stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yang P et al. | Transcriptome analysis of the Chinese white wax scale Ericerus pela with focus on genes involved in wax biosynthesis. | 2012 | PLoS ONE | pmid:22536429 |
Paul D et al. | Proteome and membrane fatty acid analyses on Oligotropha carboxidovorans OM5 grown under chemolithoautotrophic and heterotrophic conditions. | 2011 | PLoS ONE | pmid:21386900 |
Sampey BP et al. | Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. | 2012 | PLoS ONE | pmid:22701716 |
Schwab U et al. | Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism--the GENOBIN study. | 2008 | PLoS ONE | pmid:18612464 |
Schaab M et al. | Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action. | 2012 | PLoS ONE | pmid:22545089 |
Steidl S et al. | Mâ‚… muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. | 2011 | PLoS ONE | pmid:22102904 |
Meissner M et al. | Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. | 2011 | PLoS ONE | pmid:22087215 |
D'Ambrosio DN et al. | Distinct populations of hepatic stellate cells in the mouse liver have different capacities for retinoid and lipid storage. | 2011 | PLoS ONE | pmid:21949825 |
Bailey JA et al. | Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. | 2011 | PLoS ONE | pmid:21799757 |
Matsui H et al. | Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes. | 2012 | PLoS ONE | pmid:22413010 |
Lim J et al. | Solution structures of the acyl carrier protein domain from the highly reducing type I iterative polyketide synthase CalE8. | 2011 | PLoS ONE | pmid:21674045 |
Bonaduce I et al. | New insights into the ageing of linseed oil paint binder: a qualitative and quantitative analytical study. | 2012 | PLoS ONE | pmid:23166642 |
Coulon C et al. | Chemical analysis of cellular and extracellular carbohydrates of a biofilm-forming strain Pseudomonas aeruginosa PA14. | 2010 | PLoS ONE | pmid:21151973 |
A J et al. | Chronic myeloid leukemia patients sensitive and resistant to imatinib treatment show different metabolic responses. | 2010 | PLoS ONE | pmid:20949032 |
Noguchi Y et al. | Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice. | 2010 | PLoS ONE | pmid:20706589 |
Jung SW et al. | Mechanism of antibacterial activity of liposomal linolenic acid against Helicobacter pylori. | 2015 | PLoS ONE | pmid:25793403 |
Maher AC et al. | Women have higher protein content of beta-oxidation enzymes in skeletal muscle than men. | 2010 | PLoS ONE | pmid:20700461 |
Shen MC et al. | Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice. | 2014 | PLoS ONE | pmid:25222131 |
Normand-Lauzière F et al. | Increased postprandial nonesterified fatty acid appearance and oxidation in type 2 diabetes is not fully established in offspring of diabetic subjects. | 2010 | PLoS ONE | pmid:20532041 |
Carrero-Colón M et al. | Mutations in SACPD-C result in a range of elevated stearic acid concentration in soybean seed. | 2014 | PLoS ONE | pmid:24846334 |
Jin Q et al. | A novel cationic microbubble coated with stearic acid-modified polyethylenimine to enhance DNA loading and gene delivery by ultrasound. | 2013 | PLoS ONE | pmid:24086748 |
Van Hoeck V et al. | Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology. | 2011 | PLoS ONE | pmid:21858021 |
Smathers RL et al. | Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics. | 2012 | PLoS ONE | pmid:22701647 |
Lee DM et al. | Oxidative stress and inflammation in renal patients and healthy subjects. | 2011 | PLoS ONE | pmid:21829457 |
Hellemans KH et al. | Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase. | 2009 | PLoS ONE | pmid:19787047 |
Jiang L et al. | Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway. | 2009 | PLoS ONE | pmid:19727392 |
Pérez-Berná AJ et al. | Screening a peptide library by DSC and SAXD: comparison with the biological function of the parent proteins. | 2009 | PLoS ONE | pmid:19194494 |
Bazzini AA et al. | Metabolic and miRNA profiling of TMV infected plants reveals biphasic temporal changes. | 2011 | PLoS ONE | pmid:22174812 |
Pereira MG et al. | Trypanosoma cruzi epimastigotes are able to store and mobilize high amounts of cholesterol in reservosome lipid inclusions. | 2011 | PLoS ONE | pmid:21818313 |
Wang L et al. | Effect of rare Earth ions on the properties of composites composed of ethylene vinyl acetate copolymer and layered double hydroxides. | 2012 | PLoS ONE | pmid:22693627 |
Polizzotti BD et al. | Intrapericardial delivery of gelfoam enables the targeted delivery of Periostin peptide after myocardial infarction by inducing fibrin clot formation. | 2012 | PLoS ONE | pmid:22590609 |
Alloatti A et al. | Genetic and chemical evaluation of Trypanosoma brucei oleate desaturase as a candidate drug target. | 2010 | PLoS ONE | pmid:21151902 |
Song IS et al. | Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition. | 2012 | PLoS ONE | pmid:22590580 |
Toubiana D et al. | Metabolic profiling of a mapping population exposes new insights in the regulation of seed metabolism and seed, fruit, and plant relations. | 2012 | PLoS Genet. | pmid:22479206 |
Kalinina OV et al. | Combinations of protein-chemical complex structures reveal new targets for established drugs. | 2011 | PLoS Comput. Biol. | pmid:21573205 |
Kinnings SL et al. | Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis. | 2009 | PLoS Comput. Biol. | pmid:19578428 |
Su BN et al. | Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. | 2002 | Planta Med. | pmid:12494342 |
Dantas da Silva LL et al. | Antibacterial activity of a stearic acid derivative from Stemodia foliosa. | 2002 | Planta Med. | pmid:12494347 |
Fernández-Moya V et al. | Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds. | 2003 | Planta | pmid:12624771 |
Liu J et al. | Stearoyl-acyl carrier protein desaturase gene from the oleaginous microalga Chlorella zofingiensis: cloning, characterization and transcriptional analysis. | 2012 | Planta | pmid:22855030 |
Li T et al. | Defense priming by non-jasmonate producing fatty acids in maize (Zea mays). | 2016 | Plant Signal Behav | pmid:27763804 |
Bhattacharya S et al. | Increasing the stearate content in seed oil of Brassica juncea by heterologous expression of MlFatB affects lipid content and germination frequency of transgenic seeds. | 2015 | Plant Physiol. Biochem. | pmid:26351151 |
Salas JJ et al. | The biochemical characterization of a high-stearic acid sunflower mutant reveals the coordinated regulation of stearoyl-acyl carrier protein desaturases. | 2008 | Plant Physiol. Biochem. | pmid:18023195 |
Ghosh SK et al. | Characterization and cloning of a stearoyl/oleoyl specific fatty acyl-acyl carrier protein thioesterase from the seeds of Madhuca longifolia (latifolia). | 2007 | Plant Physiol. Biochem. | pmid:17977002 |
Liu Q et al. | High-stearic and High-oleic cottonseed oils produced by hairpin RNA-mediated post-transcriptional gene silencing. | 2002 | Plant Physiol. | pmid:12177486 |
Salzman RA et al. | Transcriptional profiling of sorghum induced by methyl jasmonate, salicylic acid, and aminocyclopropane carboxylic acid reveals cooperative regulation and novel gene responses. | 2005 | Plant Physiol. | pmid:15863699 |
Clemente TE and Cahoon EB | Soybean oil: genetic approaches for modification of functionality and total content. | 2009 | Plant Physiol. | pmid:19783644 |
Sorigué D et al. | Microalgae Synthesize Hydrocarbons from Long-Chain Fatty Acids via a Light-Dependent Pathway. | 2016 | Plant Physiol. | pmid:27288359 |
Do PT et al. | The influence of fruit load on the tomato pericarp metabolome in a Solanum chmielewskii introgression line population. | 2010 | Plant Physiol. | pmid:20841452 |
Lakhssassi N et al. | Stearoyl-Acyl Carrier Protein Desaturase Mutations Uncover an Impact of Stearic Acid in Leaf and Nodule Structure. | 2017 | Plant Physiol. | pmid:28461402 |