stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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Authors | Title | Published | Journal | PubMed Link |
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Bangudu AB and Pilpel N | Effects of composition, moisture and stearic acid on the plasto-elasticity and tableting of paracetamol-microcrystalline cellulose mixtures. | 1985 | J. Pharm. Pharmacol. | pmid:2862234 |
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Johansson ME | Investigations of the mixing time dependence of the lubricating properties of granular and powdered magnesium stearate. | 1985 | Acta Pharm. Suec. | pmid:3832785 |
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Habenicht AJ et al. | Cell cycle-dependent changes in arachidonic acid and glycerol metabolism in Swiss 3T3 cells stimulated by platelet-derived growth factor. | 1985 | J. Biol. Chem. | pmid:3918038 |
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Baker RR and Loh ZD | The subcellular distribution of free fatty acids released during post-decapitative ischemia in rat cerebral cortex. | 1985 | Can. J. Biochem. Cell Biol. | pmid:4084856 |
Hegde RP et al. | Studies of powder flow using a recording powder flowmeter and measurement of the dynamic angle of repose. | 1985 | J Pharm Sci | pmid:3981409 |
Crutchley DJ | Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2865954 |
Johansson ME | Influence of the granulation technique and starting material properties on the lubricating effect of granular magnesium stearate. | 1985 | J. Pharm. Pharmacol. | pmid:2867134 |
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Catalá A | Stearic acid desaturation in rat liver microsomes: stimulation by fatty acid binding protein. | 1986 | Acta Physiol Pharmacol Latinoam | pmid:2876583 |
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Smith DM and Waite M | Phospholipid metabolism in human neutrophil subfractions. | 1986 | Arch. Biochem. Biophys. | pmid:3083776 |
Singh H and Poulos A | A comparative study of stearic and lignoceric acid oxidation by human skin fibroblasts. | 1986 | Arch. Biochem. Biophys. | pmid:3767370 |
Goto S et al. | [Role of metal stearates in preparation of Eudragit RS-microcapsules containing sulfamethizole by evaporation process in water phase]. | 1986 | Yakugaku Zasshi | pmid:3701600 |
Shah KB et al. | An investigation of some factors influencing plug formation and fill weight in a dosing disk-type automatic capsule-filling machine. | 1986 | J Pharm Sci | pmid:3701614 |
Wan LS and Choong YL | The effect of excipients on the penetration of liquid into tablets. | 1986 | Pharm Acta Helv | pmid:3725815 |
Oh-Hashi Y et al. | Temperature- and growth-phase-dependent changes in membrane fatty acid compositions of Brevibacterium ammoniagenes. | 1986 | Arch. Biochem. Biophys. | pmid:3729431 |
Carter-Dawson L et al. | Rhodopsin, 11-cis vitamin A, and interstitial retinol-binding protein (IRBP) during retinal development in normal and rd mutant mice. | 1986 | Dev. Biol. | pmid:3732615 |
Chowhan ZT and Chi LH | Drug-excipient interactions resulting from powder mixing. III: Solid state properties and their effect on drug dissolution. | 1986 | J Pharm Sci | pmid:3735096 |
Chowhan ZT and Chi LH | Drug-excipient interactions resulting from powder mixing. IV: Role of lubricants and their effect on in vitro dissolution. | 1986 | J Pharm Sci | pmid:3735097 |
Fujii T et al. | Effect of exogenous lipids incorporated into the membrane of human erythrocytes on its glucose transport activity. | 1986 | Biochem. Int. | pmid:3741447 |
Chester DW et al. | The influence of saturated fatty acid modulation of bilayer physical state on cellular and membrane structure and function. | 1986 | Biochim. Biophys. Acta | pmid:3741857 |
Tsao FH | Selective use of palmitic acid over stearic acid for synthesis of phosphatidylcholine and phosphatidylglycerol in lung. | 1986 | Lipids | pmid:3796238 |
Ito Y et al. | Fatty acid synthetase as a thermoreceptor in Candida utilis. | 1986 | J. Biochem. | pmid:3745143 |
Muralidharan FN and Muralidharan VB | Phytanoyl-CoA ligase activity in rat liver. | 1986 | Biochem. Int. | pmid:3753503 |
Ball MD et al. | Acyl coenzyme A:retinol acyltransferase activity and the vitamin A content of polar bear (Ursus maritimus) liver. | 1986 | Comp. Biochem. Physiol., B | pmid:3757481 |
van den Reek MM et al. | Use of published analyses of food items to determine dietary trans octadecenoic acid. | 1986 | J Am Diet Assoc | pmid:3760430 |
Sugimoto Y et al. | A 2H NMR study on alteration of the membrane organization of mouse B16 melanoma cells treated with 12-O-tetradecanoylphorbol-13-acetate. | 1986 | J. Biochem. | pmid:3818567 |
Thompson W and Belina H | Rapid accumulation of diacyl lipid in rat liver microsomes by selective acylation of 2-acyl-sn-glycero-3-phosphorylserine. | 1986 | Biochim. Biophys. Acta | pmid:3707975 |
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Beaumelle BD and Vial HJ | Modification of the fatty acid composition of individual phospholipids and neutral lipids after infection of the simian erythrocyte by Plasmodium knowlesi. | 1986 | Biochim. Biophys. Acta | pmid:3719005 |
Pajor L et al. | Microsomal desaturation of stearic acid in relation to lymphocyte activation. | 1986 | Arch. Biochem. Biophys. | pmid:3485399 |
Ras GJ and Anderson R | An in-vitro study of oral therapeutic doses of co-trimoxazole and erythromycin stearate on abnormal polymorphonuclear leucocyte migration. | 1986 | J. Antimicrob. Chemother. | pmid:3486178 |
Peura P et al. | The effect of ethanol on the release of free fatty acids from the brain in vivo; a study with push-pull cannula. | 1986 | Arch. Toxicol. Suppl. | pmid:3468932 |
Slomiany BL et al. | Mucus glycoprotein of human saliva: differences in the associated and covalently bound lipids with caries. | 1986 | Biochim. Biophys. Acta | pmid:3518803 |
Muñoz-Espin T et al. | Erythromycin versus tetracycline for treatment of Mediterranean spotted fever. | 1986 | Arch. Dis. Child. | pmid:3535687 |
Mazière C et al. | Cyclic AMP increases incorporation of exogenous fatty acids into triacylglycerols in hamster fibroblasts. | 1986 | Lipids | pmid:3020335 |
Chalupa W et al. | Ruminal fermentation in vivo as influenced by long-chain fatty acids. | 1986 | J. Dairy Sci. | pmid:3722545 |
Sakaguchi M et al. | Effects of dietary saturated and unsaturated fatty acids on fecal bile acids and colon carcinogenesis induced by azoxymethane in rats. | 1986 | Cancer Res. | pmid:3940210 |
Bankson DD et al. | Determination of retinyl esters and retinol in serum or plasma by normal-phase liquid chromatography: method and applications. | 1986 | Clin. Chem. | pmid:3940733 |
Yamamoto O | Radiation-induced crosslinks between carboxylic acids and compounds of biological interest. | 1986 | Radiat. Res. | pmid:3952268 |
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Okabe H et al. | Effects of anti-convulsants on fatty acid metabolism in human serum. | 1986 | Tohoku J. Exp. Med. | pmid:3705068 |
Siegel I et al. | Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. | 1986 | Fertil. Steril. | pmid:2868925 |
Johansson ME and Nicklasson M | Investigation of the film formation of magnesium stearate by applying a flow-through dissolution technique. | 1986 | J. Pharm. Pharmacol. | pmid:2869127 |
Tabachnick M and Korcek L | Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. | 1986 | Biochim. Biophys. Acta | pmid:2869786 |
Alcalay J et al. | Asymptomatic liver injury due to erythromycin stearate. | 1986 Jul-Aug | Drug Intell Clin Pharm | pmid:3743417 |
Goto S et al. | Eudragit RS and RL (acrylic resins) microcapsules as pH insensitive and sustained release preparations of ketoprofen. | 1986 Oct-Dec | J Microencapsul | pmid:3508190 |
Goto S et al. | Eudragit E, L and S (acrylic resins) microcapsules as pH sensitive release preparations of ketoprofen. | 1986 Oct-Dec | J Microencapsul | pmid:3508191 |
Adebayo GI et al. | Time-dependent inhibition of theophylline elimination by erythromycin stearate. | 1986 Sep-Oct | Biopharm Drug Dispos | pmid:3779037 |
West AA et al. | The relationship between glycosyltransferase production and membrane fatty acid composition of Streptococcus sanguis NCTC 7865 grown in the presence of protonmotive force inhibitors. | 1987 | J. Gen. Microbiol. | pmid:2966234 |
Feix JB et al. | Interactions of 14N:15N stearic acid spin-label pairs: effects of host lipid alkyl chain length and unsaturation. | 1987 | Biochemistry | pmid:2820479 |
Roughan PG et al. | Metabolism of exogenous long-chain fatty acids by spinach leaves. | 1987 | Arch. Biochem. Biophys. | pmid:3426240 |
Tonnet ML and Green AG | Characterization of the seed and leaf lipids of high and low linolenic acid flax genotypes. | 1987 | Arch. Biochem. Biophys. | pmid:3813554 |
Venho VM et al. | The value of comparative bioavailability studies of marketed drugs in drug control. An example with erythromycin stearate. | 1987 | Methods Find Exp Clin Pharmacol | pmid:3683018 |
Bridges CD et al. | Rhodopsin, vitamin A, and interstitial retinol-binding protein in the rd chicken. | 1987 | Invest. Ophthalmol. Vis. Sci. | pmid:3557867 |
Hope MJ and Cullis PR | Lipid asymmetry induced by transmembrane pH gradients in large unilamellar vesicles. | 1987 | J. Biol. Chem. | pmid:3558410 |
Husebye ES and Flatmark T | Characterization of phospholipase activities in chromaffin granule ghosts isolated from the bovine adrenal medulla. | 1987 | Biochim. Biophys. Acta | pmid:3607074 |
Cavalleri A and Minoia C | Lead level of whole blood and plasma in workers exposed to lead stearate. | 1987 | Scand J Work Environ Health | pmid:3616550 |
Seimiya T et al. | Effects of composition and molecular packing on ionic properties of lipid monolayer having both cationic and anionic head groups. | 1987 | Chem. Phys. Lipids | pmid:3621383 |
Salminen S and Salminen E | Urinary excretion of orally administered oxalic acid in MYRJ 45-treated NMRI mice. | 1987 | Toxicol. Lett. | pmid:3590233 |
Masuzawa Y et al. | Distribution of dietary trans-octadecenoate among acyl-CoA and other lipid fractions of rat liver and heart. | 1987 | Biochim. Biophys. Acta | pmid:3593750 |
Kolesnick RN and Paley AE | 1,2-Diacylglycerols and phorbol esters stimulate phosphatidylcholine metabolism in GH3 pituitary cells. Evidence for separate mechanisms of action. | 1987 | J. Biol. Chem. | pmid:3597411 |
Habib NA et al. | Increased erythrocyte stearic acid desaturation in rats with chemically induced colorectal carcinomas. | 1987 | Int J Colorectal Dis | pmid:3598325 |
Pyörälä S | Effect of some vehicles used in intramammary mastitis preparations on inflammation indicators in milk. | 1987 | J. Vet. Pharmacol. Ther. | pmid:3656512 |