| MeSH term | MeSH ID | Detail |
|---|---|---|
| Decalcification, Pathologic | D003649 | 1 associated lipids |
stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with stearic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Qian MW and Eaton JW | Iron translocation by free fatty acids. | 1991 | Am. J. Pathol. | pmid:1750512 |
| Young PM et al. | Effect of moisture on the compressibility and compactibility of sodium starch glycolate. | 2007 | Pharm Dev Technol | pmid:17510894 |
| Wei GH et al. | Rhizobialide: a new stearolactone produced by Mesorhizobium sp. CCNWGX022, a rhizobial endophyte from Glycyrrhiza uralensis. | 2007 | Chem. Biodivers. | pmid:17510984 |
| Cieśliński H et al. | A cold-adapted esterase from psychrotrophic Pseudoalteromas sp. strain 643A. | 2007 | Arch. Microbiol. | pmid:17516048 |
| Yang Y et al. | Regulation of FAT/CD36 mRNA gene expression by long chain fatty acids in the differentiated 3T3-L1 cells. | 2007 | Pediatr. Surg. Int. | pmid:17516074 |
| Kauffman JF et al. | Near infrared spectroscopy of magnesium stearate hydrates and multivariate calibration of pseudopolymorph composition. | 2008 | J Pharm Sci | pmid:17546666 |
| Shimizu K et al. | Characterization of tableting using the OSDRC system. | 2007 | Pharm. Res. | pmid:17554609 |
| Berry SE et al. | The solid fat content of stearic acid-rich fats determines their postprandial effects. | 2007 | Am. J. Clin. Nutr. | pmid:17556683 |
| Raffin RP et al. | Development of HPMC and Eudragit S100 blended microparticles containing sodium pantoprazole. | 2007 | Pharmazie | pmid:17557744 |
| Dong J et al. | Crystallization of silver carboxylates from sodium carboxylate mixtures. | 2007 | Langmuir | pmid:17567157 |
| Li Y and Weng W | Surface modification of hydroxyapatite by stearic acid: characterization and in vitro behaviors. | 2008 | J Mater Sci Mater Med | pmid:17569011 |
| Harrison V et al. | Magnesium supplementation and perinatal hypoxia: outcome of a parallel group randomised trial in pregnancy. | 2007 | BJOG | pmid:17578470 |
| Bacher C et al. | Improving the compaction properties of roller compacted calcium carbonate. | 2007 | Int J Pharm | pmid:17582712 |
| Teixeira AC et al. | Microdomains in mixed monolayers of oleanolic and stearic acids: thermodynamic study and BAM observation at the air-water interface and AFM and FTIR analysis of LB monolayers. | 2007 Sep-Oct | Chem. Phys. Lipids | pmid:17583687 |
| Dubrovin EV et al. | Self-assembly effect during the adsorption of polynucleotides on stearic acid langmuir-blodgett monolayer. | 2007 | Biomacromolecules | pmid:17583947 |
| Wu H et al. | Process analytical technology (PAT): effects of instrumental and compositional variables on terahertz spectral data quality to characterize pharmaceutical materials and tablets. | 2007 | Int J Pharm | pmid:17590292 |
| Gorjão R et al. | Regulation of interleukin-2 signaling by fatty acids in human lymphocytes. | 2007 | J. Lipid Res. | pmid:17592174 |
| Del Turco S et al. | Parallel decrease of tissue factor surface exposure and increase of tissue factor microparticle release by the n-3 fatty acid docosahexaenoate in endothelial cells. | 2007 | Thromb. Haemost. | pmid:17598015 |
| Anjos JL et al. | Effects of 1,8-cineole on the dynamics of lipids and proteins of stratum corneum. | 2007 | Int J Pharm | pmid:17600646 |
| Wang X et al. | Phase characterization of indomethacin in binary solid dispersions with PVP VA64 or Myrj 52. | 2007 | Int J Pharm | pmid:17604923 |
| Morkhade DM et al. | PEGylated rosin derivatives: novel microencapsulating materials for sustained drug delivery. | 2007 | AAPS PharmSciTech | pmid:17622122 |
| Karupaiah T and Sundram K | Effects of stereospecific positioning of fatty acids in triacylglycerol structures in native and randomized fats: a review of their nutritional implications. | 2007 | Nutr Metab (Lond) | pmid:17625019 |
| Barreyro FJ et al. | Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis. | 2007 | J. Biol. Chem. | pmid:17626006 |
| Hamad ML et al. | Drug product characterization by macropixel analysis of chemical images. | 2007 | J Pharm Sci | pmid:17630646 |
| Diakogiannaki E et al. | Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells. | 2007 | J. Endocrinol. | pmid:17641278 |
| Chaudry A et al. | Essential fatty acid distribution in the plasma and tissue phospholipids of patients with benign and malignant prostatic disease. | 1991 | Br. J. Cancer | pmid:1764380 |
| MuzÃková J and Nováková P | A study of the properties of compacts from silicified microcrystalline celluloses. | 2007 | Drug Dev Ind Pharm | pmid:17654026 |
| Yuan H et al. | Preparation and characteristics of nanostructured lipid carriers for control-releasing progesterone by melt-emulsification. | 2007 | Colloids Surf B Biointerfaces | pmid:17656075 |
| Takahashi R et al. | Fatty acid composition of serum phospholipids in an elderly institutionalized Japanese population. | 1991 | J. Nutr. Sci. Vitaminol. | pmid:1765844 |
| Newton JM and Razzo FN | The in vitro bioavailability of various drugs formulated as hard gelatin capsules. | 1977 | J. Pharm. Pharmacol. | pmid:17668 |
| Kamilya T et al. | Incorporation of ovalbumin within cationic octadecylamine monolayer and a comparative study with zwitterionic DPPC and anionic stearic acid monolayer. | 2007 | J Colloid Interface Sci | pmid:17669414 |
| McHedlov-Petrossyan NO et al. | Fluorescent dye N,N'-dioctadecylrhodamine as a new interfacial acid-base indicator. | 2008 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:17681854 |
| Guchardi R et al. | Influence of fine lactose and magnesium stearate on low dose dry powder inhaler formulations. | 2008 | Int J Pharm | pmid:17689898 |
| Wu SD et al. | The role and mechanism of fatty acids in gallstones. | 2007 | HBPD INT | pmid:17690037 |
| Nyblom HK et al. | Glucose-induced de novo synthesis of fatty acyls causes proportional increases in INS-1E cellular lipids. | 2008 | NMR Biomed | pmid:17691080 |
| Newton JM and Razzo FN | The influence of additives on the presentation of a drug in hard gelatin capsules. | 1977 | J. Pharm. Pharmacol. | pmid:17694 |
| Gebauer SK et al. | The diversity of health effects of individual trans fatty acid isomers. | 2007 | Lipids | pmid:17694343 |
| Chen Y et al. | Formation of monodisperse and shape-controlled MnO nanocrystals in non-injection synthesis: self-focusing via ripening. | 2007 | J. Am. Chem. Soc. | pmid:17696349 |
| Moore DJ et al. | Infrared spectroscopy and differential scanning calorimetry studies of binary combinations of cis-6-octadecenoic acid and octadecanoic acid. | 2007 | Chem. Phys. Lipids | pmid:17697674 |
| Zhang JQ et al. | Preparation and characterization of solid lipid nanoparticles containing silibinin. | 2007 | Drug Deliv | pmid:17701527 |
| Yuan H et al. | Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells. | 2008 | Int J Pharm | pmid:17714896 |
| Wu H et al. | Process analytical technology (PAT): quantification approaches in terahertz spectroscopy for pharmaceutical application. | 2008 | J Pharm Sci | pmid:17722101 |
| You JO et al. | Incorporation of quantum dots on virus in polycationic solution. | 2006 | Int J Nanomedicine | pmid:17722262 |
| Grassi G et al. | Propaedeutic study for the delivery of nucleic acid-based molecules from PLGA microparticles and stearic acid nanoparticles. | 2006 | Int J Nanomedicine | pmid:17722283 |
| Shen LJ and Wu FL | Nanomedicines in renal transplant rejection--focus on sirolimus. | 2007 | Int J Nanomedicine | pmid:17722509 |
| Bacher C et al. | Granule fraction inhomogeneity of calcium carbonate/sorbitol in roller compacted granules. | 2008 | Int J Pharm | pmid:17765416 |
| Nowak G and Kaletha K | Molecular forms of human kidney AMP-deaminase. | 1991 | Adv. Exp. Med. Biol. | pmid:1781367 |
| Uzunović A and Vranić E | Effect of magnesium stearate concentration on dissolution properties of ranitidine hydrochloride coated tablets. | 2007 | Bosn J Basic Med Sci | pmid:17848158 |
| Yang DY et al. | Detrimental effects of post-treatment with fatty acids on brain injury in ischemic rats. | 2007 | Neurotoxicology | pmid:17854901 |
| Zhang YM et al. | A Pseudomonas aeruginosa transcription factor that senses fatty acid structure. | 2007 | Mol. Microbiol. | pmid:17877713 |
| Richardson AD et al. | Central carbon metabolism in the progression of mammary carcinoma. | 2008 | Breast Cancer Res. Treat. | pmid:17879159 |
| Soler-Argilaga C et al. | The effect of sex on the quantity and properties of the very low density lipoprotein secreted by the liver in vitro. | 1976 | J. Lipid Res. | pmid:178815 |
| Walden M et al. | The effect of ethanol on the release of opioids from oral prolonged-release preparations. | 2007 | Drug Dev Ind Pharm | pmid:17882730 |
| Xu G and Fang Y | Studies of surface-enhanced Raman scattering of C60 Langmuir-Blodgett film on a new substrate. | 2008 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:17889595 |
| Cunha-Filho MS et al. | Compatibility of the antitumoral beta-lapachone with different solid dosage forms excipients. | 2007 | J Pharm Biomed Anal | pmid:17890039 |
| Nande VS et al. | Sustained release microspheres of diclofenac sodium using PEGylated rosin derivatives. | 2007 | Drug Dev Ind Pharm | pmid:17891576 |
| Werle M | Natural and synthetic polymers as inhibitors of drug efflux pumps. | 2008 | Pharm. Res. | pmid:17896100 |
| Egashira Y et al. | Dietary protein level and dietary interaction affect quinolinic acid concentration in rats. | 2007 | Int J Vitam Nutr Res | pmid:17896587 |
| Paillard D et al. | Quantification of ruminal Clostridium proteoclasticum by real-time PCR using a molecular beacon approach. | 2007 | J. Appl. Microbiol. | pmid:17897229 |
| Matsuzaka T et al. | Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. | 2007 | Nat. Med. | pmid:17906635 |
| Rhee YS et al. | Application of instrumental evaluation of color for the pre-formulation and formulation of rabeprazole. | 2008 | Int J Pharm | pmid:17919858 |
| Jones OA et al. | A metabolomics based approach to assessing the toxicity of the polyaromatic hydrocarbon pyrene to the earthworm Lumbricus rubellus. | 2008 | Chemosphere | pmid:17928029 |
| Piao ZZ et al. | Colonic release and reduced intestinal tissue damage of coated tablets containing naproxen inclusion complex. | 2008 | Int J Pharm | pmid:17928177 |
| Stimson L et al. | Stearic acid spin labels in lipid bilayers: insight through atomistic simulations. | 2007 | J Phys Chem B | pmid:17929861 |
| Karoussi O and Hamouda AA | Macroscopic and nanoscale study of wettability alteration of oil-wet calcite surface in presence of magnesium and sulfate ions. | 2008 | J Colloid Interface Sci | pmid:17931645 |
| Fujio J et al. | Regulation of gut-derived resistin-like molecule beta expression by nutrients. | 2008 | Diabetes Res. Clin. Pract. | pmid:17936398 |
| Kositsawat J et al. | The ratio of oleic-to-stearic acid in the prostate predicts biochemical failure after radical prostatectomy for localized prostate cancer. | 2007 | J. Urol. | pmid:17936811 |
| DeÄneka SE et al. | [Experimental data on the effects of lead, barium, silver, zinc and calcium stearates on the cardiovascular system]. | 1991 | Gig Tr Prof Zabol | pmid:1794723 |
| Chatterjee A and Chowdhury R | Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor. | 2008 | Antimicrob. Agents Chemother. | pmid:17954701 |
| Krzeski P et al. | Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study. | 2007 | Arthritis Res. Ther. | pmid:17958901 |
| Likitlersuang S et al. | The effect of binary mixture composition and magnesium stearate concentration on the Hiestand Tableting Indices and other related mechanical properties. | 2007 | Pharm Dev Technol | pmid:17963153 |
| Smirnov AI | Post-processing of EPR spectra by convolution filtering: calculation of a harmonics' series and automatic separation of fast-motion components from spin-label EPR spectra. | 2008 | J. Magn. Reson. | pmid:17967556 |
| Ghosh SK et al. | Characterization and cloning of a stearoyl/oleoyl specific fatty acyl-acyl carrier protein thioesterase from the seeds of Madhuca longifolia (latifolia). | 2007 | Plant Physiol. Biochem. | pmid:17977002 |
| Bhandari KH et al. | Evaluation of physicochemical properties, skin permeation and accumulation profiles of ketorolac fatty ester prodrugs. | 2007 | Biol. Pharm. Bull. | pmid:17978504 |
| Applegate KR and Glomset JA | Effect of acyl chain unsaturation on the conformation of model diacylglycerols: a computer modeling study. | 1991 | J. Lipid Res. | pmid:1797944 |
| Widjaja E and Seah RK | Application of Raman microscopy and band-target entropy minimization to identify minor components in model pharmaceutical tablets. | 2008 | J Pharm Biomed Anal | pmid:17980994 |
| Desai D et al. | Evaluation of selected micronized poloxamers as tablet lubricants. | 2007 | Drug Deliv | pmid:17994358 |
| Kim CH et al. | Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. | 2008 | Anaerobe | pmid:17996466 |
| Hu FQ et al. | Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin. | 2008 | Eur J Pharm Biopharm | pmid:17997293 |
| Buttke TM et al. | Correlation between low-temperature immunosuppression and the absence of unsaturated fatty acid synthesis in murine T cells. | 1991 | Comp. Biochem. Physiol., B | pmid:1799970 |
| Salas JJ et al. | The biochemical characterization of a high-stearic acid sunflower mutant reveals the coordinated regulation of stearoyl-acyl carrier protein desaturases. | 2008 | Plant Physiol. Biochem. | pmid:18023195 |
| Sun CC | On the mechanism of reduced tabletability of granules prepared by roller compaction. | 2008 | Int J Pharm | pmid:18024020 |
| Kusano M et al. | Unbiased characterization of genotype-dependent metabolic regulations by metabolomic approach in Arabidopsis thaliana. | 2007 | BMC Syst Biol | pmid:18028551 |
| Vehring R | Pharmaceutical particle engineering via spray drying. | 2008 | Pharm. Res. | pmid:18040761 |
| Larsson KE et al. | LysoPC acyltransferase/PC transacylase activities in plant plasma membrane and plasma membrane-associated endoplasmic reticulum. | 2007 | BMC Plant Biol. | pmid:18045483 |
| Osman S et al. | Tetrasphaera remsis sp. nov., isolated from the Regenerative Enclosed Life Support Module Simulator (REMS) air system. | 2007 | Int. J. Syst. Evol. Microbiol. | pmid:18048719 |
| Lumor SE et al. | Synthesis and characterization of canola oil-stearic acid-based trans-free structured lipids for possible margarine application. | 2007 | J. Agric. Food Chem. | pmid:18052237 |
| Miyazaki M et al. | Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. | 2007 | Cell Metab. | pmid:18054317 |
| Ebbesson SO et al. | Consumption of omega-3 fatty acids is not associated with a reduction in carotid atherosclerosis: the Genetics of Coronary Artery Disease in Alaska Natives study. | 2008 | Atherosclerosis | pmid:18054937 |
| Sabin MA et al. | Fasting nonesterified fatty acid profiles in childhood and their relationship with adiposity, insulin sensitivity, and lipid levels. | 2007 | Pediatrics | pmid:18055661 |
| El-Enany N et al. | Spectrofluorimetric determination of oxamniquine in dosage forms and spiked human plasma through derivatization with 1-dimethylaminonaphthalene-5-sulphonyl chloride. | 2008 | J Fluoresc | pmid:18058206 |
| Maghsoodi M et al. | Improved compaction and packing properties of naproxen agglomerated crystals obtained by spherical crystallization technique. | 2007 | Drug Dev Ind Pharm | pmid:18058318 |
| Aziz HA et al. | Solubility of core materials in aqueous polymeric solution effect on microencapsulation of curcumin. | 2007 | Drug Dev Ind Pharm | pmid:18058323 |
| Vögler O et al. | Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats. | 2008 | Int J Obes (Lond) | pmid:18059405 |
| Günther S et al. | Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum. | 2007 | PLoS Pathog. | pmid:18069893 |
| Cakir T et al. | Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia. | 2007 | Theor Biol Med Model | pmid:18070347 |
| Fujimoto Y et al. | Stearic acid potently modulates the activity of cyclooxygenase-1, but not cyclooxygenase-2, in the form of its CoA ester. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18083017 |
| Ruths M et al. | Friction of fatty acids in nanometer-sized contacts of different adhesive strength. | 2008 | Langmuir | pmid:18085802 |
| Ye YQ et al. | Core-modified chitosan-based polymeric micelles for controlled release of doxorubicin. | 2008 | Int J Pharm | pmid:18096336 |
| Martino PD et al. | The role of several l-HPCs in preventing tablet capping during direct compression of metronidazole. | 2007 | Drug Dev Ind Pharm | pmid:18097804 |