stearic acid
stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with stearic acid?
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with stearic acid
PubChem Associated disorders and diseases
What pathways are associated with stearic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with stearic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with stearic acid?
Related references are published most in these journals:
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What lipids are associated with stearic acid?
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What genes are associated with stearic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with stearic acid?
Knock-out
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
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NCBI Entrez Crosslinks
All references with stearic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Narayanan VS and Storch J | Fatty acid transfer in taurodeoxycholate mixed micelles. | 1996 | Biochemistry | pmid:8652524 |
| Noy N and Zakim D | Fatty acids bound to unilamellar lipid vesicles as substrates for microsomal acyl-CoA ligase. | 1985 | Biochemistry | pmid:2931113 |
| Rich MR and Evans JS | Molecular dynamics simulations of adipocyte lipid-binding protein: effect of electrostatics and acyl chain unsaturation. | 1996 | Biochemistry | pmid:8634281 |
| Negash S et al. | Phosphorylation of phospholamban by cAMP-dependent protein kinase enhances interactions between Ca-ATPase polypeptide chains in cardiac sarcoplasmic reticulum membranes. | 1996 | Biochemistry | pmid:8784178 |
| Huber AH et al. | Fatty acid-specific fluorescent probes and their use in resolving mixtures of unbound free fatty acids in equilibrium with albumin. | 2006 | Biochemistry | pmid:17128966 |
| Wu F and Gaffney BJ | Dynamic behavior of fatty acid spin labels within a binding site of soybean lipoxygenase-1. | 2006 | Biochemistry | pmid:17029406 |
| Hamilton KS et al. | Glycosphingolipid backbone conformation and behavior in cholesterol-containing phospholipid bilayers. | 1993 | Biochemistry | pmid:8471610 |
| Zornetzer GA et al. | The length of the bound fatty acid influences the dynamics of the acyl carrier protein and the stability of the thioester bond. | 2010 | Biochemistry | pmid:20014832 |
| Richieri GV et al. | Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions. | 2000 | Biochemistry | pmid:10852718 |
| Mantipragada SB et al. | Lipid-protein interactions and effect of local anesthetics in acetylcholine receptor-rich membranes from Torpedo marmorata electric organ. | 2003 | Biochemistry | pmid:12885251 |
| Huang G et al. | Identification of the thiol ester linked lipids in apolipoprotein B. | 1988 | Biochemistry | pmid:3365394 |
| Perkins RC et al. | Equilibrium binding of spin-labeled fatty acids to bovine serum albumin: suitability as surrogate ligands for natural fatty acids. | 1982 | Biochemistry | pmid:6289869 |
| Feix JB et al. | An electron-electron double-resonance study of interactions between [14N]- and [15N]stearic acid spin-label pairs: lateral diffusion and vertical fluctuations in dimyristoylphosphatidylcholine. | 1984 | Biochemistry | pmid:6329270 |
| Murate M et al. | Phosphatidylglucoside forms specific lipid domains on the outer leaflet of the plasma membrane. | 2010 | Biochemistry | pmid:20433166 |
| Pohl J et al. | Long-chain fatty acid uptake into adipocytes depends on lipid raft function. | 2004 | Biochemistry | pmid:15065861 |
| Woodward H et al. | Isolation, purification, and properties of respiratory mucus glycoproteins. | 1982 | Biochemistry | pmid:7074033 |
| Smaby JM and Brockman HL | Novel surface phase containing cholesteryl esters. 2. Nonequivalence of cholesteryl arachidonate and those with 18-carbon, cis-unsaturated acyl groups. | 1981 | Biochemistry | pmid:7213606 |
| Chen SC et al. | Calorimetric evidence for phase transitions in spin-label lipid bilayers. | 1982 | Biochemistry | pmid:7138849 |
| Wolf BA et al. | Secretagogue-induced diacylglycerol accumulation in isolated pancreatic islets. Mass spectrometric characterization of the fatty acyl content indicates multiple mechanisms of generation. | 1989 | Biochemistry | pmid:2504278 |
| Davis PJ et al. | Gel to liquid-crystalline transition temperatures of water dispersions of two pairs of positional isomers of unsaturated mixed-acid phosphatidylcholines. | 1981 | Biochemistry | pmid:7260060 |
| HIRSHFIELD IN and KORITZ SB | THE STIMULATION OF PREGNENOLONE SYNTHESIS IN THE LARGE PARTICLES FROM RAT ADRENALS BY SOME AGENTS WHICH CAUSE MITOCHONDRIAL SWELLING. | 1964 | Biochemistry | pmid:14269324 |
| Zornetzer GA et al. | Solution structures of spinach acyl carrier protein with decanoate and stearate. | 2006 | Biochemistry | pmid:16618110 |
| Horváth LI et al. | Exchange rates at the lipid-protein interface of myelin proteolipid protein studied by spin-label electron spin resonance. | 1988 | Biochemistry | pmid:2450570 |
| Gomez GA et al. | Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. | 2004 | Biochemistry | pmid:15096040 |
| Iot T et al. | Synthesis of a new phosphatidylserine spin-label and calcium-induced lateral phase separation in phosphatidylserine-phosphatidylcholine membranes. | 1975 | Biochemistry | pmid:167814 |
| Ramanadham S et al. | Mass spectrometric characterization of arachidonate-containing plasmalogens in human pancreatic islets and in rat islet beta-cells and subcellular membranes. | 1993 | Biochemistry | pmid:8257685 |
| Malykh EV et al. | Effect of hydrophobization of basic pancreatic proteinase inhibitor on the inhibition of bovine trypsin and human leukocyte elastase. | 1998 | Biochemistry Mosc. | pmid:9864442 |
| Prasinou P et al. | Fatty acid-based lipidomics and membrane remodeling induced by apoE3 and apoE4 in human neuroblastoma cells. | 2017 | Biochim Biophys Acta Biomembr | pmid:28688796 |
| Wheelan P and Clay KL | Albumin and fatty acid effects on the stimulated production of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) by human polymorphonuclear leukocytes. | 1992 | Biochim. Biophys. Acta | pmid:1511005 |
| CREASEY WA | Observations on the activation of stearic acid by rat-liver preparations. | 1962 | Biochim. Biophys. Acta | pmid:14023748 |
| Fitch CD et al. | A role for linoleic acid in erythrocytes infected with Plasmodium berghei. | 2000 | Biochim. Biophys. Acta | pmid:11113630 |
| Aspbury RA et al. | Fatty acylation of polypeptides in the nematode Caenorhabditis elegans. | 1998 | Biochim. Biophys. Acta | pmid:9507081 |
| Clandinin MT et al. | Omega-3 fatty acid intake results in a relationship between the fatty acid composition of LDL cholesterol ester and LDL cholesterol content in humans. | 1997 | Biochim. Biophys. Acta | pmid:9219909 |
| Thompson W and Belina H | Rapid accumulation of diacyl lipid in rat liver microsomes by selective acylation of 2-acyl-sn-glycero-3-phosphorylserine. | 1986 | Biochim. Biophys. Acta | pmid:3707975 |
| Kordyukova LV et al. | Linker and/or transmembrane regions of influenza A/Group-1, A/Group-2, and type B virus hemagglutinins are packed differently within trimers. | 2011 | Biochim. Biophys. Acta | pmid:21420932 |
| Walsh CE et al. | Mechanism of arachidonic acid release in human polymorphonuclear leukocytes. | 1983 | Biochim. Biophys. Acta | pmid:6402027 |
| Galpin JR and Allen JC | The influence of micelle formation on lipoxygenase kinetics. | 1977 | Biochim. Biophys. Acta | pmid:409436 |
| Bolton P and Harwood JL | Some characteristics of soluble fatty acid synthesis in germinating pea seeds. | 1977 | Biochim. Biophys. Acta | pmid:20971 |
| DAVIDOFF FF | THE METABOLISM OF 9(10)-HYDROXYSTEARIC ACID BY THE CELLULAR SLIME MOLD, DICTYOSTELIUM DISCOIDEUM. | 1964 | Biochim. Biophys. Acta | pmid:14220732 |
| Morgan H et al. | Proton transport at the monolayer-water interface. | 1991 | Biochim. Biophys. Acta | pmid:1848448 |
| Chien JL and Hogan EL | Characterization of two gangliosides of the paragloboside series from chicken skeletal muscle. | 1980 | Biochim. Biophys. Acta | pmid:7236652 |
| ANDERSON RL and TOVE SB | GLYCERIDE DISTRIBUTION OF FATTY ACIDS ASSIMILATED BY ADIPOSE TISSUE. | 1964 | Biochim. Biophys. Acta | pmid:14250489 |
| PASCAUD M | [THE PHOSPHOLIPIDS OF THE HEPATIC CELL. FUNCTIONAL INTERPRETATION OF THEIR RENEWAL. I. NATURE. SPECIFICITY OF THEIR CONSTITUTIVE FATTY ACIDS]. | 1964 | Biochim. Biophys. Acta | pmid:14250490 |
| DOBIASOVA M et al. | FATTY ACID COMPOSITION IN DEVELOPING RATS. FATTY ACID COMPOSITION OF TRIGLYCERIDES AND PHOSPHOLIPIDS IN SOME ORGANS OF THE RAT DURING POSTNATAL DEVELOPMENT. | 1964 | Biochim. Biophys. Acta | pmid:14250492 |
| WILLEBRANDS AF | UTILIZATION OF INDIVIDUAL NON-ESTERIFIED FATTY ACIDS BY THE ISOLATED PERFUSED RAT HEART. | 1964 | Biochim. Biophys. Acta | pmid:14250498 |
| Avdulov NA et al. | Lipid binding to sterol carrier protein-2 is inhibited by ethanol. | 1999 | Biochim. Biophys. Acta | pmid:9931423 |
| Kumar SS et al. | Synthesis and characterization of curcumin loaded polymer/lipid based nanoparticles and evaluation of their antitumor effects on MCF-7 cells. | 2014 | Biochim. Biophys. Acta | pmid:24440669 |
| Redgrave TG et al. | The condensing effects of egg lecithin and cholesterol on triolein monolayers are inhibited by substitution of one saturated acyl chain in the triacylglycerol. | 1994 | Biochim. Biophys. Acta | pmid:8117751 |
| Miller RW and De La Roche IA | Properties of spin labelled membranes of Fusarium oxysporum f. sp. lycopersici. | 1976 | Biochim. Biophys. Acta | pmid:182261 |
| Tabachnick M and Korcek L | Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. | 1986 | Biochim. Biophys. Acta | pmid:2869786 |