stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Stanisz B et al. | Effect of pharmaceutical excipients on the stability of angiotensin-converting enzyme inhibitors in their solid dosage formulations. | 2013 | Drug Dev Ind Pharm | pmid:22348774 |
Vitturi DA et al. | Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase. | 2013 | J. Biol. Chem. | pmid:23878198 |
Saeedi Vahdat A et al. | Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets. | 2013 | Int J Pharm | pmid:23820132 |
Li L et al. | Drug release characteristics from chitosan-alginate matrix tablets based on the theory of self-assembled film. | 2013 | Int J Pharm | pmid:23624081 |
Neutsch L et al. | UPEC biomimickry at the urothelial barrier: lectin-functionalized PLGA microparticles for improved intravesical chemotherapy. | 2013 | Int J Pharm | pmid:23628404 |
Emken E | Human studies using isotope labeled fatty acids: answered and unanswered questions. | 2013 | J Oleo Sci | pmid:23648399 |
Zhou X et al. | The effect of saturated fatty acids on methanogenesis and cell viability of Methanobrevibacter ruminantium. | 2013 | Archaea | pmid:23710130 |
Silberstein T et al. | Saturated fatty acid composition of human milk in Israel: a comparison between Jewish and Bedouin women. | 2013 | Isr. Med. Assoc. J. | pmid:23781748 |
Otsuka Y et al. | Effects of polymorphic transformation on pharmaceutical properties of direct compressed tablets containing theophylline anhydrate bulk powder under high humidity. | 2013 | Colloids Surf B Biointerfaces | pmid:23178204 |
Azordegan N et al. | Carcinogenesis alters fatty acid profile in breast tissue. | 2013 | Mol. Cell. Biochem. | pmid:23180247 |
Delbecq F et al. | N-stearoyl amino acid derivatives: potent biomimetic hydro/organogelators as templates for preparation of gold nanoparticles. | 2013 | J Colloid Interface Sci | pmid:23089597 |
Barber E et al. | Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24012207 |
Cunha TA et al. | Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. | 2013 | AAPS PharmSciTech | pmid:23897034 |
Jaumot J et al. | Blending process modeling and control by multivariate curve resolution. | 2013 | Talanta | pmid:24209372 |
Høstmark AT et al. | Increased serum triglycerides and reduced HDL cholesterol in male rats after intake of ammonium chloride for 3 weeks. | 2013 | Lipids Health Dis | pmid:23800210 |
Saroja C and Lakshmi PK | Formulation and optimization of fenofibrate lipospheres using Taguchi's experimental design. | 2013 | Acta Pharm | pmid:23482314 |
Pethrick RA and Song M | Dielectric studies of amylose, amylopectin and amylose-stearic acid complexes. | 2013 | Carbohydr Polym | pmid:23399185 |
Subbaramaiah K et al. | Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice. | 2013 | Cancer Prev Res (Phila) | pmid:23880231 |
Tammaro A et al. | Magnesium stearate: an underestimated allergen. | 2012 Oct-Dec | J. Biol. Regul. Homeost. Agents | pmid:23241129 |
Hentzschel CM et al. | Comparison of traditional and novel tableting excipients: physical and compaction properties. | 2012 Nov-Dec | Pharm Dev Technol | pmid:21740091 |
Khan FN and Dehghan MH | Enhanced Bioavailability and Dissolution of Atorvastatin Calcium from Floating Microcapsules using Minimum Additives. | 2012 Jan-Mar | Sci Pharm | pmid:22396916 |
Pujeri SS et al. | Stress degradation studies on varenicline tartrate and development of a validated stability-indicating HPLC method. | 2012 Jan-Mar | Sci Pharm | pmid:22396908 |
Samanta AK et al. | Cone milling of compacted flakes: process parameter selection by adopting the minimal fines approach. | 2012 | Int J Pharm | pmid:22001841 |
Tay T et al. | Dissolution of a poorly water-soluble drug dry coated with magnesium and sodium stearate. | 2012 | Eur J Pharm Biopharm | pmid:22036990 |
Abe H and Otsuka M | Effects of lubricant-mixing time on prolongation of dissolution time and its prediction by measuring near infrared spectra from tablets. | 2012 | Drug Dev Ind Pharm | pmid:21954869 |
Zanon NC et al. | Immbolization of uricase enzyme in Langmuir and Langmuir-Blodgett films of fatty acids: possible use as a uric acid sensor. | 2012 | J Colloid Interface Sci | pmid:21875709 |
Sabir A et al. | The fatty acid and tocopherol constituents of the seed oil extracted from 21 grape varieties (Vitis spp.). | 2012 | J. Sci. Food Agric. | pmid:22271548 |
Vega Mercado F et al. | Modulation of the domain topography of biphasic monolayers of stearic acid and dimyristoyl phosphatidylcholine. | 2012 | Chem. Phys. Lipids | pmid:22274694 |
Milicic A et al. | Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses. | 2012 | PLoS ONE | pmid:22470545 |
Mason P et al. | SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. | 2012 | PLoS ONE | pmid:22457791 |
Morales A et al. | Quantitative analysis of hydroperoxy-, keto- and hydroxy-dienes in refined vegetable oils. | 2012 | J Chromatogr A | pmid:22321954 |
Olivieri C et al. | Phylogenetic position of a copper age sheep (Ovis aries) mitochondrial DNA. | 2012 | PLoS ONE | pmid:22457789 |
Nussbaum M and Paz Y | Ultra-thin SiO2 layers on TiO2: improved photocatalysis by enhancing products' desorption. | 2012 | Phys Chem Chem Phys | pmid:22298253 |
Ahn BJ et al. | Solvent-free acid-catalyzed ring-opening of epoxidized oleochemicals using stearates/stearic acid, and its applications. | 2012 | J. Agric. Food Chem. | pmid:22304525 |
Liu X et al. | Quantitative Proteomics of Intracellular Campylobacter jejuni Reveals Metabolic Reprogramming. | 2012 | PLoS Pathog. | pmid:22412372 |
Li D et al. | Ruminal microbe of biohydrogenation of trans-vaccenic acid to stearic acid in vitro. | 2012 | BMC Res Notes | pmid:22336099 |
Lee AL and Kim CB | The effect of erythromycin on gastrointestinal motility in subtotal gastrectomized patients. | 2012 | J Korean Surg Soc | pmid:22403748 |
Visioli F et al. | Molecular targets of omega 3 and conjugated linoleic Fatty acids - "micromanaging" cellular response. | 2012 | Front Physiol | pmid:22393325 |
Qu J et al. | Development of marker-free transgenic Jatropha plants with increased levels of seed oleic acid. | 2012 | Biotechnol Biofuels | pmid:22377043 |
Som I et al. | Status of surfactants as penetration enhancers in transdermal drug delivery. | 2012 | J Pharm Bioallied Sci | pmid:22368393 |
Sampey BP et al. | Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. | 2012 | PLoS ONE | pmid:22701716 |
Casiraghi A et al. | The influence of the polar head and the hydrophobic chain on the skin penetration enhancement effect of poly(ethylene glycol) derivatives. | 2012 | AAPS PharmSciTech | pmid:22232021 |
Wei CC and Ge ZQ | Influence of electrolyte and poloxamer 188 on the aggregation kinetics of solid lipid nanoparticles (SLNs). | 2012 | Drug Dev Ind Pharm | pmid:22181005 |
Singh AV and Nath LK | Evaluation of acetylated moth bean starch as a carrier for controlled drug delivery. | 2012 | Int. J. Biol. Macromol. | pmid:22210486 |
Basseri S and Austin RC | Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential. | 2012 | Biochem Res Int | pmid:22195283 |
Seeliger JC et al. | Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis. | 2012 | J. Biol. Chem. | pmid:22194604 |
Hao J et al. | Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design. | 2012 | Eur J Pharm Sci | pmid:22820033 |
Severino P et al. | Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. | 2012 | J Drug Deliv | pmid:22175030 |
Han K et al. | Novel gene transfer vectors based on artificial recombinant multi-functional oligopeptides. | 2012 | Int J Pharm | pmid:22796172 |
Kottala N et al. | Influence of compaction properties and interfacial topography on the performance of bilayer tablets. | 2012 | Int J Pharm | pmid:22728259 |
Chansela P et al. | Composition and localization of lipids in Penaeus merguiensis ovaries during the ovarian maturation cycle as revealed by imaging mass spectrometry. | 2012 | PLoS ONE | pmid:22432001 |
Xie YT et al. | Brain-targeting study of stearic acid-grafted chitosan micelle drug-delivery system. | 2012 | Int J Nanomedicine | pmid:22802685 |
El Semary NA | The antimicrobial profile of extracts of a Phormidium-like cyanobacterium changes with phosphate levels. | 2012 | World J. Microbiol. Biotechnol. | pmid:22806854 |
Busignies V et al. | Prediction of the compressibility of complex mixtures of pharmaceutical powders. | 2012 | Int J Pharm | pmid:22759643 |
Jubie S et al. | Synthesis, antidepressant and antimicrobial activities of some novel stearic acid analogues. | 2012 | Eur J Med Chem | pmid:22770606 |
Kakisaka K et al. | Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21995961 |
Galvao TF et al. | High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despite persistent mitochondrial defects. | 2012 | Cardiovasc. Res. | pmid:21960686 |
Tumen I et al. | A therapeutic approach for wound healing by using essential oils of cupressus and juniperus species growing in Turkey. | 2012 | Evid Based Complement Alternat Med | pmid:21941588 |
Kim DH et al. | Fabrication of pseudo-ceramide-based lipid microparticles for recovery of skin barrier function. | 2012 | Colloids Surf B Biointerfaces | pmid:22361356 |
Honkanen AM et al. | Characterization of the disappearance and formation of biohydrogenation intermediates during incubations of linoleic acid with rumen fluid in vitro. | 2012 | J. Dairy Sci. | pmid:22365221 |
Kushner J | Incorporating Turbula mixers into a blending scale-up model for evaluating the effect of magnesium stearate on tablet tensile strength and bulk specific volume. | 2012 | Int J Pharm | pmid:22405966 |
Matsui H et al. | Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes. | 2012 | PLoS ONE | pmid:22413010 |
Zhang ZH et al. | Solid lipid nanoparticles modified with stearic acid-octaarginine for oral administration of insulin. | 2012 | Int J Nanomedicine | pmid:22848162 |
Trupp M et al. | Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment. | 2012 | PLoS ONE | pmid:22808006 |
Liu J et al. | Stearoyl-acyl carrier protein desaturase gene from the oleaginous microalga Chlorella zofingiensis: cloning, characterization and transcriptional analysis. | 2012 | Planta | pmid:22855030 |
Carol D et al. | Synergistic effect of calcium stearate and photo treatment on the rate of biodegradation of low density polyethylene spent saline vials. | 2012 | Indian J. Exp. Biol. | pmid:22822530 |
Zeng XJ et al. | [Chemical constituents of Berchemia lineate]. | 2012 | Zhong Yao Cai | pmid:22822666 |
Hu FQ et al. | pH triggered doxorubicin delivery of PEGylated glycolipid conjugate micelles for tumor targeting therapy. | 2012 | Mol. Pharm. | pmid:22827551 |
Serra Bonvehi J and Orantes Bermejo FJ | Detection of adulterated commercial Spanish beeswax. | 2012 | Food Chem | pmid:26434344 |
Lou CW et al. | PLA/ β-TCP complex tubes: the mechanical properties and applications of artificial bone. | 2012 | J Biomater Sci Polym Ed | pmid:21968651 |
Varshosaz J et al. | Optimization of self-assembling properties of fatty acids grafted to methoxy poly(ethylene glycol) as nanocarriers for etoposide. | 2012 | Acta Pharm | pmid:22472447 |
Wang YN et al. | [Study on chemical constituents from Anoectochilus chapaensis]. | 2012 | Zhong Yao Cai | pmid:23236826 |
Lee SH et al. | End point determination of blending process for trimebutine tablets using principle component analysis (PCA) and partial least squares (PLS) regression. | 2012 | Arch. Pharm. Res. | pmid:23054717 |
Osmond G et al. | Metal stearate distributions in modern artists' oil paints: surface and cross-sectional investigation of reference paint films using conventional and synchrotron infrared microspectroscopy. | 2012 | Appl Spectrosc | pmid:23031696 |
McNamee CE et al. | Effect of the degree of dissociation of molecules in a monolayer at an air/water interface on the force between the monolayer and a like-charged particle in the subphase. | 2012 | J Phys Chem B | pmid:23092192 |
Chu BB et al. | [XANES study of lead speciation in duckweed]. | 2012 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:23016367 |
Sharma P et al. | Synthesis of cytarabine lipid drug conjugate for treatment of meningeal leukemia: development, characterization and in vitro cell line studies. | 2012 | J Biomed Nanotechnol | pmid:23030001 |
Pijls BG et al. | Differences in long-term fixation between mobile-bearing and fixed-bearing knee prostheses at ten to 12 years' follow-up: a single-blinded randomised controlled radiostereometric trial. | 2012 | J Bone Joint Surg Br | pmid:23015562 |
Guzzi R et al. | Dynamics and binding affinity of spin-labeled stearic acids in β-lactoglobulin: evidences from EPR spectroscopy and molecular dynamics simulation. | 2012 | J Phys Chem B | pmid:22950964 |
Charpentier PA et al. | Nano-TiO2/polyurethane composites for antibacterial and self-cleaning coatings. | 2012 | Nanotechnology | pmid:23037881 |
de Jong S et al. | A semipermanent coating for preventing protein adsorption at physiological pH in kinetic capillary electrophoresis. | 2012 | Electrophoresis | pmid:22899267 |
Akinsete JA et al. | Consumption of high ω-3 fatty acid diet suppressed prostate tumorigenesis in C3(1) Tag mice. | 2012 | Carcinogenesis | pmid:22045025 |
Baldwin AC et al. | A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death. | 2012 | Am. J. Physiol. Endocrinol. Metab. | pmid:22436701 |
Weiss VM et al. | Poly(glycerol adipate)-fatty acid esters as versatile nanocarriers: From nanocubes over ellipsoids to nanospheres. | 2012 | J Control Release | pmid:21971295 |
Tuli RA et al. | Polycaprolactone microspheres as carriers for dry powder inhalers: effect of surface coating on aerosolization of salbutamol sulfate. | 2012 | J Pharm Sci | pmid:21956254 |
Shuhendler AJ et al. | Thermally-triggered 'off-on-off' response of gadolinium-hydrogel-lipid hybrid nanoparticles defines a customizable temperature window for non-invasive magnetic resonance imaging thermometry. | 2012 | J Control Release | pmid:21939700 |
Wang X et al. | Volatile components of ethanolic extract from broccolini leaves. | 2012 | Nat. Prod. Res. | pmid:21859369 |
Suo T et al. | Fixed-point and stratified analysis of the fine structure and composition of five gallstones with Fourier transform infrared (FT-IR) specular reflection spectroscopy. | 2012 | Microsc. Res. Tech. | pmid:21809418 |
Mai K et al. | Rosiglitazone increases fatty acid Δ9-desaturation and decreases elongase activity index in human skeletal muscle in vivo. | 2012 | Metab. Clin. Exp. | pmid:21741058 |
Gören AC et al. | Fatty acid composition and chemotaxonomic evaluation of species of Stachys. | 2012 | Nat. Prod. Res. | pmid:21859257 |
Smathers RL et al. | Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics. | 2012 | PLoS ONE | pmid:22701647 |
Foster SP and Anderson KG | Synthetic rates of key stored fatty acids in the biosynthesis of sex pheromone in the moth Heliothis virescens. | 2012 | Insect Biochem. Mol. Biol. | pmid:22982110 |
Nesarikar VV et al. | Instrumented roll technology for the design space development of roller compaction process. | 2012 | Int J Pharm | pmid:22286023 |
Eili M et al. | Degradability enhancement of poly(lactic acid) by stearate-Zn(3)Al LDH nanolayers. | 2012 | Int J Mol Sci | pmid:22942682 |
Hayashi Y et al. | Latent structure analysis of the process variables and pharmaceutical responses of an orally disintegrating tablet. | 2012 | Chem. Pharm. Bull. | pmid:22878814 |
Xie J et al. | Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts. | 2012 | Nat. Prod. Res. | pmid:21707231 |
Tamokou Jde D et al. | Antioxidant and antimicrobial activities of ethyl acetate extract, fractions and compounds from stem bark of Albizia adianthifolia (Mimosoideae). | 2012 | BMC Complement Altern Med | pmid:22809287 |
Wang L et al. | Effect of rare Earth ions on the properties of composites composed of ethylene vinyl acetate copolymer and layered double hydroxides. | 2012 | PLoS ONE | pmid:22693627 |
Wong RH et al. | Chronic effects of a wild green oat extract supplementation on cognitive performance in older adults: a randomised, double-blind, placebo-controlled, crossover trial. | 2012 | Nutrients | pmid:22690320 |
Bederman I et al. | Altered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:22679004 |