stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Abortion, Spontaneous D000022 12 associated lipids
Acne Vulgaris D000152 35 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amnesia D000647 12 associated lipids
Anemia, Dyserythropoietic, Congenital D000742 2 associated lipids
Olfaction Disorders D000857 17 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Bacterial Infections D001424 21 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Brain Edema D001929 20 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchitis D001991 6 associated lipids
Burns D002056 34 associated lipids
Calculi D002137 3 associated lipids
Cattle Diseases D002418 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Chancroid D002602 4 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Decalcification, Pathologic D003649 1 associated lipids
Dermatitis D003872 30 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Edema D004487 152 associated lipids
Fatty Liver D005234 48 associated lipids
Foreign Bodies D005547 5 associated lipids
Gallbladder Neoplasms D005706 3 associated lipids
Gonorrhea D006069 7 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypopituitarism D007018 7 associated lipids
Hypothalamic Diseases D007027 3 associated lipids
Hypothyroidism D007037 32 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Infertility D007246 3 associated lipids
Insulin Resistance D007333 99 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Per page 10 20 50 100 | Total 3506
Authors Title Published Journal PubMed Link
Yasuda H et al. Biphasic liberation of arachidonic and stearic acids during cerebral ischemia. 1985 J. Neurochem. pmid:2987409
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Enk L et al. High-dose depot-medroxyprogesterone acetate--effects on the fatty acid composition of serum lecithin and cholesterol ester. 1985 Gynecol. Oncol. pmid:2933308
Canonico PL et al. Arachidonate stimulates prolactin release in vitro: a role for the fatty acid and its metabolites as intracellular regulator(s) in mammotrophs. 1985 Endocrinology pmid:2981065
Politi LE et al. Dexamethasone effect on free fatty acid and diacylglycerol accumulation during experimentally induced vasogenic brain edema. 1985 Neurochem Pathol pmid:3831846
Johansson ME Investigations of the mixing time dependence of the lubricating properties of granular and powdered magnesium stearate. 1985 Acta Pharm. Suec. pmid:3832785
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Apostolov K et al. Reduction in the stearic to oleic acid ratio in leukaemic cells--a possible chemical marker of malignancy. 1985 Blut pmid:3859340
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Habenicht AJ et al. Cell cycle-dependent changes in arachidonic acid and glycerol metabolism in Swiss 3T3 cells stimulated by platelet-derived growth factor. 1985 J. Biol. Chem. pmid:3918038
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George M and Chepenik KP Phospholipase A activities in embryonic palate mesenchyme cells in vitro. 1985 Biochim. Biophys. Acta pmid:3927980
Galey CI et al. Modulation of phospholipid metabolism in murine keratinocytes by tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. 1985 J. Invest. Dermatol. pmid:3930615
Jones PJ et al. Whole body oxidation of dietary fatty acids: implications for energy utilization. 1985 Am. J. Clin. Nutr. pmid:3933323
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Johansson ME Influence of the granulation technique and starting material properties on the lubricating effect of granular magnesium stearate. 1985 J. Pharm. Pharmacol. pmid:2867134
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Catalá A Stearic acid desaturation in rat liver microsomes: stimulation by fatty acid binding protein. 1986 Acta Physiol Pharmacol Latinoam pmid:2876583
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Giudici TA et al. Methylmalonic and propionic acidemias: lipid profiles of normal and affected human skin fibroblasts incubated with [1-14C]propionate. 1986 Biochem. Med. Metab. Biol. pmid:2872907
Marchut E et al. The inhibitory effect of various fatty acids on aerobic glycolysis in Ehrlich ascites tumour cells. 1986 Acta Biochim. Pol. pmid:2940781
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Reddy TS et al. Fatty acid composition and arachidonic acid metabolism in vitreous lipids from canine and human eyes. 1986 Curr. Eye Res. pmid:3089690
Dudley DT and Spector AA Inositol phospholipid arachidonic acid metabolism in GH3 pituitary cells. 1986 Biochem. J. pmid:3098231
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Smith DM and Waite M Phospholipid metabolism in human neutrophil subfractions. 1986 Arch. Biochem. Biophys. pmid:3083776
Singh H and Poulos A A comparative study of stearic and lignoceric acid oxidation by human skin fibroblasts. 1986 Arch. Biochem. Biophys. pmid:3767370
Goto S et al. [Role of metal stearates in preparation of Eudragit RS-microcapsules containing sulfamethizole by evaporation process in water phase]. 1986 Yakugaku Zasshi pmid:3701600
Shah KB et al. An investigation of some factors influencing plug formation and fill weight in a dosing disk-type automatic capsule-filling machine. 1986 J Pharm Sci pmid:3701614
Wan LS and Choong YL The effect of excipients on the penetration of liquid into tablets. 1986 Pharm Acta Helv pmid:3725815
Oh-Hashi Y et al. Temperature- and growth-phase-dependent changes in membrane fatty acid compositions of Brevibacterium ammoniagenes. 1986 Arch. Biochem. Biophys. pmid:3729431
Carter-Dawson L et al. Rhodopsin, 11-cis vitamin A, and interstitial retinol-binding protein (IRBP) during retinal development in normal and rd mutant mice. 1986 Dev. Biol. pmid:3732615
Chowhan ZT and Chi LH Drug-excipient interactions resulting from powder mixing. III: Solid state properties and their effect on drug dissolution. 1986 J Pharm Sci pmid:3735096
Chowhan ZT and Chi LH Drug-excipient interactions resulting from powder mixing. IV: Role of lubricants and their effect on in vitro dissolution. 1986 J Pharm Sci pmid:3735097
Fujii T et al. Effect of exogenous lipids incorporated into the membrane of human erythrocytes on its glucose transport activity. 1986 Biochem. Int. pmid:3741447
Chester DW et al. The influence of saturated fatty acid modulation of bilayer physical state on cellular and membrane structure and function. 1986 Biochim. Biophys. Acta pmid:3741857
Tsao FH Selective use of palmitic acid over stearic acid for synthesis of phosphatidylcholine and phosphatidylglycerol in lung. 1986 Lipids pmid:3796238
Ito Y et al. Fatty acid synthetase as a thermoreceptor in Candida utilis. 1986 J. Biochem. pmid:3745143
Muralidharan FN and Muralidharan VB Phytanoyl-CoA ligase activity in rat liver. 1986 Biochem. Int. pmid:3753503
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Sugimoto Y et al. A 2H NMR study on alteration of the membrane organization of mouse B16 melanoma cells treated with 12-O-tetradecanoylphorbol-13-acetate. 1986 J. Biochem. pmid:3818567
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Pajor L et al. Microsomal desaturation of stearic acid in relation to lymphocyte activation. 1986 Arch. Biochem. Biophys. pmid:3485399
Ras GJ and Anderson R An in-vitro study of oral therapeutic doses of co-trimoxazole and erythromycin stearate on abnormal polymorphonuclear leucocyte migration. 1986 J. Antimicrob. Chemother. pmid:3486178
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Johansson ME and Nicklasson M Investigation of the film formation of magnesium stearate by applying a flow-through dissolution technique. 1986 J. Pharm. Pharmacol. pmid:2869127
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DeGeorge JJ et al. Acetylcholine stimulates selective liberation and re-esterification of arachidonate and accumulation of inositol phosphates and glycerophosphoinositol in C62B glioma cells. 1987 J. Biol. Chem. pmid:3110145
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Caglayan S et al. Is medical therapy effective for regional lymphadenitis following BCG vaccination? 1987 Am. J. Dis. Child. pmid:3673975
Venho VM et al. The value of comparative bioavailability studies of marketed drugs in drug control. An example with erythromycin stearate. 1987 Methods Find Exp Clin Pharmacol pmid:3683018
Bridges CD et al. Rhodopsin, vitamin A, and interstitial retinol-binding protein in the rd chicken. 1987 Invest. Ophthalmol. Vis. Sci. pmid:3557867
Hope MJ and Cullis PR Lipid asymmetry induced by transmembrane pH gradients in large unilamellar vesicles. 1987 J. Biol. Chem. pmid:3558410
Husebye ES and Flatmark T Characterization of phospholipase activities in chromaffin granule ghosts isolated from the bovine adrenal medulla. 1987 Biochim. Biophys. Acta pmid:3607074
Cavalleri A and Minoia C Lead level of whole blood and plasma in workers exposed to lead stearate. 1987 Scand J Work Environ Health pmid:3616550