stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Larsson K and Glantz PO | Microbial adhesion to surfaces with different surface charges. | 1981 | Acta Odontol. Scand. | pmid:6948486 |
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Broekman MJ et al. | Fatty acid composition of phosphatidylinositol and phosphatidic acid in stimulated platelets. Persistence of arachidonyl-stearyl structure. | 1981 | J. Biol. Chem. | pmid:6790536 |
Bonini de Romanelli IC et al. | Phosphatidic acid, phosphatidylinositol, phosphatidylserine and cardiolipin in the course of early embryonic development. Fatty acid composition and content in whole toad embryos and in mitochondrial fractions. | 1981 | Biochim. Biophys. Acta | pmid:6791698 |
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Walsh C et al. | Arachidonate metabolism by neutrophils. | 1981 | Prog. Lipid Res. | pmid:6804984 |
McGimpsey JG et al. | Comparison of serum erythromycin concentration following administration of 100 mg erythromycin ethyl succinate intramuscularly and 500 mg erythromycin stearate orally. | 1981 | Int J Oral Surg | pmid:6807878 |
Teyssier G et al. | [Adult-type respiratory distress syndrome in children. Course of the palmitic acid/stearic acid ratio in tracheal aspirations]. | 1981 | Nouv Presse Med | pmid:7290945 |
Alam AS and Gregoriades D | Physicochemical properties of magnesium salicylate. | 1981 | J Pharm Sci | pmid:7310674 |
Królikowska-Prasał I and Zakrzewska-Grzycka T | Histochemical studies of the liver in acute and chronic lead stearate poisoning. | 1981 | Ann Univ Mariae Curie Sklodowska Med | pmid:7052786 |
Naggar VF | An in vitro study of the interaction between diazepam and some antacid or excipients. | 1981 | Pharmazie | pmid:7232481 |
Holub BJ | The suitability of different acyl acceptors as substrates for the acyl-Coa : 2-acyl-sn-glycero-3-phosphorylcholine acyltransferase in rat liver microsomes. | 1981 | Biochim. Biophys. Acta | pmid:7248321 |
Iliopoulou A et al. | Fluorimetric and microbiological assays of erythromycin concentrations in plasma and vaginal washings. | 1981 | Br J Vener Dis | pmid:7272705 |
Walzthöny D et al. | Ice crystals specifically decorate hydrophilic sites on freeze-fractured models membranes. | 1981 | Ultramicroscopy | pmid:7281365 |
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Faas FH and Carter WJ | Fatty-acid desaturation and microsomal lipid fatty-acid composition in experimental hyperthyroidism. | 1981 | Biochem. J. | pmid:7305962 |
Mather LE et al. | Absorption and bioavailability of oral erythromycin. | 1981 | Br J Clin Pharmacol | pmid:7306427 |
Baker RR and Chang HY | A comparison of lysophosphatidylcholine acyltransferase activities in neuronal nuclei and microsomes isolated from immature rabbit cerebral cortex. | 1981 | Biochim. Biophys. Acta | pmid:7306562 |
Eriksson M et al. | Absorption of erythromycin from pediatric suspension in infants and children. | 1981 | Scand. J. Infect. Dis. | pmid:7313575 |
Clayton D and Leslie A | The bioavailability of erythromycin stearate versus enteric-coated erythromycin base when taken immediately before and after food. | 1981 | J. Int. Med. Res. | pmid:7319133 |
Benes B and Bencko V | Content of lipids and esterified fatty acids in the liver of mice exposed to arsenic in drinking water. | 1981 | J Hyg Epidemiol Microbiol Immunol | pmid:7320503 |
Bolhuis GK et al. | Interaction of tablet disintegrants and magnesium stearate during mixing I: Effect on tablet disintegration. | 1981 | J Pharm Sci | pmid:7320846 |
Hsia JC and Kwan NH | Human serum albumin: binding specificity and allosteric effect of parinarate and stearate. A dianionic spin label study. | 1981 | J. Biol. Chem. | pmid:6257712 |
Cook HW | The influence of trans-acids on desaturation and elongation of fatty acids in developing brain. | 1981 | Lipids | pmid:7329212 |
Hug G et al. | Reye's syndrome simulacra in liver of mice after treatment with chemical agents and encephalomyocarditis virus. | 1981 | Lab. Invest. | pmid:6265702 |
d'Avila Nunes M | A spin label study of erythrocyte membranes during simulation of freezing. | 1981 | J. Membr. Biol. | pmid:7253007 |
Mesiha MS and El-Bitar HI | Hypoglycaemic effect of oral insulin preparations containing Brij 35, 52, 58 or 92 and stearic acid. | 1981 | J. Pharm. Pharmacol. | pmid:6118416 |
Yue KT et al. | Effect of glucose on plasma concentrations of individual non-esterified fatty acids of non-diabetic and insulin-independent diabetic men. | 1981 | Postgrad Med J | pmid:7335561 |
Sugita M et al. | Studies on glycosphingolipids of fresh-water bivalves. VI. Isolation and chemical characterization of neutral glycosphingolipids from spermatozoa of the fresh-water bivalve, Hyriopsis schlegelii. | 1981 | J. Biochem. | pmid:7338520 |
Haley K et al. | Optimal milk penicillin levels for the treatment of experimentally induced mastitis in cows. | 1981 | Can. J. Comp. Med. | pmid:7340909 |
Branigan TA et al. | The effects of erythromycin on the absorption and disposition of kinetics of theophylline. | 1981 | Eur. J. Clin. Pharmacol. | pmid:7341279 |
Prescott SM and Majerus PW | The fatty acid composition of phosphatidylinositol from thrombin-stimulated human platelets. | 1981 | J. Biol. Chem. | pmid:7451460 |
Cochran FB et al. | Myelin gangliosides: an unusual pattern in the avian central nervous system. | 1981 | J. Neurochem. | pmid:7463084 |
Bleeker J et al. | Effect of systemic erythromycin stearate on the inflammatory lesions and skin surface fatty acids in acne vulgaris. | 1981 | Dermatologica | pmid:6454598 |
Roshanai F et al. | Prostaglandin precursors in platelet phosphoglycerides following acute myocardial infarction. | 1981 Oct 1-15 | Thromb. Res. | pmid:6277036 |
Loi F and Amati R | [Lead-stearate exposure in a plastic factory in the province of Siena (author's transl)]. | 1981 Sep-Oct | Med Lav | pmid:7322018 |
RÃ¥dberg T et al. | Metabolic studies in gestational diabetic women during contraceptive treatment: effects on glucose tolerance and fatty acid composition of serum lipids. | 1982 | Gynecol. Obstet. Invest. | pmid:7035304 |
Maddux MS et al. | The effect of erythromycin on theophylline pharmacokinetics at steady state. | 1982 | Chest | pmid:7042226 |
Aprahamian SA et al. | Comparative studies on the kinetic parameters and product analyses of chicken and rat liver and yeast fatty acid synthetase. | 1982 | Comp. Biochem. Physiol., B | pmid:7044669 |
Jacques NA | Relationship between cyclopropane synthetase and the formation of cyclopropane fatty acids by Proteus vulgaris grown under various respiratory conditions. | 1982 | J. Gen. Microbiol. | pmid:7045282 |
Wei TC | Quantitative determination of chemical composition of gallstones by infrared absorption spectrophotometry. | 1982 | Taiwan Yi Xue Hui Za Zhi | pmid:6954245 |
Slomiany BL et al. | Lipid composition of the matrix of human submandibular salivary gland stones. | 1982 | Arch. Oral Biol. | pmid:6958224 |
Tinsley IJ et al. | Tissue fatty acid changes and tumor incidence in C3H mice ingesting cottonseed oil. | 1982 | Lipids | pmid:6896358 |
Goto M et al. | Evidence for a correlation between swimming velocity and membrane fluidity of Tetrahymena cells. | 1982 | Biochim. Biophys. Acta | pmid:6818990 |
Moore KH et al. | beta-Hydroxy fatty acid production by ischemic rabbit heart. | 1982 | J. Clin. Invest. | pmid:6799549 |
Hong SL and Deykin D | Activation of phospholipases A2 and C in pig aortic endothelial cells synthesizing prostacyclin. | 1982 | J. Biol. Chem. | pmid:6806265 |
Eccleston GM | The influence of fatty alcohols on the structure and stability of creams prepared with polyethylene glycol 1000 monostearate/fatty alcohols. | 1982 | Int J Cosmet Sci | pmid:19469959 |
Pharmaceutical Reimbursement Board; final maximum allowable cost (MAC) determinations for certain drug products--Health Care Financing Administration. Final notice. | 1982 | Fed Regist | pmid:10259800 | |
Perkins RC et al. | Equilibrium binding of spin-labeled fatty acids to bovine serum albumin: suitability as surrogate ligands for natural fatty acids. | 1982 | Biochemistry | pmid:6289869 |
Akesson B | Content of phospholipids in human diets studied by the duplicate-portion technique. | 1982 | Br. J. Nutr. | pmid:7066286 |
Holub BJ | The relative deacylation of different molecular species of endogenous phosphatidylethanolamine in rat liver microsomes by phospholipase activity. | 1982 | Biochim. Biophys. Acta | pmid:7093298 |
Pritzker KP et al. | Adrenal and hepatic calcium stearate crystal deposits in dogs fed a thiamine-deficient diet. | 1982 | Am. J. Vet. Res. | pmid:7103233 |
Huang YS et al. | Tissue lipids in acute acrylamide intoxicated rats. | 1982 | Can J Neurol Sci | pmid:7104883 |
Townsend LE et al. | In vitro acylation of rat brain myelin proteolipid protein. | 1982 | J. Biol. Chem. | pmid:7107590 |
Sanchez J et al. | Lipase-induced alterations of fatty acid synthesis by subcellular fractions from germinating pea (Pisum sativum L.). | 1982 | Biochem. J. | pmid:7115342 |
Boyd RD et al. | Oxidation rates of major fatty acids in fasting neonatal pigs. | 1982 | J. Anim. Sci. | pmid:7118744 |
Rosing U et al. | Relative fatty acid composition of serum lecithin in the second half of the normal pregnancy. | 1982 | Gynecol. Obstet. Invest. | pmid:7129232 |
Heimdahl A and Nord CE | Influence of erythromycin on the normal human flora and colonization of the oral cavity, throat and colon. | 1982 | Scand. J. Infect. Dis. | pmid:7071527 |
Woodward H et al. | Isolation, purification, and properties of respiratory mucus glycoproteins. | 1982 | Biochemistry | pmid:7074033 |
Katz AM et al. | Fatty acid effects on calcium influx and efflux in sarcoplasmic reticulum vesicles from rabbit skeletal muscle. | 1982 | Biochim. Biophys. Acta | pmid:7074105 |
Bridges CD et al. | Vitamin A in human eyes: amount, distribution, and composition. | 1982 | Invest. Ophthalmol. Vis. Sci. | pmid:7076416 |
Lehmann J and McGill M | Biochemical and ultrastructural alterations in platelets, reticulocytes, and lymphocytes from rats fed vitamin E-deficient diets. | 1982 | J. Lipid Res. | pmid:7077144 |
Josefsson K et al. | Dose-related pharmacokinetics after oral administration of a new formulation of erythromycin base. | 1982 | Br J Clin Pharmacol | pmid:7082537 |
NadtochiÄ VV and BrodskiÄ RA | [Absorption study of 3H-stearic acid in the rat small intestine using electron microscopic autoradiography]. | 1982 | Tsitologiia | pmid:7135486 |
Chen SC et al. | Calorimetric evidence for phase transitions in spin-label lipid bilayers. | 1982 | Biochemistry | pmid:7138849 |
Mroso PV et al. | Solid-state stability of aspirin in the presence of excipients: kinetic interpretation, modeling, and prediction. | 1982 | J Pharm Sci | pmid:7143203 |
Katz AM and Messineo FC | Fatty acid effects on membranes: possible role in the pathogenesis of ischemic myocardial damage. | 1982 | J. Mol. Cell. Cardiol. | pmid:7143451 |
Lerk CF et al. | Interaction of tablet disintegrants and magnesium stearate during mixing. II. Effect on dissolution rate. | 1982 | Pharm Acta Helv | pmid:7146030 |
Warner T and Zar JH | Fatty acid composition of brown fat and brain fat of the little brown bat, Myotis lucifugus, during hibernation. | 1982 | Comp. Biochem. Physiol., B | pmid:7151405 |
Iliopoulou A et al. | Should erythromycin dose be altered in haemodialysis patients? | 1982 | Eur. J. Clin. Pharmacol. | pmid:7151848 |
Faas FH and Carter WJ | Fatty acid desaturation and microsomal lipid fatty acid composition in experimental hypothyroidism. | 1982 | Biochem. J. | pmid:7181859 |
Bazan NG et al. | High content of 22:6 (docosahexaenoate) and active [2-3H]glycerol metabolism of phosphatidic acid from photoreceptor membranes. | 1982 | Biochim. Biophys. Acta | pmid:6215065 |
Nozawa CM and Apostolov K | Increase in the saturation of C18 fatty acids induced by coxsackie B6 virus in Vero cells. | 1982 | Virology | pmid:6285601 |
May DC et al. | The effects of erythromycin on theophylline elimination in normal males. | 1982 Feb-Mar | J Clin Pharmacol | pmid:7068935 |
della Ventura A and della Ventura D | [Clinical experiments with erythromycin stearate in surgery of the oral cavity]. | 1982 May-Jun | Odontostomatol Implantoprotesi | pmid:6984149 |
Oriel JD et al. | Treatment of gonococcal urethritis in men with a rifampicin-erythromycin combination. | 1982 Oct-Dec | Sex Transm Dis | pmid:6821502 |
Philip J and Daly RE | Test for selection of erythromycin stearate bulk drug for tablet preparation. | 1983 | J Pharm Sci | pmid:6620167 |
Shih JC and Ohsawa R | Differential effect of cholesterol on two types of 5-hydroxytryptamine binding sites. | 1983 | Neurochem. Res. | pmid:6621769 |
van Kamp HV et al. | Improvement by super disintegrants of the properties of tablets containing lactose, prepared by wet granulation. | 1983 | Pharm Weekbl Sci | pmid:6622211 |
Warhurst DC et al. | The blood schizontocidal action of erythromycin against Plasmodium knowlesi infections in Macaca mulatta. | 1983 | Ann Trop Med Parasitol | pmid:6625724 |
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Kushi Y et al. | Comparative study of acidic glycosphingolipids by field desorption and secondary ion mass spectrometry. | 1983 | J. Biochem. | pmid:6671968 |
Green B et al. | Qualitative and quantitative changes in milk fat during lactation in the tammar wallaby (Macropus eugenii). | 1983 | Aust. J. Biol. Sci. | pmid:6675645 |
Tulenko TN and Rabinowitz JL | Metabolism of C14 mevalonate by adult and fetal arteries. | 1983 | Artery | pmid:6677248 |
AkbuÄŸa J et al. | Studies on flufenamic acid capsules and tablets. | 1983 | Pharmazie | pmid:6634915 |
NadtochiÄ VV and BrodskiÄ RA | [Absorption routes of stearic acid and leucine in the small intestine of the rat after gamma irradiation]. | 1983 | Arkh Anat Gistol Embriol | pmid:6639383 |
Hundrieser KE et al. | Distribution of trans-octadecenoic acid in the major glycerolipids of human milk. | 1983 | J. Pediatr. Gastroenterol. Nutr. | pmid:6644446 |
Pethick DW et al. | The metabolism of circulating non-esterified fatty acids by the whole animal, hind-limb muscle and uterus of pregnant ewes. | 1983 | Br. J. Nutr. | pmid:6821682 |
Edwards EK and Edwards EK | Allergic reaction to triethanolamine stearate in a sunscreen. | 1983 | Cutis | pmid:6831931 |
de Haan P and Kalsbeek GL | Humoral immune response to some benzylpenicillin preparations. | 1983 | Allergy | pmid:6412583 |
Anderton P et al. | Measles-virus-persistent infection in BGM cells. Modification of the incorporation of [3H]arachidonic acid and [14C]stearic acid into lipids. | 1983 | Biochem. J. | pmid:6414459 |
Süss W | [Production of delayed-release formulations based on hydrophilic matrix forms using polyvinyl alcohol]. | 1983 | Pharmazie | pmid:6415679 |
Bascoul J et al. | Preparation of autoxidized cholesterol mixtures from [4-14C] cholesterol and cholesteryl fatty acid esters. | 1983 | J. Steroid Biochem. | pmid:6423895 |
Kemp P and Lander DJ | The hydrogenation of gamma-linolenic acid by pure cultures of two rumen bacteria. | 1983 | Biochem. J. | pmid:6318740 |
Walsh CE et al. | Mechanism of arachidonic acid release in human polymorphonuclear leukocytes. | 1983 | Biochim. Biophys. Acta | pmid:6402027 |
Yoshida S et al. | Brain free fatty acids, edema, and mortality in gerbils subjected to transient, bilateral ischemia, and effect of barbiturate anesthesia. | 1983 | J. Neurochem. | pmid:6403669 |
Swendsen CL et al. | 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a novel source of arachidonic acid in neutrophils stimulated by the calcium ionophore A23187. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6407484 |
Bleeker J | Tolerance and efficacy of erythromycin stearate tablets versus enteric-coated erythromycin base capsules in the treatment of patients with acne vulgaris. | 1983 | J. Int. Med. Res. | pmid:6219902 |
Hoover RL et al. | Role of cholesterol in the capping of surface immunoglobulin receptors on murine lymphocytes. | 1983 | J. Cell Biol. | pmid:6223042 |
Jacques NA | Membrane perturbation by cerulenin modulates glucosyltransferase secretion and acetate uptake by Streptococcus salivarius. | 1983 | J. Gen. Microbiol. | pmid:6229601 |