| MeSH term | MeSH ID | Detail |
|---|---|---|
| Obesity, Abdominal | D056128 | 3 associated lipids |
stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with stearic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with stearic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Evoli S et al. | Molecular simulations of β-lactoglobulin complexed with fatty acids reveal the structural basis of ligand affinity to internal and possible external binding sites. | 2014 | Proteins | pmid:24916607 |
| Loften JR et al. | Invited review: palmitic and stearic acid metabolism in lactating dairy cows. | 2014 | J. Dairy Sci. | pmid:24913651 |
| Shah RM et al. | Physicochemical characterization of solid lipid nanoparticles (SLNs) prepared by a novel microemulsion technique. | 2014 | J Colloid Interface Sci | pmid:24910064 |
| Park KH et al. | Elaidic acid (EA) generates dysfunctional high-density lipoproteins and consumption of EA exacerbates hyperlipidemia and fatty liver change in zebrafish. | 2014 | Mol Nutr Food Res | pmid:24863413 |
| Li N et al. | Function of SREBP1 in the milk fat synthesis of dairy cow mammary epithelial cells. | 2014 | Int J Mol Sci | pmid:25250914 |
| Shen MC et al. | Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice. | 2014 | PLoS ONE | pmid:25222131 |
| MuzÃková J et al. | A study of micronized poloxamers as lubricants in direct compression of tablets. | 2013 Nov-Dec | Acta Pol Pharm | pmid:24383332 |
| Aljaberi A et al. | Understanding and optimizing the dual excipient functionality of sodium lauryl sulfate in tablet formulation of poorly water soluble drug: wetting and lubrication. | 2013 Mar-Apr | Pharm Dev Technol | pmid:23009028 |
| Kushner J | Utilizing quantitative certificate of analysis data to assess the amount of excipient lot-to-lot variability sampled during drug product development. | 2013 Mar-Apr | Pharm Dev Technol | pmid:21877870 |
| Hussain T et al. | Effect of two hydrophobic polymers on the release of gliclazide from their matrix tablets. | 2013 Jul-Aug | Acta Pol Pharm | pmid:23923399 |
| MuzÃková J and Sináglová P | Comparison of properties of tablets and energy profile of compaction of two spray-dried lactoses. | 2013 Jan-Feb | Acta Pol Pharm | pmid:23610968 |
| Ruddle P et al. | Effect of a novel mutation in a Δ9-stearoyl-ACP-desaturase on soybean seed oil composition. | 2013 | Theor. Appl. Genet. | pmid:22961205 |
| Chu X et al. | Sterol regulatory element-binding protein-1c mediates increase of postprandial stearic acid, a potential target for improving insulin resistance, in hyperlipidemia. | 2013 | Diabetes | pmid:22966071 |
| Hu FQ et al. | Effective antitumor gene therapy delivered by polyethylenimine-conjugated stearic acid-g-chitosan oligosaccharide micelles. | 2013 | Gene Ther. | pmid:22951455 |
| Leskinen JT et al. | Real-time tablet formation monitoring with ultrasound measurements in eccentric single station tablet press. | 2013 | Int J Pharm | pmid:22985771 |
| Němcová-Fürstová V et al. | Caspase-2 and JNK activated by saturated fatty acids are not involved in apoptosis induction but modulate ER stress in human pancreatic β-cells. | 2013 | Cell. Physiol. Biochem. | pmid:23466956 |
| Sovány T et al. | Application of physicochemical properties and process parameters in the development of a neural network model for prediction of tablet characteristics. | 2013 | AAPS PharmSciTech | pmid:23413109 |
| Mirani ZA and Jamil N | Role of extra-cellular fatty acids in vancomycin induced biofilm formation by vancomycin resistant Staphylococcus aureus. | 2013 | Pak J Pharm Sci | pmid:23455211 |
| Vervaeck A et al. | Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms. | 2013 | Eur J Pharm Biopharm | pmid:23474381 |
| Risley DS et al. | Analysis of magnesium from magnesium stearate in pharmaceutical tablet formulations using hydrophilic interaction liquid chromatography with nano quantity analyte detection. | 2013 | J Pharm Biomed Anal | pmid:23474810 |
| Zamora-Rojas E et al. | Prediction of fatty acids content in pig adipose tissue by near infrared spectroscopy: at-line versus in-situ analysis. | 2013 | Meat Sci. | pmid:23793086 |
| Song W et al. | Importance of size and distribution of Ni nanoparticles for the hydrodeoxygenation of microalgae oil. | 2013 | Chemistry | pmid:23794421 |
| Qi B et al. | A Golgi and tonoplast localized S-acyl transferase is involved in cell expansion, cell division, vascular patterning and fertility in Arabidopsis. | 2013 | New Phytol. | pmid:23795888 |
| Podczeck F et al. | Investigations into the tensile failure of doubly-convex cylindrical tablets under diametral loading using finite element methodology. | 2013 | Int J Pharm | pmid:23834836 |
| Wang N et al. | The mechanism of hydrogen sulfide adsorption on fine rubber particle media (FRPM). | 2013 | J. Hazard. Mater. | pmid:23876257 |
| Ogata F et al. | Study on analysis of waste edible oil with deterioration and removal of acid value, carbonyl value, and free fatty acid by a food additive (calcium silicate). | 2013 | J Oleo Sci | pmid:23391535 |
| Ishida Y et al. | Fatty acid solubilizer from the oral disk of the blowfly. | 2013 | PLoS ONE | pmid:23326317 |
| Sharma P et al. | Structural insights into the dual strategy of recognition by peptidoglycan recognition protein, PGRP-S: structure of the ternary complex of PGRP-S with lipopolysaccharide and stearic acid. | 2013 | PLoS ONE | pmid:23326499 |
| Tükel S et al. | Optimization of lipase-catalyzed synthesis of fructose stearate using response surface methodology. | 2013 | Artif Cells Nanomed Biotechnol | pmid:23305558 |
| Lee W et al. | Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress. | 2013 | J. Biol. Chem. | pmid:23306194 |
| Wu JH et al. | Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. | 2013 | Circ Cardiovasc Genet | pmid:23362303 |
| Arukuusk P et al. | New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids. | 2013 | Biochim. Biophys. Acta | pmid:23357356 |
| Järvinen K et al. | In-line monitoring of the drug content of powder mixtures and tablets by near-infrared spectroscopy during the continuous direct compression tableting process. | 2013 | Eur J Pharm Sci | pmid:23313622 |
| Zhou QT et al. | Effect of surface coating with magnesium stearate via mechanical dry powder coating approach on the aerosol performance of micronized drug powders from dry powder inhalers. | 2013 | AAPS PharmSciTech | pmid:23196863 |
| Van Hoeck V et al. | Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights. | 2013 | Reproduction | pmid:23108110 |
| Negi JS et al. | Development of solid lipid nanoparticles (SLNs) of lopinavir using hot self nano-emulsification (SNE) technique. | 2013 | Eur J Pharm Sci | pmid:23153618 |
| Kumar N et al. | Salt dependent stability of stearic acid Langmuir-Blodgett films exposed to aqueous electrolytes. | 2013 | Langmuir | pmid:23565719 |
| Han SH et al. | Bioinspired self-assembled peptide nanofibers with thermostable multivalent α-helices. | 2013 | Biomacromolecules | pmid:23550841 |
| Khan AA et al. | Design, synthesis and in vitro anticancer evaluation of a stearic acid-based ester conjugate. | 2013 | Anticancer Res. | pmid:23749903 |
| Li C et al. | Enhanced performance and interfacial investigation of mineral-based composite phase change materials for thermal energy storage. | 2013 | Sci Rep | pmid:23712069 |
| Lakio S et al. | Challenges in detecting magnesium stearate distribution in tablets. | 2013 | AAPS PharmSciTech | pmid:23378252 |
| Järvinen MA et al. | Continuous direct tablet compression: effects of impeller rotation rate, total feed rate and drug content on the tablet properties and drug release. | 2013 | Drug Dev Ind Pharm | pmid:23163644 |
| Schrank S et al. | Microstructure of calcium stearate matrix pellets: a function of the drying process. | 2013 | J Pharm Sci | pmid:23983150 |
| Yang C et al. | Production of aviation fuel via catalytic hydrothermal decarboxylation of fatty acids in microalgae oil. | 2013 | Bioresour. Technol. | pmid:23973977 |
| Boshtam M et al. | Serum paraoxonase 1 activity is associated with fatty acid composition of high density lipoprotein. | 2013 | Dis. Markers | pmid:24167374 |
| Shibata E et al. | Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt. | 2013 | Cell. Physiol. Biochem. | pmid:24107614 |
| Zhang W et al. | Stearylated antimicrobial peptide melittin and its retro isomer for efficient gene transfection. | 2013 | Bioconjug. Chem. | pmid:24107137 |
| Neupane YR et al. | Lipid drug conjugate nanoparticle as a novel lipid nanocarrier for the oral delivery of decitabine: ex vivo gut permeation studies. | 2013 | Nanotechnology | pmid:24061410 |
| Yan J et al. | Effect of proteins with different isoelectric points on the gene transfection efficiency mediated by stearic acid grafted chitosan oligosaccharide micelles. | 2013 | Mol. Pharm. | pmid:23679858 |
| Kwan HY et al. | The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells. | 2013 | J. Gastroenterol. | pmid:22722903 |