stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Haware RV et al. | Application of multivariate methods to evaluate the functionality of bovine- and vegetable-derived magnesium stearate. | 2014 | J Pharm Sci | pmid:24596131 |
Guo H et al. | In vitro and in vivo study of Gal-OS self-assembled nanoparticles for liver-targeting delivery of doxorubicin. | 2014 | J Pharm Sci | pmid:24549734 |
Rico JE et al. | Compared with stearic acid, palmitic acid increased the yield of milk fat and improved feed efficiency across production level of cows. | 2014 | J. Dairy Sci. | pmid:24342689 |
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Nehdi IA et al. | Chamaerops humilis L. var. argentea André date palm seed oil: a potential dietetic plant product. | 2014 | J. Food Sci. | pmid:24666023 |
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Gouk SW et al. | Stearic acids at sn-1, 3 positions of TAG are more efficient at limiting fat deposition than palmitic and oleic acids in C57BL/6 mice. | 2014 | Br. J. Nutr. | pmid:24286356 |
Chen FY et al. | TNYL peptide functional chitosan-g-stearate conjugate micelles for tumor specific targeting. | 2014 | Int J Nanomedicine | pmid:25298734 |
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Li N et al. | Function of SREBP1 in the milk fat synthesis of dairy cow mammary epithelial cells. | 2014 | Int J Mol Sci | pmid:25250914 |
Shen MC et al. | Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice. | 2014 | PLoS ONE | pmid:25222131 |
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Yao JJ et al. | Efficient gene delivery system mediated by cis-aconitate-modified chitosan-g-stearic acid micelles. | 2014 | Int J Nanomedicine | pmid:24971010 |
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Park H et al. | Stacking of a stearoyl-ACP thioesterase with a dual-silenced palmitoyl-ACP thioesterase and ∆12 fatty acid desaturase in transgenic soybean. | 2014 | Plant Biotechnol. J. | pmid:24909647 |
Gillman JD et al. | Deletions of the SACPD-C locus elevate seed stearic acid levels but also result in fatty acid and morphological alterations in nitrogen fixing nodules. | 2014 | BMC Plant Biol. | pmid:24886084 |
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