stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fungwe TV et al. | Fatty acids modulate lecithin:cholesterol acyltransferase secretion independently of effects on triglyceride secretion in primary rat hepatocytes. | 1998 | J. Nutr. | pmid:9687543 |
Mikami T et al. | Characterization of a O-fatty-acylated sulfatide from equine brain. | 1998 | Eur. J. Biochem. | pmid:9692930 |
Eliasz AW et al. | Phospholipid phase transitions. Effects of n-alcohols, n-monocarboxylic acids, phenylalkyl alcohols and quaternary ammonium compounds. | 1976 | Biochim. Biophys. Acta | pmid:971432 |
Sevi A et al. | Rumen-protected methionine or lysine supplementation of Comisana ewes' diets: effects on milk fatty acid composition. | 1998 | J. Dairy Res. | pmid:9718494 |
Enjalbert F et al. | Duodenal infusions of palmitic, stearic or oleic acids differently affect mammary gland metabolism of fatty acids in lactating dairy cows. | 1998 | J. Nutr. | pmid:9732314 |
Howes D et al. | The fate of ingested glyceran esters of condensed castor oil fatty acids [polyglycerol polyricinoleate (PGPR)] in the rat. | 1998 Sep-Oct | Food Chem. Toxicol. | pmid:9737418 |
Sentex E et al. | Is the cytoprotective effect of trimetazidine associated with lipid metabolism? | 1998 | Am. J. Cardiol. | pmid:9737482 |
Matorras R et al. | Fatty acid composition of fertilization-failed human oocytes. | 1998 | Hum. Reprod. | pmid:9756301 |
Merlo AO et al. | Ribozymes targeted to stearoyl-ACP delta9 desaturase mRNA produce heritable increases of stearic acid in transgenic maize leaves. | 1998 | Plant Cell | pmid:9761789 |
Graham KC et al. | Simple thin-layer chromatographic identification method for erythromycin stearate. | 1976 | J. Chromatogr. | pmid:977688 |