stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Vanderveen JE | Regulatory history for stearic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7977156 |
Metabolic Consequences of Stearic Acid Relative to Other Long-Chain Fatty Acids, Atlanta, Georgia, November 5-6, 1993 and Chocolate in Perspective: Cocoa Butter, a Unique Saturated Fat, Dallas, Texas, February 9, 1994. Symposium proceedings. | 1994 | Am. J. Clin. Nutr. | pmid:7977155 | |
Schoene NW et al. | Dissimilar responses of platelets to dietary stearic and palmitic acids. | 1994 | Am. J. Clin. Nutr. | pmid:7977151 |
Blair IA et al. | Dietary stearic acid and thromboxane-prostacyclin biosynthesis in normal human subjects. | 1994 | Am. J. Clin. Nutr. | pmid:7977150 |
Hoak JC | Stearic acid, clotting, and thrombosis. | 1994 | Am. J. Clin. Nutr. | pmid:7977149 |
Denke MA | Role of beef and beef tallow, an enriched source of stearic acid, in a cholesterol-lowering diet. | 1994 | Am. J. Clin. Nutr. | pmid:7977148 |
Dougherty RM et al. | Total and low-density-lipoprotein cholesterol lipoprotein fractions and fecal fatty acid excretion of men consuming diets containing high concentrations of stearic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7977147 |
Kris-Etherton PM and Mustad VA | Chocolate feeding studies: a novel approach for evaluating the plasma lipid effects of stearic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7977145 |
Emken EA | Metabolism of dietary stearic acid relative to other fatty acids in human subjects. | 1994 | Am. J. Clin. Nutr. | pmid:7977144 |
Denke MA | Effects of cocoa butter on serum lipids in humans: historical highlights. | 1994 | Am. J. Clin. Nutr. | pmid:7977142 |
Fuller CJ and Jialal I | Effects of antioxidants and fatty acids on low-density-lipoprotein oxidation. | 1994 | Am. J. Clin. Nutr. | pmid:7977141 |
Adewusi SR and Ilori MO | Nutritional evaluation of spent grains from sorghum malts and maize grit. | 1994 | Plant Foods Hum Nutr | pmid:7971786 |
Ikeda I et al. | Lymphatic transport of stearic acid and its effect on cholesterol transport in rats. | 1994 | J. Nutr. Sci. Vitaminol. | pmid:7965216 |
Shenai JP and Chytil F | Effect of maternal dexamethasone treatment on fetal lung vitamin A stores in the perinatal rat. | 1994 | Int J Vitam Nutr Res | pmid:7960497 |
Awad AB et al. | In vitro activation and inhibition of rat colonic phospholipase D by fatty acids. | 1994 | Cancer Lett. | pmid:7954345 |
Oe H et al. | Calcium overload and cardiac myocyte cell damage induced by arachidonate lipoxygenation. | 1994 | Am. J. Physiol. | pmid:7943384 |
Richieri GV et al. | Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. | 1994 | J. Biol. Chem. | pmid:7929039 |
Young AC et al. | Structural studies on human muscle fatty acid binding protein at 1.4 A resolution: binding interactions with three C18 fatty acids. | 1994 | Structure | pmid:7922029 |
Scholz WK | An ibotenate-selective metabotropic glutamate receptor mediates protein phosphorylation in cultured hippocampal pyramidal neurons. | 1994 | J. Neurochem. | pmid:7908944 |
Zoukhri D and Dartt DA | Cholinergic activation of phospholipase D in lacrimal gland acini is independent of protein kinase C and calcium. | 1995 | Am. J. Physiol. | pmid:7900776 |