| MeSH term | MeSH ID | Detail |
|---|---|---|
| Decalcification, Pathologic | D003649 | 1 associated lipids |
stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with stearic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Emken EA et al. | Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans. | 1993 | Biochim. Biophys. Acta | pmid:8399342 |
| Christensen E et al. | Beta-oxidation of medium chain (C8-C14) fatty acids studied in isolated liver cells. | 1989 | Biochim. Biophys. Acta | pmid:2752017 |
| Longmuir KJ and Rossi ME | Fatty acid chain-shortening activity in the pulmonary type II cell. | 1988 | Biochim. Biophys. Acta | pmid:3289622 |
| Wisniewska A et al. | Depth dependence of the perturbing effect of placing a bulky group (oxazolidine ring spin labels) in the membrane on the membrane phase transition. | 1996 | Biochim. Biophys. Acta | pmid:8611609 |
| Gorrissen H et al. | Deuterium magnetic resonance of selectively deuterated cholesteryl esters in dipalmitoyl phosphatidylcholine dispersions. | 1981 | Biochim. Biophys. Acta | pmid:6894863 |
| Kaya K and Kusumi T | Isolation and structural characterization of a diacyltaurolipid in cells of Tetrahymena mimbres. | 1988 | Biochim. Biophys. Acta | pmid:3132980 |
| Stein Y et al. | Intralysosomal hydrolysis of cholesterol esters of varying fatty acid composition in cultured human skin fibroblasts. | 1978 | Biochim. Biophys. Acta | pmid:698242 |
| Goto M et al. | Evidence for a correlation between swimming velocity and membrane fluidity of Tetrahymena cells. | 1982 | Biochim. Biophys. Acta | pmid:6818990 |
| Bonini de Romanelli IC et al. | Phosphatidic acid, phosphatidylinositol, phosphatidylserine and cardiolipin in the course of early embryonic development. Fatty acid composition and content in whole toad embryos and in mitochondrial fractions. | 1981 | Biochim. Biophys. Acta | pmid:6791698 |
| Yamauchi T et al. | Thermal adaptation of Tetrahymena membranes with special reference to mitochondria. Role of cardiolipin in fluidity of mitochondrial membranes. | 1981 | Biochim. Biophys. Acta | pmid:6797472 |
| Murakami C et al. | A novel DNA polymerase inhibitor and a potent apoptosis inducer: 2-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)-glyceride with stearic acid. | 2003 | Biochim. Biophys. Acta | pmid:12535613 |
| Whorton AR et al. | The metabolism of (1-14C) stearic acid in rat testicular tissue. | 1976 | Biochim. Biophys. Acta | pmid:1252481 |
| Chester DW et al. | The influence of saturated fatty acid modulation of bilayer physical state on cellular and membrane structure and function. | 1986 | Biochim. Biophys. Acta | pmid:3741857 |
| Schreiber R et al. | Retinyl ester hydrolases and their roles in vitamin A homeostasis. | 2012 | Biochim. Biophys. Acta | pmid:21586336 |
| Giacobino JP and Chmelar M | The role of chain elongation systems in the supplying of fatty acids to the adipocyte membrane lipids. | 1977 | Biochim. Biophys. Acta | pmid:861235 |
| AlegrÃa AE et al. | Semiquinones derived from anthraquinone-containing antitumor drugs can partition into phosphatidylcholine bilayers. | 1990 | Biochim. Biophys. Acta | pmid:2166575 |
| Kitagawa S et al. | Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. | 1990 | Biochim. Biophys. Acta | pmid:2166588 |
| Anel A et al. | Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. | 1990 | Biochim. Biophys. Acta | pmid:2114179 |
| Rich MR | Conformational analysis of arachidonic and related fatty acids using molecular dynamics simulations. | 1993 | Biochim. Biophys. Acta | pmid:8329458 |
| Husebye ES and Flatmark T | Characterization of phospholipase activities in chromaffin granule ghosts isolated from the bovine adrenal medulla. | 1987 | Biochim. Biophys. Acta | pmid:3607074 |
| Cevc G et al. | Phosphatidylcholine-fatty acid membranes. I. Effects of protonation, salt concentration, temperature and chain-length on the colloidal and phase properties of mixed vesicles, bilayers and nonlamellar structures. | 1988 | Biochim. Biophys. Acta | pmid:2835979 |
| Masuzawa Y et al. | Distribution of dietary trans-octadecenoate among acyl-CoA and other lipid fractions of rat liver and heart. | 1987 | Biochim. Biophys. Acta | pmid:3593750 |
| Kedryna T et al. | Pyruvate kinase from cytosolic fractions of the Ehrlich ascites tumour, normal mouse liver and skeletal muscle. | 1990 | Biochim. Biophys. Acta | pmid:2354196 |
| Morimoto K and Kanoh H | The role of the de novo synthetic pathway in forming molecular species of phospholipids in resting lymphocytes from human tonsils. | 1980 | Biochim. Biophys. Acta | pmid:7353023 |
| Shires SE et al. | Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. | 1989 | Biochim. Biophys. Acta | pmid:2493807 |
| Skrede S et al. | The effects of alkylthioacetic acids (3-thia fatty acids) on fatty acid metabolism in isolated hepatocytes. | 1989 | Biochim. Biophys. Acta | pmid:2804058 |
| Privat JP et al. | Incorporation of spin-labeled fatty acids into bovine brain clathrin coated vesicles. | 1990 | Biochim. Biophys. Acta | pmid:2158352 |
| ELSBACH P | COMPARISON OF UPTAKE OF PALMITIC, STEARIC, OLEIC AND LINOLEIC ACID BY POLYMORPHONUCLEAR LEUKOCYTES. | 1964 | Biochim. Biophys. Acta | pmid:14124760 |
| Prasinou P et al. | Fatty acid-based lipidomics and membrane remodeling induced by apoE3 and apoE4 in human neuroblastoma cells. | 2017 | Biochim Biophys Acta Biomembr | pmid:28688796 |
| Malykh EV et al. | Effect of hydrophobization of basic pancreatic proteinase inhibitor on the inhibition of bovine trypsin and human leukocyte elastase. | 1998 | Biochemistry Mosc. | pmid:9864442 |
| Narayanan VS and Storch J | Fatty acid transfer in taurodeoxycholate mixed micelles. | 1996 | Biochemistry | pmid:8652524 |
| Negash S et al. | Phosphorylation of phospholamban by cAMP-dependent protein kinase enhances interactions between Ca-ATPase polypeptide chains in cardiac sarcoplasmic reticulum membranes. | 1996 | Biochemistry | pmid:8784178 |
| Huber AH et al. | Fatty acid-specific fluorescent probes and their use in resolving mixtures of unbound free fatty acids in equilibrium with albumin. | 2006 | Biochemistry | pmid:17128966 |
| Feix JB et al. | Interactions of 14N:15N stearic acid spin-label pairs: effects of host lipid alkyl chain length and unsaturation. | 1987 | Biochemistry | pmid:2820479 |
| Bach R et al. | Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine. | 1988 | Biochemistry | pmid:3166978 |
| Wu F and Gaffney BJ | Dynamic behavior of fatty acid spin labels within a binding site of soybean lipoxygenase-1. | 2006 | Biochemistry | pmid:17029406 |
| Hamilton KS et al. | Glycosphingolipid backbone conformation and behavior in cholesterol-containing phospholipid bilayers. | 1993 | Biochemistry | pmid:8471610 |
| Mantipragada SB et al. | Lipid-protein interactions and effect of local anesthetics in acetylcholine receptor-rich membranes from Torpedo marmorata electric organ. | 2003 | Biochemistry | pmid:12885251 |
| Pohl EE et al. | Changes of intrinsic membrane potentials induced by flip-flop of long-chain fatty acids. | 2000 | Biochemistry | pmid:10677234 |
| Huang G et al. | Identification of the thiol ester linked lipids in apolipoprotein B. | 1988 | Biochemistry | pmid:3365394 |
| Perkins RC et al. | Equilibrium binding of spin-labeled fatty acids to bovine serum albumin: suitability as surrogate ligands for natural fatty acids. | 1982 | Biochemistry | pmid:6289869 |
| Feix JB et al. | An electron-electron double-resonance study of interactions between [14N]- and [15N]stearic acid spin-label pairs: lateral diffusion and vertical fluctuations in dimyristoylphosphatidylcholine. | 1984 | Biochemistry | pmid:6329270 |
| Murate M et al. | Phosphatidylglucoside forms specific lipid domains on the outer leaflet of the plasma membrane. | 2010 | Biochemistry | pmid:20433166 |
| Wolf BA et al. | Secretagogue-induced diacylglycerol accumulation in isolated pancreatic islets. Mass spectrometric characterization of the fatty acyl content indicates multiple mechanisms of generation. | 1989 | Biochemistry | pmid:2504278 |
| HIRSHFIELD IN and KORITZ SB | THE STIMULATION OF PREGNENOLONE SYNTHESIS IN THE LARGE PARTICLES FROM RAT ADRENALS BY SOME AGENTS WHICH CAUSE MITOCHONDRIAL SWELLING. | 1964 | Biochemistry | pmid:14269324 |
| Zornetzer GA et al. | Solution structures of spinach acyl carrier protein with decanoate and stearate. | 2006 | Biochemistry | pmid:16618110 |
| Gomez GA et al. | Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. | 2004 | Biochemistry | pmid:15096040 |
| Mogelson S and Lange LG | Nonoxidative ethanol metabolism in rabbit myocardium: purification to homogeneity of fatty acyl ethyl ester synthase. | 1984 | Biochemistry | pmid:6487591 |
| Iot T et al. | Synthesis of a new phosphatidylserine spin-label and calcium-induced lateral phase separation in phosphatidylserine-phosphatidylcholine membranes. | 1975 | Biochemistry | pmid:167814 |
| Ramanadham S et al. | Mass spectrometric characterization of arachidonate-containing plasmalogens in human pancreatic islets and in rat islet beta-cells and subcellular membranes. | 1993 | Biochemistry | pmid:8257685 |