| MeSH term | MeSH ID | Detail |
|---|---|---|
| Decalcification, Pathologic | D003649 | 1 associated lipids |
stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with stearic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fujimoto Y et al. | Stearic acid potently modulates the activity of cyclooxygenase-1, but not cyclooxygenase-2, in the form of its CoA ester. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18083017 |
| Fujimoto Y et al. | Effects of fatty acyl coenzyme A esters on lipoxygenase and cyclooxygenase metabolism of arachidonic acid in rabbit platelets. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7784474 |
| Alava MA et al. | Fatty acid desaturation: effect of alphafetoprotein on alpha-linolenic acid conversion by fetal rat hepatocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10359023 |
| Sakuma S et al. | The effects of fatty acyl CoA esters on the formation of prostaglandin and arachidonoyl-CoA formed from arachidonic acid in rabbit kidney medulla microsomes. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161586 |
| Glew RH et al. | Fatty acid composition of the milk lipids of Nepalese women: correlation between fatty acid composition of serum phospholipids and melting point. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728165 |
| Ulmann L et al. | Brain and hippocampus fatty acid composition in phospholipid classes of aged-relative cognitive deficit rats. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334555 |
| Cunnane SC | Problems with essential fatty acids: time for a new paradigm? | 2003 | Prog. Lipid Res. | pmid:14559071 |
| Salas JJ et al. | Biochemistry of high stearic sunflower, a new source of saturated fats. | 2014 | Prog. Lipid Res. | pmid:24858414 |
| Walsh C et al. | Arachidonate metabolism by neutrophils. | 1981 | Prog. Lipid Res. | pmid:6804984 |
| Hohl C and Rösen P | Arachidonic acid metabolism in isolated rat heart myocytes. | 1987 | Prog. Clin. Biol. Res. | pmid:3118380 |
| Johnson PE et al. | Effects of stearic acid and beef tallow on iron utilization by the rat. | 1992 | Proc. Soc. Exp. Biol. Med. | pmid:1508937 |
| WELD JT et al. | Production of octadecenoic acid in plasma by Staphylococcus aureus. | 1963 | Proc. Soc. Exp. Biol. Med. | pmid:13999824 |
| Knopp RH et al. | One-year effects of increasingly fat-restricted, carbohydrate-enriched diets on lipoprotein levels in free-living subjects. | 2000 | Proc. Soc. Exp. Biol. Med. | pmid:11082213 |
| BLOMSTRAND R et al. | Asymmetric incorporation of linoleic acid-1-C14 and stearic acid-1-C14 into human lymph lecithins during fat absorption. | 1959 | Proc. Soc. Exp. Biol. Med. | pmid:13645714 |
| LEVEILLE GA and SAUBERLICH HE | RELATIVE DISTRIBUTION OF CHOLESTEROL IN PLASMA AND LIVER COMPARTMENTS OF CHICKS FED DIFFERENT FATTY ACIDS. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14244917 |
| KAPILOFF P et al. | A COMPARISON OF THE DISPOSITION OF INTRAVENOUSLY-INJECTED, ALBUMIN-BOUND STEARIC ACID-1-C14 AND PALMITIC ACID-1-C14 IN THE RAT. | 1965 | Proc. Soc. Exp. Biol. Med. | pmid:14264563 |
| TOMPKINS MJ and DAYTON S | RELATIONSHIP OF WHOLE BLOOD CLOTTING TIME TO PHYSIOLOGICAL VARIATIONS IN CIRCULATING SATURATED FREE FATTY ACIDS. | 1965 | Proc. Soc. Exp. Biol. Med. | pmid:14328950 |
| Blechert S et al. | The octadecanoic pathway: signal molecules for the regulation of secondary pathways. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7753776 |
| Carratù L et al. | Membrane lipid perturbation modifies the set point of the temperature of heat shock response in yeast. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8632982 |
| Dennis M and Kolattukudy PE | A cobalt-porphyrin enzyme converts a fatty aldehyde to a hydrocarbon and CO. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1608940 |
| Newman MJ | Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2371287 |
| Buttke TM et al. | Absence of unsaturated fatty acid synthesis in murine T lymphocytes. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2569740 |
| Terés S et al. | Oleic acid content is responsible for the reduction in blood pressure induced by olive oil. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18772370 |
| Ghanouni P et al. | Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11353823 |
| Tachibana H | Green tea polyphenol sensing. | 2011 | Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. | pmid:21422740 |
| Berry SE and Sanders TA | Influence of triacylglycerol structure of stearic acid-rich fats on postprandial lipaemia. | 2005 | Proc Nutr Soc | pmid:15960865 |
| Pillai KG et al. | Spontaneous tooth exfoliation, maxillary osteomyelitis and facial scarring following trigeminal herpes zoster infection. | 2006 | Prim Dent Care | pmid:16836817 |
| Terekhova EA et al. | [Stearic acid methyl ether: a new extracellular metabolite of the obligate methylotrophic bacterium Methylophilus quaylei]. | 2010 Mar-Apr | Prikl. Biokhim. Mikrobiol. | pmid:20391761 |
| Antimicrobial efficacy of erythromycin stearate. A report from the general Practitioner Research Group. | 1974 | Practitioner | pmid:4591200 | |
| Sirri F et al. | Fatty acid composition and productive traits of broiler fed diets containing conjugated linoleic acid. | 2003 | Poult. Sci. | pmid:12943310 |
| Mossab A et al. | Utilization of soybean oil and tallow in young turkeys compared with young chickens. | 2000 | Poult. Sci. | pmid:11020079 |
| Fujii M et al. | Fatty acid compositions of triacylglycerols and phospholipids in hen liver lipid before and after sexual maturity. | 1985 | Poult. Sci. | pmid:4022907 |
| Yue KT et al. | Effect of glucose on plasma concentrations of individual non-esterified fatty acids of non-diabetic and insulin-independent diabetic men. | 1981 | Postgrad Med J | pmid:7335561 |
| Wang S et al. | Insertion of an esterase gene into a specific locust pathogen (Metarhizium acridum) enables it to infect caterpillars. | 2011 | PLoS Pathog. | pmid:21731492 |
| Liu X et al. | Quantitative Proteomics of Intracellular Campylobacter jejuni Reveals Metabolic Reprogramming. | 2012 | PLoS Pathog. | pmid:22412372 |
| Günther S et al. | Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum. | 2007 | PLoS Pathog. | pmid:18069893 |
| Yang P et al. | Transcriptome analysis of the Chinese white wax scale Ericerus pela with focus on genes involved in wax biosynthesis. | 2012 | PLoS ONE | pmid:22536429 |
| Milicic A et al. | Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses. | 2012 | PLoS ONE | pmid:22470545 |
| Mason P et al. | SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. | 2012 | PLoS ONE | pmid:22457791 |
| Olivieri C et al. | Phylogenetic position of a copper age sheep (Ovis aries) mitochondrial DNA. | 2012 | PLoS ONE | pmid:22457789 |
| Schaab M et al. | Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action. | 2012 | PLoS ONE | pmid:22545089 |
| Steidl S et al. | Mâ‚… muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. | 2011 | PLoS ONE | pmid:22102904 |
| Meissner M et al. | Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. | 2011 | PLoS ONE | pmid:22087215 |
| Ruiz M et al. | A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. | 2012 | PLoS ONE | pmid:23056435 |
| Trupp M et al. | Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment. | 2012 | PLoS ONE | pmid:22808006 |
| Brown JD et al. | VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses. | 2011 | PLoS ONE | pmid:21750705 |
| Guan Q et al. | In vitro and in vivo evaluation of docetaxel-loaded stearic acid-modified Bletilla striata polysaccharide copolymer micelles. | 2017 | PLoS ONE | pmid:28334044 |
| Bonaduce I et al. | New insights into the ageing of linseed oil paint binder: a qualitative and quantitative analytical study. | 2012 | PLoS ONE | pmid:23166642 |
| Flowers MT et al. | Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism. | 2011 | PLoS ONE | pmid:21573029 |
| A J et al. | Chronic myeloid leukemia patients sensitive and resistant to imatinib treatment show different metabolic responses. | 2010 | PLoS ONE | pmid:20949032 |