stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Butzler JP et al. | Clinical and pharmacological evaluation of different preparations of oral erythromycin. | 1979 | Chemotherapy | pmid:316377 |
Colmano G et al. | Activated silver coatings for surgical implants. | 1979 | Va Med | pmid:316624 |
Dunlop EM et al. | Penicillin levels in blood and CSF achieved by treatment of syphilis. | 1979 | JAMA | pmid:374763 |
Malmborg AS | Effect of food on absorption of erythromycin. A study of two derivatives, the stearate and the base. | 1979 | J. Antimicrob. Chemother. | pmid:500517 |
Wosilait WD and Ryan MP | The effects of oleic acid, tolbutamide, and oxyphenbutazone on the binding of warfarin by human serum albumin. | 1979 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:504792 |
Rutland J et al. | The influence of food on the bioavailability of new formulations of erythromycin stearate and base. | 1979 | Br J Clin Pharmacol | pmid:508509 |
Yakatan GJ et al. | Single-dose fasting bioequivalence assessment of erythromycin stearate tablets in man. | 1979 | J Pharmacokinet Biopharm | pmid:512842 |
Molloy PL and Eisenstadt JM | Erythromycin resistance in mouse L cells. | 1979 | Somatic Cell Genet. | pmid:531731 |
Nicoletti R et al. | [Palmitic acid-stearic acid ratio with reference to the fatty tissue properties in the human species]. | 1979 May-Jun | Arch Kriminol | pmid:573992 |
Pinzauti S and La Porta E | Assay of a cetylpyridinium-dequalinium chlorides combination in compressed lozenges: uptake of quaternary ammonium salts by magnesium stearate. | 1979 Sep-Oct | J Pharm Belg | pmid:512830 |
Sanders KL et al. | Relapse of Legionnaires' disease in a renal transplant recipient. | 1980 | Arch. Intern. Med. | pmid:6992727 |
Fraser DG | Selection of an oral erythromycin product. | 1980 | Am J Hosp Pharm | pmid:6998290 |
Selenke WM et al. | Nonantibiotic effects of macrolide antibiotics of the oleandomycin-erythromycin group with special reference to their "steroid-sparing" effects. | 1980 | J. Allergy Clin. Immunol. | pmid:6966289 |
Hambleton PL et al. | Dietary fat and exercise conditioning effect on metabolic parameters in the horse. | 1980 | J. Anim. Sci. | pmid:7204274 |
Nakagawa H et al. | [Effects of particle size of rifampicin and addition of magnesium stearate on release of rifampicin from hard gelatin capsules (author's transl)]. | 1980 | Yakugaku Zasshi | pmid:7205556 |
Wenzel DG and Kleoppel JW | Incorporation of saturated and cis- and trans-unsaturated long chain fatty acids in rat myocytes and increased susceptibility to arrhythmias. | 1980 | Toxicology | pmid:7210021 |
Oriel JD and Ridgway GL | Comparison of erythromycin and oxytetracycline in the treatment of cervical infection by Chlamydia trachomatis. | 1980 | J. Infect. | pmid:7185927 |
Chien JL and Hogan EL | Characterization of two gangliosides of the paragloboside series from chicken skeletal muscle. | 1980 | Biochim. Biophys. Acta | pmid:7236652 |
Jordan BR and Harwood JL | Fatty acid elongation by a particulate fraction from germinating pea. | 1980 | Biochem. J. | pmid:7283974 |
Thompson SE et al. | Gonococcal tenosynovitis-dermatitis and septic arthritis. Intravenous penicillin vs oral erythromycin. | 1980 | JAMA | pmid:7411761 |
Baker RR and Chang H | The fatty acid composition of lipids of neuronal and glial nuclear fractions isolated from 15-day-old rabbit cerebral cortex. | 1980 | Can. J. Biochem. | pmid:6161681 |
Hyono A et al. | ESR studies on the membrane properties of a moderately halophilic bacterium. I. Physical properties of lipid bilayers in whole cells. | 1980 | J. Biochem. | pmid:6257661 |
Pollard MR and Stumpf PK | Biosynthesis of C(20) and C(22) Fatty Acids by Developing Seeds of Limnanthes alba: CHAIN ELONGATION AND Delta5 DESATURATION. | 1980 | Plant Physiol. | pmid:16661496 |
Udeala OK et al. | Preliminary evaluation of dika fat, a new tablet lubricant. | 1980 | J. Pharm. Pharmacol. | pmid:6102130 |
Clarke CW et al. | A new formulation of erythromycin stearate: blood and sputum levels in patients with chronic lower respiratory tract infection. | 1980 | J. Antimicrob. Chemother. | pmid:7400071 |
Matocha M and Wood R | Changes in host animal plasma lipids during hepatoma growth. | 1980 | Lipids | pmid:7401940 |
Holub BJ et al. | Relative suitability of 1-palmitoyl and 1-stearoyl homologues of 1-acyl-sn-glycerylphosphorylcholine and different acyl donors for phosphatidylcholine synthesis via acyl-CoA:1-acyl-sn-glycero-3-phosphorylcholine acyltransferase in rat lung microsomes. | 1980 | Can. J. Biochem. | pmid:7407680 |
Morimoto K and Kanoh H | The role of the de novo synthetic pathway in forming molecular species of phospholipids in resting lymphocytes from human tonsils. | 1980 | Biochim. Biophys. Acta | pmid:7353023 |
Shepherd J et al. | Effects of saturated and polyunsaturated fat diets on the chemical composition and metabolism of low density lipoproteins in man. | 1980 | J. Lipid Res. | pmid:7354257 |
Wood R et al. | Effect of methyl 2-hexadecynoate on hepatic fatty acid metabolism. | 1980 | Lipids | pmid:7374364 |
Herrmann H and Gercken G | Incorporation of [1-14C]octadecanol into the lipids of Leishmania donovani. | 1980 | Lipids | pmid:7374369 |
Craven PA et al. | Calcium-dependent action of osmolality on adenosine 3',5'-monophosphate accumulation in rat renal inner medulla: evidence for a relationship to calcium-responsive arachidonate release and prostaglandin synthesis. | 1980 | J. Clin. Invest. | pmid:6243313 |
Marlin GE et al. | Plasma and sputum erythromycin concentrations in chronic bronchitis. | 1980 | Thorax | pmid:7434299 |
Søndergaard D et al. | Magnesium stearate given perorally to rats. A short term study. | 1980 | Toxicology | pmid:7434368 |
Colmano G et al. | Activation of antibacterial silver coatings on surgical implants by direct current: preliminary studies in rabbits. | 1980 | Am. J. Vet. Res. | pmid:7436092 |
Jaffe JH et al. | Abuse potential of loperamide. | 1980 | Clin. Pharmacol. Ther. | pmid:7438696 |
Polnikorn N et al. | Penicillin concentrations in cerebrospinal fluid after different treatment regimens for syphilis. | 1980 | Br J Vener Dis | pmid:7448578 |
Stavchansky S et al. | Correlation of in vivo bioavailability of erythromycin stearate tablets with in vitro tests. | 1980 | J Pharm Sci | pmid:7452460 |
Kaur R et al. | Comparison of polyethylene glycol and polyoxyethylene stearate as excipients for solid dispersion systems of griseofulvin and tolbutamide I: phase equilibria. | 1980 | J Pharm Sci | pmid:7452463 |
Kaur R et al. | Comparison of polyethylene glycol and polyoxyethylene stearate as excipients for solid dispersion systems of griseofulvin and tolbutamide II: dissolution and solubility studies. | 1980 | J Pharm Sci | pmid:7452464 |
Light ND and Bailey AJ | Polymeric C-terminal cross-linked material from type-I collagen. A modified method for purification, anomalous behaviour on gel filtration, molecular weight estimation, carbohydrate content and lipid content. | 1980 | Biochem. J. | pmid:7458897 |
McGimpsey JG et al. | Comparison of serum erythromycin concentration following administration of 100 mg erythromycin ethyl succinate intramuscularly and 500 mg erythromycin stearate orally. | 1981 | Int J Oral Surg | pmid:6807878 |
Naggar VF | An in vitro study of the interaction between diazepam and some antacid or excipients. | 1981 | Pharmazie | pmid:7232481 |
Holub BJ | The suitability of different acyl acceptors as substrates for the acyl-Coa : 2-acyl-sn-glycero-3-phosphorylcholine acyltransferase in rat liver microsomes. | 1981 | Biochim. Biophys. Acta | pmid:7248321 |
Iliopoulou A et al. | Fluorimetric and microbiological assays of erythromycin concentrations in plasma and vaginal washings. | 1981 | Br J Vener Dis | pmid:7272705 |
Walzthöny D et al. | Ice crystals specifically decorate hydrophilic sites on freeze-fractured models membranes. | 1981 | Ultramicroscopy | pmid:7281365 |
Haley K et al. | Optimal milk penicillin levels for the treatment of experimentally induced mastitis in cows. | 1981 | Can. J. Comp. Med. | pmid:7340909 |
Branigan TA et al. | The effects of erythromycin on the absorption and disposition of kinetics of theophylline. | 1981 | Eur. J. Clin. Pharmacol. | pmid:7341279 |
Prescott SM and Majerus PW | The fatty acid composition of phosphatidylinositol from thrombin-stimulated human platelets. | 1981 | J. Biol. Chem. | pmid:7451460 |
Bleeker J et al. | Effect of systemic erythromycin stearate on the inflammatory lesions and skin surface fatty acids in acne vulgaris. | 1981 | Dermatologica | pmid:6454598 |