol. | pmid:3147335 |
Bach R et al. | Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine. | 1988 | Biochemistry | pmid:3166978 |
Bull AW et al. | Structural requirements for stimulation of colonic cell proliferation by oxidized fatty acids. | 1988 | Cancer Res. | pmid:3349456 |
Sanjurjo P et al. | Plasma fatty acid composition during the first week of life following feeding with human milk or formula. | 1988 | Acta Paediatr Scand | pmid:3354331 |
Graham A et al. | Fatty acid specificity for the synthesis of triacylglycerol and phosphatidylcholine and for the secretion of very-low-density lipoproteins and lysophosphatidylcholine by cultures of rat hepatocytes. | 1988 | Biochem. J. | pmid:3355493 |
Bonanome A and Grundy SM | Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels. | 1988 | N. Engl. J. Med. | pmid:3362176 |
Rosenberg IH and Schaefer EJ | Dietary saturated fatty acids and blood cholesterol. | 1988 | N. Engl. J. Med. | pmid:3362180 |
Zanetti R and Catalá A | Lipid binding properties of fatty acid binding protein isolated from mouse liver. | 1988 | Acta Physiol Pharmacol Latinoam | pmid:3201993 |
Sparace SA et al. | A preliminary analysis of Fatty Acid synthesis in pea roots. | 1988 | Plant Physiol. | pmid:16666088 |
Loscalzo J et al. | Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. | 1987 Sep-Oct | Arteriosclerosis | pmid:3675304 |
Shani J et al. | Efficacy of sustained-release radioprotective drugs in vivo. | 1987 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:2966504 |
Kringsholm B and Christoffersen P | The nature and the occurrence of birefringent material in different organs in fatal drug addiction. | 1987 May-Jun | Forensic Sci. Int. | pmid:3036675 |
Udod VM et al. | [Microbial breakdown of stearox-6 and a study of the genetic determination of the nature of the degradative activity]. | 1987 May-Jun | Mikrobiol. Zh. | pmid:3150493 |
Fatemi SH et al. | The glycophospholipid anchor of Thy-1. Biosynthetic labeling experiments with wild-type and class E Thy-1 negative lymphomas. | 1987 | J. Biol. Chem. | pmid:2881925 |
Nakanishi H et al. | Comparative studies on additive effects of sodium dodecylbenzensulfonate and sodium stearate on uptake of chemicals by willow shiner (Gnathopogon caerulescens). | 1987 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:2882933 |
Bergquist SO et al. | Erythromycin in the treatment of pertussis: a study of bacteriologic and clinical effects. | 1987 | Pediatr. Infect. Dis. J. | pmid:2885802 |
Ogata S et al. | Chemical identification of lipid components in the membranous form of rat liver alkaline phosphatase. | 1987 | J. Biochem. | pmid:2834351 |
Swendsen CL et al. | Human neutrophils incorporate arachidonic acid and saturated fatty acids into separate molecular species of phospholipids. | 1987 | Biochim. Biophys. Acta | pmid:3105590 |
DeGeorge JJ et al. | Acetylcholine stimulates selective liberation and re-esterification of arachidonate and accumulation of inositol phosphates and glycerophosphoinositol in C62B glioma cells. | 1987 | J. Biol. Chem. | pmid:3110145 |
Morse DR et al. | Infectious flare-ups and serious sequelae following endodontic treatment: a prospective randomized trial on efficacy of antibiotic prophylaxis in cases of asymptomatic pulpal-periapical lesions. | 1987 | Oral Surg. Oral Med. Oral Pathol. | pmid:3112672 |
Crost S et al. | Hormonal effects on mitochondrial respiration: potential role of endogenous lipolytic activities. | 1987 | Arch. Biochem. Biophys. | pmid:3113334 |
Halát G et al. | Effects of incomplete ischemia and subsequent recirculation on free palmitate, stearate, oleate and arachidonate levels in lumbar and cervical spinal cord of rabbit. | 1987 | Gen. Physiol. Biophys. | pmid:3117617 |
Hohl C and Rösen P | Arachidonic acid metabolism in isolated rat heart myocytes. | 1987 | Prog. Clin. Biol. Res. | pmid:3118380 |
Taylor AJ et al. | An alternative explanation for the changes in erythrocyte fatty acids observed in diabetes mellitus. | 1987 | Clin. Chem. | pmid:3119255 |
Shanson DC | Antibiotic prophylaxis of infective endocarditis in the United Kingdom and Europe. | 1987 | J. Antimicrob. Chemother. | pmid:3119557 |
Dudley DT et al. | Depletion of arachidonic acid from GH3 cells. Effects on inositol phospholipid turnover and cellular activation. | 1987 | Biochem. J. | pmid:3120699 |
Faden AI et al. | Alterations in lipid metabolism, Na+,K+-ATPase activity, and tissue water content of spinal cord following experimental traumatic injury. | 1987 | J. Neurochem. | pmid:3033150 |
Imai A and Gershengorn MC | Measurement of lipid turnover in response to thyrotropin-releasing hormone. | 1987 | Meth. Enzymol. | pmid:3037241 |
Roughan PG et al. | Metabolism of exogenous long-chain fatty acids by spinach leaves. | 1987 | Arch. Biochem. Biophys. | pmid:3426240 |
Habib NA et al. | Stearic acid and carcinogenesis. | 1987 | Br. J. Cancer | pmid:3689663 |
Kaya K and Nohara K | Effect of di-n-octyl phthalate on fatty acid composition of phosphatidylcholine in Tetrahymena. | 1987 | Chem. Biol. Interact. | pmid:3690725 |
Ong DE et al. | Acyl-CoA-independent esterification of retinol bound to cellular retinol-binding protein (type II) by microsomes from rat small intestine. | 1987 | J. Biol. Chem. | pmid:3818619 |
Berlin E et al. | Influence of saturated and unsaturated fats on platelet fatty acids in cholesterol-fed rabbits. | 1987 | Atherosclerosis | pmid:3827974 |
Albertini G et al. | Studies of structural modifications induced by gamma-irradiation in distearoylphosphatidylcholine liposomes. | 1987 | Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. | pmid:3496306 |
Carter BL et al. | Gastrointestinal side effects with erythromycin preparations. | 1987 | Drug Intell Clin Pharm | pmid:3498618 |
Seifert R et al. | Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3426598 |
Bos CE et al. | Native starch in tablet formulations: properties on compaction. | 1987 | Pharm Weekbl Sci | pmid:3432037 |
Nadai M et al. | [Correlation between in vitro dissolution characteristics of macrolide antibiotic tablets and bioavailability in man]. | 1987 | Yakugaku Zasshi | pmid:3437396 |
Hasin Y et al. | Dietary lipid intake and myocardial electrophysiology. | 1987 | Isr. J. Med. Sci. | pmid:3440741 |
Cutler RR et al. | The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. | 1987 | Tubercle | pmid:3448797 |
Matsui MS and Jeffrey AM | Fatty acid modification of C3H 10T 1/2 fibroblast cells: changes in benzo(a)pyrene metabolism and phorbol ester binding. | 1987 | Cancer Res. | pmid:3471326 |
Habib NA et al. | Desaturation-producing factor present in the tissue, blood, and urine of cancer patients. | 1987 | Cancer Detect. Prev. | pmid:3568009 |
Wang ST et al. | A comparison of fatty acid composition of cholesteryl esters in subjects at various concentrations of serum lipid. | 1987 | Clin. Biochem. | pmid:3568345 |
Emken EA et al. | Metabolism in humans of cis-12,trans-15-octadecadienoic acid relative to palmitic, stearic, oleic and linoleic acids. | 1987 | Lipids | pmid:3306237 |
Dinman BD | Aluminum in the lung: the pyropowder conundrum. | 1987 | J Occup Med | pmid:3316541 |
Hattori T et al. | Membrane phospholipid composition and membrane fluidity of human brain tumour: a spin label study. | 1987 | Neurol. Res. | pmid:2883605 |
Søreide O et al. | Inadequacy of oleic acid in erythrocytes as a marker of malignancies. | 1987 | Br Med J (Clin Res Ed) | pmid:3103770 |
McCormack WM et al. | Effect on birth weight of erythromycin treatment of pregnant women. | 1987 | Obstet Gynecol | pmid:3543767 |