stearic acid is a lipid of Fatty Acyls (FA) class. Stearic acid is associated with abnormalities such as Helminthiasis, Exanthema, Chronic disease, Obesity and Dyslipidemias. The involved functions are known as acyltransferase activity, Mutation, Cell division, cell fate and Fatty Acid Metabolism. Stearic acid often locates in membrane fraction, Mouse Liver, Membrane, Body tissue and Endoplasmic reticulum, membrane. The associated genes with stearic acid are Homologous Gene, ACLY gene, Transgenes, FATE1 gene and Alleles. The related lipids are Lysophospholipids, Stearic acid, Fatty Acids, cis-vaccenic acid and Phosphatidylserines. The related experimental models are Knock-out.
To understand associated biological information of stearic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
stearic acid is suspected in Obesity, Diabetes, Fatty Liver, Hyperinsulinism, Cardiovascular Diseases, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with stearic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.' (Anderson EK et al., 2012) and Knock-out are used in the study 'Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.' (Wu JH et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Decsi T et al. | Trans isomeric octadecenoic acids are related inversely to arachidonic acid and DHA and positively related to mead acid in umbilical vessel wall lipids. | 2002 | Lipids | pmid:12530555 |
Murakami C et al. | A novel DNA polymerase inhibitor and a potent apoptosis inducer: 2-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)-glyceride with stearic acid. | 2003 | Biochim. Biophys. Acta | pmid:12535613 |
Vink BW et al. | A case of rhinolithiasis in botswana: a mineralogical, microscopic and chemical study. | 2002 | J Laryngol Otol | pmid:12537618 |
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Higashi N and Senoo H | Distribution of vitamin A-storing lipid droplets in hepatic stellate cells in liver lobules--a comparative study. | 2003 | Anat Rec A Discov Mol Cell Evol Biol | pmid:12552640 |
Heurtault B et al. | The influence of lipid nanocapsule composition on their size distribution. | 2003 | Eur J Pharm Sci | pmid:12554073 |
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Alvarez-Lueje A et al. | A selective HPLC method for determination of lercanidipine in tablets. | 2003 | J Pharm Biomed Anal | pmid:12560043 |
Ulloth JE et al. | Palmitic and stearic fatty acids induce caspase-dependent and -independent cell death in nerve growth factor differentiated PC12 cells. | 2003 | J. Neurochem. | pmid:12562510 |
Matera M et al. | History of L-carnitine: implications for renal disease. | 2003 | J Ren Nutr | pmid:12563618 |
Rastogi S et al. | Effect of treatment for Chlamydia trachomatis during pregnancy. | 2003 | Int J Gynaecol Obstet | pmid:12566185 |
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Chen DB et al. | [In vitro and in vivo study of two kinds of long-circulating solid lipid nanoparticles containing paclitaxel]. | 2002 | Yao Xue Xue Bao | pmid:12579901 |
Steinberg FM et al. | Cocoa and chocolate flavonoids: implications for cardiovascular health. | 2003 | J Am Diet Assoc | pmid:12589329 |
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Spencer MM et al. | Mapping the Fas locus controlling stearic acid content in soybean. | 2003 | Theor. Appl. Genet. | pmid:12595989 |
Lisetski LN et al. | Effects of membranotropic agents on mono- and multilayer structures of dipalmitoylphosphatidylcholine. | 2002 | Eur. Biophys. J. | pmid:12602341 |
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Adams ML and Kwon GS | Relative aggregation state and hemolytic activity of amphotericin B encapsulated by poly(ethylene oxide)-block-poly(N-hexyl-L-aspartamide)-acyl conjugate micelles: effects of acyl chain length. | 2003 | J Control Release | pmid:12618020 |
Al-Belasy FA and Hairam AR | The efficacy of azithromycin in the treatment of acute infraorbital space infection. | 2003 | J. Oral Maxillofac. Surg. | pmid:12618970 |
Fernández-Moya V et al. | Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds. | 2003 | Planta | pmid:12624771 |
Yamashita T et al. | [Blood concentration and urinary excretion in human of OE-7, a gastric hard capsule containing enteric-coated granules. I (author's transl)]. | 1976 | Jpn J Antibiot | pmid:1263346 |
Musiał W and Kubis A | Preliminary assessment of alginic acid as a factor buffering triethanolamine interacting with artificial skin sebum. | 2003 | Eur J Pharm Biopharm | pmid:12637103 |
Adlof RO and List GR | Synthesis and analysis of symmetrical and nonsymmetrical disaturated/monounsaturated triacylglycerols. | 2003 | J. Agric. Food Chem. | pmid:12643679 |
Grassi M et al. | Preparation and evaluation of a melt pelletised paracetamol/stearic acid sustained release delivery system. | 2003 | J Control Release | pmid:12644364 |
Sabbah A | [Letter: Immunodepressive action of erythromycin ethyl-succinate and erythromycin stearate. Study by the lymphoblastic transformation test and natural and rheumatoid rosette test]. | 1976 | Nouv Presse Med | pmid:1264643 |
Sugimoto T et al. | Synthesis of uniform anatase TiO2 nanoparticles by gel-sol method. 4. Shape control. | 2003 | J Colloid Interface Sci | pmid:12651133 |
Roy S et al. | Characterization of physical mixtures and directly compressed tablets of sulfamerazine polymorphs: implications on in vitro release characteristics. | 2003 | J Pharm Sci | pmid:12661061 |
Sanders TA et al. | Influence of triacylglycerol structure on the postprandial response of factor VII to stearic acid-rich fats. | 2003 | Am. J. Clin. Nutr. | pmid:12663272 |
Heude B et al. | Cognitive decline and fatty acid composition of erythrocyte membranes--The EVA Study. | 2003 | Am. J. Clin. Nutr. | pmid:12663275 |
Eitel K et al. | Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. | 2003 | Diabetes | pmid:12663471 |
Guo M and Augsburger LL | Potential application of silicified microcrystalline cellulose in direct-fill formulations for automatic capsule-filling machines. | 2003 | Pharm Dev Technol | pmid:12665197 |
Lundberg B | Thermal properties of systems containing cholesteryl esters and triglycerides. | 1976 | Acta Chem. Scand., B, Org. Chem. Biochem. | pmid:1266525 |
Bolhuis GK et al. | Hollow filler-binders as excipients for direct compaction. | 2003 | Pharm. Res. | pmid:12669977 |
Pickart LR and Thaler MM | Free fatty acids and albumin as mediators of thrombin-stimulated fibrinogen synthesis. | 1976 | Am. J. Physiol. | pmid:1267031 |
Bonaventure G et al. | Disruption of the FATB gene in Arabidopsis demonstrates an essential role of saturated fatty acids in plant growth. | 2003 | Plant Cell | pmid:12671095 |
Feller SE et al. | Rhodopsin exhibits a preference for solvation by polyunsaturated docosohexaenoic acid. | 2003 | J. Am. Chem. Soc. | pmid:12683809 |
Lu ZH et al. | Saturated free fatty acids, palmitic acid and stearic acid, induce apoptosis by stimulation of ceramide generation in rat testicular Leydig cell. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12684033 |
Ayvaz G et al. | Acute and chronic effects of different concentrations of free fatty acids on the insulin secreting function of islets. | 2002 | Diabetes Metab. | pmid:12688627 |
Sauvant P et al. | Amounts and types of fatty acids in meals affect the pattern of retinoids secreted in human chylomicrons after a high-dose preformed vitamin A intake. | 2003 | Metab. Clin. Exp. | pmid:12701068 |
AbuGhazaleh AA et al. | Milk conjugated linoleic acid response to fish oil supplementation of diets differing in fatty acid profiles. | 2003 | J. Dairy Sci. | pmid:12703631 |
Siswoyo TA and Morita N | Thermal properties of partially hydrolyzed starch-glycerophosphatidylcholine complexes with various acyl chains. | 2003 | J. Agric. Food Chem. | pmid:12720409 |
Eitel K et al. | [Apoptosis induced by free fatty acids]. | 2003 | Med. Klin. (Munich) | pmid:12721668 |
Mashek DG and Grummer RR | Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liver. | 2003 | J. Dairy Sci. | pmid:12741546 |
Adams ML et al. | Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. | Biomacromolecules | pmid:12741794 | |
Gorinstein S et al. | Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging tests. | 2003 | J. Nutr. Biochem. | pmid:12742543 |