stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kwon Y et al. | Arabidopsis serine decarboxylase mutants implicate the roles of ethanolamine in plant growth and development. | 2012 | Int J Mol Sci | pmid:22489147 |
Arya A et al. | Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. | 2012 | Evid Based Complement Alternat Med | pmid:22474512 |
Milicic A et al. | Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses. | 2012 | PLoS ONE | pmid:22470545 |
Mason P et al. | SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. | 2012 | PLoS ONE | pmid:22457791 |
Olivieri C et al. | Phylogenetic position of a copper age sheep (Ovis aries) mitochondrial DNA. | 2012 | PLoS ONE | pmid:22457789 |
Li D et al. | Ruminal microbe of biohydrogenation of trans-vaccenic acid to stearic acid in vitro. | 2012 | BMC Res Notes | pmid:22336099 |
Aling J and Podczeck F | The filling of powdered herbs into two-piece hard capsules using hydrogenated cotton seed oil as lubricant. | 2012 | Eur J Pharm Sci | pmid:22960627 |
Kottala N et al. | Evaluation of the performance characteristics of bilayer tablets: Part II. Impact of environmental conditions on the strength of bilayer tablets. | 2012 | AAPS PharmSciTech | pmid:22965660 |
Wolańska D and Kłosiewicz-Latoszek L | [Fatty acids intake and serum lipids profile in overweighted and obese adults]. | 2012 | Rocz Panstw Zakl Hig | pmid:22928362 |
Casiraghi A et al. | The influence of the polar head and the hydrophobic chain on the skin penetration enhancement effect of poly(ethylene glycol) derivatives. | 2012 | AAPS PharmSciTech | pmid:22232021 |
Singh AV and Nath LK | Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery. | 2012 | Int. J. Biol. Macromol. | pmid:22210486 |
Basseri S and Austin RC | Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential. | 2012 | Biochem Res Int | pmid:22195283 |
Busignies V et al. | Prediction of the compressibility of complex mixtures of pharmaceutical powders. | 2012 | Int J Pharm | pmid:22759643 |
Jubie S et al. | Synthesis, antidepressant and antimicrobial activities of some novel stearic acid analogues. | 2012 | Eur J Med Chem | pmid:22770606 |
Krogager TP et al. | Identification of a potential biomarker panel for the intake of the common dietary trans fat elaidic acid (trans∆9-C18:1). | 2012 | J Proteomics | pmid:22483997 |
Pawar AA et al. | Influence of precursor solvent properties on matrix crystallinity and drug release rates from nanoparticle aerosol lipid matrices. | 2012 | Int J Pharm | pmid:22469694 |
Zhu S et al. | Lysosomal delivery of a lipophilic gemcitabine prodrug using novel acid-sensitive micelles improved its antitumor activity. | 2012 | Bioconjug. Chem. | pmid:22471294 |
Wajid NA and Halpern BP | Oral cavity discrimination of vapor-phase long-chain 18-carbon fatty acids. | 2012 | Chem. Senses | pmid:22459162 |
Gröblacher B et al. | Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis. | 2012 | Bioorg. Med. Chem. | pmid:22459211 |
Reddy KR et al. | Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C. | 2012 | Clin Trials | pmid:22058086 |
Ruiz M et al. | A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. | 2012 | PLoS ONE | pmid:23056435 |
Kakisaka K et al. | Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21995961 |
Hu FQ et al. | pH triggered doxorubicin delivery of PEGylated glycolipid conjugate micelles for tumor targeting therapy. | 2012 | Mol. Pharm. | pmid:22827551 |
Sellami M et al. | Enzymatic transesterification of palm stearin and olein blends to produce zero-trans margarine fat. | 2012 | BMC Biotechnol. | pmid:22889174 |
Li Y et al. | New bactericidal surgical suture coating. | 2012 | Langmuir | pmid:22877364 |
Das SC and Stewart PJ | Characterising surface energy of pharmaceutical powders by inverse gas chromatography at finite dilution. | 2012 | J. Pharm. Pharmacol. | pmid:22881445 |
Lou CW et al. | PLA/ β-TCP complex tubes: the mechanical properties and applications of artificial bone. | 2012 | J Biomater Sci Polym Ed | pmid:21968651 |
Schreiber R et al. | Retinyl ester hydrolases and their roles in vitamin A homeostasis. | 2012 | Biochim. Biophys. Acta | pmid:21586336 |
Wang YN et al. | [Study on chemical constituents from Anoectochilus chapaensis]. | 2012 | Zhong Yao Cai | pmid:23236826 |
McNamee CE et al. | Effect of the degree of dissociation of molecules in a monolayer at an air/water interface on the force between the monolayer and a like-charged particle in the subphase. | 2012 | J Phys Chem B | pmid:23092192 |
Chu BB et al. | [XANES study of lead speciation in duckweed]. | 2012 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:23016367 |
Pijls BG et al. | Differences in long-term fixation between mobile-bearing and fixed-bearing knee prostheses at ten to 12 years' follow-up: a single-blinded randomised controlled radiostereometric trial. | 2012 | J Bone Joint Surg Br | pmid:23015562 |
Guzzi R et al. | Dynamics and binding affinity of spin-labeled stearic acids in β-lactoglobulin: evidences from EPR spectroscopy and molecular dynamics simulation. | 2012 | J Phys Chem B | pmid:22950964 |
de Jong S et al. | A semipermanent coating for preventing protein adsorption at physiological pH in kinetic capillary electrophoresis. | 2012 | Electrophoresis | pmid:22899267 |
Dziewulska A et al. | Monounsaturated fatty acids are required for membrane translocation of protein kinase C-theta induced by lipid overload in skeletal muscle. | 2012 | Mol. Membr. Biol. | pmid:22881371 |
Zhang WY et al. | Chronic unpredictable mild stress affects myocardial metabolic profiling of SD rats. | 2012 | J Pharm Biomed Anal | pmid:22658902 |
Tuli RA et al. | Studies on the effect of the size of polycaprolactone microspheres for the dispersion of salbutamol sulfate from dry powder inhaler formulations. | 2012 | Pharm. Res. | pmid:22584947 |
Akinsete JA et al. | Consumption of high ω-3 fatty acid diet suppressed prostate tumorigenesis in C3(1) Tag mice. | 2012 | Carcinogenesis | pmid:22045025 |
Baldwin AC et al. | A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death. | 2012 | Am. J. Physiol. Endocrinol. Metab. | pmid:22436701 |
Suo T et al. | Fixed-point and stratified analysis of the fine structure and composition of five gallstones with Fourier transform infrared (FT-IR) specular reflection spectroscopy. | 2012 | Microsc. Res. Tech. | pmid:21809418 |
Mai K et al. | Rosiglitazone increases fatty acid Δ9-desaturation and decreases elongase activity index in human skeletal muscle in vivo. | 2012 | Metab. Clin. Exp. | pmid:21741058 |
Dobrzyn P et al. | Increased availability of endogenous and dietary oleic acid contributes to the upregulation of cardiac fatty acid oxidation. | 2012 | Mitochondrion | pmid:21664496 |
Tokudome Y and Otsuka M | Possibility of alveolar bone promoting enhancement by using lipophilic and/or hydrophilic zinc related compounds in zinc-deficient osteoporosis rats. | 2012 | Biol. Pharm. Bull. | pmid:22975500 |
Dawes J et al. | An investigation into the impact of magnesium stearate on powder feeding during roller compaction. | 2012 | Drug Dev Ind Pharm | pmid:21810064 |
Lu J et al. | A molecular mechanism for modulating plasma Zn speciation by fatty acids. | 2012 | J. Am. Chem. Soc. | pmid:22239162 |
Foster SP and Anderson KG | Synthetic rates of key stored fatty acids in the biosynthesis of sex pheromone in the moth Heliothis virescens. | 2012 | Insect Biochem. Mol. Biol. | pmid:22982110 |
Toubiana D et al. | Metabolic profiling of a mapping population exposes new insights in the regulation of seed metabolism and seed, fruit, and plant relations. | 2012 | PLoS Genet. | pmid:22479206 |
Eili M et al. | Degradability enhancement of poly(lactic acid) by stearate-Zn(3)Al LDH nanolayers. | 2012 | Int J Mol Sci | pmid:22942682 |
Hayashi Y et al. | Latent structure analysis of the process variables and pharmaceutical responses of an orally disintegrating tablet. | 2012 | Chem. Pharm. Bull. | pmid:22878814 |
Tamokou Jde D et al. | Antioxidant and antimicrobial activities of ethyl acetate extract, fractions and compounds from stem bark of Albizia adianthifolia (Mimosoideae). | 2012 | BMC Complement Altern Med | pmid:22809287 |