stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Gonçalves-Araújo T et al. | Application of percolation theory in the study of an extended release Verapamil hydrochloride formulation. | 2008 | Int J Pharm | pmid:18621491 |
Late SG and Banga AK | Thermal and non-thermal methods to evaluate compatibility of granisetron hydrochloride with tablet excipients. | 2008 | Pharmazie | pmid:18604989 |
De Girolamo J et al. | Layer-by-layer assembled composite films of side-functionalized poly(3-hexylthiophene) and CdSe nanocrystals: electrochemical, spectroelectrochemical and photovoltaic properties. | 2008 | Phys Chem Chem Phys | pmid:18597017 |
Reyna SM et al. | Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. | 2008 | Diabetes | pmid:18633101 |
Ikonen M et al. | Controlled complexation of plasmid DNA with cationic polymers: effect of surfactant on the complexation and stability of the complexes. | 2008 | Colloids Surf B Biointerfaces | pmid:18583110 |
Yee JK et al. | Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells. | 2008 | J. Lipid Res. | pmid:18599738 |
Shah RB et al. | Stability indicating validated HPLC method for quantification of levothyroxine with eight degradation peaks in the presence of excipients. | 2008 | Int J Pharm | pmid:18524511 |
Liang L and Fang Y | Photoluminescence of a mixed Langmuir-Blodgett film of C(60) and stearic acid at room temperature. | 2008 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:17499018 |
Whitby CP et al. | Effect of oil soluble surfactant in emulsions stabilised by clay particles. | 2008 | J Colloid Interface Sci | pmid:18452938 |
He X et al. | Formulation development and process scale up of a high shear wet granulation formulation containing a poorly wettable drug. | 2008 | J Pharm Sci | pmid:18449937 |
John Wallace R | Gut microbiology - broad genetic diversity, yet specific metabolic niches. | 2008 | Animal | pmid:22443591 |
Bermúdez L et al. | A candidate gene survey of quantitative trait loci affecting chemical composition in tomato fruit. | 2008 | J. Exp. Bot. | pmid:18552354 |
Chen Y et al. | Isolation of 5-hydroxypyrrolidin-2-one and other constituents from the young fronds of Pteridium aquilinum. | 2008 | J Nat Med | pmid:18437503 |
Riegler J et al. | Blue shift of CdSe/ZnS nanocrystal-labels upon DNA-hybridization. | 2008 | J Nanobiotechnology | pmid:18489732 |
Simon MN et al. | Persistent activation of Akt or ERK prevents the toxicity induced by saturated and polyunsaturated fatty acids in RINm5F β-cells. | 2008 | Toxicol In Vitro | pmid:18395405 |
Arida AI and Al-Tabakha MM | Cellactose a co-processed excipient: a comparison study. | 2008 | Pharm Dev Technol | pmid:18379907 |
Ranji A et al. | Determination of calcium stearate in polyolefin samples by gas chromatographic technique after performing dispersive liquid-liquid microextraction. | 2008 | Anal Sci | pmid:18469468 |
McHedlov-Petrossyan NO et al. | Fluorescent dye N,N'-dioctadecylrhodamine as a new interfacial acid-base indicator. | 2008 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:17681854 |
Jones PJ | Dietary agents that target gastrointestinal and hepatic handling of bile acids and cholesterol. | 2008 | J Clin Lipidol | pmid:21291720 |
Shah RB et al. | Comparative evaluation of flow for pharmaceutical powders and granules. | 2008 | AAPS PharmSciTech | pmid:18446489 |
Lee YH et al. | Separation and determination of polyethylene glycol fatty acid esters in cosmetics by a reversed-phase HPLC/ELSD. | 2008 | Talanta | pmid:18371826 |
Darole PS et al. | Formulation and evaluation of microemulsion based delivery system for amphotericin B. | 2008 | AAPS PharmSciTech | pmid:18446472 |
Flasiński M et al. | Per-6-O-(tert-butyldimethylsilyl)cyclodextrins (TBDMS-CDs) in Langmuir monolayers: the importance of a spreading solvent in the preparation of LB layers suitable for sensor application. | 2008 | J Phys Chem B | pmid:18358030 |
Fujimoto Y et al. | Stearic acid potently modulates the activity of cyclooxygenase-1, but not cyclooxygenase-2, in the form of its CoA ester. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18083017 |
Salas JJ et al. | The biochemical characterization of a high-stearic acid sunflower mutant reveals the coordinated regulation of stearoyl-acyl carrier protein desaturases. | 2008 | Plant Physiol. Biochem. | pmid:18023195 |
Lee DY and Fiehn O | High quality metabolomic data for Chlamydomonas reinhardtii. | 2008 | Plant Methods | pmid:18442406 |
Sun CC | On the mechanism of reduced tabletability of granules prepared by roller compaction. | 2008 | Int J Pharm | pmid:18024020 |
Schwab U et al. | Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study. | 2008 | PLoS ONE | pmid:18612464 |
Jose R et al. | Dependence of luminescence efficiency of cdse quantum dots on chemical environments. | 2008 | J Nanosci Nanotechnol | pmid:19198279 |
Ebbesson SO et al. | Consumption of omega-3 fatty acids is not associated with a reduction in carotid atherosclerosis: the Genetics of Coronary Artery Disease in Alaska Natives study. | 2008 | Atherosclerosis | pmid:18054937 |
Patel DM and Patel MM | Optimization of fast dissolving etoricoxib tablets prepared by sublimation technique. | 2008 | Indian J Pharm Sci | pmid:20390084 |
Widjaja E and Seah RK | Application of Raman microscopy and band-target entropy minimization to identify minor components in model pharmaceutical tablets. | 2008 | J Pharm Biomed Anal | pmid:17980994 |
Jithan AV et al. | Development and evaluation of a chloramphenicol hypertonic ophthalmic solution. | 2008 | Indian J Pharm Sci | pmid:20390083 |
Darwish IA et al. | New spectrofluorimetric method with enhanced sensitivity for determination of paroxetine in dosage forms and plasma. | 2008 | Anal Chem Insights | pmid:19609398 |
Bacher C et al. | Granule fraction inhomogeneity of calcium carbonate/sorbitol in roller compacted granules. | 2008 | Int J Pharm | pmid:17765416 |
Rahman N and Haque SM | Optimized and validated spectrophotometric methods for the determination of enalapril maleate in commercial dosage forms. | 2008 | Anal Chem Insights | pmid:19609388 |
Piao ZZ et al. | Colonic release and reduced intestinal tissue damage of coated tablets containing naproxen inclusion complex. | 2008 | Int J Pharm | pmid:17928177 |
Jones OA et al. | A metabolomics based approach to assessing the toxicity of the polyaromatic hydrocarbon pyrene to the earthworm Lumbricus rubellus. | 2008 | Chemosphere | pmid:17928029 |
El-Enany N et al. | Spectrofluorimetric determination of oxamniquine in dosage forms and spiked human plasma through derivatization with 1-dimethylaminonaphthalene-5-sulphonyl chloride. | 2008 | J Fluoresc | pmid:18058206 |
Yuan H et al. | Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells. | 2008 | Int J Pharm | pmid:17714896 |
Rhee YS et al. | Application of instrumental evaluation of color for the pre-formulation and formulation of rabeprazole. | 2008 | Int J Pharm | pmid:17919858 |
Guchardi R et al. | Influence of fine lactose and magnesium stearate on low dose dry powder inhaler formulations. | 2008 | Int J Pharm | pmid:17689898 |
Vehring R | Pharmaceutical particle engineering via spray drying. | 2008 | Pharm. Res. | pmid:18040761 |
Wu H et al. | Process analytical technology (PAT): quantification approaches in terahertz spectroscopy for pharmaceutical application. | 2008 | J Pharm Sci | pmid:17722101 |
Hamad ML et al. | Functionality of magnesium stearate derived from bovine and vegetable sources: dry granulated tablets. | 2008 | J Pharm Sci | pmid:18351597 |
Guo J et al. | Phenolic molding compound filled with nonmetals of waste PCBs. | 2008 | Environ. Sci. Technol. | pmid:18284173 |
Nyblom HK et al. | Glucose-induced de novo synthesis of fatty acyls causes proportional increases in INS-1E cellular lipids. | 2008 | NMR Biomed | pmid:17691080 |
Werle M | Natural and synthetic polymers as inhibitors of drug efflux pumps. | 2008 | Pharm. Res. | pmid:17896100 |
Moate PJ et al. | Milk fatty acids II: prediction of the production of individual fatty acids in bovine milk. | 2008 | J. Dairy Sci. | pmid:18292274 |
Almaya A and Aburub A | Effect of particle size on compaction of materials with different deformation mechanisms with and without lubricants. | 2008 | AAPS PharmSciTech | pmid:18431664 |
Bushra R et al. | Formulation development and optimization of Ibuprofen tablets by direct compression method. | 2008 | Pak J Pharm Sci | pmid:18390440 |
Kuno Y et al. | Effect of the type of lubricant on the characteristics of orally disintegrating tablets manufactured using the phase transition of sugar alcohol. | 2008 | Eur J Pharm Biopharm | pmid:18396020 |
Moore IM et al. | Methotrexate-induced alterations in beta-oxidation correlate with cognitive abilities in children with acute lymphoblastic leukemia. | 2008 | Biol Res Nurs | pmid:18398226 |
Bacher C et al. | Compressibility and compactibility of granules produced by wet and dry granulation. | 2008 | Int J Pharm | pmid:18407441 |
Teixeira AC et al. | Phase behaviour of binary mixtures involving tristearin, stearyl stearate and stearic acid: thermodynamic study and BAM observation at the air-water interface and AFM analysis of LB films. | 2008 | Chem. Phys. Lipids | pmid:18407835 |
Gmucová K et al. | Orientation ordering of nanoparticle Ag/Co cores controlled by electric and magnetic fields. | 2008 | Chemphyschem | pmid:18386264 |
Houmadi S et al. | Langmuir-Blodgett film of hydrophobin protein from Pleurotus ostreatus at the air-water interface. | 2008 | Langmuir | pmid:18925762 |
Crowe FL et al. | Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition. | 2008 | Am. J. Clin. Nutr. | pmid:18996872 |
Isaev NP and Dzuba SA | Fast stochastic librations and slow rotations of spin labeled stearic acids in a model phospholipid bilayer at cryogenic temperatures. | 2008 | J Phys Chem B | pmid:18826269 |
Koseki T et al. | Development of novel fast-disintegrating tablets by direct compression using sucrose stearic acid ester as a disintegration-accelerating agent. | 2008 | Chem. Pharm. Bull. | pmid:18827375 |
Navarro-Tarazaga ML et al. | Fatty acid effect on hydroxypropyl methylcellulose-beeswax edible film properties and postharvest quality of coated 'Ortanique' mandarins. | 2008 | J. Agric. Food Chem. | pmid:18950188 |
Dillon R et al. | Development of a novel LC/MS method to quantitate cellular stearoyl-CoA desaturase activity. | 2008 | Anal. Chim. Acta | pmid:18790132 |
Abbasi M et al. | Further investigation of lipid-substituted poly(L-Lysine) polymers for transfection of human skin fibroblasts. | 2008 | Biomacromolecules | pmid:18498191 |
Pi K et al. | [Study on liposoluble constituents of Teucrium labiosum]. | 2008 | Zhong Yao Cai | pmid:18973016 |
Hernández ML et al. | The utilization and desaturation of oleate and linoleate during glycerolipid biosynthesis in olive (Olea europaea L.) callus cultures. | 2008 | J. Exp. Bot. | pmid:18515829 |
Fang YP et al. | Physicochemical and safety evaluation of 5-aminolevulinic acid in novel liposomes as carrier for skin delivery. | 2008 | J Liposome Res | pmid:18348070 |
Lasserre R et al. | Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation. | 2008 | Nat. Chem. Biol. | pmid:18641634 |
Zhang JX et al. | Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat. | 2008 | Chem. Senses | pmid:18515819 |
Kirtsreesakul V et al. | Microbiology and antimicrobial susceptibility patterns of commensal flora in the middle nasal meatus. | 2008 | Ann. Otol. Rhinol. Laryngol. | pmid:19140538 |
Ellison CD et al. | Measuring the distribution of density and tabletting force in pharmaceutical tablets by chemical imaging. | 2008 | J Pharm Biomed Anal | pmid:18539424 |
Fernández EG et al. | Rapid development and optimization of tablet manufacturing using statistical tools. | 2008 | AAPS PharmSciTech | pmid:18459048 |
Chang CK et al. | Roller compaction, granulation and capsule product dissolution of drug formulations containing a lactose or mannitol filler, starch, and talc. | 2008 | AAPS PharmSciTech | pmid:18459052 |
Zeng Q et al. | Highly luminescent CdSe/ZnSe core-shell quantum dots of one-pot preparation in octadecene. | 2008 | J Nanosci Nanotechnol | pmid:18468151 |
Kordyukova LV et al. | S acylation of the hemagglutinin of influenza viruses: mass spectrometry reveals site-specific attachment of stearic acid to a transmembrane cysteine. | 2008 | J. Virol. | pmid:18596092 |
Richardson AD et al. | Central carbon metabolism in the progression of mammary carcinoma. | 2008 | Breast Cancer Res. Treat. | pmid:17879159 |
Smirnov AI | Post-processing of EPR spectra by convolution filtering: calculation of a harmonics' series and automatic separation of fast-motion components from spin-label EPR spectra. | 2008 | J. Magn. Reson. | pmid:17967556 |
Liu C et al. | In situ intestinal absorption of cyclosporine A solid dispersion in rats. | 2008 | Drug Dev Ind Pharm | pmid:18568913 |
Fini A et al. | Raman and thermal analysis of indomethacin/PVP solid dispersion enteric microparticles. | 2008 | Eur J Pharm Biopharm | pmid:18621516 |
Liu LX et al. | Effect of particle properties on the flowability of ibuprofen powders. | 2008 | Int J Pharm | pmid:18652883 |
Lumor SE et al. | Optimization of solid fat content and crystal properties of a trans-free structured lipid by blending with palm midfraction. | 2008 | J. Agric. Food Chem. | pmid:18781758 |
Moon CD et al. | Reclassification of Clostridium proteoclasticum as Butyrivibrio proteoclasticus comb. nov., a butyrate-producing ruminal bacterium. | 2008 | Int. J. Syst. Evol. Microbiol. | pmid:18768601 |
Terés S et al. | Oleic acid content is responsible for the reduction in blood pressure induced by olive oil. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18772370 |
Weber D et al. | Quantification of lubricant activity of magnesium stearate by atomic force microscopy. | 2008 | Drug Dev Ind Pharm | pmid:18777241 |
Simonsick WJ and Petkovska VI | Detailed structural elucidation of polyesters and acrylates using Fourier transform mass spectrometry. | 2008 | Anal Bioanal Chem | pmid:18719895 |
Almeida IF et al. | Moisturizing effect of oleogel/hydrogel mixtures. | 2008 | Pharm Dev Technol | pmid:18720247 |
Badillo N and Ghaly ES | In vitro evaluation of theophylline matrices using xyloglucan. | 2008 | Pharm Dev Technol | pmid:18720251 |
Ling XY et al. | Supramolecular layer-by-layer assembly of 3D multicomponent nanostructures via multivalent molecular recognition. | 2008 | Int J Mol Sci | pmid:19325764 |
Tolson J et al. | A green humidifier chamber. | 2008 | Eur. Respir. J. | pmid:18669801 |
Bigucci F et al. | Chitosan salts coated with stearic acid as colon-specific delivery systems for vancomycin. | 2008 | Drug Deliv | pmid:18763159 |
Ye YQ et al. | Core-modified chitosan-based polymeric micelles for controlled release of doxorubicin. | 2008 | Int J Pharm | pmid:18096336 |
Mazumder B et al. | Flow of Formulation Granules through a Conical Hopper. | 2008 | Indian J Pharm Sci | pmid:21369452 |
Teixeira AC et al. | Microdomains in mixed monolayers of oleanolic and stearic acids: thermodynamic study and BAM observation at the air-water interface and AFM and FTIR analysis of LB monolayers. | 2007 Sep-Oct | Chem. Phys. Lipids | pmid:17583687 |
Naidu KA et al. | P53 enhances ascorbyl stearate-induced G2/M arrest of human ovarian cancer cells. | 2007 Nov-Dec | Anticancer Res. | pmid:18225552 |
Desai D et al. | Evaluation of selected micronized poloxamers as tablet lubricants. | 2007 | Drug Deliv | pmid:17994358 |
Kambayashi Y et al. | Various Molecular Species of Diacylglycerol Hydroperoxide Activate Human Neutrophils via PKC Activation. | 2007 | J Clin Biochem Nutr | pmid:18392102 |
Dong J et al. | Crystallization of silver carboxylates from sodium carboxylate mixtures. | 2007 | Langmuir | pmid:17567157 |
Raffin RP et al. | Development of HPMC and Eudragit S100 blended microparticles containing sodium pantoprazole. | 2007 | Pharmazie | pmid:17557744 |
Wong HL et al. | In vivo evaluation of a new polymer-lipid hybrid nanoparticle (PLN) formulation of doxorubicin in a murine solid tumor model. | 2007 | Eur J Pharm Biopharm | pmid:17156986 |
Anjos JL et al. | Effects of 1,8-cineole on the dynamics of lipids and proteins of stratum corneum. | 2007 | Int J Pharm | pmid:17600646 |
Yang Y et al. | Regulation of FAT/CD36 mRNA gene expression by long chain fatty acids in the differentiated 3T3-L1 cells. | 2007 | Pediatr. Surg. Int. | pmid:17516074 |