stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Rosenthal MD and Whitehurst MC | Selective effects of isomeric cis and trans fatty acids on fatty acyl delta 9 and delta 6 desaturation by human skin fibroblasts. | 1983 | Biochim. Biophys. Acta | pmid:6615875 |
Hwang CC and Danti AG | Percutaneous absorption of flufenamic acid in rabbits: effect of dimethyl sulfoxide and various nonionic surface-active agents. | 1983 | J Pharm Sci | pmid:6620136 |
Philip J and Daly RE | Test for selection of erythromycin stearate bulk drug for tablet preparation. | 1983 | J Pharm Sci | pmid:6620167 |
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Kohn MC and Garfinkel D | Computer simulation of metabolism in palmitate-perfused rat heart. I. Palmitate oxidation. | 1983 | Ann Biomed Eng | pmid:6592996 |
Duncan MO et al. | Treatment of chancroid with erythromycin. A clinical and microbiological appraisal. | 1983 | Br J Vener Dis | pmid:6603249 |
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Warrell DA et al. | Pathophysiology and immunology of the Jarisch-Herxheimer-like reaction in louse-borne relapsing fever: comparison of tetracycline and slow-release penicillin. | 1983 | J. Infect. Dis. | pmid:6842024 |
Zeisel SH et al. | Formation of methylamines from ingested choline and lecithin. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6842395 |
Foot M et al. | Some properties, including the substrate in vivo, of the delta 9-desaturase in Micrococcus cryophilus. | 1983 | Biochem. J. | pmid:6847622 |
Quinn PA et al. | Efficacy of antibiotic therapy in preventing spontaneous pregnancy loss among couples colonized with genital mycoplasmas. | 1983 | Am. J. Obstet. Gynecol. | pmid:6849358 |
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Sobel JD et al. | Legionella bozemanii. Still another cause of pneumonia. | 1983 | JAMA | pmid:6854903 |
Stults BM et al. | Effect of erythromycin stearate on serum theophylline concentration in patients with chronic obstructive lung disease. | 1983 | South. Med. J. | pmid:6857302 |
Slomiany A et al. | Isolation of fatty acids covalently bound to the gastric mucus glycoprotein of normal and cystic fibrosis patients. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6860340 |
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Khan KA et al. | The effect of mixing time of magnesium stearate on the tableting properties of dried microcrystalline cellulose. | 1983 | Pharm Acta Helv | pmid:6867042 |
Shanson DC et al. | High dose oral erythromycin for preventing endocarditis. | 1983 | Lancet | pmid:6130318 |
Inman WH and Rawson NS | Erythromycin estolate and jaundice. | 1983 | Br Med J (Clin Res Ed) | pmid:6407653 |
Carli F and Colombo I | Influence of porosity on the contact angle of non-wet solids. | 1983 | J. Pharm. Pharmacol. | pmid:6135790 |
Gabriel SM and Simpkins JW | Effects of a sustained-release naloxone pellet on luteinizing hormone secretion in female rats. | 1983 | Neuroendocrinology | pmid:6139759 |
Agrawal HC et al. | In vivo incorporation of [3H]palmitic acid into PO protein, the major intrinsic protein of rat sciatic nerve myelin. | 1983 | J. Biol. Chem. | pmid:6189827 |
Neufeld EJ et al. | High affinity esterification of eicosanoid precursor fatty acids by platelets. | 1983 | J. Clin. Invest. | pmid:6308046 |
Hashisaki P et al. | Erythromycin failure in the treatment of syphilis in a pregnant woman. | 1983 Jan-Mar | Sex Transm Dis | pmid:6601848 |
Robson HG et al. | Comparison of rosaramicin and erythromycin stearate for treatment of cervical infection with Chlamydia trachomatis. | 1983 Jul-Sep | Sex Transm Dis | pmid:6648747 |
Rosén C et al. | Acute otitis media in older children and adults treated with phenoxymethyl penicillin or erythromycin stearate. Bacteriological and immunological aspects. | 1983 Sep-Oct | Acta Otolaryngol. | pmid:6416018 |
Abdulrazik M et al. | Formulation for slow release of oral radiation-protection drugs. | 1984 | Int J Nucl Med Biol | pmid:6610665 |
Foudin L et al. | Ethanol consumption and serum lipid profiles in Sinclair(S-1) miniature swine. | 1984 | Life Sci. | pmid:6700380 |
Sakaguchi M et al. | Effect of dietary unsaturated and saturated fats on azoxymethane-induced colon carcinogenesis in rats. | 1984 | Cancer Res. | pmid:6704963 |
Anderson R et al. | Studies on the effects of ingestion of a single 500 mg oral dose of erythromycin stearate on leucocyte motility and transformation and on release in vitro of prostaglandin E2 by stimulated leucocytes. | 1984 | J. Antimicrob. Chemother. | pmid:6592163 |
Colombo I and Carli F | Comparative evaluation of structure and micromeritics properties of magnesium stearate. | 1984 | Farmaco Prat | pmid:6510514 |
Romanowski B and Grace M | Non-gonococcal urethritis: a comparison of therapy with minicycline, tetracycline and erthromycin. | 1984 | Can Fam Physician | pmid:21278971 |
Kemp P et al. | The hydrogenation of some cis- and trans-octadecenoic acids to stearic acid by a rumen Fusocillus sp. | 1984 | Br. J. Nutr. | pmid:6743636 |
Greenberg DS et al. | Fatty acid composition of lizard tissue lipids and the effects of estradiol on serum free fatty acids. | 1984 | Comp. Biochem. Physiol., B | pmid:6744817 |
Pediconi MF and RodrÃguez de Turco EB | Free fatty acid content and release kinetics as manifestations of cerebral lateralization in mouse brain. | 1984 | J. Neurochem. | pmid:6726237 |
MacDonald RC et al. | Inhibition of sendai virus-induced hemolysis by long chain fatty acids. | 1984 | Virology | pmid:6324464 |
Goldberg I et al. | Gangrene of the upper extremity following intra-arterial injection of drugs. A case report and review of the literature. | 1984 | Clin. Orthop. Relat. Res. | pmid:6380862 |
Buttke TM and Cuchens MA | Inhibition of lymphocyte proliferation by free fatty acids. II. Toxicity of stearic acid towards phytohaemagglutinin-activated T cells. | 1984 | Immunology | pmid:6333387 |
Walstad RA and Hellum KB | Penetration of erythromycin in respiratory tract infections. | 1984 | Acta Otolaryngol Suppl | pmid:6333775 |
Shanson DC et al. | The pharmacokinetics and tolerance of oral erythromycin stearate compared with erythromycin ethylsuccinate: implications for preventing endocarditis. | 1984 | J. Antimicrob. Chemother. | pmid:6334070 |
Tjandramaga TB et al. | Relative bioavailability of enteric coated pellets, stearate and ethylsuccinate formulations of erythromycin. | 1984 | Pharmacology | pmid:6334320 |
Aylsworth CF et al. | Promotion of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis by high dietary fat in the rat: possible role of intercellular communication. | 1984 | J. Natl. Cancer Inst. | pmid:6422115 |
Kido H et al. | Inhibition of chymase activity by long chain fatty acids. | 1984 | Arch. Biochem. Biophys. | pmid:6424574 |
Feix JB et al. | An electron-electron double-resonance study of interactions between [14N]- and [15N]stearic acid spin-label pairs: lateral diffusion and vertical fluctuations in dimyristoylphosphatidylcholine. | 1984 | Biochemistry | pmid:6329270 |
Ohki K et al. | Effect of alpha-tocopherol on lipid peroxidation and acyl chain mobility of liver microsomes from vitamin E-difficient rat. | 1984 | J. Nutr. Sci. Vitaminol. | pmid:6092586 |
Lem NW and Stumpf PK | In Vitro Fatty Acid Synthesis and Complex Lipid Metabolism in the Cyanobacterium, Anabaena Variabilis: II. Acyl Transfer and Complex Lipid Formation. | 1984 | Plant Physiol. | pmid:16663690 |
Francis H et al. | Severe vascular spasm due to erythromycin-ergotamine interaction. | 1984 | Clin. Rheumatol. | pmid:6236021 |
Bhakoo KK et al. | Regional studies of changes in brain fatty acids following experimental ischaemia and reperfusion in the gerbil. | 1984 | J. Neurochem. | pmid:6236282 |
Abumrad NA et al. | Permeation of long-chain fatty acid into adipocytes. Kinetics, specificity, and evidence for involvement of a membrane protein. | 1984 | J. Biol. Chem. | pmid:6746632 |
Zoeller RA and Wood R | Effects of cyclopropene fatty acids on the lipid composition of the Morris hepatoma 7288C. | 1984 | Lipids | pmid:6431218 |
Sivarajan M et al. | Regulation of intracellular arachidonate in normal and stressed endothelial cells. | 1984 | Biochim. Biophys. Acta | pmid:6433983 |
Rosén C et al. | Acute otitis media in older children and adults treated with penicillin or erythromycin. | 1984 | Acta Otolaryngol Suppl | pmid:6437133 |
Dixon JF and Hokin LE | Secretogogue-stimulated phosphatidylinositol breakdown in the exocrine pancreas liberates arachidonic acid, stearic acid, and glycerol by sequential actions of phospholipase C and diglyceride lipase. | 1984 | J. Biol. Chem. | pmid:6438097 |
Forsberg NE et al. | Roles of acetate and its interactions with glucose and lactate in cow mammary tissue. | 1984 | J. Dairy Sci. | pmid:6438200 |
Desudchit P et al. | Rifampicin-erythromycin combination for the treatment of gonococcal urethritis in men. | 1984 | Southeast Asian J. Trop. Med. Public Health | pmid:6441265 |
Bridges CD et al. | Visual cycle in the mammalian eye. Retinoid-binding proteins and the distribution of 11-cis retinoids. | 1984 | Vision Res. | pmid:6543481 |
Fenyvest E et al. | Cyclodextrin polymer, a new tablet disintegrating agent. | 1984 | Pharmazie | pmid:6494226 |
Junginger H | [The ratio of free and fixed interlamellar water as quality criteria for O/W creams]. | 1984 | Pharmazie | pmid:6504995 |
Kennett FF et al. | Inhibition of myocardial rotenone-insensitive NADH cytochrome c reductase by amphiphilic compounds. | 1984 | Am. J. Physiol. | pmid:6507637 |
Wirthensohn G et al. | Phospholipid metabolism in rat kidney cortical tubules. I. Effect of renal substrates. | 1984 | Biochim. Biophys. Acta | pmid:6477951 |
Shechter Y and Henis YI | Cis-unsaturated fatty acids induce both lipogenesis and calcium binding in adipocytes. | 1984 | Biochim. Biophys. Acta | pmid:6477975 |
Bogdanov AA et al. | Immobilization of alpha-chymotrypsin on sucrose stearate--palmitate containing liposomes. | 1984 | FEBS Lett. | pmid:6479332 |
Junginger HE | Colloidal structures of O/W creams. | 1984 | Pharm Weekbl Sci | pmid:6483570 |
Mogelson S and Lange LG | Nonoxidative ethanol metabolism in rabbit myocardium: purification to homogeneity of fatty acyl ethyl ester synthase. | 1984 | Biochemistry | pmid:6487591 |
Boakes AJ et al. | Treatment of uncomplicated gonorrhoea in women with a combination of rifampicin and erythromycin. | 1984 | Br J Vener Dis | pmid:6487986 |
Fernandes AC et al. | Enhancement of human polymorphonuclear leucocyte motility by erythromycin in vitro and in vivo. | 1984 | S. Afr. Med. J. | pmid:6463793 |
Yoshida S and Takeshita M | Arachidoyl- and arachidonoyl-CoA elongation mechanism in swine cerebral microsomes. | 1984 | Biochim. Biophys. Acta | pmid:6466693 |
Waldman SA et al. | Acyl composition and phospholipase activities in plasma membranes isolated from rat embryos. | 1984 | Int. J. Biochem. | pmid:6468725 |
Slevin ML et al. | The pharmacokinetics of subcutaneous bolus cytosine arabinoside in an arachis oil plus aluminium distearate suspension. | 1984 | Invest New Drugs | pmid:6511233 |
Vandermeerschen-Doizé F and Paquay R | Effects of continuous long-term intravenous infusion of long-chain fatty acids on feeding behaviour and blood components of adult sheep. | 1984 | Appetite | pmid:6517567 |
Hunter JM and Sommerville RG | Erythromycin stearate in treating chlamydial infection of the cervix. | 1984 | Br J Vener Dis | pmid:6518350 |
Farkas T | Adaptation of fatty acid composition to temperature--a study on carp (Cyprinus carpio L.) liver slices. | 1984 | Comp. Biochem. Physiol., B | pmid:6518757 |
Magill A and Becker AR | Spectrophotometric method for quantitation of peroxides in sorbitan monooleate and monostearate. | 1984 | J Pharm Sci | pmid:6520780 |
Ueda A et al. | Experimental study on the pathological changes in lung tissue caused by zinc stearate dust. | 1984 | Ind Health | pmid:6526700 |
Ras GJ et al. | Chemoprophylaxis with erythromycin stearate or amoxycillin in patients with chronic bronchitis--effects on cellular and humoral immune functions. | 1984 Dec 22-29 | S. Afr. Med. J. | pmid:6515508 |
Holub BJ and Celi B | Evaluation of the fatty acid selectivity of a phosphatidylinositol-specific cytosolic phospholipase C from pig and human platelets. | 1984 Feb-Mar | Can. J. Biochem. Cell Biol. | pmid:6518412 |
Blackett PR et al. | Hyperlipidemia in acute lymphoblastic leukemia. | 1984 Mar-Apr | Ann. Clin. Lab. Sci. | pmid:6585175 |
Hanna GM | Nuclear magnetic resonance spectroscopic determination of dicyclomine hydrochloride in tablet, capsule, and injection dosage forms. | 1984 Mar-Apr | J Assoc Off Anal Chem | pmid:6725188 |
Schreiner A and Digranes A | Absorption of erythromycin stearate and enteric-coated erythromycin base after a single oral dose immediately before breakfast. | 1984 Sep-Oct | Infection | pmid:6511088 |
Ragnarsson G and Sjögren J | Force-displacement measurements in tableting. | 1985 | J. Pharm. Pharmacol. | pmid:2858558 |
Esezobo S | The effect of some excipients on the physical properties of a paracetamol tablet formulation. | 1985 | J. Pharm. Pharmacol. | pmid:2858567 |
Zoeller RA and Wood R | The importance of the stearoyl-CoA desaturase system in octadecenoate metabolism in the Morris hepatoma 7288C. | 1985 | Biochim. Biophys. Acta | pmid:2860925 |
Bangudu AB and Pilpel N | Effects of composition, moisture and stearic acid on the plasto-elasticity and tableting of paracetamol-microcrystalline cellulose mixtures. | 1985 | J. Pharm. Pharmacol. | pmid:2862234 |
Onoda T et al. | Antitumor activity of D-mannosamine in vitro: cytotoxic effect produced by mannosamine in combination with free fatty acids on human leukemia T-cell lines. | 1985 | Jpn. J. Clin. Oncol. | pmid:3877190 |
Shanson DC et al. | Erythromycin stearate, 1.5 g, for the oral prophylaxis of streptococcal bacteraemia in patients undergoing dental extraction: efficacy and tolerance. | 1985 | J. Antimicrob. Chemother. | pmid:3882657 |
Roughan PG | Phosphatidylglycerol and chilling sensitivity in plants. | 1985 | Plant Physiol. | pmid:16664127 |
Wood CB et al. | Reduction in the stearic to oleic acid ratio in the circulating red blood cells: a possible tumour marker in solid human neoplasms. | 1985 | Eur J Surg Oncol | pmid:4007173 |
Harrison GA et al. | Resistance in oral streptococci after repeated three-dose erythromycin prophylaxis. | 1985 | J. Antimicrob. Chemother. | pmid:4008379 |
Roblot L et al. | Effect of lubricant level and applied compressional pressure on surface friction of tablets. | 1985 | J Pharm Sci | pmid:4020661 |
Fujii M et al. | Fatty acid compositions of triacylglycerols and phospholipids in hen liver lipid before and after sexual maturity. | 1985 | Poult. Sci. | pmid:4022907 |
Carranco E et al. | Carbamazepine toxicity induced by concurrent erythromycin therapy. | 1985 | Arch. Neurol. | pmid:3977647 |
Ruwart MJ et al. | 16,16-Dimethyl PGE2 and fatty acids protect hepatocytes against CCl4-induced damage. | 1985 | In Vitro Cell. Dev. Biol. | pmid:4030626 |
Sklan D et al. | Digestion and absorption of lipids and bile acids in sheep fed stearic acid, oleic acid, or tristearin. | 1985 | J. Dairy Sci. | pmid:4031186 |
Bridges CD et al. | Vitamin A and interstitial retinol-binding protein in an eye with recessive retinitis pigmentosa. | 1985 | Invest. Ophthalmol. Vis. Sci. | pmid:4039711 |
Beckurts TE et al. | Kinetics of different 123I- and 14C-labelled fatty acids in normal and diabetic rat myocardium in vivo. | 1985 | Nucl Med Commun | pmid:4047532 |
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