stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bos CE et al. | Native starch in tablet formulations: properties on compaction. | 1987 | Pharm Weekbl Sci | pmid:3432037 |
Nadai M et al. | [Correlation between in vitro dissolution characteristics of macrolide antibiotic tablets and bioavailability in man]. | 1987 | Yakugaku Zasshi | pmid:3437396 |
Hasin Y et al. | Dietary lipid intake and myocardial electrophysiology. | 1987 | Isr. J. Med. Sci. | pmid:3440741 |
Cutler RR et al. | The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. | 1987 | Tubercle | pmid:3448797 |
Peura P et al. | The effect of ethanol on the release of free fatty acids from the brain in vivo; a study with push-pull cannula. | 1986 | Arch. Toxicol. Suppl. | pmid:3468932 |
Matsui MS and Jeffrey AM | Fatty acid modification of C3H 10T 1/2 fibroblast cells: changes in benzo(a)pyrene metabolism and phorbol ester binding. | 1987 | Cancer Res. | pmid:3471326 |
Pajor L et al. | Microsomal desaturation of stearic acid in relation to lymphocyte activation. | 1986 | Arch. Biochem. Biophys. | pmid:3485399 |
Ras GJ and Anderson R | An in-vitro study of oral therapeutic doses of co-trimoxazole and erythromycin stearate on abnormal polymorphonuclear leucocyte migration. | 1986 | J. Antimicrob. Chemother. | pmid:3486178 |
Albertini G et al. | Studies of structural modifications induced by gamma-irradiation in distearoylphosphatidylcholine liposomes. | 1987 | Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. | pmid:3496306 |
Carter BL et al. | Gastrointestinal side effects with erythromycin preparations. | 1987 | Drug Intell Clin Pharm | pmid:3498618 |
Goto S et al. | Eudragit RS and RL (acrylic resins) microcapsules as pH insensitive and sustained release preparations of ketoprofen. | 1986 Oct-Dec | J Microencapsul | pmid:3508190 |
Goto S et al. | Eudragit E, L and S (acrylic resins) microcapsules as pH sensitive release preparations of ketoprofen. | 1986 Oct-Dec | J Microencapsul | pmid:3508191 |
Slomiany BL et al. | Mucus glycoprotein of human saliva: differences in the associated and covalently bound lipids with caries. | 1986 | Biochim. Biophys. Acta | pmid:3518803 |
Muñoz-Espin T et al. | Erythromycin versus tetracycline for treatment of Mediterranean spotted fever. | 1986 | Arch. Dis. Child. | pmid:3535687 |
McCormack WM et al. | Effect on birth weight of erythromycin treatment of pregnant women. | 1987 | Obstet Gynecol | pmid:3543767 |
Bridges CD et al. | Rhodopsin, vitamin A, and interstitial retinol-binding protein in the rd chicken. | 1987 | Invest. Ophthalmol. Vis. Sci. | pmid:3557867 |
Hope MJ and Cullis PR | Lipid asymmetry induced by transmembrane pH gradients in large unilamellar vesicles. | 1987 | J. Biol. Chem. | pmid:3558410 |
Habib NA et al. | Desaturation-producing factor present in the tissue, blood, and urine of cancer patients. | 1987 | Cancer Detect. Prev. | pmid:3568009 |
Wang ST et al. | A comparison of fatty acid composition of cholesteryl esters in subjects at various concentrations of serum lipid. | 1987 | Clin. Biochem. | pmid:3568345 |
PospÃsilová B and Kubes J | [Stability of erythromycin stearate in coated tablets during the action of gastric juice in vitro]. | 1987 | Cesk Farm | pmid:3581192 |
Salminen S and Salminen E | Urinary excretion of orally administered oxalic acid in MYRJ 45-treated NMRI mice. | 1987 | Toxicol. Lett. | pmid:3590233 |
Masuzawa Y et al. | Distribution of dietary trans-octadecenoate among acyl-CoA and other lipid fractions of rat liver and heart. | 1987 | Biochim. Biophys. Acta | pmid:3593750 |
Kolesnick RN and Paley AE | 1,2-Diacylglycerols and phorbol esters stimulate phosphatidylcholine metabolism in GH3 pituitary cells. Evidence for separate mechanisms of action. | 1987 | J. Biol. Chem. | pmid:3597411 |
Habib NA et al. | Increased erythrocyte stearic acid desaturation in rats with chemically induced colorectal carcinomas. | 1987 | Int J Colorectal Dis | pmid:3598325 |
Husebye ES and Flatmark T | Characterization of phospholipase activities in chromaffin granule ghosts isolated from the bovine adrenal medulla. | 1987 | Biochim. Biophys. Acta | pmid:3607074 |
Cavalleri A and Minoia C | Lead level of whole blood and plasma in workers exposed to lead stearate. | 1987 | Scand J Work Environ Health | pmid:3616550 |
Seimiya T et al. | Effects of composition and molecular packing on ionic properties of lipid monolayer having both cationic and anionic head groups. | 1987 | Chem. Phys. Lipids | pmid:3621383 |
Pyörälä S | Effect of some vehicles used in intramammary mastitis preparations on inflammation indicators in milk. | 1987 | J. Vet. Pharmacol. Ther. | pmid:3656512 |
Worman CP et al. | Saturation index of blood cell membrane fatty acids before and after IFN treatment in hairy cell leukemia. | 1987 | Leukemia | pmid:3669764 |
Mäntylä R et al. | Bioavailability and effect of food on the gastrointestinal absorption of two erythromycin derivatives. | 1978 | Ann. Clin. Res. | pmid:367255 |
Caglayan S et al. | Is medical therapy effective for regional lymphadenitis following BCG vaccination? | 1987 | Am. J. Dis. Child. | pmid:3673975 |
Loscalzo J et al. | Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. | 1987 Sep-Oct | Arteriosclerosis | pmid:3675304 |
Venho VM et al. | The value of comparative bioavailability studies of marketed drugs in drug control. An example with erythromycin stearate. | 1987 | Methods Find Exp Clin Pharmacol | pmid:3683018 |
Habib NA et al. | Stearic acid and carcinogenesis. | 1987 | Br. J. Cancer | pmid:3689663 |
Kaya K and Nohara K | Effect of di-n-octyl phthalate on fatty acid composition of phosphatidylcholine in Tetrahymena. | 1987 | Chem. Biol. Interact. | pmid:3690725 |
Goto S et al. | [Role of metal stearates in preparation of Eudragit RS-microcapsules containing sulfamethizole by evaporation process in water phase]. | 1986 | Yakugaku Zasshi | pmid:3701600 |
Shah KB et al. | An investigation of some factors influencing plug formation and fill weight in a dosing disk-type automatic capsule-filling machine. | 1986 | J Pharm Sci | pmid:3701614 |
Okabe H et al. | Effects of anti-convulsants on fatty acid metabolism in human serum. | 1986 | Tohoku J. Exp. Med. | pmid:3705068 |
Thompson W and Belina H | Rapid accumulation of diacyl lipid in rat liver microsomes by selective acylation of 2-acyl-sn-glycero-3-phosphorylserine. | 1986 | Biochim. Biophys. Acta | pmid:3707975 |
Heape AM et al. | Technique for injection into the sciatic nerve of the mouse for quantitative in vivo metabolic studies. | 1986 | Anal. Biochem. | pmid:3717558 |
Caponnetto A et al. | [Correlations between unsaturated fatty acids and medium C-chain triglycerides]. | 1986 | Boll. Soc. Ital. Biol. Sper. | pmid:3718739 |
Beaumelle BD and Vial HJ | Modification of the fatty acid composition of individual phospholipids and neutral lipids after infection of the simian erythrocyte by Plasmodium knowlesi. | 1986 | Biochim. Biophys. Acta | pmid:3719005 |
Chalupa W et al. | Ruminal fermentation in vivo as influenced by long-chain fatty acids. | 1986 | J. Dairy Sci. | pmid:3722545 |
Wan LS and Choong YL | The effect of excipients on the penetration of liquid into tablets. | 1986 | Pharm Acta Helv | pmid:3725815 |
Oh-Hashi Y et al. | Temperature- and growth-phase-dependent changes in membrane fatty acid compositions of Brevibacterium ammoniagenes. | 1986 | Arch. Biochem. Biophys. | pmid:3729431 |
Carter-Dawson L et al. | Rhodopsin, 11-cis vitamin A, and interstitial retinol-binding protein (IRBP) during retinal development in normal and rd mutant mice. | 1986 | Dev. Biol. | pmid:3732615 |
Chowhan ZT and Chi LH | Drug-excipient interactions resulting from powder mixing. III: Solid state properties and their effect on drug dissolution. | 1986 | J Pharm Sci | pmid:3735096 |
Chowhan ZT and Chi LH | Drug-excipient interactions resulting from powder mixing. IV: Role of lubricants and their effect on in vitro dissolution. | 1986 | J Pharm Sci | pmid:3735097 |
Fujii T et al. | Effect of exogenous lipids incorporated into the membrane of human erythrocytes on its glucose transport activity. | 1986 | Biochem. Int. | pmid:3741447 |
Chester DW et al. | The influence of saturated fatty acid modulation of bilayer physical state on cellular and membrane structure and function. | 1986 | Biochim. Biophys. Acta | pmid:3741857 |