stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Vega Mercado F et al. | Modulation of the domain topography of biphasic monolayers of stearic acid and dimyristoyl phosphatidylcholine. | 2012 | Chem. Phys. Lipids | pmid:22274694 |
Morales A et al. | Quantitative analysis of hydroperoxy-, keto- and hydroxy-dienes in refined vegetable oils. | 2012 | J Chromatogr A | pmid:22321954 |
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Ahn BJ et al. | Solvent-free acid-catalyzed ring-opening of epoxidized oleochemicals using stearates/stearic acid, and its applications. | 2012 | J. Agric. Food Chem. | pmid:22304525 |
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Li D et al. | Ruminal microbe of biohydrogenation of trans-vaccenic acid to stearic acid in vitro. | 2012 | BMC Res Notes | pmid:22336099 |
Lee AL and Kim CB | The effect of erythromycin on gastrointestinal motility in subtotal gastrectomized patients. | 2012 | J Korean Surg Soc | pmid:22403748 |
Visioli F et al. | Molecular targets of omega 3 and conjugated linoleic Fatty acids - "micromanaging" cellular response. | 2012 | Front Physiol | pmid:22393325 |
Qu J et al. | Development of marker-free transgenic Jatropha plants with increased levels of seed oleic acid. | 2012 | Biotechnol Biofuels | pmid:22377043 |
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Sampey BP et al. | Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. | 2012 | PLoS ONE | pmid:22701716 |
Severino P et al. | Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. | 2012 | J Drug Deliv | pmid:22175030 |
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Kottala N et al. | Influence of compaction properties and interfacial topography on the performance of bilayer tablets. | 2012 | Int J Pharm | pmid:22728259 |
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Xie YT et al. | Brain-targeting study of stearic acid-grafted chitosan micelle drug-delivery system. | 2012 | Int J Nanomedicine | pmid:22802685 |
El Semary NA | The antimicrobial profile of extracts of a Phormidium-like cyanobacterium changes with phosphate levels. | 2012 | World J. Microbiol. Biotechnol. | pmid:22806854 |
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Jubie S et al. | Synthesis, antidepressant and antimicrobial activities of some novel stearic acid analogues. | 2012 | Eur J Med Chem | pmid:22770606 |
Galvao TF et al. | High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despite persistent mitochondrial defects. | 2012 | Cardiovasc. Res. | pmid:21960686 |
Tumen I et al. | A therapeutic approach for wound healing by using essential oils of cupressus and juniperus species growing in Turkey. | 2012 | Evid Based Complement Alternat Med | pmid:21941588 |
Zhang ZH et al. | Solid lipid nanoparticles modified with stearic acid-octaarginine for oral administration of insulin. | 2012 | Int J Nanomedicine | pmid:22848162 |
Liu J et al. | Stearoyl-acyl carrier protein desaturase gene from the oleaginous microalga Chlorella zofingiensis: cloning, characterization and transcriptional analysis. | 2012 | Planta | pmid:22855030 |
Carol D et al. | Synergistic effect of calcium stearate and photo treatment on the rate of biodegradation of low density polyethylene spent saline vials. | 2012 | Indian J. Exp. Biol. | pmid:22822530 |
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Hu FQ et al. | pH triggered doxorubicin delivery of PEGylated glycolipid conjugate micelles for tumor targeting therapy. | 2012 | Mol. Pharm. | pmid:22827551 |
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Lou CW et al. | PLA/ β-TCP complex tubes: the mechanical properties and applications of artificial bone. | 2012 | J Biomater Sci Polym Ed | pmid:21968651 |
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Osmond G et al. | Metal stearate distributions in modern artists' oil paints: surface and cross-sectional investigation of reference paint films using conventional and synchrotron infrared microspectroscopy. | 2012 | Appl Spectrosc | pmid:23031696 |
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Pijls BG et al. | Differences in long-term fixation between mobile-bearing and fixed-bearing knee prostheses at ten to 12 years' follow-up: a single-blinded randomised controlled radiostereometric trial. | 2012 | J Bone Joint Surg Br | pmid:23015562 |
Guzzi R et al. | Dynamics and binding affinity of spin-labeled stearic acids in β-lactoglobulin: evidences from EPR spectroscopy and molecular dynamics simulation. | 2012 | J Phys Chem B | pmid:22950964 |
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Suo T et al. | Fixed-point and stratified analysis of the fine structure and composition of five gallstones with Fourier transform infrared (FT-IR) specular reflection spectroscopy. | 2012 | Microsc. Res. Tech. | pmid:21809418 |
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Smathers RL et al. | Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics. | 2012 | PLoS ONE | pmid:22701647 |
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