stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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el-Sharkawy SH et al. | Microbiological transformations of lipids: acyl-specific hydrolysis of lard by yeasts. | 1993 | Appl. Environ. Microbiol. | pmid:8480999 |
Woldseth B et al. | Incorporation of stearic acid (18:0) and palmitic acid (16:0) in phospholipid molecular species studied in isolated rat liver cells. | 1993 | Biochim. Biophys. Acta | pmid:8481391 |
Doering TL et al. | Trypanosome metabolism of myristate, the fatty acid required for the variant surface glycoprotein membrane anchor. | 1993 | J. Biol. Chem. | pmid:8486622 |
Mustad VA et al. | Comparison of the effects of diets rich in stearic acid versus myristic acid and lauric acid on platelet fatty acids and excretion of thromboxane A2 and PGI2 metabolites in healthy young men. | 1993 | Metab. Clin. Exp. | pmid:8487669 |
Sastri MS et al. | In vitro and in vivo studies on slow release propranolol hydrochloride suppositories. Pharmacokinetic and pharmacodynamic evaluation. | 1993 | Arzneimittelforschung | pmid:8489559 |
Sylvester PW et al. | Effects of specific fatty acids on prolactin-induced NB2 lymphoma cell proliferation. | 1993 | Life Sci. | pmid:8505862 |
Melik-Nubarov NS et al. | Interaction of hydrophobized antiviral antibodies with influenza virus infected MDCK cells. | 1993 | Biochem. Mol. Biol. Int. | pmid:8508145 |
Cárdenas L et al. | Isolation, chemical structures and biological activity of the lipo-chitin oligosaccharide nodulation signals from Rhizobium etli. | 1995 | Plant Mol. Biol. | pmid:8534845 |
Iskhakova FKh et al. | [Synthesis of stearoyl derivatives of proline-containing hydrophobic peptides]. | 1995 | Bioorg. Khim. | pmid:8540900 |
Singh S et al. | Multiple emulsion-based systems carrying insulin: development and characterization. | 1995 Nov-Dec | J Microencapsul | pmid:8558383 |
Lin HH et al. | Increased norfloxacin skin permeability for fatty alcohol propylene glycol (FAPG) ointment by optimized process of preparation: behavior of stearic acid in stratum corneum lipids. | 1995 | Biol. Pharm. Bull. | pmid:8593480 |
Schwab US et al. | Different effects of palmitic and stearic acid-enriched diets on serum lipids and lipoproteins and plasma cholesteryl ester transfer protein activity in healthy young women. | 1996 | Metab. Clin. Exp. | pmid:8596480 |
Blaha CD et al. | Improved electrochemical properties of stearate-graphite paste electrodes after albumin and phospholipid treatments. | 1996 | Biosens Bioelectron | pmid:8600916 |
Routi T et al. | Effects of prospective, randomized cholesterol-lowering dietary intervention and apolipoprotein E phenotype on serum lipoprotein(a) concentrations of infants aged 7-24 mo. | 1996 | Am. J. Clin. Nutr. | pmid:8602597 |
Pearson TA and Kris-Etherton PM | Effects of diets containing high or low amounts of stearic acid on plasma lipoprotein fractions and fecal fatty acid excretion of men. | 1996 | Am. J. Clin. Nutr. | pmid:8602600 |
Ntambi JM et al. | A model cell line to study regulation of stearoyl-CoA desaturase gene 1 expression by insulin and polyunsaturated fatty acids. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607881 |
Wisniewska A et al. | Depth dependence of the perturbing effect of placing a bulky group (oxazolidine ring spin labels) in the membrane on the membrane phase transition. | 1996 | Biochim. Biophys. Acta | pmid:8611609 |
Giacobino JP and Chmelar M | The role of chain elongation systems in the supplying of fatty acids to the adipocyte membrane lipids. | 1977 | Biochim. Biophys. Acta | pmid:861235 |
Watanabe S and Sato T | Effects of free fatty acids on the binding of bovine and human serum albumin with steroid hormones. | 1996 | Biochim. Biophys. Acta | pmid:8620023 |
Carratù L et al. | Membrane lipid perturbation modifies the set point of the temperature of heat shock response in yeast. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8632982 |
Rich MR and Evans JS | Molecular dynamics simulations of adipocyte lipid-binding protein: effect of electrostatics and acyl chain unsaturation. | 1996 | Biochemistry | pmid:8634281 |
Cheng B et al. | Characterization and identification of an adrenal age-related nonpolar fluorescent substance. | 1996 | Endocrinology | pmid:8641198 |
Narayanan VS and Storch J | Fatty acid transfer in taurodeoxycholate mixed micelles. | 1996 | Biochemistry | pmid:8652524 |
Ohyama H et al. | Age-related differences in synaptosomal membrane fluidity. | 1995 | Biochem. Mol. Biol. Int. | pmid:8653075 |
Bruce JS and Salter AM | Metabolic fate of oleic acid, palmitic acid and stearic acid in cultured hamster hepatocytes. | 1996 | Biochem. J. | pmid:8670161 |
van Greevenbroek MM et al. | Effects of saturated, mono-, and polyunsaturated fatty acids on the secretion of apo B containing lipoproteins by Caco-2 cells. | 1996 | Atherosclerosis | pmid:8678919 |
Tholstrup T et al. | Acute effect of high-fat meals rich in either stearic or myristic acid on hemostatic factors in healthy young men. | 1996 | Am. J. Clin. Nutr. | pmid:8694016 |
Watts GF et al. | Dietary fatty acids and progression of coronary artery disease in men. | 1996 | Am. J. Clin. Nutr. | pmid:8694021 |
Sakai M et al. | Pharmacological effects of phosphatidylserine enzymatically synthesized from soybean lecithin on brain functions in rodents. | 1996 | J. Nutr. Sci. Vitaminol. | pmid:8708821 |
Lassus A et al. | Erythromycin and lymecycline treatment in chlamydia-positive and Chlamydia-negative non-gonococcal urethritis--a partner-controlled study. | 1979 | Acta Derm. Venereol. | pmid:87096 |
Sherrington EJ et al. | Lack of effect of different dietary saturated fatty acids on adipose tissue deposition in the rat. | 1996 | Biochem. Soc. Trans. | pmid:8736816 |
Britten JR et al. | Studies on powder plug formation using a simulated capsule filling machine. | 1996 | J. Pharm. Pharmacol. | pmid:8737048 |
Xiong W et al. | [Hydrothobic constituents of Nyssa sinensis Oliv]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8737471 |
Shu R et al. | [Chemical constituents of Cyclocarya paliurus (Batal.) Iljinsk]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8737472 |
Mansbach CM | The origin of chylomicron phosphatidylcholine in the rat. | 1977 | J. Clin. Invest. | pmid:874099 |
Veit M et al. | Cytoplasmic tail length influences fatty acid selection for acylation of viral glycoproteins. | 1996 | Biochem. J. | pmid:8761467 |
Schmidt-Weber CB et al. | Apoptotic cell death in activated monocytes following incorporation of clodronate-liposomes. | 1996 | J. Leukoc. Biol. | pmid:8773585 |
Zakhariv OIa and Ianovich VG | [The utilization of [9,10-(3)H] stearic and [1-(14)C] linolenic acids in the in-vitro synthesis of lipids in ruminant tissues]. | 1995 Jul-Aug | Zh. Evol. Biokhim. Fiziol. | pmid:8779280 |
Hughes TA et al. | Comparative lipoprotein metabolism of myristate, palmitate, and stearate in normolipidemic men. | 1996 | Metab. Clin. Exp. | pmid:8781298 |
Negash S et al. | Phosphorylation of phospholamban by cAMP-dependent protein kinase enhances interactions between Ca-ATPase polypeptide chains in cardiac sarcoplasmic reticulum membranes. | 1996 | Biochemistry | pmid:8784178 |
Mastronicolis SK et al. | Diversity of the polar lipids of the food-borne pathogen Listeria monocytogenes. | 1996 | Lipids | pmid:8784744 |
Reverey H et al. | Differential fatty acid selection during biosynthetic S-acylation of a transmembrane protein (HEF) and other proteins in insect cells (Sf9) and in mammalian cells (CV1). | 1996 | J. Biol. Chem. | pmid:8798573 |
Kirsch AJ et al. | Effects of diode laser welding with dye-enhanced glue on tensile strength of sutures commonly used in urology. | 1996 | Lasers Surg Med | pmid:8833285 |
Pai T and Yeh YY | Stearic acid unlike shorter-chain saturated fatty acids is poorly utilized for triacylglycerol synthesis and beta-oxidation in cultured rat hepatocytes. | 1996 | Lipids | pmid:8835403 |
Gotoh N et al. | Inhibition of oxidation of low density lipoprotein by vitamin E and related compounds. | 1996 | Free Radic. Res. | pmid:8845913 |
Shetty HU et al. | Identification of two molecular species of rat brain phosphatidylcholine that rapidly incorporate and turn over arachidonic acid in vivo. | 1996 | J. Neurochem. | pmid:8858956 |
Uchida T et al. | Microencapsulation of ovalbumin in poly(lactide-co-glycolide) by an oil-in-oil (o/o) solvent evaporation method. | 1996 Sep-Oct | J Microencapsul | pmid:8864988 |
Murkovic M et al. | Variability of fatty acid content in pumpkin seeds (Cucurbita pepo L.). | 1996 | Z Lebensm Unters Forsch | pmid:8873459 |
Wargo DJ and Drennen JK | Near-infrared spectroscopic characterization of pharmaceutical powder blends. | 1996 | J Pharm Biomed Anal | pmid:8877847 |
Peck MD et al. | Fatty acid unsaturation increases expression and capping of murine lymphocyte CD44 and CD45. | 1996 | Nutrition | pmid:8878171 |