stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Phadtare S et al. | Improved performance of preordered fungal protease-stearic acid biocomposites: enhanced catalytic activity, reusability, and temporal stability. | 2002 Jul-Aug | Biotechnol. Prog. | pmid:12153301 |
Liu Q et al. | High-stearic and High-oleic cottonseed oils produced by hairpin RNA-mediated post-transcriptional gene silencing. | 2002 | Plant Physiol. | pmid:12177486 |
Lin JT et al. | Molecular species of acylglycerols incorporating radiolabeled fatty acids from castor (Ricinus communis L.) microsomal incubations. | 2002 | J. Agric. Food Chem. | pmid:12188611 |
LaFontaine MA et al. | 3-nitropropionic acid-induced changes in bilayer fluidity in synaptosomal membranes: implications for Huntington's disease. | 2002 | Neurochem. Res. | pmid:12199156 |
Chen Y et al. | [Studies on chemical constituents of Forsythia suspensa (Thunb) Vahl]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12205888 |
Berzins A et al. | Surface damage in machined ram-extruded and net-shape molded retrieved polyethylene tibial inserts of total knee replacements. | 2002 | J Bone Joint Surg Am | pmid:12208909 |
Giesy JG et al. | Effect of dose of calcium salts of conjugated linoleic acid (CLA) on percentage and fatty acid content of milk fat in midlactation holstein cows. | 2002 | J. Dairy Sci. | pmid:12214995 |
Yim B et al. | Sonolysis of surfactants in aqueous solutions: an accumulation of solute in the interfacial region of the cavitation bubbles. | 2002 | Ultrason Sonochem | pmid:12219583 |
Pollet S et al. | [Substrates and products of fatty acid elongation in mouse brain microsomes]. | 1975 | Biochimie | pmid:1222143 |
Li C et al. | Resistance of cultivated tomato to cell content-feeding herbivores is regulated by the octadecanoid-signaling pathway. | 2002 | Plant Physiol. | pmid:12226528 |
Pohl J et al. | Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway. | 2002 | J. Lipid Res. | pmid:12235170 |
Li S et al. | Effect of formulation variables on the floating properties of gastric floating drug delivery system. | 2002 | Drug Dev Ind Pharm | pmid:12236064 |
Rahmouni M et al. | Influence of physical parameters and lubricants on the compaction properties of granulated and non-granulated cross-linked high amylose starch. | 2002 | Chem. Pharm. Bull. | pmid:12237529 |
Shimono N et al. | Design of controlled release system with multi-layers of powder. | 2002 | Chem. Pharm. Bull. | pmid:12237531 |
Gu W et al. | [Chemical composition of Fordia cauliflora Hemsl]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12242814 |
Arici M et al. | Fatty acids carried on albumin modulate proximal tubular cell fibronectin production: a role for protein kinase C. | 2002 | Nephrol. Dial. Transplant. | pmid:12270980 |
Tola S | Occupational lead exposure in Finland. IV. The polyvinyl chloride plastic industry. | 1975 | Scand J Work Environ Health | pmid:1228897 |
Vicentino C et al. | Long-chain fatty acid uptake and oxidation in the perfused liver of Walker-256 tumour-bearing rats. | 2002 | Liver | pmid:12296968 |
Ahmed M and Enever RP | Influence of magnesium stearate on the dissolution and biological availability of sulphadiazine tablet formulations [proceedings]. | 1976 | J. Pharm. Pharmacol. | pmid:12326 |
Kopp F et al. | Instability of Langmuir-Blodgett layers of barium stearate, cadmium arachidate and tripalmitin, studied by means of electron microscopy and infrared spectroscopy. | 1975 | Biophys. Struct. Mech. | pmid:1234025 |
Gray AP and Guardina WJ | Long-acting narcotic antagonist complexes. | 1975 | Natl Inst Drug Abuse Res Monogr Ser | pmid:1234981 |
Houmard JA et al. | Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects. | 2002 | Diabetes | pmid:12351433 |
Phadke RS | Sedimentation test for procaine benzylpenicillin in oil with aluminium monostearate. III. Substitution of the sedimentation rate for the blood-level duration test of WHO in rabbits. | 1975 Aug-Nov | Hindustan Antibiot Bull | pmid:1236093 |
Cowles RL et al. | Dietary stearic acid alters gallbladder bile acid composition in hamsters fed cereal-based diets. | 2002 | J. Nutr. | pmid:12368404 |
Sudah OS et al. | Mixing of cohesive pharmaceutical formulations in tote (bin) blenders. | 2002 | Drug Dev Ind Pharm | pmid:12378960 |
Okamoto H et al. | Development of polymer film dosage forms of lidocaine for buccal administration: II. Comparison of preparation methods. | 2002 | J Pharm Sci | pmid:12379928 |
Samoylov AM et al. | Peptide biosensor for recognition of cross-species cell surface markers. | 2002 Jul-Aug | J. Mol. Recognit. | pmid:12382237 |
Jandura P et al. | Inverse gas chromatography study on partially esterified paper fiber. | 2002 | J Chromatogr A | pmid:12385400 |
Mougios V et al. | Duration of coffee- and exercise-induced changes in the fatty acid profile of human serum. | 2003 | J. Appl. Physiol. | pmid:12391036 |
Shanker G et al. | Methylmercury enhances arachidonic acid release and cytosolic phospholipase A2 expression in primary cultures of neonatal astrocytes. | 2002 | Brain Res. Mol. Brain Res. | pmid:12393259 |
Young PM et al. | Characterization of a surface modified dry powder inhalation carrier prepared by "particle smoothing". | 2002 | J. Pharm. Pharmacol. | pmid:12396294 |
Ercoli N | [Clinical and experimental study on an anti-inflammatory preparation of topical use. The 10-undecentil-l-ll pseudothiourea (AHR-1911)]. | 1975 | Med Cutan Ibero Lat Am | pmid:1241792 |
Thies C | Development of injectable microcapsules for use in the treatment of narcotic addiction. | 1975 | Natl Inst Drug Abuse Res Monogr Ser | pmid:1241971 |
Rodante F et al. | Compatibility between active components of a commercial drug. | 2002 | Farmaco | pmid:12420879 |
Treadwell RM et al. | Glyceride stearic acid content and structure affect the energy available to growing rats. | 2002 | J. Nutr. | pmid:12421851 |
Korhonen M et al. | Rheological properties of three component creams containing sorbitan monoesters as surfactants. | 2002 | Int J Pharm | pmid:12429489 |
Yamaguchi M et al. | Synthesis and selectin-binding activity of N-deacetylsialyl Lewis X ganglioside. | 2002 | Carbohydr. Res. | pmid:12433475 |
Ring A et al. | Evidence for vesicles that mediate long-chain fatty acid uptake by human microvascular endothelial cells. | 2002 | J. Lipid Res. | pmid:12454271 |
Eitel K et al. | Different role of saturated and unsaturated fatty acids in beta-cell apoptosis. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12470657 |
Vaithiyalingam SR et al. | Formulation and stability evaluation of ketoprofen sustained-release tablets prepared by fluid bed granulation with Carbopol 971P solution. | 2002 | Drug Dev Ind Pharm | pmid:12476869 |
Rege PR et al. | Chitinosan-drug complexes: effect of electrolyte on naproxen release in vitro. | 2003 | Int J Pharm | pmid:12480291 |
Su BN et al. | Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. | 2002 | Planta Med. | pmid:12494342 |
Dantas da Silva LL et al. | Antibacterial activity of a stearic acid derivative from Stemodia foliosa. | 2002 | Planta Med. | pmid:12494347 |
Kerti A et al. | Content of retinol and retinyl esters in blood plasma, liver, kidney and reproductive organs of Japanese quails. | 2002 | Acta Vet. Hung. | pmid:12498148 |
von Eggelkraut-Gottanka SG et al. | Roller compaction and tabletting of St. John's wort plant dry extract using a gap width and force controlled roller compactor. I. Granulation and tabletting of eight different extract batches. | 2002 | Pharm Dev Technol | pmid:12503525 |
von Eggelkraut-Gottanka SG et al. | Roller compaction and tabletting of St. John's wort plant dry extract using a gap width and force controlled roller compactor. II. Study of roller compaction variables on granule and tablet properties by a 3(3) factorial design. | 2002 | Pharm Dev Technol | pmid:12503526 |
Sobal G and Sinzinger H | Binding of [99mTc]chondroitin sulfate to scavenger receptors on human chondrocytes as compared to binding of oxidized [125I]LDL on human macrophages. | J. Recept. Signal Transduct. Res. | pmid:12503634 | |
Sugihara A et al. | Purification and characterization of a novel cholesterol esterase from Pseudomonas aeruginosa, with its application to cleaning lipid-stained contact lenses. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12506971 |
Papanikolaou S et al. | Accumulation of a cocoa-butter-like lipid by Yarrowia lipolytica cultivated on agro-industrial residues. | 2003 | Curr. Microbiol. | pmid:12520368 |
Whorton AR et al. | The metabolism of (1-14C) stearic acid in rat testicular tissue. | 1976 | Biochim. Biophys. Acta | pmid:1252481 |