stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Rosenthal MD and Whitehurst MC | Selective effects of isomeric cis and trans fatty acids on fatty acyl delta 9 and delta 6 desaturation by human skin fibroblasts. | 1983 | Biochim. Biophys. Acta | pmid:6615875 |
Hwang CC and Danti AG | Percutaneous absorption of flufenamic acid in rabbits: effect of dimethyl sulfoxide and various nonionic surface-active agents. | 1983 | J Pharm Sci | pmid:6620136 |
Philip J and Daly RE | Test for selection of erythromycin stearate bulk drug for tablet preparation. | 1983 | J Pharm Sci | pmid:6620167 |
Shih JC and Ohsawa R | Differential effect of cholesterol on two types of 5-hydroxytryptamine binding sites. | 1983 | Neurochem. Res. | pmid:6621769 |
van Kamp HV et al. | Improvement by super disintegrants of the properties of tablets containing lactose, prepared by wet granulation. | 1983 | Pharm Weekbl Sci | pmid:6622211 |
Warhurst DC et al. | The blood schizontocidal action of erythromycin against Plasmodium knowlesi infections in Macaca mulatta. | 1983 | Ann Trop Med Parasitol | pmid:6625724 |
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Kushi Y et al. | Comparative study of acidic glycosphingolipids by field desorption and secondary ion mass spectrometry. | 1983 | J. Biochem. | pmid:6671968 |
Green B et al. | Qualitative and quantitative changes in milk fat during lactation in the tammar wallaby (Macropus eugenii). | 1983 | Aust. J. Biol. Sci. | pmid:6675645 |
Tulenko TN and Rabinowitz JL | Metabolism of C14 mevalonate by adult and fetal arteries. | 1983 | Artery | pmid:6677248 |
AkbuÄŸa J et al. | Studies on flufenamic acid capsules and tablets. | 1983 | Pharmazie | pmid:6634915 |
NadtochiÄ VV and BrodskiÄ RA | [Absorption routes of stearic acid and leucine in the small intestine of the rat after gamma irradiation]. | 1983 | Arkh Anat Gistol Embriol | pmid:6639383 |
Hundrieser KE et al. | Distribution of trans-octadecenoic acid in the major glycerolipids of human milk. | 1983 | J. Pediatr. Gastroenterol. Nutr. | pmid:6644446 |
Pethick DW et al. | The metabolism of circulating non-esterified fatty acids by the whole animal, hind-limb muscle and uterus of pregnant ewes. | 1983 | Br. J. Nutr. | pmid:6821682 |
Edwards EK and Edwards EK | Allergic reaction to triethanolamine stearate in a sunscreen. | 1983 | Cutis | pmid:6831931 |
Shanson DC et al. | High dose oral erythromycin for preventing endocarditis. | 1983 | Lancet | pmid:6130318 |
de Haan P and Kalsbeek GL | Humoral immune response to some benzylpenicillin preparations. | 1983 | Allergy | pmid:6412583 |
Anderton P et al. | Measles-virus-persistent infection in BGM cells. Modification of the incorporation of [3H]arachidonic acid and [14C]stearic acid into lipids. | 1983 | Biochem. J. | pmid:6414459 |
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Bascoul J et al. | Preparation of autoxidized cholesterol mixtures from [4-14C] cholesterol and cholesteryl fatty acid esters. | 1983 | J. Steroid Biochem. | pmid:6423895 |
Kemp P and Lander DJ | The hydrogenation of gamma-linolenic acid by pure cultures of two rumen bacteria. | 1983 | Biochem. J. | pmid:6318740 |
Walsh CE et al. | Mechanism of arachidonic acid release in human polymorphonuclear leukocytes. | 1983 | Biochim. Biophys. Acta | pmid:6402027 |
Yoshida S et al. | Brain free fatty acids, edema, and mortality in gerbils subjected to transient, bilateral ischemia, and effect of barbiturate anesthesia. | 1983 | J. Neurochem. | pmid:6403669 |
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Bleeker J | Tolerance and efficacy of erythromycin stearate tablets versus enteric-coated erythromycin base capsules in the treatment of patients with acne vulgaris. | 1983 | J. Int. Med. Res. | pmid:6219902 |
Hoover RL et al. | Role of cholesterol in the capping of surface immunoglobulin receptors on murine lymphocytes. | 1983 | J. Cell Biol. | pmid:6223042 |
Jacques NA | Membrane perturbation by cerulenin modulates glucosyltransferase secretion and acetate uptake by Streptococcus salivarius. | 1983 | J. Gen. Microbiol. | pmid:6229601 |
Hashisaki P et al. | Erythromycin failure in the treatment of syphilis in a pregnant woman. | 1983 Jan-Mar | Sex Transm Dis | pmid:6601848 |
Robson HG et al. | Comparison of rosaramicin and erythromycin stearate for treatment of cervical infection with Chlamydia trachomatis. | 1983 Jul-Sep | Sex Transm Dis | pmid:6648747 |
Rosén C et al. | Acute otitis media in older children and adults treated with phenoxymethyl penicillin or erythromycin stearate. Bacteriological and immunological aspects. | 1983 Sep-Oct | Acta Otolaryngol. | pmid:6416018 |
Abdulrazik M et al. | Formulation for slow release of oral radiation-protection drugs. | 1984 | Int J Nucl Med Biol | pmid:6610665 |
Foudin L et al. | Ethanol consumption and serum lipid profiles in Sinclair(S-1) miniature swine. | 1984 | Life Sci. | pmid:6700380 |
Sakaguchi M et al. | Effect of dietary unsaturated and saturated fats on azoxymethane-induced colon carcinogenesis in rats. | 1984 | Cancer Res. | pmid:6704963 |
Anderson R et al. | Studies on the effects of ingestion of a single 500 mg oral dose of erythromycin stearate on leucocyte motility and transformation and on release in vitro of prostaglandin E2 by stimulated leucocytes. | 1984 | J. Antimicrob. Chemother. | pmid:6592163 |
Colombo I and Carli F | Comparative evaluation of structure and micromeritics properties of magnesium stearate. | 1984 | Farmaco Prat | pmid:6510514 |
Romanowski B and Grace M | Non-gonococcal urethritis: a comparison of therapy with minicycline, tetracycline and erthromycin. | 1984 | Can Fam Physician | pmid:21278971 |
Kemp P et al. | The hydrogenation of some cis- and trans-octadecenoic acids to stearic acid by a rumen Fusocillus sp. | 1984 | Br. J. Nutr. | pmid:6743636 |
Greenberg DS et al. | Fatty acid composition of lizard tissue lipids and the effects of estradiol on serum free fatty acids. | 1984 | Comp. Biochem. Physiol., B | pmid:6744817 |
Pediconi MF and RodrÃguez de Turco EB | Free fatty acid content and release kinetics as manifestations of cerebral lateralization in mouse brain. | 1984 | J. Neurochem. | pmid:6726237 |
MacDonald RC et al. | Inhibition of sendai virus-induced hemolysis by long chain fatty acids. | 1984 | Virology | pmid:6324464 |
Goldberg I et al. | Gangrene of the upper extremity following intra-arterial injection of drugs. A case report and review of the literature. | 1984 | Clin. Orthop. Relat. Res. | pmid:6380862 |
Buttke TM and Cuchens MA | Inhibition of lymphocyte proliferation by free fatty acids. II. Toxicity of stearic acid towards phytohaemagglutinin-activated T cells. | 1984 | Immunology | pmid:6333387 |
Walstad RA and Hellum KB | Penetration of erythromycin in respiratory tract infections. | 1984 | Acta Otolaryngol Suppl | pmid:6333775 |
Shanson DC et al. | The pharmacokinetics and tolerance of oral erythromycin stearate compared with erythromycin ethylsuccinate: implications for preventing endocarditis. | 1984 | J. Antimicrob. Chemother. | pmid:6334070 |
Tjandramaga TB et al. | Relative bioavailability of enteric coated pellets, stearate and ethylsuccinate formulations of erythromycin. | 1984 | Pharmacology | pmid:6334320 |
Aylsworth CF et al. | Promotion of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis by high dietary fat in the rat: possible role of intercellular communication. | 1984 | J. Natl. Cancer Inst. | pmid:6422115 |
Kido H et al. | Inhibition of chymase activity by long chain fatty acids. | 1984 | Arch. Biochem. Biophys. | pmid:6424574 |
Feix JB et al. | An electron-electron double-resonance study of interactions between [14N]- and [15N]stearic acid spin-label pairs: lateral diffusion and vertical fluctuations in dimyristoylphosphatidylcholine. | 1984 | Biochemistry | pmid:6329270 |
Ohki K et al. | Effect of alpha-tocopherol on lipid peroxidation and acyl chain mobility of liver microsomes from vitamin E-difficient rat. | 1984 | J. Nutr. Sci. Vitaminol. | pmid:6092586 |
Lem NW and Stumpf PK | In Vitro Fatty Acid Synthesis and Complex Lipid Metabolism in the Cyanobacterium, Anabaena Variabilis: II. Acyl Transfer and Complex Lipid Formation. | 1984 | Plant Physiol. | pmid:16663690 |
Francis H et al. | Severe vascular spasm due to erythromycin-ergotamine interaction. | 1984 | Clin. Rheumatol. | pmid:6236021 |
Bhakoo KK et al. | Regional studies of changes in brain fatty acids following experimental ischaemia and reperfusion in the gerbil. | 1984 | J. Neurochem. | pmid:6236282 |
Abumrad NA et al. | Permeation of long-chain fatty acid into adipocytes. Kinetics, specificity, and evidence for involvement of a membrane protein. | 1984 | J. Biol. Chem. | pmid:6746632 |
Zoeller RA and Wood R | Effects of cyclopropene fatty acids on the lipid composition of the Morris hepatoma 7288C. | 1984 | Lipids | pmid:6431218 |
Sivarajan M et al. | Regulation of intracellular arachidonate in normal and stressed endothelial cells. | 1984 | Biochim. Biophys. Acta | pmid:6433983 |
Rosén C et al. | Acute otitis media in older children and adults treated with penicillin or erythromycin. | 1984 | Acta Otolaryngol Suppl | pmid:6437133 |
Dixon JF and Hokin LE | Secretogogue-stimulated phosphatidylinositol breakdown in the exocrine pancreas liberates arachidonic acid, stearic acid, and glycerol by sequential actions of phospholipase C and diglyceride lipase. | 1984 | J. Biol. Chem. | pmid:6438097 |
Forsberg NE et al. | Roles of acetate and its interactions with glucose and lactate in cow mammary tissue. | 1984 | J. Dairy Sci. | pmid:6438200 |
Desudchit P et al. | Rifampicin-erythromycin combination for the treatment of gonococcal urethritis in men. | 1984 | Southeast Asian J. Trop. Med. Public Health | pmid:6441265 |
Bridges CD et al. | Visual cycle in the mammalian eye. Retinoid-binding proteins and the distribution of 11-cis retinoids. | 1984 | Vision Res. | pmid:6543481 |
Fenyvest E et al. | Cyclodextrin polymer, a new tablet disintegrating agent. | 1984 | Pharmazie | pmid:6494226 |
Junginger H | [The ratio of free and fixed interlamellar water as quality criteria for O/W creams]. | 1984 | Pharmazie | pmid:6504995 |
Kennett FF et al. | Inhibition of myocardial rotenone-insensitive NADH cytochrome c reductase by amphiphilic compounds. | 1984 | Am. J. Physiol. | pmid:6507637 |
Wirthensohn G et al. | Phospholipid metabolism in rat kidney cortical tubules. I. Effect of renal substrates. | 1984 | Biochim. Biophys. Acta | pmid:6477951 |
Shechter Y and Henis YI | Cis-unsaturated fatty acids induce both lipogenesis and calcium binding in adipocytes. | 1984 | Biochim. Biophys. Acta | pmid:6477975 |
Bogdanov AA et al. | Immobilization of alpha-chymotrypsin on sucrose stearate--palmitate containing liposomes. | 1984 | FEBS Lett. | pmid:6479332 |
Junginger HE | Colloidal structures of O/W creams. | 1984 | Pharm Weekbl Sci | pmid:6483570 |
Mogelson S and Lange LG | Nonoxidative ethanol metabolism in rabbit myocardium: purification to homogeneity of fatty acyl ethyl ester synthase. | 1984 | Biochemistry | pmid:6487591 |
Boakes AJ et al. | Treatment of uncomplicated gonorrhoea in women with a combination of rifampicin and erythromycin. | 1984 | Br J Vener Dis | pmid:6487986 |
Fernandes AC et al. | Enhancement of human polymorphonuclear leucocyte motility by erythromycin in vitro and in vivo. | 1984 | S. Afr. Med. J. | pmid:6463793 |
Yoshida S and Takeshita M | Arachidoyl- and arachidonoyl-CoA elongation mechanism in swine cerebral microsomes. | 1984 | Biochim. Biophys. Acta | pmid:6466693 |
Waldman SA et al. | Acyl composition and phospholipase activities in plasma membranes isolated from rat embryos. | 1984 | Int. J. Biochem. | pmid:6468725 |
Slevin ML et al. | The pharmacokinetics of subcutaneous bolus cytosine arabinoside in an arachis oil plus aluminium distearate suspension. | 1984 | Invest New Drugs | pmid:6511233 |
Vandermeerschen-Doizé F and Paquay R | Effects of continuous long-term intravenous infusion of long-chain fatty acids on feeding behaviour and blood components of adult sheep. | 1984 | Appetite | pmid:6517567 |
Hunter JM and Sommerville RG | Erythromycin stearate in treating chlamydial infection of the cervix. | 1984 | Br J Vener Dis | pmid:6518350 |
Farkas T | Adaptation of fatty acid composition to temperature--a study on carp (Cyprinus carpio L.) liver slices. | 1984 | Comp. Biochem. Physiol., B | pmid:6518757 |
Magill A and Becker AR | Spectrophotometric method for quantitation of peroxides in sorbitan monooleate and monostearate. | 1984 | J Pharm Sci | pmid:6520780 |
Ueda A et al. | Experimental study on the pathological changes in lung tissue caused by zinc stearate dust. | 1984 | Ind Health | pmid:6526700 |
Ras GJ et al. | Chemoprophylaxis with erythromycin stearate or amoxycillin in patients with chronic bronchitis--effects on cellular and humoral immune functions. | 1984 Dec 22-29 | S. Afr. Med. J. | pmid:6515508 |
Holub BJ and Celi B | Evaluation of the fatty acid selectivity of a phosphatidylinositol-specific cytosolic phospholipase C from pig and human platelets. | 1984 Feb-Mar | Can. J. Biochem. Cell Biol. | pmid:6518412 |
Blackett PR et al. | Hyperlipidemia in acute lymphoblastic leukemia. | 1984 Mar-Apr | Ann. Clin. Lab. Sci. | pmid:6585175 |
Hanna GM | Nuclear magnetic resonance spectroscopic determination of dicyclomine hydrochloride in tablet, capsule, and injection dosage forms. | 1984 Mar-Apr | J Assoc Off Anal Chem | pmid:6725188 |
Schreiner A and Digranes A | Absorption of erythromycin stearate and enteric-coated erythromycin base after a single oral dose immediately before breakfast. | 1984 Sep-Oct | Infection | pmid:6511088 |
Canonico PL et al. | Arachidonate stimulates prolactin release in vitro: a role for the fatty acid and its metabolites as intracellular regulator(s) in mammotrophs. | 1985 | Endocrinology | pmid:2981065 |
Politi LE et al. | Dexamethasone effect on free fatty acid and diacylglycerol accumulation during experimentally induced vasogenic brain edema. | 1985 | Neurochem Pathol | pmid:3831846 |
Johansson ME | Investigations of the mixing time dependence of the lubricating properties of granular and powdered magnesium stearate. | 1985 | Acta Pharm. Suec. | pmid:3832785 |
Goto S et al. | [Effect of magnesium stearate in preparation of eudragit RS-microcapsules containing drugs]. | 1985 | Yakugaku Zasshi | pmid:3835255 |
Apostolov K et al. | Reduction in the stearic to oleic acid ratio in leukaemic cells--a possible chemical marker of malignancy. | 1985 | Blut | pmid:3859340 |
Habenicht AJ et al. | Cell cycle-dependent changes in arachidonic acid and glycerol metabolism in Swiss 3T3 cells stimulated by platelet-derived growth factor. | 1985 | J. Biol. Chem. | pmid:3918038 |
Bridges CD et al. | Vitamin A and interstitial retinol-binding protein in an eye with recessive retinitis pigmentosa. | 1985 | Invest. Ophthalmol. Vis. Sci. | pmid:4039711 |
Beckurts TE et al. | Kinetics of different 123I- and 14C-labelled fatty acids in normal and diabetic rat myocardium in vivo. | 1985 | Nucl Med Commun | pmid:4047532 |
Plachy J et al. | In vitro biopharmaceutical test for wetting rate. | 1985 | Acta Pharm Hung | pmid:4050448 |
Griffiths G et al. | The acylation of sn-glycerol 3-phosphate and the metabolism of phosphatidate in microsomal preparations from the developing cotyledons of safflower (Carthamus tinctorius L.) seed. | 1985 | Biochem. J. | pmid:4052051 |
Stubbs C et al. | Determination of erythromycin in serum and urine by high-performance liquid chromatography with ultraviolet detection. | 1985 | J Pharm Sci | pmid:4078714 |
Baker RR and Loh ZD | The subcellular distribution of free fatty acids released during post-decapitative ischemia in rat cerebral cortex. | 1985 | Can. J. Biochem. Cell Biol. | pmid:4084856 |
Hegde RP et al. | Studies of powder flow using a recording powder flowmeter and measurement of the dynamic angle of repose. | 1985 | J Pharm Sci | pmid:3981409 |
Tse AG et al. | A glycophospholipid tail at the carboxyl terminus of the Thy-1 glycoprotein of neurons and thymocytes. | 1985 | Science | pmid:2865810 |
Crutchley DJ | Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2865954 |
Johansson ME | Influence of the granulation technique and starting material properties on the lubricating effect of granular magnesium stearate. | 1985 | J. Pharm. Pharmacol. | pmid:2867134 |
Staniforth JN | Relationship between particle packing and the physical stability of powder mixes. | 1985 | J. Pharm. Pharmacol. | pmid:2867136 |