MeSH term | MeSH ID | Detail |
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Obesity, Abdominal | D056128 | 3 associated lipids |
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Turpeinen AM et al. | Similar effects of diets rich in stearic acid or trans-fatty acids on platelet function and endothelial prostacyclin production in humans. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9484999 |
Prasad MR et al. | Regional membrane phospholipid alterations in Alzheimer's disease. | 1998 | Neurochem. Res. | pmid:9482271 |
Zerbini E et al. | [Characterization of fatty acids and mycolic acid degradation products in mycobacterial species of major incidence in Argentina]. | 1997 Oct-Dec | Rev. Argent. Microbiol. | pmid:9472140 |
Ali S et al. | Acyl chain-length asymmetry alters the interfacial elastic interactions of phosphatidylcholines. | 1998 | Biophys. J. | pmid:9449334 |
Coulomb B et al. | Biafine applied on human epidermal wounds is chemotactic for macrophages and increases the IL-1/IL-6 ratio. | 1997 | Skin Pharmacol. | pmid:9449167 |
Jono K et al. | Effect of additives on dissolution and swelling of soybean lecithin microcapsules prepared using the Wurster process. | 1997 | Chem. Pharm. Bull. | pmid:9433778 |
Miyamoto M et al. | Design and preparation of gadolinium-reservoir microcapsules for neutron-capture therapy by means of the Wurster process. | 1997 | Chem. Pharm. Bull. | pmid:9433776 |
Storm H et al. | Comparison of a carbohydrate-rich diet and diets rich in stearic or palmitic acid in NIDDM patients. Effects on lipids, glycemic control, and diurnal blood pressure. | 1997 | Diabetes Care | pmid:9405898 |
Ali I and Steele JE | Evidence that free fatty acids in trophocytes of Periplaneta americana fat body may be regulated by the activity of phospholipase A2 and cyclooxygenase. | 1997 | Insect Biochem. Mol. Biol. | pmid:9404012 |
Pérez FR et al. | cis-FFA do not alter membrane depolarization but block Ca2+ influx and GH secretion in KCl-stimulated somatotroph cells. Suggestion for a direct cis-FFA perturbation of the Ca2+ channel opening. | 1997 | Biochim. Biophys. Acta | pmid:9371418 |