stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Hao J et al. | Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design. | 2012 | Eur J Pharm Sci | pmid:22820033 |
Ahrabi SF et al. | Influence of neutron activation factors on matrix tablets for site specific delivery to the colon. | 2000 | Eur J Pharm Sci | pmid:10767600 |
Järvinen K et al. | In-line monitoring of the drug content of powder mixtures and tablets by near-infrared spectroscopy during the continuous direct compression tableting process. | 2013 | Eur J Pharm Sci | pmid:23313622 |
Wu PC et al. | Design and evaluation of sustained release microspheres of potassium chloride prepared by Eudragit. | 2003 | Eur J Pharm Sci | pmid:12791413 |
Negi JS et al. | Development of solid lipid nanoparticles (SLNs) of lopinavir using hot self nano-emulsification (SNE) technique. | 2013 | Eur J Pharm Sci | pmid:23153618 |
Avalle P et al. | Interrogating erosion-based drug liberation phenomena from hydrophilic matrices using near infrared (NIR) spectroscopy. | 2013 | Eur J Pharm Sci | pmid:23059372 |
Salazar J et al. | Application of the combinative particle size reduction technology H 42 to produce fast dissolving glibenclamide tablets. | 2013 | Eur J Pharm Sci | pmid:23587645 |
Zhou QT et al. | Understanding the influence of powder flowability, fluidization and de-agglomeration characteristics on the aerosolization of pharmaceutical model powders. | 2010 | Eur J Pharm Sci | pmid:20433919 |
Crowley ME et al. | Near-infrared monitoring of roller compacted ribbon density: Investigating sources of variation contributing to noisy spectral data. | 2017 | Eur J Pharm Sci | pmid:28216342 |
Haware RV et al. | Vegetable-derived magnesium stearate functionality evaluation by DM(3) approach. | 2016 | Eur J Pharm Sci | pmid:27108117 |
Das SC et al. | Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate. | 2011 | Eur J Pharm Sci | pmid:21621612 |
Pandey M et al. | Erythrocyte membrane stearic to oleic acid ratio in carcinoma of the gallbladder: a preliminary study. | 1998 | Eur J Surg Oncol | pmid:9542515 |
Wood CB et al. | Reduction in the stearic to oleic acid ratio in the circulating red blood cells: a possible tumour marker in solid human neoplasms. | 1985 | Eur J Surg Oncol | pmid:4007173 |
Lisetski LN et al. | Effects of membranotropic agents on mono- and multilayer structures of dipalmitoylphosphatidylcholine. | 2002 | Eur. Biophys. J. | pmid:12602341 |
Pantusa M and Bartucci R | Kinetics of stearic acid transfer between human serum albumin and sterically stabilized liposomes. | 2010 | Eur. Biophys. J. | pmid:20306030 |
Chigorno V et al. | Biosynthesis of gangliosides containing C18:1 and C20:1 [3-14C]sphingosine after administrating [1-14C]palmitic acid and [1-14C]stearic acid to rat cerebellar granule cells in culture. | 1994 | Eur. J. Biochem. | pmid:8181467 |
Irvine RF et al. | The calcium-dependent phosphatidylinositol-phosphodiesterase of rat brain. Mechanisms of suppression and stimulation. | 1979 | Eur. J. Biochem. | pmid:227685 |
Das T et al. | Characterization of cardiac fatty-acid-binding protein from human placenta. Comparison with placenta hepatic types. | 1993 | Eur. J. Biochem. | pmid:8436130 |
Wright LC et al. | The origin of 1H NMR-visible triacylglycerol in human neutrophils. Highfatty acid environments result in preferential sequestration of palmitic acid into plasma membrane triacylglycerol. | 2000 | Eur. J. Biochem. | pmid:10601852 |
Harwood JL and James AT | Metabolism of trans-3-hexadecenoic acid in broad bean. | 1975 | Eur. J. Biochem. | pmid:1126340 |
Torres A et al. | Characterization of surface n-alkanes and fatty acids of the epiphytic lichen Xanthoria parietina, its photobiont a green alga Trebouxia sp., and its mycobiont, from the Jerusalem hills. | 2003 | Eur. J. Biochem. | pmid:12752431 |
Brodersen R et al. | Palmitate binding to serum albumin, measured by rate of dialysis. | 1988 | Eur. J. Biochem. | pmid:3371363 |
Thompson W and MacDonald G | Cytidine diphosphate diglyceride of bovine brain. Positional distribution of fatty acids and analysis of major molecular species. | 1976 | Eur. J. Biochem. | pmid:776622 |
Lee I and Kadenbach B | Palmitate decreases proton pumping of liver-type cytochrome c oxidase. | 2001 | Eur. J. Biochem. | pmid:11737187 |
Mikami T et al. | Characterization of a O-fatty-acylated sulfatide from equine brain. | 1998 | Eur. J. Biochem. | pmid:9692930 |
Kita K et al. | Characterization of the reversible nature of the reaction catalyzed by sphingolipid ceramide N-deacylase. A novel form of reverse hydrolysis reaction. | 2001 | Eur. J. Biochem. | pmid:11168398 |
Brodersen R et al. | Serum albumin binding of palmitate and stearate. Multiple binding theory for insoluble ligands. | 1989 | Eur. J. Biochem. | pmid:2731550 |
Wanten GJ et al. | Saturated triglycerides and fatty acids activate neutrophils depending on carbon chain-length. | 2002 | Eur. J. Clin. Invest. | pmid:11952815 |
Iliopoulou A et al. | Should erythromycin dose be altered in haemodialysis patients? | 1982 | Eur. J. Clin. Pharmacol. | pmid:7151848 |
Branigan TA et al. | The effects of erythromycin on the absorption and disposition of kinetics of theophylline. | 1981 | Eur. J. Clin. Pharmacol. | pmid:7341279 |
Mermigkis C et al. | A green oral appliance. | 2009 | Eur. Respir. J. | pmid:19181918 |
Tolson J et al. | A green humidifier chamber. | 2008 | Eur. Respir. J. | pmid:18669801 |
Jeon JH et al. | Novel lipolytic enzymes identified from metagenomic library of deep-sea sediment. | 2011 | Evid Based Complement Alternat Med | pmid:21845199 |
Arya A et al. | Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. | 2012 | Evid Based Complement Alternat Med | pmid:22474512 |
Rozema E et al. | Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds. | 2012 | Evid Based Complement Alternat Med | pmid:22675394 |
Tumen I et al. | A therapeutic approach for wound healing by using essential oils of cupressus and juniperus species growing in Turkey. | 2012 | Evid Based Complement Alternat Med | pmid:21941588 |
Zhang H et al. | Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways. | 2011 | Evid Based Complement Alternat Med | pmid:21760826 |
Süntar I et al. | Wound Healing Activity of Rubus sanctus Schreber (Rosaceae): Preclinical Study in Animal Models. | 2011 | Evid Based Complement Alternat Med | pmid:19755505 |
Ordelheide AM et al. | The myocyte expression of adiponectin receptors and PPARδ is highly coordinated and reflects lipid metabolism of the human donors. | 2011 | Exp Diabetes Res | pmid:21331343 |
Sylvester PW et al. | Fatty acid modulation of epidermal growth factor-induced mouse mammary epithelial cell proliferation in vitro. | 1994 | Exp. Cell Res. | pmid:8082717 |
Moers A and Schrezenmeir J | Palmitic acid but not stearic acid inhibits NO-production in endothelial cells. | 1997 | Exp. Clin. Endocrinol. Diabetes | pmid:9288552 |
AMENTA JS and DOMINGUEZ AM | FATTY ACID FLUX AND TRIGLYCERIDE SECRETION IN THE HYDRAZINE-INDUCED FATTY LIVER. | 1965 | Exp. Mol. Pathol. | pmid:14300114 |
Dhillon HS et al. | Time course of changes in lactate and free fatty acids after experimental brain injury and relationship to morphologic damage. | 1997 | Exp. Neurol. | pmid:9225757 |
Asahi H et al. | Plasmodium falciparum: differing effects of non-esterified fatty acids and phospholipids on intraerythrocytic growth in serum-free medium. | 2011 | Exp. Parasitol. | pmid:21095186 |
Rabkin SW et al. | Stearic acid-induced cardiac lipotoxicity is independent of cellular lipid and is mitigated by the fatty acids oleic and capric acid but not by the PPAR agonist troglitazone. | 2009 | Exp. Physiol. | pmid:19482900 |
Abreu P et al. | Contractile function recovery in severely injured gastrocnemius muscle of rats treated with either oleic or linoleic acid. | 2016 | Exp. Physiol. | pmid:27579497 |
Royter M et al. | Thermostable lipases from the extreme thermophilic anaerobic bacteria Thermoanaerobacter thermohydrosulfuricus SOL1 and Caldanaerobacter subterraneus subsp. tengcongensis. | 2009 | Extremophiles | pmid:19579003 |
Rodante F et al. | Compatibility between active components of a commercial drug. | 2002 | Farmaco | pmid:12420879 |
Di Martino P et al. | Particle interaction of lubricated or unlubricated binary mixtures according to their particle size and densification mechanism. | 2004 | Farmaco | pmid:15337442 |
Bulut-Oner F et al. | Sustained release isoniazid tablets. I--Formulation and in vitro evaluation. | 1989 Jul-Aug | Farmaco | pmid:2590371 |
Hong CY | Discovery of gemifloxacin (Factive, LB20304a): a quinolone of a new generation. | 2001 Jan-Feb | Farmaco | pmid:11347965 |
Colombo I and Carli F | Comparative evaluation of structure and micromeritics properties of magnesium stearate. | 1984 | Farmaco Prat | pmid:6510514 |
Morasso MI et al. | Effect of mixing on the biopharmaceutical properties of sulfadiazine tablets. | 1988 | Farmaco Prat | pmid:3181415 |
Conte U et al. | The effect of magnesium stearate and polytetrafluoroethylene as lubricants in direct compression of acetylsalicylic acid. | 1972 | Farmaco Prat | pmid:5049531 |
Zhao L et al. | Serum stearic acid/palmitic acid ratio as a potential predictor of diabetes remission after Roux-en-Y gastric bypass in obesity. | 2017 | FASEB J. | pmid:28007782 |
Tanka-Salamon A et al. | Suppressed catalytic efficiency of plasmin in the presence of long-chain fatty acids. Identification of kinetic parameters from continuous enzymatic assay with Monte Carlo simulation. | 2008 | FEBS J. | pmid:18279394 |
Le Guédard M et al. | PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast. | 2009 | FEBS J. | pmid:19796168 |
Mantzaris MD et al. | Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells. | 2011 | FEBS J. | pmid:21182590 |
Isaac G et al. | Sulfatide with short fatty acid dominates in astrocytes and neurons. | 2006 | FEBS J. | pmid:16623713 |
Söderhäll I et al. | Characterization of a hemocyte intracellular fatty acid-binding protein from crayfish (Pacifastacus leniusculus) and shrimp (Penaeus monodon). | 2006 | FEBS J. | pmid:16734719 |
Piel J et al. | Cellulysin from the plant parasitic fungus Trichoderma viride elicits volatile biosynthesis in higher plants via the octadecanoid signalling cascade. | 1997 | FEBS Lett. | pmid:9369200 |
Thiel C and Kadenbach B | Influence of non-esterified fatty acids on respiratory control of reconstituted cytochrome-c oxidase. | 1989 | FEBS Lett. | pmid:2546826 |
Bora PS et al. | Purification to homogeneity and characterization of major fatty acid ethyl ester synthase from human myocardium. | 1989 | FEBS Lett. | pmid:2599089 |
Severin SE et al. | Synapsin I from human brain. Phosphorylation by Ca2+, phospholipid-dependent protein kinase. | 1989 | FEBS Lett. | pmid:2513229 |
Bogdanov AA et al. | Immobilization of alpha-chymotrypsin on sucrose stearate--palmitate containing liposomes. | 1984 | FEBS Lett. | pmid:6479332 |
Oviedo JM et al. | Pulmonary surfactant protein SP-B is significantly more immunoreactive in anionic than in zwitterionic bilayers. | 2001 | FEBS Lett. | pmid:11311247 |
SHABANOVA IA | MYOCARDIAL FATTY ACIDS IN NORMAL RABBITS AND RABBITS WITH EXPERIMENTAL MYOCARDITIS. | 1965 Mar-Apr | Fed Proc Transl Suppl | pmid:14304768 |
Pharmaceutical Reimbursement Board; final maximum allowable cost (MAC) determinations for certain drug products--Health Care Financing Administration. Final notice. | 1982 | Fed Regist | pmid:10259800 | |
Radwan SS et al. | Effects of lipids on n-alkane attenuation in media supporting oil-utilizing microorganisms from the oily Arabian Gulf coasts. | 2001 | FEMS Microbiol. Lett. | pmid:11430415 |
John Wallace R et al. | Clostridium proteoclasticum: A ruminal bacterium that forms stearic acid from linoleic acid. | 2006 | FEMS Microbiol. Lett. | pmid:17147764 |
Siegel I et al. | Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. | 1986 | Fertil. Steril. | pmid:2868925 |
Ruan HL et al. | Ferulic acid esters from Euphorbia hylonoma. | 2007 | Fitoterapia | pmid:17067756 |
COSCIA G et al. | [ASPECTS OF THE FECAL AND URINARY ELIMINATION OF LEAD IN 2 CASES OF POISONING WITH STEARATE OF LEAD]. | 1963 | Folia Med (Napoli) | pmid:14159390 |
Ocloo FCK et al. | Effects of stearic acid and gamma irradiation, alone and in combination, on pasting properties of high amylose maize starch. | 2016 | Food Chem | pmid:26212935 |
Bootello MA et al. | Effect of solvents on the fractionation of high oleic-high stearic sunflower oil. | 2015 | Food Chem | pmid:25442612 |
Serra Bonvehi J and Orantes Bermejo FJ | Detection of adulterated commercial Spanish beeswax. | 2012 | Food Chem | pmid:26434344 |
Yang TS et al. | Functionalities of chitosan conjugated with stearic acid and gallic acid and application of the modified chitosan in stabilizing labile aroma compounds in an oil-in-water emulsion. | 2017 | Food Chem | pmid:28317761 |
Bayard M et al. | Free fatty acids and their esters modulate isothermal crystallization of anhydrous milk fat. | 2017 | Food Chem | pmid:27719901 |
Noker PE et al. | Metabolism of 14C-labelled sucrose esters of stearic acid in rats. | 1997 | Food Chem. Toxicol. | pmid:9225017 |
Howes D et al. | The fate of ingested glyceran esters of condensed castor oil fatty acids [polyglycerol polyricinoleate (PGPR)] in the rat. | 1998 Sep-Oct | Food Chem. Toxicol. | pmid:9737418 |
Thilakarathna SH et al. | Investigations of in vitro bioaccessibility from interesterified stearic and oleic acid-rich blends. | 2016 | Food Funct | pmid:26961726 |
Kringsholm B and Christoffersen P | The nature and the occurrence of birefringent material in different organs in fatal drug addiction. | 1987 May-Jun | Forensic Sci. Int. | pmid:3036675 |
Cabirol N et al. | Comparison of lipid composition in two types of human putrefactive liquid. | 1998 | Forensic Sci. Int. | pmid:9670483 |
Croxton RS et al. | Variation in amino acid and lipid composition of latent fingerprints. | 2010 | Forensic Sci. Int. | pmid:20413233 |
Østdal H et al. | Reaction between protein radicals and other biomolecules. | 2002 | Free Radic. Biol. Med. | pmid:12106816 |
Gotoh N et al. | Inhibition of oxidation of low density lipoprotein by vitamin E and related compounds. | 1996 | Free Radic. Res. | pmid:8845913 |
Di Pierro D et al. | Separation of representative lipid compounds of biological membranes and lipid derivatives from peroxidized polyunsaturated fatty acids by reversed phase high-performance liquid chromatography. | 1997 | Free Radic. Res. | pmid:9167935 |
Müller K et al. | Cell-mediated oxidation of LDL: comparison of different cell types of the atherosclerotic lesion. | 1998 | Free Radic. Res. | pmid:9802552 |
Fatibello-Filho O and Vieira IC | Construction and analytical application of a biosensor based on stearic acid-graphite powder modified with sweet potato tissue in organic solvents. | 2000 | Fresenius J Anal Chem | pmid:11227501 |
Watanabe H et al. | Biosynthetic Pathway for Sex Pheromone Components Produced in a Plusiinae Moth, Plusia festucae. | 2011 | Front Endocrinol (Lausanne) | pmid:22649385 |
Ghanam RH et al. | Role of the HIV-1 Matrix Protein in Gag Intracellular Trafficking and Targeting to the Plasma Membrane for Virus Assembly. | 2012 | Front Microbiol | pmid:22363329 |
Bevilacqua A et al. | Selection of Yeasts as Starter Cultures for Table Olives: A Step-by-Step Procedure. | 2012 | Front Microbiol | pmid:22666220 |
Wang XH et al. | High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2. | 2017 | Front Pharmacol | pmid:28555106 |
Visioli F et al. | Molecular targets of omega 3 and conjugated linoleic Fatty acids - "micromanaging" cellular response. | 2012 | Front Physiol | pmid:22393325 |
Invernizzi G et al. | Sustained upregulation of stearoyl-CoA desaturase in bovine mammary tissue with contrasting changes in milk fat synthesis and lipogenic gene networks caused by lipid supplements. | 2010 | Funct. Integr. Genomics | pmid:20607344 |
Van Rafelghem MJ and Andersen ME | The effects of perfluorodecanoic acid on hepatic stearoyl-coenzyme A desaturase and mixed function oxidase activities in rats. | 1988 | Fundam Appl Toxicol | pmid:2906022 |
Yan S et al. | Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species. | 2015 | Fungal Genet. Biol. | pmid:25498164 |
Wilson RA et al. | Two Delta9-stearic acid desaturases are required for Aspergillus nidulans growth and development. | 2004 | Fungal Genet. Biol. | pmid:15050539 |
Heim CB and Gillman JD | Genotyping-by-Sequencing-Based Investigation of the Genetic Architecture Responsible for a ∼Sevenfold Increase in Soybean Seed Stearic Acid. | 2017 | G3 (Bethesda) | pmid:27866151 |
Yodono H et al. | [A case of hepatocellular carcinoma effectively treated by intraarterial infusion of CDDP and other agents]. | 1989 | Gan To Kagaku Ryoho | pmid:2551253 |