stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Decalcification, Pathologic D003649 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


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What lipids are associated with stearic acid?

Related references are published most in these journals:

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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Chen H et al. Effect of cholesterol on miscibility and phase behavior in binary mixtures with synthetic ceramide 2 and octadecanoic acid. Infrared studies. 2001 Biochim. Biophys. Acta pmid:11406112
Christensen E et al. Beta-oxidation of medium chain (C8-C14) fatty acids studied in isolated liver cells. 1989 Biochim. Biophys. Acta pmid:2752017
Morrow MR et al. Glycosphingolipid acyl chain order profiles: substituent effects. 1995 Biochim. Biophys. Acta pmid:7756331
Longmuir KJ and Rossi ME Fatty acid chain-shortening activity in the pulmonary type II cell. 1988 Biochim. Biophys. Acta pmid:3289622
Wheelan P and Clay KL Albumin and fatty acid effects on the stimulated production of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) by human polymorphonuclear leukocytes. 1992 Biochim. Biophys. Acta pmid:1511005
Eliasz AW et al. Phospholipid phase transitions. Effects of n-alcohols, n-monocarboxylic acids, phenylalkyl alcohols and quaternary ammonium compounds. 1976 Biochim. Biophys. Acta pmid:971432
Callaghan R et al. Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties. 1993 Biochim. Biophys. Acta pmid:8435444
Clandinin MT et al. Omega-3 fatty acid intake results in a relationship between the fatty acid composition of LDL cholesterol ester and LDL cholesterol content in humans. 1997 Biochim. Biophys. Acta pmid:9219909
Sparks JD et al. Effects of fatty acids on apolipoprotein B secretion by McArdle RH-7777 rat hepatoma cells. 1997 Biochim. Biophys. Acta pmid:9233686
Thompson W and Belina H Rapid accumulation of diacyl lipid in rat liver microsomes by selective acylation of 2-acyl-sn-glycero-3-phosphorylserine. 1986 Biochim. Biophys. Acta pmid:3707975
Schreiber R et al. Retinyl ester hydrolases and their roles in vitamin A homeostasis. 2012 Biochim. Biophys. Acta pmid:21586336
Beaumelle BD and Vial HJ Modification of the fatty acid composition of individual phospholipids and neutral lipids after infection of the simian erythrocyte by Plasmodium knowlesi. 1986 Biochim. Biophys. Acta pmid:3719005
Arukuusk P et al. New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids. 2013 Biochim. Biophys. Acta pmid:23357356
Galpin JR and Allen JC The influence of micelle formation on lipoxygenase kinetics. 1977 Biochim. Biophys. Acta pmid:409436
Bolton P and Harwood JL Some characteristics of soluble fatty acid synthesis in germinating pea seeds. 1977 Biochim. Biophys. Acta pmid:20971
Alegría AE et al. Semiquinones derived from anthraquinone-containing antitumor drugs can partition into phosphatidylcholine bilayers. 1990 Biochim. Biophys. Acta pmid:2166575
Kitagawa S et al. Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. 1990 Biochim. Biophys. Acta pmid:2166588
Anel A et al. Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. 1990 Biochim. Biophys. Acta pmid:2114179
BURTON RM and GIBBONS JM LIPID COMPOSITION OF A RAT-BRAIN SYNAPTIC-VESICLE FRACTION. 1964 Biochim. Biophys. Acta pmid:14181307
ROWE CE THE OCCURRENCE AND METABOLISM IN VITRO OF UNESTERIFIED FATTY ACID IN MOUSE BRAIN. 1964 Biochim. Biophys. Acta pmid:14230816
KELLERMAN GM and JOLLOW DJ CONVERSION OF STEARIC ACID INTO OLEIC ACID IN ADIPOSE TISSUE. 1964 Biochim. Biophys. Acta pmid:14230826
Cevc G et al. Phosphatidylcholine-fatty acid membranes. I. Effects of protonation, salt concentration, temperature and chain-length on the colloidal and phase properties of mixed vesicles, bilayers and nonlamellar structures. 1988 Biochim. Biophys. Acta pmid:2835979
Chien JL and Hogan EL Characterization of two gangliosides of the paragloboside series from chicken skeletal muscle. 1980 Biochim. Biophys. Acta pmid:7236652
Holub BJ The suitability of different acyl acceptors as substrates for the acyl-Coa : 2-acyl-sn-glycero-3-phosphorylcholine acyltransferase in rat liver microsomes. 1981 Biochim. Biophys. Acta pmid:7248321
Kedryna T et al. Pyruvate kinase from cytosolic fractions of the Ehrlich ascites tumour, normal mouse liver and skeletal muscle. 1990 Biochim. Biophys. Acta pmid:2354196
Yoshida S et al. Effect of phospholipase A2 and free fatty acids on lipid-protein interactions in long- and very-long-chain fatty acyl-CoA elongation enzyme systems of brain microsomes. 1989 Biochim. Biophys. Acta pmid:2502180
Morandi S et al. Association of sugar-based carboranes with cationic liposomes: an electron spin resonance and light scattering study. 2004 Biochim. Biophys. Acta pmid:15238258
Shires SE et al. Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. 1989 Biochim. Biophys. Acta pmid:2493807
Redgrave TG et al. The condensing effects of egg lecithin and cholesterol on triolein monolayers are inhibited by substitution of one saturated acyl chain in the triacylglycerol. 1994 Biochim. Biophys. Acta pmid:8117751
Privat JP et al. Incorporation of spin-labeled fatty acids into bovine brain clathrin coated vesicles. 1990 Biochim. Biophys. Acta pmid:2158352
Golovina EA and Tikhonov AN The structural differences between the embryos of viable and nonviable wheat seeds as studied with the EPR spectroscopy of lipid-soluble spin labels. 1994 Biochim. Biophys. Acta pmid:8142440
Yoshida S and Takeshita M Arachidoyl- and arachidonoyl-CoA elongation mechanism in swine cerebral microsomes. 1984 Biochim. Biophys. Acta pmid:6466693
Miller RW and De La Roche IA Properties of spin labelled membranes of Fusarium oxysporum f. sp. lycopersici. 1976 Biochim. Biophys. Acta pmid:182261
Ruf HH and Gratzl M Binding of nitroxide stearate spin labels to bovine serum albumin. 1976 Biochim. Biophys. Acta pmid:184832
ELSBACH P COMPARISON OF UPTAKE OF PALMITIC, STEARIC, OLEIC AND LINOLEIC ACID BY POLYMORPHONUCLEAR LEUKOCYTES. 1964 Biochim. Biophys. Acta pmid:14124760
Watanabe L et al. Structural insights for fatty acid binding in a Lys49-phospholipase A2: crystal structure of myotoxin II from Bothrops moojeni complexed with stearic acid. 2005 Biochimie pmid:15760708
Pollet S et al. [Substrates and products of fatty acid elongation in mouse brain microsomes]. 1975 Biochimie pmid:1222143
Zhu S et al. Lysosomal delivery of a lipophilic gemcitabine prodrug using novel acid-sensitive micelles improved its antitumor activity. 2012 Bioconjug. Chem. pmid:22471294
Zhang W et al. Stearylated antimicrobial peptide melittin and its retro isomer for efficient gene transfection. 2013 Bioconjug. Chem. pmid:24107137
Futaki S et al. Stearylated arginine-rich peptides: a new class of transfection systems. 2001 Nov-Dec Bioconjug. Chem. pmid:11716693
Fabianowski W et al. Integrated circuits protection with the Langmuir-Blodgett Films. 2005 Bioelectrochemistry pmid:15833702
Petelska AD et al. Interfacial tension of the lipid membrane formed from lipid-fatty acid and lipid-amine systems. 2007 Bioelectrochemistry pmid:16713376
Staritsyn SN et al. [Mixed monolayers of amphiphile-modified nucleic bases and diynoic acids. I. Phase states at air-water interface and in Langmuir-Blodgett films]. 2004 Jul-Aug Biofizika pmid:15458246
Saatov TS et al. [Content, intensity of exchange, and metabolic interaction of phospholipids and glycolipids in various tissues in experimental diabetes]. 1983 Biokhimiia pmid:6671113
Moore IM et al. Methotrexate-induced alterations in beta-oxidation correlate with cognitive abilities in children with acute lymphoblastic leukemia. 2008 Biol Res Nurs pmid:18398226
Droke EA et al. Fatty acids alter monolayer integrity, paracellular transport, and iron uptake and transport in Caco-2 cells. 2003 Biol Trace Elem Res pmid:14665727
Finley JW and Davis CD Manganese absorption and retention in rats is affected by the type of dietary fat. 2001 Biol Trace Elem Res pmid:11697763
Miersch O and Wasternack C Octadecanoid and jasmonate signaling in tomato (Lycopersicon esculentum Mill.) leaves: endogenous jasmonates do not induce jasmonate biosynthesis. 2000 Biol. Chem. pmid:11030429
Rüdiger M et al. Are biochemical parameters of lung maturation from gastric, tracheal, and pharyngeal aspirates comparable? 1998 Biol. Neonate pmid:9618052
Onishi H et al. In vitro and in vivo evaluations of buccal tablet formulations of ritodrine hydrochloride. 2015 Biol. Pharm. Bull. pmid:26027834