| MeSH term | MeSH ID | Detail |
|---|---|---|
| Decalcification, Pathologic | D003649 | 1 associated lipids |
stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with stearic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ragnarsson G and Sjögren J | Force-displacement measurements in tableting. | 1985 | J. Pharm. Pharmacol. | pmid:2858558 |
| Esezobo S | The effect of some excipients on the physical properties of a paracetamol tablet formulation. | 1985 | J. Pharm. Pharmacol. | pmid:2858567 |
| Ravi PR et al. | A hybrid design to optimize preparation of lopinavir loaded solid lipid nanoparticles and comparative pharmacokinetic evaluation with marketed lopinavir/ritonavir coformulation. | 2014 | J. Pharm. Pharmacol. | pmid:24697749 |
| Newton JM and Razzo FN | The in vitro bioavailability of various drugs formulated as hard gelatin capsules. | 1977 | J. Pharm. Pharmacol. | pmid:17668 |
| Newton JM and Razzo FN | The influence of additives on the presentation of a drug in hard gelatin capsules. | 1977 | J. Pharm. Pharmacol. | pmid:17694 |
| Carli F and Colombo I | Influence of porosity on the contact angle of non-wet solids. | 1983 | J. Pharm. Pharmacol. | pmid:6135790 |
| Vorum H et al. | Palmitate and stearate binding to human serum albumin. Determination of relative binding constants. | 1997 | J. Pept. Res. | pmid:9176819 |
| Hundrieser KE et al. | Distribution of trans-octadecenoic acid in the major glycerolipids of human milk. | 1983 | J. Pediatr. Gastroenterol. Nutr. | pmid:6644446 |
| Hoppu U et al. | Breast milk fatty acid composition is associated with development of atopic dermatitis in the infant. | 2005 | J. Pediatr. Gastroenterol. Nutr. | pmid:16131990 |
| McKellop HA et al. | Effect of molecular weight, calcium stearate, and sterilization methods on the wear of ultra high molecular weight polyethylene acetabular cups in a hip joint simulator. | 1999 | J. Orthop. Res. | pmid:10376720 |
| Dean DD et al. | Effect of polymer molecular weight and addition of calcium stearate on response of MG63 osteoblast-like cells to UHMWPE particles. | 2001 | J. Orthop. Res. | pmid:11347688 |
| McKAY AF and BADER AR | The preparation and properties of the eight diastereoisomers of 9,10,12,13-tetrahydroxystearic acid. | 1948 | J. Org. Chem. | pmid:18917710 |
| McKAY AF | Occurrence of stearic acid in bayberry tallow (wax). | 1948 | J. Org. Chem. | pmid:18917711 |
| Al-Belasy FA and Hairam AR | The efficacy of azithromycin in the treatment of acute infraorbital space infection. | 2003 | J. Oral Maxillofac. Surg. | pmid:12618970 |
| Sakai M et al. | Pharmacological effects of phosphatidylserine enzymatically synthesized from soybean lecithin on brain functions in rodents. | 1996 | J. Nutr. Sci. Vitaminol. | pmid:8708821 |
| Ikeda I et al. | Lymphatic transport of stearic acid and its effect on cholesterol transport in rats. | 1994 | J. Nutr. Sci. Vitaminol. | pmid:7965216 |
| Yagi T et al. | Lymphatic absorption of structured triacylglycerols, 1(3)-stearoyl-2,3 (1)-dilinoleoylglycerol and 2-linoleoyl-1,3-distearoylglycerol in rats. | 2004 | J. Nutr. Sci. Vitaminol. | pmid:15895523 |
| Takahashi R et al. | Fatty acid composition of serum phospholipids in an elderly institutionalized Japanese population. | 1991 | J. Nutr. Sci. Vitaminol. | pmid:1765844 |
| Ohki K et al. | Effect of alpha-tocopherol on lipid peroxidation and acyl chain mobility of liver microsomes from vitamin E-difficient rat. | 1984 | J. Nutr. Sci. Vitaminol. | pmid:6092586 |
| Tuomasjukka SS et al. | Regio-distribution of stearic acid is not conserved in chylomicrons after ingestion of randomised, stearic acid-rich fat in a single meal. | 2009 | J. Nutr. Biochem. | pmid:19195862 |
| Gorinstein S et al. | Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging tests. | 2003 | J. Nutr. Biochem. | pmid:12742543 |
| Zeman M et al. | N-3 fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination. | 2006 | J. Nutr. Biochem. | pmid:16214329 |
| Matsumoto K et al. | Electron paramagnetic resonance decay constant and oxidative stresses in liver microsomes of the selenium-deficient rat. | 2006 | J. Nutr. Biochem. | pmid:16517143 |
| Brown AW et al. | Plant sterol and stanol substrate specificity of pancreatic cholesterol esterase. | 2010 | J. Nutr. Biochem. | pmid:19615880 |
| Afonso MS et al. | Dietary interesterified fat enriched with palmitic acid induces atherosclerosis by impairing macrophage cholesterol efflux and eliciting inflammation. | 2016 | J. Nutr. Biochem. | pmid:27142741 |
| Imaizumi K et al. | Fat containing stearic acid increases fecal neutral steroid excretion and catabolism of low density lipoproteins without affecting plasma cholesterol concentration in hamsters fed a cholesterol-containing diet. | 1993 | J. Nutr. | pmid:8410360 |
| YOUNG RJ and GARRETT RL | EFFECT OF OLEIC AND LINOLEIC ACIDS ON THE ABSORPTION OF SATURATED FATTY ACIDS IN THE CHICK. | 1963 | J. Nutr. | pmid:14100991 |
| Cowles RL et al. | Dietary stearic acid alters gallbladder bile acid composition in hamsters fed cereal-based diets. | 2002 | J. Nutr. | pmid:12368404 |
| Flynn TT et al. | Modification of plasma and hepatic lipids of guinea pigs by feeding high oleic acid pork compared with regular pork. | 1992 | J. Nutr. | pmid:1512635 |
| Treadwell RM et al. | Glyceride stearic acid content and structure affect the energy available to growing rats. | 2002 | J. Nutr. | pmid:12421851 |
| Thijssen MA et al. | Stearic, oleic, and linoleic acids have comparable effects on markers of thrombotic tendency in healthy human subjects. | 2005 | J. Nutr. | pmid:16317124 |
| Hassel CA et al. | Dietary stearic acid reduces plasma and hepatic cholesterol concentrations without increasing bile acid excretion in cholesterol-fed hamsters. | 1997 | J. Nutr. | pmid:9187629 |
| Brink EJ et al. | Positional distribution of stearic acid and oleic acid in a triacylglycerol and dietary calcium concentration determines the apparent absorption of these fatty acids in rats. | 1995 | J. Nutr. | pmid:7666256 |
| WAIBEL PE and MRAZ FR | CALCIUM, STRONTIUM AND PHOSPHORUS UTILIZATION BY CHICKS AS INFLUENCED BY NUTRITIONAL AND ENDOCRINE VARIATIONS. | 1964 | J. Nutr. | pmid:14210023 |
| Fretts AM et al. | Associations of Plasma Phospholipid SFAs with Total and Cause-Specific Mortality in Older Adults Differ According to SFA Chain Length. | 2016 | J. Nutr. | pmid:26701797 |
| Enjalbert F et al. | Duodenal infusions of palmitic, stearic or oleic acids differently affect mammary gland metabolism of fatty acids in lactating dairy cows. | 1998 | J. Nutr. | pmid:9732314 |
| Rasmussen HE et al. | Reduction in cholesterol absorption is enhanced by stearate-enriched plant sterol esters in hamsters. | 2006 | J. Nutr. | pmid:17056791 |
| Fungwe TV et al. | Fatty acids modulate lecithin:cholesterol acyltransferase secretion independently of effects on triglyceride secretion in primary rat hepatocytes. | 1998 | J. Nutr. | pmid:9687543 |
| Furr HC et al. | The effect of dietary fatty acid composition on liver retinyl ester (vitamin A ester) composition in the rat. | 1989 | J. Nutr. | pmid:2703916 |
| Baer DJ et al. | Stearic acid absorption and its metabolizable energy value are minimally lower than those of other fatty acids in healthy men fed mixed diets. | 2003 | J. Nutr. | pmid:14652360 |
| GLENDE EA and CORNATZER WE | FATTY ACID COMPOSITION OF RAT LIVER LIPIDS DURING CHOLINE DEFICIENCY. | 1965 | J. Nutr. | pmid:14302120 |
| Lai HC and Ney DM | Corn oil, palm oil and butterfat fractions affect postprandial lipemia and lipoprotein lipase in meal-fed rats. | 1995 | J. Nutr. | pmid:7782908 |
| TOVE SB | TOXICITY OF SATURATED FAT. | 1964 | J. Nutr. | pmid:14227501 |
| Gupta SV and Khosla P | Palmitic and stearic acids similarly affect plasma lipoprotein metabolism in cynomolgus monkeys fed diets with adequate levels of linoleic acid. | 2001 | J. Nutr. | pmid:11481404 |
| LYMAN RL et al. | LIVER LIPID ACCUMULATION IN ISOLEUCINE-DEFICIENT RATS. | 1964 | J. Nutr. | pmid:14151129 |
| Wonsil BJ et al. | Dietary and ruminally derived trans-18:1 fatty acids alter bovine milk lipids. | 1994 | J. Nutr. | pmid:8145078 |
| Lee YJ and Jenkins TC | Biohydrogenation of linolenic acid to stearic acid by the rumen microbial population yields multiple intermediate conjugated diene isomers. | 2011 | J. Nutr. | pmid:21653571 |
| Yu MD et al. | The effect of formulation on reduced radioiodide thyroid uptake. | 2002 | J. Nucl. Med. | pmid:11801703 |
| Mérian J et al. | Synthetic lipid nanoparticles targeting steroid organs. | 2013 | J. Nucl. Med. | pmid:24071507 |
| Demediuk P et al. | Traumatic brain injury in the rat: effects on lipid metabolism, tissue magnesium, and water content. | 1988 | J. Neurotrauma | pmid:3066912 |
| Reddy TS and Bazan NG | Arachidonic acid, stearic acid, and diacylglycerol accumulation correlates with the loss of phosphatidylinositol 4,5-bisphosphate in cerebrum 2 seconds after electroconvulsive shock: complete reversion of changes 5 minutes after stimulation. | 1987 | J. Neurosci. Res. | pmid:2830409 |
| Demediuk P et al. | Changes in free fatty acids, phospholipids, and cholesterol following impact injury to the rat spinal cord. | 1989 | J. Neurosci. Res. | pmid:2520534 |
| Hillered L and Chan PH | Brain mitochondrial swelling induced by arachidonic acid and other long chain free fatty acids. | 1989 | J. Neurosci. Res. | pmid:2531232 |
| Pacini L et al. | Arachidonic acid modulates [14C]stearic acid incorporation into phosphatidylinositol, in human neuroblastoma cells. | 1997 | J. Neurooncol. | pmid:9049841 |
| Koike R et al. | Physiological significance of fatty acid elongation system in adrenoleukodystrophy. | 1991 | J. Neurol. Sci. | pmid:1880537 |
| Yasuda H et al. | Biphasic liberation of arachidonic and stearic acids during cerebral ischemia. | 1985 | J. Neurochem. | pmid:2987409 |
| Yoshida S et al. | Cerebral phosphoinositide, triacylglycerol, and energy metabolism in reversible ischemia: origin and fate of free fatty acids. | 1986 | J. Neurochem. | pmid:3016186 |
| Faden AI et al. | Alterations in lipid metabolism, Na+,K+-ATPase activity, and tissue water content of spinal cord following experimental traumatic injury. | 1987 | J. Neurochem. | pmid:3033150 |
| Singh H et al. | Mitochondrial and peroxisomal beta-oxidation of stearic and lignoceric acids by rat brain. | 1989 | J. Neurochem. | pmid:2809586 |
| Edmond J et al. | Fatty acid transport and utilization for the developing brain. | 1998 | J. Neurochem. | pmid:9489745 |
| Ginóbili de MartÃnez MS et al. | Asymmetry of diacylglycerol metabolism in rat cerebral hemispheres. | 1986 | J. Neurochem. | pmid:3083043 |
| Shetty HU et al. | Identification of two molecular species of rat brain phosphatidylcholine that rapidly incorporate and turn over arachidonic acid in vivo. | 1996 | J. Neurochem. | pmid:8858956 |
| Ulloth JE et al. | Palmitic and stearic fatty acids induce caspase-dependent and -independent cell death in nerve growth factor differentiated PC12 cells. | 2003 | J. Neurochem. | pmid:12562510 |
| Pediconi MF and RodrÃguez de Turco EB | Free fatty acid content and release kinetics as manifestations of cerebral lateralization in mouse brain. | 1984 | J. Neurochem. | pmid:6726237 |
| Amaya KR et al. | Small molecule analysis and imaging of fatty acids in the zebra finch song system using time-of-flight-secondary ion mass spectrometry. | 2011 | J. Neurochem. | pmid:21496023 |
| Aveldano MI and Bazán NG | Rapid production of diacylglycerols enriched in arachidonate and stearate during early brain ischemia. | 1975 | J. Neurochem. | pmid:1206411 |
| PILZ H and JATZKEWITZ H | [DETERMINATION OF C18- AND C24-SPHINGOMYELIN BY THIN-LAYER CHROMATOGRAPHY IN NORMAL AND PATHOLOGICAL BRAINS, INCLUDING A CASE OF NIEMANN-PICK DISEASE]. | 1964 | J. Neurochem. | pmid:14206462 |
| Yoshida S et al. | Brain free fatty acids, edema, and mortality in gerbils subjected to transient, bilateral ischemia, and effect of barbiturate anesthesia. | 1983 | J. Neurochem. | pmid:6403669 |
| Visioli F et al. | Free fatty acid and diacylglycerol accumulation in the rat brain during recurrent seizures is related to cortical oxygenation. | 1993 | J. Neurochem. | pmid:8228997 |
| Scholz WK | An ibotenate-selective metabotropic glutamate receptor mediates protein phosphorylation in cultured hippocampal pyramidal neurons. | 1994 | J. Neurochem. | pmid:7908944 |
| Bhakoo KK et al. | Regional studies of changes in brain fatty acids following experimental ischaemia and reperfusion in the gerbil. | 1984 | J. Neurochem. | pmid:6236282 |
| Horwitz J | Bradykinin activates a phospholipase D that hydrolyzes phosphatidylcholine in PC12 cells. | 1991 | J. Neurochem. | pmid:1988554 |
| Cochran FB et al. | Myelin gangliosides: an unusual pattern in the avian central nervous system. | 1981 | J. Neurochem. | pmid:7463084 |
| Bentejac M et al. | Utilization of high-density lipoprotein sphingomyelin by the developing and mature brain in the rat. | 1989 | J. Neurochem. | pmid:2709013 |
| Upreti GC et al. | Membrane lipids of hepatic tissue. I. Neutral lipids from subcellular fractions of liver and hepatoma 7288CTC. | 1983 | J. Natl. Cancer Inst. | pmid:6572743 |
| Aylsworth CF et al. | Promotion of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis by high dietary fat in the rat: possible role of intercellular communication. | 1984 | J. Natl. Cancer Inst. | pmid:6422115 |
| Crowe FL et al. | Circulating fatty acids and prostate cancer risk: individual participant meta-analysis of prospective studies. | 2014 | J. Natl. Cancer Inst. | pmid:25210201 |
| Chen JJ et al. | seco-Abietane diterpenoids, a phenylethanoid derivative, and antitubercular constituents from Callicarpa pilosissima. | 2009 | J. Nat. Prod. | pmid:19193025 |
| Carballeira NM et al. | Identification and total synthesis of novel fatty acids from the Siphonarid limpet Siphonaria denticulata. | 2001 | J. Nat. Prod. | pmid:11720525 |
| Samoylov AM et al. | Peptide biosensor for recognition of cross-species cell surface markers. | 2002 Jul-Aug | J. Mol. Recognit. | pmid:12382237 |
| Katz AM and Messineo FC | Fatty acid effects on membranes: possible role in the pathogenesis of ischemic myocardial damage. | 1982 | J. Mol. Cell. Cardiol. | pmid:7143451 |
| Takenaka T et al. | Effects of arachidonic acid and the other long-chain fatty acids on the membrane currents in the squid giant axon. | 1988 | J. Membr. Biol. | pmid:3147335 |
| d'Avila Nunes M | A spin label study of erythrocyte membranes during simulation of freezing. | 1981 | J. Membr. Biol. | pmid:7253007 |
| Uyesaka N et al. | Lanthanum and some other cation-induced changes in fluidity of synaptosomal membrane studied with nitroxide stearate spin labels. | 1976 | J. Membr. Biol. | pmid:181579 |
| Uyesaka N | Lanthanum and some other cation-induced changes in fluidity of synaptosomal membrane studied with nitroxide stearate spin labels. J. Membrane Biol. 27:283. | 1977 | J. Membr. Biol. | pmid:190405 |
| Cozzini P et al. | Simple, intuitive calculations of free energy of binding for protein-ligand complexes. 1. Models without explicit constrained water. | 2002 | J. Med. Chem. | pmid:12036355 |
| Gray AP and Yamauchi TN | Steroid antifertility agents. Ionic complexes of basic derivatives for prolonged action. | 1978 | J. Med. Chem. | pmid:671469 |
| Pedersen PJ et al. | Liposomal formulation of retinoids designed for enzyme triggered release. | 2010 | J. Med. Chem. | pmid:20405849 |
| Rahman MD et al. | Effects of sulfur-containing analogues of stearic acid on growth and fatty acid biosynthesis in the protozoan Crithidia fasciculata. | 1988 | J. Med. Chem. | pmid:3398003 |
| Fabiano A et al. | Metabolomic analysis of bronchoalveolar lavage fluid in preterm infants complicated by respiratory distress syndrome: preliminary results. | 2011 | J. Matern. Fetal. Neonatal. Med. | pmid:21781003 |
| Junk MJ et al. | DEER in biological multispin-systems: a case study on the fatty acid binding to human serum albumin. | 2011 | J. Magn. Reson. | pmid:21450500 |
| Subczynski WK et al. | Spin-label oximetry at Q- and W-band. | 2011 | J. Magn. Reson. | pmid:21277814 |
| Smirnov AI | Post-processing of EPR spectra by convolution filtering: calculation of a harmonics' series and automatic separation of fast-motion components from spin-label EPR spectra. | 2008 | J. Magn. Reson. | pmid:17967556 |
| Mizushima H et al. | Phase behavior of artificial stratum corneum lipids containing a synthetic pseudo-ceramide: a study of the function of cholesterol. | 1996 | J. Lipid Res. | pmid:9026533 |
| Staprans I et al. | Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats. | 1996 | J. Lipid Res. | pmid:9026539 |
| Lehmann J and McGill M | Biochemical and ultrastructural alterations in platelets, reticulocytes, and lymphocytes from rats fed vitamin E-deficient diets. | 1982 | J. Lipid Res. | pmid:7077144 |
| Aarsland A and Wolfe RR | Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men. | 1998 | J. Lipid Res. | pmid:9643360 |
| Sassa T et al. | Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid. | 2014 | J. Lipid Res. | pmid:24489110 |
| Masuda M et al. | Activating transcription factor 4 regulates stearate-induced vascular calcification. | 2012 | J. Lipid Res. | pmid:22628618 |
| Gorjão R et al. | Regulation of interleukin-2 signaling by fatty acids in human lymphocytes. | 2007 | J. Lipid Res. | pmid:17592174 |