stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sun GY | Metabolism of arachidonate and stearate injected simultaneously into the mouse brain. | 1977 | Lipids | pmid:895416 |
Awad AB et al. | The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. | 1996 | Cancer Lett. | pmid:8950205 |
Kankofer M et al. | The analysis of fatty acid content and phospholipase A2 activity in placenta of cows with and without retained fetal membranes. | 1996 | Zentralbl Veterinarmed A | pmid:8940891 |
Kole HK et al. | A synthetic peptide derived from a COOH-terminal domain of the insulin receptor specifically enhances insulin receptor signaling. | 1996 | J. Biol. Chem. | pmid:8940181 |
Peck MD et al. | Association of murine splenocyte CD3 complex to the cytoskeleton: absence of modulation by exogenous fatty acids. | 1996 | Cell Biol. Int. | pmid:8938986 |
Halliwell KJ et al. | Release of individual fatty acids from human adipose tissue in vivo after an overnight fast. | 1996 | J. Lipid Res. | pmid:8895050 |
Peck MD et al. | Fatty acid unsaturation increases expression and capping of murine lymphocyte CD44 and CD45. | 1996 | Nutrition | pmid:8878171 |
Wargo DJ and Drennen JK | Near-infrared spectroscopic characterization of pharmaceutical powder blends. | 1996 | J Pharm Biomed Anal | pmid:8877847 |
Murkovic M et al. | Variability of fatty acid content in pumpkin seeds (Cucurbita pepo L.). | 1996 | Z Lebensm Unters Forsch | pmid:8873459 |
Uchida T et al. | Microencapsulation of ovalbumin in poly(lactide-co-glycolide) by an oil-in-oil (o/o) solvent evaporation method. | 1996 Sep-Oct | J Microencapsul | pmid:8864988 |