stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Decalcification, Pathologic D003649 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


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Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Torres A et al. Characterization of surface n-alkanes and fatty acids of the epiphytic lichen Xanthoria parietina, its photobiont a green alga Trebouxia sp., and its mycobiont, from the Jerusalem hills. 2003 Eur. J. Biochem. pmid:12752431
Garzón Serra Mde L and Villafuerte Robles L Compactibility of agglomerated mixtures of calcium carbonate and microcrystalline cellulose. 2003 Int J Pharm pmid:12753762
Planinsek O and Buckton G Inverse gas chromatography: considerations about appropriate use for amorphous and crystalline powders. 2003 J Pharm Sci pmid:12761817
Lo YL Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines. 2003 J Control Release pmid:12767705
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Bulotta A et al. GLP-1 stimulates glucose-derived de novo fatty acid synthesis and chain elongation during cell differentiation and insulin release. 2003 J. Lipid Res. pmid:12777469
Ogwal S and Xide TU Bioavailability and stability of erythromycin delayed release tablets. 2001 Afr Health Sci pmid:12789122
Wu PC et al. Design and evaluation of sustained release microspheres of potassium chloride prepared by Eudragit. 2003 Eur J Pharm Sci pmid:12791413
Tholstrup T et al. Difference in effect of myristic and stearic acid on plasma HDL cholesterol within 24 h in young men. 2003 Eur J Clin Nutr pmid:12792657
Brunengraber DZ et al. Influence of diet on the modeling of adipose tissue triglycerides during growth. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:12799315
del Carmen Ramírez-Medeles M et al. Amino acid sequence, biochemical characterization, and comparative modeling of a nonspecific lipid transfer protein from Amaranthus hypochondriacus. 2003 Arch. Biochem. Biophys. pmid:12801509
Wu PC et al. Preparation and evaluation of sustained release microspheres of potassium chloride prepared with ethylcellulose. 2003 Int J Pharm pmid:12818816
Mittendorfer B et al. What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean? 2003 Diabetes pmid:12829627
Yang L et al. Peroxisome proliferator-activated receptor gamma and ligands inhibit surfactant protein B gene expression in the lung. 2003 J. Biol. Chem. pmid:12829715
McNamara S et al. Effect of offering rumen-protected fat supplements on fertility and performance in spring-calving Holstein-Friesian cows. 2003 Anim. Reprod. Sci. pmid:12853178
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Mantipragada SB et al. Lipid-protein interactions and effect of local anesthetics in acetylcholine receptor-rich membranes from Torpedo marmorata electric organ. 2003 Biochemistry pmid:12885251
Duong NH et al. A homogeneity study using NIR spectroscopy: tracking magnesium stearate in Bohle bin-blender. 2003 Drug Dev Ind Pharm pmid:12889786
Ceschel GC et al. Degradation of components in drug formulations: a comparison between HPLC and DSC methods. 2003 J Pharm Biomed Anal pmid:12899995
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Mashek DG and Grummer RR Effects of long chain fatty acids on lipid and glucose metabolism in monolayer cultures of bovine hepatocytes. 2003 J. Dairy Sci. pmid:12906057
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Lyon RC et al. Near-infrared spectral imaging for quality assurance of pharmaceutical products: analysis of tablets to assess powder blend homogeneity. 2002 AAPS PharmSciTech pmid:12916932
Swaminathan V and Kildsig DO Effect of magnesium stearate on the content uniformity of active ingredient in pharmaceutical powder mixtures. 2002 AAPS PharmSciTech pmid:12916934
Muzíková J and Horácek J [The dry binders, Vivapur 102, Vivapur 12 and the effect of magnesium stearate on the strength of tablets containing these substances]. 2003 Ceska Slov Farm pmid:12924068
Ohta KM et al. Effect of geometric structure and surface wettability of glidant on tablet hardness. 2003 Int J Pharm pmid:12927389
Bracconi P et al. Structural properties of magnesium stearate pseudopolymorphs: effect of temperature. 2003 Int J Pharm pmid:12927393
El-Assaad W et al. Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. 2003 Endocrinology pmid:12933690
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Kajikawa M et al. MpFAE3, a beta-ketoacyl-CoA synthase gene in the liverwort Marchantia polymorpha L., is preferentially involved in elongation of palmitic acid to stearic acid. 2003 Biosci. Biotechnol. Biochem. pmid:12951498
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DOXIADIS SA Procaine penicillin with aluminium monostearate; infrequent injections for children. 1953 Lancet pmid:13085786
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SHAFER JK and SMITH CA Treatment of early infectious syphilis with N,N'-dibenzylethylenediamine dipenicillin G; a second report. 1954 Bull. World Health Organ. pmid:13182589
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SCRIBANTE P and FAVARGER P [Studies on digestibility of stearic acid and its glyceric esters in rat]. 1954 Helv Physiol Pharmacol Acta pmid:13201008
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