stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Staiger K et al. | Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation. | 2006 | Diabetes | pmid:17065351 |
Nohynek GJ et al. | Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing age. | 2006 | Toxicol. Lett. | pmid:16243460 |
Tavilani H et al. | Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. | 2006 | Andrologia | pmid:16961570 |
Kiuru PS and Wähälä K | Microwave-assisted synthesis of deuterium labeled estrogen fatty acid esters. | 2006 | Steroids | pmid:16198386 |
Huang YF et al. | One new anthraquinone from marine Streptomyces sp. FX-58. | 2006 | Nat. Prod. Res. | pmid:17127510 |
Harper DP and Wolcott MP | Chemical imaging of wood-polypropylene composites. | 2006 | Appl Spectrosc | pmid:16925926 |
Föger F et al. | In vivo comparison of various polymeric and low molecular mass inhibitors of intestinal P-glycoprotein. | 2006 | Biomaterials | pmid:16919723 |
Sunagane N et al. | [Possibility of interactions between prescription drugs and OTC drugs (2nd report)--interaction between levodopa preparation and OTC Kampo medicines for upset stomach]. | 2006 | Yakugaku Zasshi | pmid:17077621 |
Kumon M et al. | Novel approach to DPI carrier lactose with mechanofusion process with additives and evaluation by IGC. | 2006 | Chem. Pharm. Bull. | pmid:17077547 |
Johnston WL et al. | The eggshell is required for meiotic fidelity, polar-body extrusion and polarization of the C. elegans embryo. | 2006 | BMC Biol. | pmid:17042944 |
Wu F and Gaffney BJ | Dynamic behavior of fatty acid spin labels within a binding site of soybean lipoxygenase-1. | 2006 | Biochemistry | pmid:17029406 |
Gibon Y et al. | Integration of metabolite with transcript and enzyme activity profiling during diurnal cycles in Arabidopsis rosettes. | 2006 | Genome Biol. | pmid:16916443 |
Wong HG | Potential adverse and allergic reactions from complementary and alternative medicine and dietary supplements. | 2006 | Allergy Asthma Clin Immunol | pmid:20525159 |
Polat M | Kinetic estimation of the adsorbate distribution on the surface from adsorbed amounts. | 2006 | J Colloid Interface Sci | pmid:16445933 |
Sayari A and Gargouri Y | [Enzymatic synthesis of homogenous triacylglycerol in media without solvent]. | 2006 | Arch Inst Pasteur Tunis | pmid:19388599 |
Garton NJ and Sutcliffe IC | Identification of a lipoarabinomannan-like lipoglycan in the actinomycete Gordonia bronchialis. | 2006 | Arch. Microbiol. | pmid:16320036 |
Yao HT et al. | The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. | 2006 | Life Sci. | pmid:16978661 |
Duan Y et al. | Effect of molecular sieves on lipase-catalyzed esterification of rutin with stearic acid. | 2006 | J. Agric. Food Chem. | pmid:16910711 |
Kazmierczak SC et al. | Electron spin resonance spectroscopy of serum albumin: a novel new test for cancer diagnosis and monitoring. | 2006 | Clin. Chem. | pmid:16990414 |
Shankar BV and Patnaik A | J-aggregates in matrix stabilized two-dimensional azobenzene derivatives. | 2006 | J Colloid Interface Sci | pmid:16844137 |
Miranda LA et al. | Performance of UASB and DAEB reactors in the anaerobic digestion of synthetic wastewater containing sodium oleate and sodium stereate. | 2006 | Water Sci. Technol. | pmid:16939093 |
Colla E et al. | Amaranthus cruentus flour edible films: influence of stearic acid addition, plasticizer concentration, and emulsion stirring speed on water vapor permeability and mechanical properties. | 2006 | J. Agric. Food Chem. | pmid:16939322 |
Renaville B et al. | Eicosapentaenoic acid and 3,10 dithia stearic acid inhibit the desaturation of trans-vaccenic acid into cis-9, trans-11-conjugated linoleic acid through different pathways in Caco-2 and T84 cells. | 2006 | Br. J. Nutr. | pmid:16571147 |
Fukuda S et al. | Augmentation of vaccenate production and suppression of vaccenate biohydrogenation in cultures of mixed ruminal microbes. | 2006 | J. Dairy Sci. | pmid:16507700 |
Salles HC et al. | The venomous secrets of the web droplets from the viscid spiral of the orb-weaver spider Nephila clavipes (Araneae, Tetragnatidae). | 2006 | Chem. Biodivers. | pmid:17193305 |
John Wallace R et al. | Clostridium proteoclasticum: A ruminal bacterium that forms stearic acid from linoleic acid. | 2006 | FEMS Microbiol. Lett. | pmid:17147764 |
Hirai N et al. | Improvement of the agitation granulation method to prepare granules containing a high content of a very hygroscopic drug. | 2006 | J. Pharm. Pharmacol. | pmid:17132205 |
Müller H et al. | Control of CaCO3 crystallization by demixing of monolayers. | 2006 | Langmuir | pmid:17154582 |
Song GY et al. | High-fat feeding reduces endothelium-dependent vasodilation in rats: differential mechanisms for saturated and unsaturated fatty acids? | 2006 | Clin. Exp. Pharmacol. Physiol. | pmid:16895544 |
El Hagrasy AS et al. | Evaluation of risk and benefit in the implementation of near-infrared spectroscopy for monitoring of lubricant mixing. | 2006 | Pharm Dev Technol | pmid:16895841 |
Rasmussen HE et al. | Reduction in cholesterol absorption is enhanced by stearate-enriched plant sterol esters in hamsters. | 2006 | J. Nutr. | pmid:17056791 |
Brouwer DH et al. | Size selective dustiness and exposure; simulated workplace comparisons. | 2006 | Ann Occup Hyg | pmid:16524926 |
Tsakalof AK et al. | Pitfalls in drying oils identification in art objects by gas chromatography. | 2006 | J Sep Sci | pmid:16922282 |
Govindarajan R et al. | Ionization states in the microenvironment of solid dosage forms: effect of formulation variables and processing. | 2006 | Pharm. Res. | pmid:16933092 |
Otsuka M and Yamane I | Prediction of tablet hardness based on near infrared spectra of raw mixed powders by chemometrics. | 2006 | J Pharm Sci | pmid:16721793 |
Zou T et al. | Support vector regression for determination of component of compound oxytetracycline powder on near-infrared spectroscopy. | 2006 | Anal. Biochem. | pmid:16723110 |
Planinsek O et al. | Surface analysis of powder binary mixtures with ATR FTIR spectroscopy. | 2006 | Int J Pharm | pmid:16730933 |
Söderhäll I et al. | Characterization of a hemocyte intracellular fatty acid-binding protein from crayfish (Pacifastacus leniusculus) and shrimp (Penaeus monodon). | 2006 | FEBS J. | pmid:16734719 |
Lee SH et al. | Fatty acid synthesis by elongases in trypanosomes. | 2006 | Cell | pmid:16923389 |
Murphy DJ | The extracellular pollen coat in members of the Brassicaceae: composition, biosynthesis, and functions in pollination. | 2006 | Protoplasma | pmid:16937052 |
Gelders GG et al. | Potato phosphorylase catalyzed synthesis of amylose-lipid complexes. | 2005 Sep-Oct | Biomacromolecules | pmid:16153100 |
Parra-Barraza H et al. | Chitosan-cholesterol and chitosan-stearic acid interactions at the air-water interface. | 2005 Sep-Oct | Biomacromolecules | pmid:16153076 |
Stanisz B | The influence of pharmaceutical excipients on quinapril hydrochloride stability. | 2005 May-Jun | Acta Pol Pharm | pmid:16193811 |
Menéndez R et al. | In vitro and in vivo study of octacosanol metabolism. | 2005 Mar-Apr | Arch. Med. Res. | pmid:15847942 |
Staiger H et al. | Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro. | 2005 | Diabetologia | pmid:16132959 |
Grabowski A et al. | Characterization of long-chain fatty-acid-degrading syntrophic associations from a biodegraded oil reservoir. | 2005 | Res. Microbiol. | pmid:15939576 |
Wurster DE et al. | The influence of magnesium stearate on the Hiestand Tableting Indices and other related mechanical properties of maltodextrins. | 2005 | Pharm Dev Technol | pmid:16370175 |
Fukami J et al. | Development of fast disintegrating compressed tablets using amino acid as disintegration accelerator: evaluation of wetting and disintegration of tablet on the basis of surface free energy. | 2005 | Chem. Pharm. Bull. | pmid:16327184 |
Jahn T and Steffens KJ | Press chamber coating as external lubrication for high speed rotary presses: lubricant spray rate optimization. | 2005 | Drug Dev Ind Pharm | pmid:16316850 |
Thijssen MA et al. | Stearic, oleic, and linoleic acids have comparable effects on markers of thrombotic tendency in healthy human subjects. | 2005 | J. Nutr. | pmid:16317124 |
Wang L et al. | [Synthesis, characterization and evaluation of octadecyl ester-bonded monolithic column]. | 2005 | Se Pu | pmid:16350795 |
Hackl H et al. | Molecular processes during fat cell development revealed by gene expression profiling and functional annotation. | 2005 | Genome Biol. | pmid:16420668 |
Navaneethan CV et al. | Application of powder rheometer to determine powder flow properties and lubrication efficiency of pharmaceutical particulate systems. | 2005 | AAPS PharmSciTech | pmid:16353997 |
Soares LA et al. | Dry granulation and compression of spray-dried plant extracts. | 2005 | AAPS PharmSciTech | pmid:16353993 |
Tatavarti AS et al. | Assessment of NIR spectroscopy for nondestructive analysis of physical and chemical attributes of sulfamethazine bolus dosage forms. | 2005 | AAPS PharmSciTech | pmid:16353969 |
Mayer KM et al. | Linking enzyme sequence to function using Conserved Property Difference Locator to identify and annotate positions likely to control specific functionality. | 2005 | BMC Bioinformatics | pmid:16318626 |
Chiang EP et al. | Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. | 2005 | Arthritis Res. Ther. | pmid:16277693 |
Wang X et al. | Solid state characteristics of ternary solid dispersions composed of PVP VA64, Myrj 52 and itraconazole. | 2005 | Int J Pharm | pmid:16105723 |
Dong J et al. | Silver carboxylate nanostructure nucleation and growth on AgBr crystals. | 2005 | Nanotechnology | pmid:21727481 |
Verma RK and Garg S | Selection of excipients for extended release formulations of glipizide through drug-excipient compatibility testing. | 2005 | J Pharm Biomed Anal | pmid:15967291 |
Harris RK et al. | Quantification of bambuterol hydrochloride in a formulated product using solid-state NMR. | 2005 | J Pharm Biomed Anal | pmid:15869858 |
Tomassetti M et al. | Thermal analysis study of the interactions between acetaminophen and excipients in solid dosage forms and in some binary mixtures. | 2005 | J Pharm Biomed Anal | pmid:15862672 |
Ibáñez L et al. | Population-based drug-induced agranulocytosis. | 2005 | Arch. Intern. Med. | pmid:15851637 |
Egerton TA et al. | Characterization of TiO2 nanoparticles surface modified with aluminum stearate. | 2005 | Langmuir | pmid:15780001 |
Fujii M et al. | Preparation, characterization, and tableting of a solid dispersion of indomethacin with crospovidone. | 2005 | Int J Pharm | pmid:15778052 |
Aoshima H et al. | Glycerin fatty acid esters as a new lubricant of tablets. | 2005 | Int J Pharm | pmid:15778041 |
Serrano-Vega MJ et al. | Lipid characterization of seed oils from high-palmitic, low-palmitoleic, and very high-stearic acid sunflower lines. | 2005 | Lipids | pmid:16028719 |
Nkondjock A et al. | Specific fatty acid intake and the risk of pancreatic cancer in Canada. | 2005 | Br. J. Cancer | pmid:15685231 |
Zadmard R and Schrader T | Nanomolar protein sensing with embedded receptor molecules. | 2005 | J. Am. Chem. Soc. | pmid:15656628 |
Afonso C et al. | Structural characterization of fatty acids cationized with copper by electrospray ionization mass spectrometry under low-energy collision-induced dissociation. | 2005 | J Mass Spectrom | pmid:15674862 |
Fichtner F et al. | Particle size distribution and evolution in tablet structure during and after compaction. | 2005 | Int J Pharm | pmid:15725568 |
Xie FM et al. | [Preparation of stearic acid solid lipid nanoparticles containing podophyllotoxin]. | 2005 | Di Yi Jun Yi Da Xue Xue Bao | pmid:15684011 |
Cury-Boaventura MF and Curi R | Regulation of reactive oxygen species (ROS) production by C18 fatty acids in Jurkat and Raji cells. | 2005 | Clin. Sci. | pmid:15563273 |
Vanholder T et al. | Effect of non-esterified fatty acids on bovine granulosa cell steroidogenesis and proliferation in vitro. | 2005 | Anim. Reprod. Sci. | pmid:15885439 |
Li W and Worosila GD | Quantitation of active pharmaceutical ingredients and excipients in powder blends using designed multivariate calibration models by near-infrared spectroscopy. | 2005 | Int J Pharm | pmid:15848006 |
Scaglia N and Igal RA | Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells. | 2005 | J. Biol. Chem. | pmid:15851470 |
Donoso M and Ghaly ES | Prediction of tablets disintegration times using near-infrared diffuse reflectance spectroscopy as a nondestructive method. | 2005 | Pharm Dev Technol | pmid:15926669 |
Katsuta Y et al. | Unsaturated fatty acids induce calcium influx into keratinocytes and cause abnormal differentiation of epidermis. | 2005 | J. Invest. Dermatol. | pmid:15854043 |
Green RL et al. | Comparison of near-infrared and laser-induced breakdown spectroscopy for determination of magnesium stearate in pharmaceutical powders and solid dosage forms. | 2005 | Appl Spectrosc | pmid:15901316 |
Sahin N et al. | Lipase-catalyzed acidolysis of tripalmitin with hazelnut oil fatty acids and stearic acid to produce human milk fat substitutes. | 2005 | J. Agric. Food Chem. | pmid:15998148 |
Sampath H and Ntambi JM | The fate and intermediary metabolism of stearic acid. | 2005 | Lipids | pmid:16477801 |
Kris-Etherton PM et al. | Dietary stearic acid and risk of cardiovascular disease: intake, sources, digestion, and absorption. | 2005 | Lipids | pmid:16477802 |
Mensink RP | Effects of stearic acid on plasma lipid and lipoproteins in humans. | 2005 | Lipids | pmid:16477803 |
Sanders TA and Berry SE | Influence of stearic acid on postprandial lipemia and hemostatic function. | 2005 | Lipids | pmid:16477806 |
Tholstrup T | Influence of stearic acid on hemostatic risk factors in humans. | 2005 | Lipids | pmid:16477807 |
Ehling S et al. | Formation of acrylamide from lipids. | 2005 | Adv. Exp. Med. Biol. | pmid:16438301 |
Le Jossic-Corcos C et al. | Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids. | 2005 | Biochem. J. | pmid:15473864 |
Mishra R and Simonson MS | Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G. | 2005 | Cardiovasc Diabetol | pmid:15642122 |
Csallany AS et al. | Effect of high stearic acid containing fat on markers for in vivo lipid peroxidation. | 2005 | Int J Food Sci Nutr | pmid:16638661 |
Hong J et al. | The short-term effect of fatty acids on glucagon secretion is influenced by their chain length, spatial configuration, and degree of unsaturation: studies in vitro. | 2005 | Metab. Clin. Exp. | pmid:16154432 |
Thijssen MA and Mensink RP | Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. | 2005 | Am. J. Clin. Nutr. | pmid:16155261 |
Rao KP et al. | Impact of solid-state properties on lubrication efficacy of magnesium stearate. | 2005 | Pharm Dev Technol | pmid:16176023 |
Leroy JL et al. | Non-esterified fatty acids in follicular fluid of dairy cows and their effect on developmental capacity of bovine oocytes in vitro. | 2005 | Reproduction | pmid:16183866 |
Jonat S et al. | Influence of compacted hydrophobic and hydrophilic colloidal silicon dioxide on tableting properties of pharmaceutical excipients. | 2005 | Drug Dev Ind Pharm | pmid:16207616 |
Jurkiewicz K | Adsorptive bubble separation of zinc and cadmium cations in presence of ferric and aluminum hydroxides. | 2005 | J Colloid Interface Sci | pmid:15897071 |
St-Onge L et al. | Rapid quantitative analysis of magnesium stearate in tablets using laser-induced breakdown spectroscopy. | 2005 | J Pharm Pharm Sci | pmid:16124938 |
Guo LJ et al. | [The structure and properties of self-assembly complex LB films of silver nanoparticles]. | 2005 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:16128074 |
Hoppu U et al. | Breast milk fatty acid composition is associated with development of atopic dermatitis in the infant. | 2005 | J. Pediatr. Gastroenterol. Nutr. | pmid:16131990 |
Choi MY et al. | Pheromone biosynthetic pathways in the moths Heliothis subflexa and Heliothis virescens. | 2005 | Arch. Insect Biochem. Physiol. | pmid:15898118 |
Iwahashi M et al. | Dynamical dimer structure and liquid structure of fatty acids in their binary liquid mixture: decanoic/octadecanoic acid and decanoic/dodecanoic acid systems. | 2005 | Chem. Phys. Lipids | pmid:15642581 |