stearic acid

stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with stearic acid?

stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with stearic acid

MeSH term MeSH ID Detail
Brain Edema D001929 20 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Bacterial Infections D001424 21 associated lipids
Birth Weight D001724 23 associated lipids
Cattle Diseases D002418 24 associated lipids
Breast Neoplasms D001943 24 associated lipids
Insulinoma D007340 28 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Dermatitis D003872 30 associated lipids
Hypothyroidism D007037 32 associated lipids
Burns D002056 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Acne Vulgaris D000152 35 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Adenoma D000236 40 associated lipids
Occupational Diseases D009784 42 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Fatty Liver D005234 48 associated lipids
Thrombosis D013927 49 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Reperfusion Injury D015427 65 associated lipids
Neuroblastoma D009447 66 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Coronary Disease D003327 70 associated lipids
Hyperlipidemias D006949 73 associated lipids
Alzheimer Disease D000544 76 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Atherosclerosis D050197 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Insulin Resistance D007333 99 associated lipids
Weight Gain D015430 101 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Edema D004487 152 associated lipids
Lung Neoplasms D008175 171 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with stearic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with stearic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with stearic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with stearic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with stearic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with stearic acid?

Knock-out

Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with stearic acid

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Authors Title Published Journal PubMed Link
Liu Z et al. [Chemical constituents from root bark of Tripterygium hypoglaucum]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22256754
Broderick PA and Kolodny EH Biosensors for brain trauma and dual laser doppler flowmetry: enoxaparin simultaneously reduces stroke-induced dopamine and blood flow while enhancing serotonin and blood flow in motor neurons of brain, in vivo. 2011 Sensors (Basel) pmid:22346571
Rojas J and Kumar V Comparative evaluation of silicified microcrystalline cellulose II as a direct compression vehicle. 2011 Int J Pharm pmid:21708237
Veit M and Thaa B Association of influenza virus proteins with membrane rafts. 2011 Adv Virol pmid:22312341
Potta SG et al. Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. 2011 J Microencapsul pmid:21171818
Mosca M et al. Effect of membrane composition on lipid oxidation in liposomes. 2011 Chem. Phys. Lipids pmid:21185813
de Lima-Salgado TM et al. Molecular mechanisms by which saturated fatty acids modulate TNF-α expression in mouse macrophage lineage. 2011 Cell Biochem. Biophys. pmid:20809180
James J et al. Two-dimensional surface properties of PEO-PPO-PEO triblock copolymer film at the air/water interface in the absence and presence of Tyr-Phe dipeptide, Val-Tyr-Val tripeptide, SDS and stearic acid. 2011 Colloids Surf B Biointerfaces pmid:20888193
Arora G et al. Formulation and evaluation of controlled release matrix mucoadhesive tablets of domperidone using Salvia plebeian gum. 2011 J Adv Pharm Technol Res pmid:22171313
Sathiyaraj S et al. Lornoxicam gastro retentive floating matrix tablets: Design and in vitro evaluation. 2011 J Adv Pharm Technol Res pmid:22171312
Solanki SS and Dahima R Formulation and evaluation of aceclofenac mouth-dissolving tablet. 2011 J Adv Pharm Technol Res pmid:22171305
Negi JS et al. Effect of bioadhesion on initial in vitro buoyancy of effervescent floating matrix tablets of ciprofloxacin HCL. 2011 J Adv Pharm Technol Res pmid:22171304
Stahl J et al. The effect of formulation vehicles on the in vitro percutaneous permeation of ibuprofen. 2011 BMC Pharmacol. pmid:22168832
Chen M et al. [Study on the chemical constituents from Fructus Toosendan (III)]. 2011 Zhong Yao Cai pmid:22500422
Rajpurohit H et al. Hordeum vulgare hull in the design of fast disintegrating tablets. 2011 J Young Pharm pmid:21897660
Patel D et al. Design of Controlled Release Non-erodible Polymeric Matrix Tablet Using Microwave Oven-assisted Sintering Technique. 2011 J Young Pharm pmid:21897655
Huntemann M et al. Complete genome sequence of the thermophilic sulfur-reducer Hippea maritima type strain (MH(2)). 2011 Stand Genomic Sci pmid:21886857
Hu C et al. Simultaneous utilization of glucose and xylose for lipid production by Trichosporon cutaneum. 2011 Biotechnol Biofuels pmid:21864398
Véret J et al. Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells. 2011 Biochem. J. pmid:21592087
Eggerath J et al. EDX-Element Analysis of the In Vitro Effect of Fluoride Oral Hygiene Tablets on Artificial Caries Lesion Formation and Remineralization in Human Enamel. 2011 Open Dent J pmid:21687564
Jeon I et al. Evaluation of roll compaction as a preparation method for hydroxypropyl cellulose-based matrix tablets. 2011 J Pharm Bioallied Sci pmid:21687348
Tong M et al. The effect of Zn-Al-hydrotalcites composited with calcium stearate and β-diketone on the thermal stability of PVC. 2011 Int J Mol Sci pmid:21673921
Feng H et al. Pharmacokinetics study of bio-adhesive tablet of Panax notoginseng saponins. 2011 Int Arch Med pmid:21658246
Elokely KM et al. Fluorescence Spectrometric Determination of Drugs Containing α-Methylene Sulfone/Sulfonamide Functional Groups Using N-Methylnicotinamide Chloride as a Fluorogenic Agent. 2011 Int J Anal Chem pmid:21647288
Lim J et al. Solution structures of the acyl carrier protein domain from the highly reducing type I iterative polyketide synthase CalE8. 2011 PLoS ONE pmid:21674045
Salem H et al. Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler. 2011 Int J Nanomedicine pmid:21383856
Nicholls HT et al. Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. 2011 Diabetes pmid:21378177
Meng Y et al. Two-step synthesis of fatty acid ethyl ester from soybean oil catalyzed by Yarrowia lipolytica lipase. 2011 Biotechnol Biofuels pmid:21366905
Idris AM Screening of conditions controlling spectrophotometric sequential injection analysis. 2011 Chem Cent J pmid:21333024
Ordelheide AM et al. The myocyte expression of adiponectin receptors and PPARδ is highly coordinated and reflects lipid metabolism of the human donors. 2011 Exp Diabetes Res pmid:21331343
Gallardo LA et al. Europium stearate additives delay oxidation of UHMWPE for orthopaedic applications: a pilot study. 2011 Clin. Orthop. Relat. Res. pmid:21153455
Liu D et al. Synthesis and characterization of upconverting NaYF4:Er3+, Yb3+ nanocrystals via thermal decomposition of stearate precursor. 2011 J Nanosci Nanotechnol pmid:22413291
Hayashi Y et al. Modeling of latent structure of indomethacin solid dispersion tablet using Bayesian networks. 2011 Drug Dev Ind Pharm pmid:21702729
Naumowicz M et al. Impedance analysis of complex formation equilibria in phosphatidylcholine bilayers containing decanoic acid or decylamine. 2011 Cell Biochem. Biophys. pmid:21340532
Hsouna AB et al. Chemical composition, cytotoxicity effect and antimicrobial activity of Ceratonia siliqua essential oil with preservative effects against Listeria inoculated in minced beef meat. 2011 Int. J. Food Microbiol. pmid:21601302
Gallardo LA et al. Effect of europium(II) stearate on the mechanical properties and the oxidation resistance of UHMWPE. 2011 J Mech Behav Biomed Mater pmid:21565729
Abdel-Mottaleb MM et al. Lipid nanocapsules for dermal application: a comparative study of lipid-based versus polymer-based nanocarriers. 2011 Eur J Pharm Biopharm pmid:21558002
El Andaloussi S et al. Cell-penetrating peptides-based strategies for the delivery of splice redirecting antisense oligonucleotides. 2011 Methods Mol. Biol. pmid:21748634
Li Y et al. Building layer-by-layer 3D supramolecular nanostructures at the terephthalic acid/stearic acid interface. 2011 Chem. Commun. (Camb.) pmid:21755081
Kumar A et al. Phytochemical investigation and antifeedant activity of Premna latifolia leaves. 2011 Nat. Prod. Res. pmid:21756197
Hirose A et al. Clofibric acid increases the formation of oleic acid in endoplasmic reticulum of the liver of rats. 2011 J. Pharmacol. Sci. pmid:21757842
Choi SE et al. Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells. 2011 Nutr Res pmid:21745629
Fameau AL et al. Smart foams: switching reversibly between ultrastable and unstable foams. 2011 Angew. Chem. Int. Ed. Engl. pmid:21780260
Tsai MJ et al. Oral apomorphine delivery from solid lipid nanoparticles with different monostearate emulsifiers: pharmacokinetic and behavioral evaluations. 2011 J Pharm Sci pmid:20740670
Perrault M et al. An experimental investigation of the effect of the amount of lubricant on tablet properties. 2011 Drug Dev Ind Pharm pmid:20704461
Stingl JC et al. Protocol for minimizing the risk of metachronous adenomas of the colorectum with green tea extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population. 2011 BMC Cancer pmid:21851602
Farboud ES et al. Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies. 2011 Int J Nanomedicine pmid:21674018
Tiţa B et al. Compatibility study between ketoprofen and pharmaceutical excipients used in solid dosage forms. 2011 J Pharm Biomed Anal pmid:21665404
Göker M et al. Complete genome sequence of the thermophilic sulfur-reducer Desulfurobacterium thermolithotrophum type strain (BSA(T)) from a deep-sea hydrothermal vent. 2011 Stand Genomic Sci pmid:22675590
Mercado FV et al. Phase diagram of mixed monolayers of stearic acid and dimyristoylphosphatidylcholine. Effect of the acid ionization. 2011 Chem. Phys. Lipids pmid:21635875
Abbasi M et al. siRNA-mediated down-regulation of P-glycoprotein in a Xenograft tumor model in NOD-SCID mice. 2011 Pharm. Res. pmid:21638135
Lee YJ and Jenkins TC Biohydrogenation of linolenic acid to stearic acid by the rumen microbial population yields multiple intermediate conjugated diene isomers. 2011 J. Nutr. pmid:21653571
Sloat BR et al. In vitro and in vivo anti-tumor activities of a gemcitabine derivative carried by nanoparticles. 2011 Int J Pharm pmid:21371545
Chaturvedi K et al. Floating matrix dosage form for propranolol hydrochloride based on gas formation technique: development and in vitro evaluation. 2010 Oct-Dec Sci Pharm pmid:21179326
Terekhova EA et al. [Stearic acid methyl ether: a new extracellular metabolite of the obligate methylotrophic bacterium Methylophilus quaylei]. 2010 Mar-Apr Prikl. Biokhim. Mikrobiol. pmid:20391761
Kristó K et al. Effect of lubricant on spreading of coating liquid on surface of tablets containing pancreatin. 2010 Jul-Aug Pharm Dev Technol pmid:19772392
Badawy SI et al. Effect of spray-dried mannitol on the performance of microcrystalline cellulose-based wet granulated tablet formulation. 2010 Jul-Aug Pharm Dev Technol pmid:20088677
Kaur G et al. Chitosan-carboxymethyl tamarind kernel powder interpolymer complexation: investigations for colon drug delivery. 2010 Jan-Mar Sci Pharm pmid:21179370
Stanisz B et al. Influence of humidity and hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate or magnesium stearate on the degradation kinetics of quinapril hydrochloride in solid phase. 2010 Jan-Feb Acta Pol Pharm pmid:20210086
Aburahma MH et al. Preparation and in vitro/in vivo characterization of porous sublingual tablets containing ternary kneaded solid system of vinpocetine with î-cyclodextrin and hydroxy Acid. 2010 Apr-Jun Sci Pharm pmid:21179352
Singh B et al. Formulation optimization of hydrodynamically balanced oral controlled release bioadhesive tablets of tramadol hydrochloride. 2010 Apr-Jun Sci Pharm pmid:21179349
Zhang JW et al. [Studies on the chemical constituents of Toricellia angulata var. intermedia]. 2010 Zhong Yao Cai pmid:21434432
Fang X et al. Development and analysis of an in vivo-compatible metabolic network of Mycobacterium tuberculosis. 2010 BMC Syst Biol pmid:21092312
Westerbacka J et al. Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease. 2010 Gastroenterology pmid:20600015
Liu TY and Lin YL Novel pH-sensitive chitosan-based hydrogel for encapsulating poorly water-soluble drugs. 2010 Acta Biomater pmid:19819354
Kiss H et al. Complete genome sequence of Denitrovibrio acetiphilus type strain (N2460). 2010 Stand Genomic Sci pmid:21304711
Jain S et al. Development of a floating dosage form of ranitidine hydrochloride by statistical optimization technique. 2010 J Young Pharm pmid:21264091
Naumova EA et al. Influence of individual saliva secretion on fluoride bioavailability. 2010 Open Dent J pmid:21221176
Liu RS and Tang YJ Quantitative analysis for the effect of plant oil and fatty acid on Tuber melanosporum culture by uniform design combined with partial least squares regression. 2010 Appl. Microbiol. Biotechnol. pmid:20473608
Sorek N et al. An S-acylation switch of conserved G domain cysteines is required for polarity signaling by ROP GTPases. 2010 Curr. Biol. pmid:20451389
Murate M et al. Phosphatidylglucoside forms specific lipid domains on the outer leaflet of the plasma membrane. 2010 Biochemistry pmid:20433166
Sun H et al. Complete genome sequence of Desulfarculus baarsii type strain (2st14). 2010 Stand Genomic Sci pmid:21304732
Zhou QT et al. Improving aerosolization of drug powders by reducing powder intrinsic cohesion via a mechanical dry coating approach. 2010 Int J Pharm pmid:20435112
Cohn JS et al. Reduction in intestinal cholesterol absorption by various food components: mechanisms and implications. 2010 Atheroscler Suppl pmid:20439167
Pantusa M and Bartucci R Kinetics of stearic acid transfer between human serum albumin and sterically stabilized liposomes. 2010 Eur. Biophys. J. pmid:20306030
Pennick G et al. Superior effect of isostearyl isostearate on improvement in stratum corneum water permeability barrier function as examined by the plastic occlusion stress test. 2010 Int J Cosmet Sci pmid:20642769
Wieder DR and Pattimakiel L Examining the efficacy, safety, and patient acceptability of the combined contraceptive vaginal ring (NuvaRing). 2010 Int J Womens Health pmid:21151688
Remya K et al. Formulation development, evaluation and comparative study of effects of super disintegrants in cefixime oral disintegrating tablets. 2010 J Young Pharm pmid:21042477
Bolton B and Halpern BP Orthonasal and retronasal but not oral-cavity-only discrimination of vapor-phase fatty acids. 2010 Chem. Senses pmid:20100787
Lu L et al. Near infrared spectroscopy of stearic acid adsorbed on montmorillonite. 2010 Spectrochim Acta A Mol Biomol Spectrosc pmid:20071218
Roblegg E et al. Development of lipophilic calcium stearate pellets using ibuprofen as model drug. 2010 Eur J Pharm Biopharm pmid:20080179
Rao KS and Srinivas K RP-HPLC Method for the Determination of Losartan Potassium and Ramipril in Combined Dosage Form. 2010 Indian J Pharm Sci pmid:20582199
Pan PH et al. Stearic acid attenuates cholestasis-induced liver injury. 2010 Biochem. Biophys. Res. Commun. pmid:20036638
Keny RV et al. Formulation and evaluation of rizatriptan benzoate mouth disintegrating tablets. 2010 Indian J Pharm Sci pmid:20582194
Eftaiha AF et al. Bioadhesive controlled metronidazole release matrix based on chitosan and xanthan gum. 2010 Mar Drugs pmid:20559494
Normand-Lauzière F et al. Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjects. 2010 PLoS ONE pmid:20532041
Rivera CA et al. Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis. 2010 BMC Gastroenterol pmid:20509914
Saravanakumari P and Mani K Structural characterization of a novel xylolipid biosurfactant from Lactococcus lactis and analysis of antibacterial activity against multi-drug resistant pathogens. 2010 Bioresour. Technol. pmid:20637606
Invernizzi G et al. Sustained upregulation of stearoyl-CoA desaturase in bovine mammary tissue with contrasting changes in milk fat synthesis and lipogenic gene networks caused by lipid supplements. 2010 Funct. Integr. Genomics pmid:20607344
Chon B et al. Shell and ligand-dependent blinking of CdSe-based core/shell nanocrystals. 2010 Phys Chem Chem Phys pmid:20607188
Lin SY et al. Solid-state transformation of different gabapentin polymorphs upon milling and co-milling. 2010 Int J Pharm pmid:20561572
Bunn RC et al. Palmitate and insulin synergistically induce IL-6 expression in human monocytes. 2010 Cardiovasc Diabetol pmid:21054880
Asai T and Fujimoto Y Cyclic fatty acyl glycosides in the glandular trichome exudate of Silene gallica. 2010 Phytochemistry pmid:20541780
Jun HY et al. Long residence time of ultrasound microbubbles targeted to integrin in murine tumor model. 2010 Acad Radiol pmid:19815430
Jian WX et al. [Detection and analysis on plasma metabolomics in patient with coronary heart disease of Xin-blood stasis syndrome pattern]. 2010 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:20815270
Lai TY et al. Alterations in serum fatty acid concentrations and desaturase activities in Bietti crystalline dystrophy unaffected by CYP4V2 genotypes. 2010 Invest. Ophthalmol. Vis. Sci. pmid:19797200
Gonzalez-Mira E et al. Design and ocular tolerance of flurbiprofen loaded ultrasound-engineered NLC. 2010 Colloids Surf B Biointerfaces pmid:20719479
Chakraborty S et al. Utilization of adsorption technique in the development of oral delivery system of lipid based nanoparticles. 2010 Colloids Surf B Biointerfaces pmid:20728320
Tripathi B et al. Fortification of sorghum (Sorghum vulgare) and pearl millet (Pennisetum glaucum) flour with zinc. 2010 J Trace Elem Med Biol pmid:20685098
Thomas CP et al. Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation. 2010 J. Biol. Chem. pmid:20061396